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The map label for this gene is fumC

Identifier: 57650640

GI number: 57650640

Start: 1963566

End: 1964951

Strand: Reverse

Name: fumC

Synonym: SACOL1908

Alternate gene names: 57650640

Gene position: 1964951-1963566 (Counterclockwise)

Preceding gene: 57650641

Following gene: 57650638

Centisome position: 69.94

GC content: 34.56

Gene sequence:

>1386_bases
ATGTCAGTAAGAATTGAACATGATACTTTTGGAGAAATAGAAGTACCTGCAGATAAATATTGGGGTGCTCAAACAGAAAG
AAGTAAACGTAATTTCCCAGTTGGTAAAGAGCGTATGCCAATCGAAGTAGTTTATGGTTTTGCACAACTAAAGCGTGCAG
CAGCAATAGCTAATTTTGATTTAGGAAAATTAAGCGAGGCAAAGAAAGATGCCATTGTATACGCATGTGATCAAATTTTA
TCAGGTGAATTAGATGAACACTTCCCACTAGTTGTATGGCAAACAGGAAGCGGTACACAAAGTAATATGAATGTGAACGA
AGTAGTAAGTTATGTTGCTAATATGTATTTAAAAGATCATCAAAGTGATGAAAGTATCCACCCAAATGATGATGTAAATA
AATCTCAAAGTTCGAATGATACATTCCCAACTGCTATGCACGTTGCATTATATCAAGAGGTTGAAACAAAATTAGAACCT
GCATTAAAACTTTTAAGAAATACTTTGAAAGAAAAAGAAGATAAATTTGATTCAATTATTAAAATTGGTCGTACACATTT
ACAAGATGCAACGCCGATCAAACTAGGACAAGAGATTAGTGGCTGGCGTTATATGCTTGACCGTTGTGAAACAATGTTAT
CTGAATCTAAGAAGCACATTTTAAATCTTGCCATCGGTGGTACGGCTGTTGGTACTGGTATTAATGCGCATCCTGAATTT
GGTGATAAAGTGGCACATTATATTTCAGAAAATACGGGTTATCCATTTGTATCTTCTGAAAATAAATTCCACGCACTTAC
AGCGCATGATGAAGTTGTTCAATTGCATGGAACATTGAAGGCATTAGCAGGAGACTTAATGAAAATTGCTAATGATGTGA
GATGGTTGGCTTCAGGGCCACGAGCTGGTTTGGCAGAAATTTCTATCCCTGAAAATGAACCAGGTTCATCAATTATGCCT
GGTAAAGTTAATCCTACACAATGTGAAATGTTAACAATGGTTGCAGTCCAAGTAATGGGTAATGATACAGTTGTTGGCTT
CGCAAGTTCACAAGGTAACTTTGAATTGAATGTTTATAAACCAGTTATTATGCATAATACACTACAATCAATTTATCTTT
TAGCTGATGGTATGGAAACATTTAATAACAATTGTGCAGTGGGCATTGAACCAATCGAAGAGAATATTGATAATTATTTA
AATCAATCATTAATGTTAGTTACTGCATTAAATCCACATATTGGTTATGAAAAAGCAGCTCAAATTGCTAAGAAAGCCCA
TAAAGAAGGTTTAACTTTAAAAGAATCTGCAATTCAAACTGGATATGTTACAGAAGAACAATTTGAAGCATGGATTAAAC
CAGAAGATATGGTAGATCCTCATTAA

Upstream 100 bases:

>100_bases
TTTATTTCAAATTATGAAAACGTTTTAATCATAAATTGCTCAATTAAATTATTTAATGATATACTACAGTTAAATAAACA
GTGATAAGGGGAGAAATTGA

Downstream 100 bases:

>100_bases
TTAAATATTAATATAAAATAAAGTTTGGGCATTACAGGTAGATGTAGTGTTCAAGCTTTATTTTTTGTCTATGTCAAATT
GAACTTATAAGTCTGATTTG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAAIANFDLGKLSEAKKDAIVYACDQIL
SGELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDHQSDESIHPNDDVNKSQSSNDTFPTAMHVALYQEVETKLEP
ALKLLRNTLKEKEDKFDSIIKIGRTHLQDATPIKLGQEISGWRYMLDRCETMLSESKKHILNLAIGGTAVGTGINAHPEF
GDKVAHYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGPRAGLAEISIPENEPGSSIMP
GKVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYKPVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYL
NQSLMLVTALNPHIGYEKAAQIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH

Sequences:

>Translated_461_residues
MSVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAAIANFDLGKLSEAKKDAIVYACDQIL
SGELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDHQSDESIHPNDDVNKSQSSNDTFPTAMHVALYQEVETKLEP
ALKLLRNTLKEKEDKFDSIIKIGRTHLQDATPIKLGQEISGWRYMLDRCETMLSESKKHILNLAIGGTAVGTGINAHPEF
GDKVAHYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGPRAGLAEISIPENEPGSSIMP
GKVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYKPVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYL
NQSLMLVTALNPHIGYEKAAQIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH
>Mature_460_residues
SVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAAIANFDLGKLSEAKKDAIVYACDQILS
GELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDHQSDESIHPNDDVNKSQSSNDTFPTAMHVALYQEVETKLEPA
LKLLRNTLKEKEDKFDSIIKIGRTHLQDATPIKLGQEISGWRYMLDRCETMLSESKKHILNLAIGGTAVGTGINAHPEFG
DKVAHYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGPRAGLAEISIPENEPGSSIMPG
KVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYKPVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYLN
QSLMLVTALNPHIGYEKAAQIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=57.1428571428571, Blast_Score=516, Evalue=1e-146,
Organism=Escherichia coli, GI1787896, Length=458, Percent_Identity=60.4803493449782, Blast_Score=566, Evalue=1e-162,
Organism=Escherichia coli, GI87082375, Length=464, Percent_Identity=37.5, Blast_Score=313, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=57.4837310195228, Blast_Score=542, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=57.361963190184, Blast_Score=392, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=54.6637744034707, Blast_Score=509, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=57.0498915401301, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=57.0498915401301, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=56.4935064935065, Blast_Score=522, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=51.7316017316017, Blast_Score=473, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=46.5367965367965, Blast_Score=429, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FUMC_STAAC (Q5HES4)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_186733.1
- ProteinModelPortal:   Q5HES4
- SMR:   Q5HES4
- STRING:   Q5HES4
- EnsemblBacteria:   EBSTAT00000009513
- GeneID:   3237674
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL1908
- TIGR:   SACOL1908
- eggNOG:   COG0114
- GeneTree:   EBGT00050000024474
- HOGENOM:   HBG284369
- OMA:   RIEKDTM
- ProtClustDB:   PRK00485
- BioCyc:   SAUR93062:SACOL1908-MONOMER
- HAMAP:   MF_00743
- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00979

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.2.1.2

Molecular weight: Translated: 51108; Mature: 50977

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: BINDING 99-99

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAAIANFD
CCEEECCCCCCCEECCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
LGKLSEAKKDAIVYACDQILSGELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDH
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
QSDESIHPNDDVNKSQSSNDTFPTAMHVALYQEVETKLEPALKLLRNTLKEKEDKFDSII
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPIKLGQEISGWRYMLDRCETMLSESKKHILNLAIGGTAVGTGINAHPEF
HHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCEEECCCCCCCCCH
GDKVAHYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGP
HHHHHHHHHCCCCCCEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RAGLAEISIPENEPGSSIMPGKVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYK
CCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEC
PVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYLNQSLMLVTALNPHIGYEKAA
HHHHHHHHHHHHHHHCCHHHHCCCCEEECCHHHHHHHHHHCCCEEEEEECCCCCCHHHHH
QIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH
HHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAAIANFD
CEEECCCCCCCEECCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
LGKLSEAKKDAIVYACDQILSGELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDH
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCC
QSDESIHPNDDVNKSQSSNDTFPTAMHVALYQEVETKLEPALKLLRNTLKEKEDKFDSII
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPIKLGQEISGWRYMLDRCETMLSESKKHILNLAIGGTAVGTGINAHPEF
HHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCEEECCCCCCCCCH
GDKVAHYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGP
HHHHHHHHHCCCCCCEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RAGLAEISIPENEPGSSIMPGKVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYK
CCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEC
PVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYLNQSLMLVTALNPHIGYEKAA
HHHHHHHHHHHHHHHCCHHHHCCCCEEECCHHHHHHHHHHCCCEEEEEECCCCCCHHHHH
QIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH
HHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA