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The map label for this gene is hemG [H]

Identifier: 57650620

GI number: 57650620

Start: 1942065

End: 1943465

Strand: Reverse

Name: hemG [H]

Synonym: SACOL1887

Alternate gene names: 57650620

Gene position: 1943465-1942065 (Counterclockwise)

Preceding gene: 57650621

Following gene: 57650618

Centisome position: 69.18

GC content: 34.98

Gene sequence:

>1401_bases
GTGACTAAATCAGTGGCTATTATAGGAGCGGGGATAACAGGTTTATCAAGTGCATATTTTTTAAAACAGCAAGATCCTAA
TATTGATGTAACCATCTTTGAAGCATCGAATCGTCCGGGGGGAAAGATTCAATCGTATCGTAAAGATGGTTATATGATTG
AACTAGGGCCTGAATCTTATTTAGGTAGAAAAACGATTATGACAGAATTAGCGAAAGATATTGGATTAGAACAAGATATT
GTTACAAATACGACTGGACAATCATATATTTTTGCGAAAAATAAATTATATCCGATTCCAGGTGGTTCAATTATGGGTAT
TCCAACAGATATTAAACCATTTGTTACTACAAAATTAATATCGCCACTTGGTAAATTAAGAGCAGGGTTTGATTTATTAA
AAAAACCTACTCAAATGCAGGATGGTGACATTTCTGTTGGTGCATTTTTCAGAGCAAGATTAGGTAATGAGGTACTTGAG
AATTTAATAGAGCCTTTAATGGGTGGTATTTATGGTACCGATATTGATAAATTAAGTTTGATGAGTACGTTTCCTAATTT
TAAAGAAAAAGAAGAGGCATTCGGAAGTCTGATAAAAGGTATGAAGGATGAGAAAAATAAGCGTCTGAAACAAAGACAAT
TATATCCTGGCGCACCGAAAGGACAATTCAAACAATTTAAGCATGGTTTAAGCTCATTTATTGAAGCATTAGAACAAGAT
GTTAAAAATAAAGGTGTGACAATACGCTACAATACGTCAGTGGATGATATAATTACATCTCAAAAACAATATAAAATTGT
TTACAATGATCAACTAGAAGAAGTGTATGATGGCGTATTAGTAACGACACCACATCAAGTGTTTTTAAATTGGTTCGGAC
AAGATCCAGCATTTGATTACTTTAAAACGATGGATAGTACGACTGTTGCAACTGTTGTATTGGCATTTGATGAAAAAGAC
ATTGAAAATACCCATGATGGTACTGGCTTCGTAATTGCGAGAACGAGTGATACAGACATTACCGCATGTACTTGGACATC
GAAAAAATGGCCATTTACTACACCGGAAGGTAAGGTTTTGATTCGTGCGTATGTAGGTAAACCAGGTGATACTGTGGTTG
ATGATCATACAGATAATGAATTAGTATCGATTGTACGTAGAGATTTAAGTCAAATGATGACATTTAAAGGTGATCCTGAA
TTTACAATTGTCAATCGTTTGCCGAAAAGTATGCCACAGTACCATGTCGGTCATATTCAACAAATTAGACAGATTCAAGC
ACATATTAAACAAACATATCCACGACTTAGAGTAACTGGTGCATCTTTTGAAGCGGTTGGACTACCTGATTGTATTACGC
AAGGTAAAGTTGCTGCTGAAGAAGTAATCGCAGAGTTGTAA

Upstream 100 bases:

>100_bases
ATTATCGTCCAAAAATGCCGAATACACATCCATTATTTATCGGTGCAATTGTTGATGAAATCAAGTCTATATTTTAATGA
CGAAAGAAGCGTGAAACGTT

Downstream 100 bases:

>100_bases
GTTAATTGTTGGATGGTGTTGGTGTAGGTGCGACGCCTTTAGATAATGTTTGATGAAATATAGTCATTTTTAAGTTATAT
AATGGTGGAAGTAATGTGTA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTKSVAIIGAGITGLSSAYFLKQQDPNIDVTIFEASNRPGGKIQSYRKDGYMIELGPESYLGRKTIMTELAKDIGLEQDI
VTNTTGQSYIFAKNKLYPIPGGSIMGIPTDIKPFVTTKLISPLGKLRAGFDLLKKPTQMQDGDISVGAFFRARLGNEVLE
NLIEPLMGGIYGTDIDKLSLMSTFPNFKEKEEAFGSLIKGMKDEKNKRLKQRQLYPGAPKGQFKQFKHGLSSFIEALEQD
VKNKGVTIRYNTSVDDIITSQKQYKIVYNDQLEEVYDGVLVTTPHQVFLNWFGQDPAFDYFKTMDSTTVATVVLAFDEKD
IENTHDGTGFVIARTSDTDITACTWTSKKWPFTTPEGKVLIRAYVGKPGDTVVDDHTDNELVSIVRRDLSQMMTFKGDPE
FTIVNRLPKSMPQYHVGHIQQIRQIQAHIKQTYPRLRVTGASFEAVGLPDCITQGKVAAEEVIAEL

Sequences:

>Translated_466_residues
MTKSVAIIGAGITGLSSAYFLKQQDPNIDVTIFEASNRPGGKIQSYRKDGYMIELGPESYLGRKTIMTELAKDIGLEQDI
VTNTTGQSYIFAKNKLYPIPGGSIMGIPTDIKPFVTTKLISPLGKLRAGFDLLKKPTQMQDGDISVGAFFRARLGNEVLE
NLIEPLMGGIYGTDIDKLSLMSTFPNFKEKEEAFGSLIKGMKDEKNKRLKQRQLYPGAPKGQFKQFKHGLSSFIEALEQD
VKNKGVTIRYNTSVDDIITSQKQYKIVYNDQLEEVYDGVLVTTPHQVFLNWFGQDPAFDYFKTMDSTTVATVVLAFDEKD
IENTHDGTGFVIARTSDTDITACTWTSKKWPFTTPEGKVLIRAYVGKPGDTVVDDHTDNELVSIVRRDLSQMMTFKGDPE
FTIVNRLPKSMPQYHVGHIQQIRQIQAHIKQTYPRLRVTGASFEAVGLPDCITQGKVAAEEVIAEL
>Mature_465_residues
TKSVAIIGAGITGLSSAYFLKQQDPNIDVTIFEASNRPGGKIQSYRKDGYMIELGPESYLGRKTIMTELAKDIGLEQDIV
TNTTGQSYIFAKNKLYPIPGGSIMGIPTDIKPFVTTKLISPLGKLRAGFDLLKKPTQMQDGDISVGAFFRARLGNEVLEN
LIEPLMGGIYGTDIDKLSLMSTFPNFKEKEEAFGSLIKGMKDEKNKRLKQRQLYPGAPKGQFKQFKHGLSSFIEALEQDV
KNKGVTIRYNTSVDDIITSQKQYKIVYNDQLEEVYDGVLVTTPHQVFLNWFGQDPAFDYFKTMDSTTVATVVLAFDEKDI
ENTHDGTGFVIARTSDTDITACTWTSKKWPFTTPEGKVLIRAYVGKPGDTVVDDHTDNELVSIVRRDLSQMMTFKGDPEF
TIVNRLPKSMPQYHVGHIQQIRQIQAHIKQTYPRLRVTGASFEAVGLPDCITQGKVAAEEVIAEL

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=488, Percent_Identity=23.7704918032787, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4506001, Length=488, Percent_Identity=23.7704918032787, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320851, Length=210, Percent_Identity=31.4285714285714, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24649745, Length=460, Percent_Identity=24.5652173913043, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 51984; Mature: 51853

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSVAIIGAGITGLSSAYFLKQQDPNIDVTIFEASNRPGGKIQSYRKDGYMIELGPESY
CCCCEEEEECCHHHCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHCCCCEEEEECCHHH
LGRKTIMTELAKDIGLEQDIVTNTTGQSYIFAKNKLYPIPGGSIMGIPTDIKPFVTTKLI
HHHHHHHHHHHHHCCCCCHHEECCCCCEEEEECCEEEECCCCCEECCCCCCHHHHHHHHH
SPLGKLRAGFDLLKKPTQMQDGDISVGAFFRARLGNEVLENLIEPLMGGIYGTDIDKLSL
HHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
MSTFPNFKEKEEAFGSLIKGMKDEKNKRLKQRQLYPGAPKGQFKQFKHGLSSFIEALEQD
HHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VKNKGVTIRYNTSVDDIITSQKQYKIVYNDQLEEVYDGVLVTTPHQVFLNWFGQDPAFDY
HHHCCEEEEECCCHHHHHCCCCCEEEEECCCHHHHHCCEEEECCHHHHHHHCCCCCCHHH
FKTMDSTTVATVVLAFDEKDIENTHDGTGFVIARTSDTDITACTWTSKKWPFTTPEGKVL
HHHCCCCEEEEEEEEECCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCEE
IRAYVGKPGDTVVDDHTDNELVSIVRRDLSQMMTFKGDPEFTIVNRLPKSMPQYHVGHIQ
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCHHHHHHHH
QIRQIQAHIKQTYPRLRVTGASFEAVGLPDCITQGKVAAEEVIAEL
HHHHHHHHHHHHCCCEEEECCCEEECCCCHHHHCCCHHHHHHHHCC
>Mature Secondary Structure 
TKSVAIIGAGITGLSSAYFLKQQDPNIDVTIFEASNRPGGKIQSYRKDGYMIELGPESY
CCCEEEEECCHHHCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHCCCCEEEEECCHHH
LGRKTIMTELAKDIGLEQDIVTNTTGQSYIFAKNKLYPIPGGSIMGIPTDIKPFVTTKLI
HHHHHHHHHHHHHCCCCCHHEECCCCCEEEEECCEEEECCCCCEECCCCCCHHHHHHHHH
SPLGKLRAGFDLLKKPTQMQDGDISVGAFFRARLGNEVLENLIEPLMGGIYGTDIDKLSL
HHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
MSTFPNFKEKEEAFGSLIKGMKDEKNKRLKQRQLYPGAPKGQFKQFKHGLSSFIEALEQD
HHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VKNKGVTIRYNTSVDDIITSQKQYKIVYNDQLEEVYDGVLVTTPHQVFLNWFGQDPAFDY
HHHCCEEEEECCCHHHHHCCCCCEEEEECCCHHHHHCCEEEECCHHHHHHHCCCCCCHHH
FKTMDSTTVATVVLAFDEKDIENTHDGTGFVIARTSDTDITACTWTSKKWPFTTPEGKVL
HHHCCCCEEEEEEEEECCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCEE
IRAYVGKPGDTVVDDHTDNELVSIVRRDLSQMMTFKGDPEFTIVNRLPKSMPQYHVGHIQ
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCHHHHHHHH
QIRQIQAHIKQTYPRLRVTGASFEAVGLPDCITQGKVAAEEVIAEL
HHHHHHHHHHHHCCCEEEECCCEEECCCCHHHHCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]