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The map label for this gene is menB

Identifier: 57650239

GI number: 57650239

Start: 1060326

End: 1061147

Strand: Direct

Name: menB

Synonym: SACOL1054

Alternate gene names: 57650239

Gene position: 1060326-1061147 (Clockwise)

Preceding gene: 57650238

Following gene: 57650245

Centisome position: 37.74

GC content: 38.69

Gene sequence:

>822_bases
ATGACTAACAGACAATGGGAAACACTTAGAGAATATGATGAAATCAAATATGAATTTTACGAAGGGATTGCTAAGGTAAC
AATAAATCGCCCTGAAGTACGCAATGCGTTTACACCTAAAACAGTTGCTGAAATGATTGACGCATTTTCACGTGCACGTG
ATGATCAAAACGTTTCAGTTATCGTATTAACTGGTGAAGGTGATTTAGCATTCTGTTCTGGTGGTGACCAGAAGAAACGT
GGACATGGTGGTTATGTAGGTGAAGACCAAATCCCTCGCTTAAATGTATTAGATTTACAGCGTTTAATTCGTATTATTCC
AAAACCGGTTATCGCGATGGTAAAAGGTTATGCTGTAGGTGGCGGTAATGTACTAAATGTTGTTTGTGACTTAACGATTG
CTGCTGATAATGCTATTTTTGGACAAACTGGTCCTAAAGTAGGTTCATTTGATGCGGGTTATGGTTCAGGATATTTAGCA
CGTATCGTTGGACATAAGAAAGCACGTGAAATTTGGTACTTATGTCGTCAATACAATGCACAAGAAGCTTTAGATATGGG
TCTAGTAAATACAGTGGTACCTTTAGAGAAAGTTGAAGATGAAACTGTGCAATGGTGTAAAGAGATTATGAAACACTCAC
CAACAGCGTTACGATTCCTTAAAGCAGCTATGAATGCTGACACAGATGGTTTAGCTGGTTTACAACAAATGGCTGGGGAT
GCAACATTGCTTTATTACACAACTGATGAAGCGAAAGAAGGCCGTGATGCGTTTAAAGAAAAACGTGATCCTGACTTCGA
TCAATTCCCTAAATTCCCATAA

Upstream 100 bases:

>100_bases
AGTAAATGTAAATTAATTTCTGCTACAGGTCATACAATTCATGTGGAAGATAGTGATGAATTTGATACAATGATATTAGG
ATTTTTAAAGGAGGAGCAAA

Downstream 100 bases:

>100_bases
GTTATTTTGAATATGATATTAAGTCACTTGCGTCGTTTATTAGCGACGATAGGTGGCTTTTTTATTTTATAAGAATTTAA
AAGGGCATTTTAATTAATTA

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MTNRQWETLREYDEIKYEFYEGIAKVTINRPEVRNAFTPKTVAEMIDAFSRARDDQNVSVIVLTGEGDLAFCSGGDQKKR
GHGGYVGEDQIPRLNVLDLQRLIRIIPKPVIAMVKGYAVGGGNVLNVVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLA
RIVGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEKVEDETVQWCKEIMKHSPTALRFLKAAMNADTDGLAGLQQMAGD
ATLLYYTTDEAKEGRDAFKEKRDPDFDQFPKFP

Sequences:

>Translated_273_residues
MTNRQWETLREYDEIKYEFYEGIAKVTINRPEVRNAFTPKTVAEMIDAFSRARDDQNVSVIVLTGEGDLAFCSGGDQKKR
GHGGYVGEDQIPRLNVLDLQRLIRIIPKPVIAMVKGYAVGGGNVLNVVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLA
RIVGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEKVEDETVQWCKEIMKHSPTALRFLKAAMNADTDGLAGLQQMAGD
ATLLYYTTDEAKEGRDAFKEKRDPDFDQFPKFP
>Mature_272_residues
TNRQWETLREYDEIKYEFYEGIAKVTINRPEVRNAFTPKTVAEMIDAFSRARDDQNVSVIVLTGEGDLAFCSGGDQKKRG
HGGYVGEDQIPRLNVLDLQRLIRIIPKPVIAMVKGYAVGGGNVLNVVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLAR
IVGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEKVEDETVQWCKEIMKHSPTALRFLKAAMNADTDGLAGLQQMAGDA
TLLYYTTDEAKEGRDAFKEKRDPDFDQFPKFP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) (Probable)

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family

Homologues:

Organism=Homo sapiens, GI194097323, Length=243, Percent_Identity=32.5102880658436, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI31542718, Length=266, Percent_Identity=28.9473684210526, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI260274832, Length=204, Percent_Identity=30.8823529411765, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI45643119, Length=204, Percent_Identity=30.8823529411765, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI260275230, Length=204, Percent_Identity=30.8823529411765, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI4502327, Length=278, Percent_Identity=28.7769784172662, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI70995211, Length=236, Percent_Identity=27.9661016949153, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1788597, Length=272, Percent_Identity=64.7058823529412, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1787659, Length=245, Percent_Identity=33.0612244897959, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI221142681, Length=257, Percent_Identity=31.1284046692607, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI87082183, Length=263, Percent_Identity=28.8973384030418, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787660, Length=252, Percent_Identity=29.7619047619048, Blast_Score=84, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI25145438, Length=248, Percent_Identity=33.0645161290323, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17554946, Length=249, Percent_Identity=30.5220883534137, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17540714, Length=222, Percent_Identity=30.1801801801802, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17560910, Length=189, Percent_Identity=32.8042328042328, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17549921, Length=207, Percent_Identity=28.9855072463768, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17535521, Length=253, Percent_Identity=25.296442687747, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17536985, Length=223, Percent_Identity=26.9058295964126, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=263, Percent_Identity=26.9961977186312, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI20129971, Length=269, Percent_Identity=33.8289962825279, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24653477, Length=269, Percent_Identity=33.8289962825279, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24653139, Length=255, Percent_Identity=29.4117647058824, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19922422, Length=268, Percent_Identity=24.6268656716418, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357171, Length=187, Percent_Identity=31.5508021390374, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24650670, Length=267, Percent_Identity=27.7153558052434, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24654903, Length=266, Percent_Identity=24.4360902255639, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MENB_STAAC (Q5HH38)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_185919.1
- PDB:   2UZF
- PDBsum:   2UZF
- ProteinModelPortal:   Q5HH38
- SMR:   Q5HH38
- STRING:   Q5HH38
- EnsemblBacteria:   EBSTAT00000010235
- GeneID:   3236163
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL1054
- TIGR:   SACOL1054
- eggNOG:   COG0447
- GeneTree:   EBGT00050000025451
- HOGENOM:   HBG748731
- OMA:   DEMTEAF
- ProtClustDB:   PRK07396
- BioCyc:   SAUR93062:SACOL1054-MONOMER
- InterPro:   IPR001753
- InterPro:   IPR010198
- TIGRFAMs:   TIGR01929

Pfam domain/function: PF00378 ECH

EC number: =4.1.3.36

Molecular weight: Translated: 30426; Mature: 30295

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: BINDING 143-143 BINDING 149-149

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRQWETLREYDEIKYEFYEGIAKVTINRPEVRNAFTPKTVAEMIDAFSRARDDQNVSV
CCCCHHHHHHHHHHHHHHHHHHHHHEEECCCHHCCCCCHHHHHHHHHHHHHCCCCCCEEE
IVLTGEGDLAFCSGGDQKKRGHGGYVGEDQIPRLNVLDLQRLIRIIPKPVIAMVKGYAVG
EEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCC
GGNVLNVVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARIVGHKKAREIWYLCRQYNA
CCHHEEHEEEEEEECCCCEECCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCH
QEALDMGLVNTVVPLEKVEDETVQWCKEIMKHSPTALRFLKAAMNADTDGLAGLQQMAGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCC
ATLLYYTTDEAKEGRDAFKEKRDPDFDQFPKFP
EEEEEEECCCHHHHHHHHHHCCCCCHHHCCCCC
>Mature Secondary Structure 
TNRQWETLREYDEIKYEFYEGIAKVTINRPEVRNAFTPKTVAEMIDAFSRARDDQNVSV
CCCHHHHHHHHHHHHHHHHHHHHHEEECCCHHCCCCCHHHHHHHHHHHHHCCCCCCEEE
IVLTGEGDLAFCSGGDQKKRGHGGYVGEDQIPRLNVLDLQRLIRIIPKPVIAMVKGYAVG
EEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCC
GGNVLNVVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARIVGHKKAREIWYLCRQYNA
CCHHEEHEEEEEEECCCCEECCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCH
QEALDMGLVNTVVPLEKVEDETVQWCKEIMKHSPTALRFLKAAMNADTDGLAGLQQMAGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCC
ATLLYYTTDEAKEGRDAFKEKRDPDFDQFPKFP
EEEEEEECCCHHHHHHHHHHCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA