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The map label for this gene is htrA [C]

Identifier: 57650214

GI number: 57650214

Start: 1036719

End: 1039028

Strand: Direct

Name: htrA [C]

Synonym: SACOL1028

Alternate gene names: 57650214

Gene position: 1036719-1039028 (Clockwise)

Preceding gene: 57650213

Following gene: 57650215

Centisome position: 36.9

GC content: 31.39

Gene sequence:

>2310_bases
GTGGATATTGGTAAAAAACATGTAATTCCTAAAAGTCAGTACCGACGTAAGCGTCGTGAATTCTTCCACAACGAAGACAG
AGAAGAAAATTTAAATCAACATCAAGATAAACAAAATATAGATAATACAACATCAAAAAAAGCAGATAAGCAAATACATA
AAGATTCAATTGATAAGCACGAACGTTTTAAAAATAGTTTATCATCGCATTTAGAACAGAGAAACCGTGATGTTAATGAG
AATAAAGCTGAAGAAAGTAAAAGTAATCAGGATAGTAAGTCAGCATATAACAGAGATCATTATTTAACAGACGATGTATC
TAAAAAACAAAATTCATTAGATTCAGTGGACCAAGATACAGAGAAATCAAAATATTATGAGCAAAATTCTGAAGCGACTT
TATCAACTAAATCAACCGATAAAGTAGAATCAACTGAAATGAGAAAGCTAAGTTCAGATAAAAACAAAGTTGGTCATGAA
GAGCAACATGTACTTTCTAAACCTTCAGAACATGATAAAGAGACTAGAATTGATTCTGAGTCTTCAAGAACTGATTCAGA
CAGCTCGATGCAGACAGAGAAAATAAAAAAAGACAGTTCAGATGGAAATAAAAGTAGTAATCTGAAATCTGAAGTAATAT
CAGACAAATCAAATACAGTACCAAAATTGTCGGAATCTGATGATGAAGTAAATAATCAGAAGCCATTAACTTTACCGGAA
GAACAGAAATTGAAAAGACAGCAAAGTCAAAATGAGCAAACAAAAACCTATACATATGGTGATAGCGAACAAAATGACAA
GTCTAATCATGAAAATGATTTAAGTCATCATATACCATCGATAAGTGATGATAAAGATAACGTCATGAGAGAAAATCATA
TTGTTGACGATAATCCTGATAATGATATCAATACACCATCATTATCAAAAACAGATGACGATCGAAAACTTGATGAAAAA
ATTCATGTTGAAGATAAACATAAACAAAATGCAGACTCGTCTGAAACGGTGGGATATCAAAGTCAGTCAACTGCATCTCA
TCGTAGCACTGAAAAAAGAAATATTTCTATTAATGACCATGATAAATTAAACGGTCAAAAAACAAATACAAAGACATCGG
CAAATAATAATCAAAAAAAGGCTACATCAAAATTGAACAAAGGGCGCGCTACGAATAATAATTATAGTGACATTTTGAAA
AAGTTTTGGATGATGTATTGGCCTAAATTAGTTATTCTAATGGGTATTATTATTCTAATTGTTATTTTGAATGCCATTTT
TAATAATGTGAACAAAAATGATCGCATGAATGATAATAATGATGCAGATGCTCAAAAATATACGACAACGATGAAAAATG
CCAATAACACAGTTAAATCGGTCGTTACAGTTGAAAATGAAACATCAAAAGATTCATCATTACCTAAAGATAAAGCATCT
CAAGACGAAGTGGGATCAGGTGTTGTATATAAAAAATCTGGAGATACGTTATATATTGTTACGAATGCACACGTTGTCGG
TGATAAAGAAAATCAAAAAATAACTTTCTCGAATAATAAAAGTGTTGTTGGGAAAGTGCTTGGTAAAGATAAATGGTCAG
ATTTAGCTGTTGTTAAAGCAACTTCTTCAGACAGTTCAGTGAAAGAGATAGCTATTGGAGATTCAAATAATTTAGTGTTA
GGAGAGCCAATATTAGTCGTAGGTAATCCACTTGGTGTAGACTTTAAAGGCACTGTGACAGAAGGTATTATTTCAGGTCT
GAACAGAAATGTTCCTATTGATTTCGATAAAGATAATAAATATGATATGTTGATGAAAGCTTTCCAAATTGATGCATCAG
TAAATCCAGGTAACTCGGGTGGTGCTGTCGTCAATAGAGAAGGAAAATTAATAGGTGTAGTTGCAGCTAAAATTAGTATG
CCAAACGTTGAAAATATGTCATTTGCAATACCTGTTAATGAAGTACAAAAGATTGTAAAAGATTTAGAAACAAAAGGTAA
AATTGACTATCCCGATGTAGGTGTTAAAATGAAGAATATTGCCAGTCTAAATAGTTTTGAAAGACAAGCAGTTAAATTGC
CAGGAAAAGTTAAGAACGGTGTTGTTGTAGATCAAGTTGACAACAATGGTTTAGCAGATCAATCTGGTCTGAAAAAAGGT
GATGTAATTACTGAATTAGATGGCAAACTTTTAGAAGATGATTTACGCTTTAGGCAGATTATATTTAGTCATAAAGATGA
CTTGAAATCAATTACAGCGAAGATTTATAGAGATGGTAAAGAGAAAGAAATTAATATTAAACTAAAATAA

Upstream 100 bases:

>100_bases
TATTTAGCATTTTTTCAATAGAAATTATATAGATTTTAAAGCAAATTAGGTGTTAATGTGTCATAATGATAAGTGATTTT
ATTGAATGGAGTGGACATTA

Downstream 100 bases:

>100_bases
TGTTGAGGTGAACAACGTGTCAATTTTTAGCCAGTTTTTAAAAAGATCAAGCCCTCAACAAGGTATTGTATTGTACTATA
TCGTCGCAATTGTCATTGCA

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 769; Mature: 769

Protein sequence:

>769_residues
MDIGKKHVIPKSQYRRKRREFFHNEDREENLNQHQDKQNIDNTTSKKADKQIHKDSIDKHERFKNSLSSHLEQRNRDVNE
NKAEESKSNQDSKSAYNRDHYLTDDVSKKQNSLDSVDQDTEKSKYYEQNSEATLSTKSTDKVESTEMRKLSSDKNKVGHE
EQHVLSKPSEHDKETRIDSESSRTDSDSSMQTEKIKKDSSDGNKSSNLKSEVISDKSNTVPKLSESDDEVNNQKPLTLPE
EQKLKRQQSQNEQTKTYTYGDSEQNDKSNHENDLSHHIPSISDDKDNVMRENHIVDDNPDNDINTPSLSKTDDDRKLDEK
IHVEDKHKQNADSSETVGYQSQSTASHRSTEKRNISINDHDKLNGQKTNTKTSANNNQKKATSKLNKGRATNNNYSDILK
KFWMMYWPKLVILMGIIILIVILNAIFNNVNKNDRMNDNNDADAQKYTTTMKNANNTVKSVVTVENETSKDSSLPKDKAS
QDEVGSGVVYKKSGDTLYIVTNAHVVGDKENQKITFSNNKSVVGKVLGKDKWSDLAVVKATSSDSSVKEIAIGDSNNLVL
GEPILVVGNPLGVDFKGTVTEGIISGLNRNVPIDFDKDNKYDMLMKAFQIDASVNPGNSGGAVVNREGKLIGVVAAKISM
PNVENMSFAIPVNEVQKIVKDLETKGKIDYPDVGVKMKNIASLNSFERQAVKLPGKVKNGVVVDQVDNNGLADQSGLKKG
DVITELDGKLLEDDLRFRQIIFSHKDDLKSITAKIYRDGKEKEINIKLK

Sequences:

>Translated_769_residues
MDIGKKHVIPKSQYRRKRREFFHNEDREENLNQHQDKQNIDNTTSKKADKQIHKDSIDKHERFKNSLSSHLEQRNRDVNE
NKAEESKSNQDSKSAYNRDHYLTDDVSKKQNSLDSVDQDTEKSKYYEQNSEATLSTKSTDKVESTEMRKLSSDKNKVGHE
EQHVLSKPSEHDKETRIDSESSRTDSDSSMQTEKIKKDSSDGNKSSNLKSEVISDKSNTVPKLSESDDEVNNQKPLTLPE
EQKLKRQQSQNEQTKTYTYGDSEQNDKSNHENDLSHHIPSISDDKDNVMRENHIVDDNPDNDINTPSLSKTDDDRKLDEK
IHVEDKHKQNADSSETVGYQSQSTASHRSTEKRNISINDHDKLNGQKTNTKTSANNNQKKATSKLNKGRATNNNYSDILK
KFWMMYWPKLVILMGIIILIVILNAIFNNVNKNDRMNDNNDADAQKYTTTMKNANNTVKSVVTVENETSKDSSLPKDKAS
QDEVGSGVVYKKSGDTLYIVTNAHVVGDKENQKITFSNNKSVVGKVLGKDKWSDLAVVKATSSDSSVKEIAIGDSNNLVL
GEPILVVGNPLGVDFKGTVTEGIISGLNRNVPIDFDKDNKYDMLMKAFQIDASVNPGNSGGAVVNREGKLIGVVAAKISM
PNVENMSFAIPVNEVQKIVKDLETKGKIDYPDVGVKMKNIASLNSFERQAVKLPGKVKNGVVVDQVDNNGLADQSGLKKG
DVITELDGKLLEDDLRFRQIIFSHKDDLKSITAKIYRDGKEKEINIKLK
>Mature_769_residues
MDIGKKHVIPKSQYRRKRREFFHNEDREENLNQHQDKQNIDNTTSKKADKQIHKDSIDKHERFKNSLSSHLEQRNRDVNE
NKAEESKSNQDSKSAYNRDHYLTDDVSKKQNSLDSVDQDTEKSKYYEQNSEATLSTKSTDKVESTEMRKLSSDKNKVGHE
EQHVLSKPSEHDKETRIDSESSRTDSDSSMQTEKIKKDSSDGNKSSNLKSEVISDKSNTVPKLSESDDEVNNQKPLTLPE
EQKLKRQQSQNEQTKTYTYGDSEQNDKSNHENDLSHHIPSISDDKDNVMRENHIVDDNPDNDINTPSLSKTDDDRKLDEK
IHVEDKHKQNADSSETVGYQSQSTASHRSTEKRNISINDHDKLNGQKTNTKTSANNNQKKATSKLNKGRATNNNYSDILK
KFWMMYWPKLVILMGIIILIVILNAIFNNVNKNDRMNDNNDADAQKYTTTMKNANNTVKSVVTVENETSKDSSLPKDKAS
QDEVGSGVVYKKSGDTLYIVTNAHVVGDKENQKITFSNNKSVVGKVLGKDKWSDLAVVKATSSDSSVKEIAIGDSNNLVL
GEPILVVGNPLGVDFKGTVTEGIISGLNRNVPIDFDKDNKYDMLMKAFQIDASVNPGNSGGAVVNREGKLIGVVAAKISM
PNVENMSFAIPVNEVQKIVKDLETKGKIDYPDVGVKMKNIASLNSFERQAVKLPGKVKNGVVVDQVDNNGLADQSGLKKG
DVITELDGKLLEDDLRFRQIIFSHKDDLKSITAKIYRDGKEKEINIKLK

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=277, Percent_Identity=27.0758122743682, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI4506141, Length=257, Percent_Identity=30.7392996108949, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI24308541, Length=254, Percent_Identity=31.8897637795276, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI7019477, Length=260, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI1786356, Length=288, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1789629, Length=300, Percent_Identity=31.3333333333333, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1789630, Length=250, Percent_Identity=30.8, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24646839, Length=260, Percent_Identity=29.6153846153846, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 86432; Mature: 86432

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIGKKHVIPKSQYRRKRREFFHNEDREENLNQHQDKQNIDNTTSKKADKQIHKDSIDKH
CCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ERFKNSLSSHLEQRNRDVNENKAEESKSNQDSKSAYNRDHYLTDDVSKKQNSLDSVDQDT
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCHH
EKSKYYEQNSEATLSTKSTDKVESTEMRKLSSDKNKVGHEEQHVLSKPSEHDKETRIDSE
HHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHCCCCC
SSRTDSDSSMQTEKIKKDSSDGNKSSNLKSEVISDKSNTVPKLSESDDEVNNQKPLTLPE
CCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCH
EQKLKRQQSQNEQTKTYTYGDSEQNDKSNHENDLSHHIPSISDDKDNVMRENHIVDDNPD
HHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHCCCCCCCCC
NDINTPSLSKTDDDRKLDEKIHVEDKHKQNADSSETVGYQSQSTASHRSTEKRNISINDH
CCCCCCCCCCCCCHHHHHHHCCCCHHHHCCCCCCHHCCCCCCCCHHHHCCCCCCCCCCCC
DKLNGQKTNTKTSANNNQKKATSKLNKGRATNNNYSDILKKFWMMYWPKLVILMGIIILI
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VILNAIFNNVNKNDRMNDNNDADAQKYTTTMKNANNTVKSVVTVENETSKDSSLPKDKAS
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCC
QDEVGSGVVYKKSGDTLYIVTNAHVVGDKENQKITFSNNKSVVGKVLGKDKWSDLAVVKA
CHHCCCCEEEEECCCEEEEEECCEEECCCCCCEEEECCCCHHHHHHHCCCCCCCEEEEEE
TSSDSSVKEIAIGDSNNLVLGEPILVVGNPLGVDFKGTVTEGIISGLNRNVPIDFDKDNK
CCCCCCCEEEEECCCCCEEECCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCH
YDMLMKAFQIDASVNPGNSGGAVVNREGKLIGVVAAKISMPNVENMSFAIPVNEVQKIVK
HHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEEECCCCCCCCEEEECHHHHHHHHH
DLETKGKIDYPDVGVKMKNIASLNSFERQAVKLPGKVKNGVVVDQVDNNGLADQSGLKKG
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCC
DVITELDGKLLEDDLRFRQIIFSHKDDLKSITAKIYRDGKEKEINIKLK
CEEEHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure
MDIGKKHVIPKSQYRRKRREFFHNEDREENLNQHQDKQNIDNTTSKKADKQIHKDSIDKH
CCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ERFKNSLSSHLEQRNRDVNENKAEESKSNQDSKSAYNRDHYLTDDVSKKQNSLDSVDQDT
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCHH
EKSKYYEQNSEATLSTKSTDKVESTEMRKLSSDKNKVGHEEQHVLSKPSEHDKETRIDSE
HHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHCCCCC
SSRTDSDSSMQTEKIKKDSSDGNKSSNLKSEVISDKSNTVPKLSESDDEVNNQKPLTLPE
CCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCH
EQKLKRQQSQNEQTKTYTYGDSEQNDKSNHENDLSHHIPSISDDKDNVMRENHIVDDNPD
HHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHCCCCCCCCC
NDINTPSLSKTDDDRKLDEKIHVEDKHKQNADSSETVGYQSQSTASHRSTEKRNISINDH
CCCCCCCCCCCCCHHHHHHHCCCCHHHHCCCCCCHHCCCCCCCCHHHHCCCCCCCCCCCC
DKLNGQKTNTKTSANNNQKKATSKLNKGRATNNNYSDILKKFWMMYWPKLVILMGIIILI
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VILNAIFNNVNKNDRMNDNNDADAQKYTTTMKNANNTVKSVVTVENETSKDSSLPKDKAS
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCC
QDEVGSGVVYKKSGDTLYIVTNAHVVGDKENQKITFSNNKSVVGKVLGKDKWSDLAVVKA
CHHCCCCEEEEECCCEEEEEECCEEECCCCCCEEEECCCCHHHHHHHCCCCCCCEEEEEE
TSSDSSVKEIAIGDSNNLVLGEPILVVGNPLGVDFKGTVTEGIISGLNRNVPIDFDKDNK
CCCCCCCEEEEECCCCCEEECCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCH
YDMLMKAFQIDASVNPGNSGGAVVNREGKLIGVVAAKISMPNVENMSFAIPVNEVQKIVK
HHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEEECCCCCCCCEEEECHHHHHHHHH
DLETKGKIDYPDVGVKMKNIASLNSFERQAVKLPGKVKNGVVVDQVDNNGLADQSGLKKG
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCC
DVITELDGKLLEDDLRFRQIIFSHKDDLKSITAKIYRDGKEKEINIKLK
CEEEHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA