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The map label for this gene is degU [H]

Identifier: 41410415

GI number: 41410415

Start: 4787856

End: 4788512

Strand: Reverse

Name: degU [H]

Synonym: MAP4317c

Alternate gene names: 41410415

Gene position: 4788512-4787856 (Counterclockwise)

Preceding gene: 41410416

Following gene: 41410409

Centisome position: 99.15

GC content: 71.54

Gene sequence:

>657_bases
GTGACCGACCCGGCCCCCGAGATCGCCGTGCTGCTCGTCGACGACCAGGACTTGGTGCGTTCCGGGCTGCGCCGGATCCT
GCGCCGCAAGGACGGATTCGTCATCGTCGCCGAGTGCGCCGACGGCGACGAGGTGCCCGCCGCGATCGCCGCGCACCGGC
CCGACGTCGTCGTGATGGACCTGCGGATGCGCCGCGTCGACGGCATCGAGGCGACCCGCCGGCTGGGCGGCAGACCGCCG
GTGCTCGCGCTGACCACCTTCAACGAGGACGAGCTGTTGTCCGGGGCGCTGCGCGCCGGCGCGGCGGGCTTCGTGCTCAA
AGACTCGTCCGCCGAGGAACTGATCCGCGCGGTGCGGGCGGTCGCCCGGGGCGAGGGCTACCTCGACCCCGCGGTGACCT
CGCGGGTGCTCACCACTTACCGCAAGGCCGCGCCCGGCCCCCGCGGCGCCGCGATCGCCGAACTGACCACCCGCGAGCGG
GACGTGTTGACGTTGATCGGAAAAGGCTTGTCCAACAGCGAGATCGCCGACGAGCTGTGCATCTCCGGGGTCACCGTGAA
AAGCCACATCGGCCGGATCTTCGGCAAACTCGATCTGCGCGACCGGGCCGCCGCGATCGTCTACGCCTACGACAACGGCA
TCGTCGCCCCGCGCTGA

Upstream 100 bases:

>100_bases
CCATCGACGTCGGCCCCACCCGGGACGGGTGGTCGGTGTGCGCCGAGATCCCGCTGCAGGAAAGCGACGGCTCCTGGCGA
CCGTGGTGGTGTGGTAAGGC

Downstream 100 bases:

>100_bases
CGAGCCACCGGGGGCCTACAGGGGCGCCGCCGGCTCCGCGAGATTGAGCAGCAGGTAGGCCATGCACATCAGGAAGTTGA
TCACCACCATGATCAGCCCG

Product: hypothetical protein

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MTDPAPEIAVLLVDDQDLVRSGLRRILRRKDGFVIVAECADGDEVPAAIAAHRPDVVVMDLRMRRVDGIEATRRLGGRPP
VLALTTFNEDELLSGALRAGAAGFVLKDSSAEELIRAVRAVARGEGYLDPAVTSRVLTTYRKAAPGPRGAAIAELTTRER
DVLTLIGKGLSNSEIADELCISGVTVKSHIGRIFGKLDLRDRAAAIVYAYDNGIVAPR

Sequences:

>Translated_218_residues
MTDPAPEIAVLLVDDQDLVRSGLRRILRRKDGFVIVAECADGDEVPAAIAAHRPDVVVMDLRMRRVDGIEATRRLGGRPP
VLALTTFNEDELLSGALRAGAAGFVLKDSSAEELIRAVRAVARGEGYLDPAVTSRVLTTYRKAAPGPRGAAIAELTTRER
DVLTLIGKGLSNSEIADELCISGVTVKSHIGRIFGKLDLRDRAAAIVYAYDNGIVAPR
>Mature_217_residues
TDPAPEIAVLLVDDQDLVRSGLRRILRRKDGFVIVAECADGDEVPAAIAAHRPDVVVMDLRMRRVDGIEATRRLGGRPPV
LALTTFNEDELLSGALRAGAAGFVLKDSSAEELIRAVRAVARGEGYLDPAVTSRVLTTYRKAAPGPRGAAIAELTTRERD
VLTLIGKGLSNSEIADELCISGVTVKSHIGRIFGKLDLRDRAAAIVYAYDNGIVAPR

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=196, Percent_Identity=33.1632653061224, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1788521, Length=208, Percent_Identity=36.0576923076923, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787473, Length=219, Percent_Identity=31.9634703196347, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1790102, Length=194, Percent_Identity=31.9587628865979, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786747, Length=205, Percent_Identity=27.8048780487805, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788712, Length=207, Percent_Identity=25.1207729468599, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23380; Mature: 23249

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPAPEIAVLLVDDQDLVRSGLRRILRRKDGFVIVAECADGDEVPAAIAAHRPDVVVMD
CCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHCCCCCEEEEE
LRMRRVDGIEATRRLGGRPPVLALTTFNEDELLSGALRAGAAGFVLKDSSAEELIRAVRA
CHHHHHCCHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
VARGEGYLDPAVTSRVLTTYRKAAPGPRGAAIAELTTRERDVLTLIGKGLSNSEIADELC
HHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHCCCCCCCHHHHHHH
ISGVTVKSHIGRIFGKLDLRDRAAAIVYAYDNGIVAPR
HCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCC
>Mature Secondary Structure 
TDPAPEIAVLLVDDQDLVRSGLRRILRRKDGFVIVAECADGDEVPAAIAAHRPDVVVMD
CCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHCCCCCEEEEE
LRMRRVDGIEATRRLGGRPPVLALTTFNEDELLSGALRAGAAGFVLKDSSAEELIRAVRA
CHHHHHCCHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
VARGEGYLDPAVTSRVLTTYRKAAPGPRGAAIAELTTRERDVLTLIGKGLSNSEIADELC
HHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHCCCCCCCHHHHHHH
ISGVTVKSHIGRIFGKLDLRDRAAAIVYAYDNGIVAPR
HCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]