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Identifier: 41410298

GI number: 41410298

Start: 4669870

End: 4670670

Strand: Direct

Name: map'

Synonym: MAP4200

Alternate gene names: 41410298

Gene position: 4669870-4670670 (Clockwise)

Preceding gene: 41410297

Following gene: 41410299

Centisome position: 96.69

GC content: 74.03

Gene sequence:

>801_bases
ATGAACGCGCTGGCGCGGCTGCGGGGCCGCAAGGTGGTGCCGCAGCGCAGCGACGGCGAACTCGACGCGATGGCCGCCGC
GGGCGCGGTGGTGGCCGCCGCGCTGCAGGCGGTCCGCGCGGCCGCGGTCGCCGGGGTGTCGACGCTGAGCCTGGACCAGA
TCGCCGAGTCGGTGATCCGCGATGCCGGCGCGGTGCCGTCGTTCCTGGGCTACCACGGTTACCCGGCCTCCATCTGCGCC
TCCGTCAACGACCGGGTGGTGCACGGAATCCCCTCGGCCGCAGAGGTTTTGGCGCCCGGCGACCTGGTGTCGATCGACTG
CGGCGCGGTGCTGGACGGCTGGCACGGGGACGCGGCGATCACCTTCGGGGTGGGCGCCCTGGACCCGGCCGACGAGGCGC
TGTGCCAGGGCACCCGGGAGTCGCTGGAAGCCGGGATCGCGGCGATGGTGCCCGGGAACCGGTTGACCGACGTCTCGCAC
GCCATCGAGCTGGGCACCCGCGCCGCCGAGACCCGGCACGGGCGGGCGTTCGGCATCGTCGAGGGCTACGGCGGGCACGG
CATCGGCCGGCAGATGCACATGGACCCGTTCCTGCCCAACGAGGGCTCGCCGGGCCGCGGTCCGCTGCTGGCCCCCGGCT
CGGTGCTGGCCATCGAGCCGATGCTGACCCTGGGCACCGGCAAGACCGTGGTGCTCGACGACCAGTGGACGGTCATCACC
ACCGACGGCTCGCGTGCGGCACACTGGGAGCACACCGTTGCCGTCACCGACGCCGGGCCGCGCATCCTGACGATCGGGTA
G

Upstream 100 bases:

>100_bases
CGCTGCTGGACTACTACCGCGACCAGCTCAAGACGGTCGACGCCGTCGGCACCCTGGACGAGGTGTTCGCCCGGGCGCTG
TGCGCGCTGGGCAAGTAGGA

Downstream 100 bases:

>100_bases
GGGCGCACCGGGTCGGGGCCGTTGAACCGAACCTTCGCCGGGCTCGTTTCCCCGGCAGGAGGTGATCGAGTGGCTCGTGT
GGTCGGCATTTCCAGGGCGT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MNALARLRGRKVVPQRSDGELDAMAAAGAVVAAALQAVRAAAVAGVSTLSLDQIAESVIRDAGAVPSFLGYHGYPASICA
SVNDRVVHGIPSAAEVLAPGDLVSIDCGAVLDGWHGDAAITFGVGALDPADEALCQGTRESLEAGIAAMVPGNRLTDVSH
AIELGTRAAETRHGRAFGIVEGYGGHGIGRQMHMDPFLPNEGSPGRGPLLAPGSVLAIEPMLTLGTGKTVVLDDQWTVIT
TDGSRAAHWEHTVAVTDAGPRILTIG

Sequences:

>Translated_266_residues
MNALARLRGRKVVPQRSDGELDAMAAAGAVVAAALQAVRAAAVAGVSTLSLDQIAESVIRDAGAVPSFLGYHGYPASICA
SVNDRVVHGIPSAAEVLAPGDLVSIDCGAVLDGWHGDAAITFGVGALDPADEALCQGTRESLEAGIAAMVPGNRLTDVSH
AIELGTRAAETRHGRAFGIVEGYGGHGIGRQMHMDPFLPNEGSPGRGPLLAPGSVLAIEPMLTLGTGKTVVLDDQWTVIT
TDGSRAAHWEHTVAVTDAGPRILTIG
>Mature_266_residues
MNALARLRGRKVVPQRSDGELDAMAAAGAVVAAALQAVRAAAVAGVSTLSLDQIAESVIRDAGAVPSFLGYHGYPASICA
SVNDRVVHGIPSAAEVLAPGDLVSIDCGAVLDGWHGDAAITFGVGALDPADEALCQGTRESLEAGIAAMVPGNRLTDVSH
AIELGTRAAETRHGRAFGIVEGYGGHGIGRQMHMDPFLPNEGSPGRGPLLAPGSVLAIEPMLTLGTGKTVVLDDQWTVIT
TDGSRAAHWEHTVAVTDAGPRILTIG

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=260, Percent_Identity=32.6923076923077, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI40385867, Length=249, Percent_Identity=30.9236947791165, Blast_Score=131, Evalue=5e-31,
Organism=Escherichia coli, GI1786364, Length=251, Percent_Identity=38.2470119521912, Blast_Score=178, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71996291, Length=258, Percent_Identity=32.9457364341085, Blast_Score=146, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323273, Length=255, Percent_Identity=33.7254901960784, Blast_Score=143, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24583427, Length=251, Percent_Identity=35.0597609561753, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI21355531, Length=258, Percent_Identity=34.4961240310078, Blast_Score=148, Evalue=5e-36,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27158; Mature: 27158

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALARLRGRKVVPQRSDGELDAMAAAGAVVAAALQAVRAAAVAGVSTLSLDQIAESVIR
CCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
DAGAVPSFLGYHGYPASICASVNDRVVHGIPSAAEVLAPGDLVSIDCGAVLDGWHGDAAI
HCCCCCHHHCCCCCCHHHHHCCCCCEEECCCCHHHHCCCCCEEEECCCCEECCCCCCEEE
TFGVGALDPADEALCQGTRESLEAGIAAMVPGNRLTDVSHAIELGTRAAETRHGRAFGIV
EEECCCCCHHHHHHHHCCHHHHHCCEEEECCCCCHHHHHHHHHHCCHHHHCCCCCEEEEE
EGYGGHGIGRQMHMDPFLPNEGSPGRGPLLAPGSVLAIEPMLTLGTGKTVVLDDQWTVIT
ECCCCCCCCCCEECCCCCCCCCCCCCCCEECCCCEEEECCEEEECCCCEEEECCCEEEEE
TDGSRAAHWEHTVAVTDAGPRILTIG
ECCCCCCCCEEEEEEECCCCEEEEEC
>Mature Secondary Structure
MNALARLRGRKVVPQRSDGELDAMAAAGAVVAAALQAVRAAAVAGVSTLSLDQIAESVIR
CCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
DAGAVPSFLGYHGYPASICASVNDRVVHGIPSAAEVLAPGDLVSIDCGAVLDGWHGDAAI
HCCCCCHHHCCCCCCHHHHHCCCCCEEECCCCHHHHCCCCCEEEECCCCEECCCCCCEEE
TFGVGALDPADEALCQGTRESLEAGIAAMVPGNRLTDVSHAIELGTRAAETRHGRAFGIV
EEECCCCCHHHHHHHHCCHHHHHCCEEEECCCCCHHHHHHHHHHCCHHHHCCCCCEEEEE
EGYGGHGIGRQMHMDPFLPNEGSPGRGPLLAPGSVLAIEPMLTLGTGKTVVLDDQWTVIT
ECCCCCCCCCCEECCCCCCCCCCCCCCCEECCCCEEEECCEEEECCCCEEEECCCEEEEE
TDGSRAAHWEHTVAVTDAGPRILTIG
ECCCCCCCCEEEEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]