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The map label for this gene is glkA [H]

Identifier: 41410221

GI number: 41410221

Start: 4596576

End: 4597496

Strand: Direct

Name: glkA [H]

Synonym: MAP4123

Alternate gene names: 41410221

Gene position: 4596576-4597496 (Clockwise)

Preceding gene: 41410220

Following gene: 41410222

Centisome position: 95.17

GC content: 74.7

Gene sequence:

>921_bases
ATGCTCACCCTCGGCCTGGACATCGGCGGCACCAAAATCGCTGCCGCACTTGTTGATTCGGTCGGCACGCTGGTCCACAC
CGCTGTCCGCCCCACCCCCAACCCGGCCCCGGCCGACGATGTGTGGGATGTGGTGCACGCCCTGATCGCCGAGGTGGTGC
GGGCGGCCGGCGCCCCGATCGCGGCCGTGGGTATCGCGTCGGCGGGGCCCGTCGACCTGCCCAGCGGATCCGTCAGCCCG
ATCAACATCGCCGGCTGGCACCGTTTCCCGTTGCGCGACAAGGTCGCCGCGGCGGTGCCCGCGACACCGGTGGTGCTGGG
CGGCGACGGGCTCTGCATGGCGCTGGGGGAGCAGTGGCTGGGCGCGGGACGCGGCGCCCGTTTCCTGCTGGGCATGGTGG
TCTCCACGGGGGTGGGTGGCGGCCTGGTGCTCGACGGCGCCCCCTACCCGGGCCGCACCGGCAACGCCGGTCACGTCGGG
CACGTGGTGGTCGAACTGGACGGCCGGCCCTGCACCTGCGGCGGGCATGGCTGCGTGGAGACGGTGGCCTCCGGGCCGTC
GATGGTGCGCTGGGCGCGCGAAAACGGGTGGTCGGCGGCGCCGGGGGCCGGCGCCCGGGACCTGGCCGCCGCCGCGGCCT
CAGACCCGTTGGCGCAGAAGGCGTTTCACCGGTCGGCCGACGCGCTCGCGGCGATGATCGCCTCGGTCGGTGCGGTGTGC
GATCTGGACGTGGTGGTGATCGGGGGAGGCGTCGCCCAGTCCGGGCCGCTGCTGTTCGACCCGCTGCGCGAAAGGCTGGC
CCACTACGCCGGGCTGGACTTCCTGTCCGGGCTGACGGTGGTGCCGGGGGAACTCGGCGGCAATGCCGGGCTGATCGGCG
CGGCCCGGCTGGCGACCCTGGCGCGACCCGCCGGCTCCTAG

Upstream 100 bases:

>100_bases
GGCTGGACGAACGCCGCGCCGCGCTGGTGCGGCTCGCGCCCGGCTACGAGCATCCCGGCGACCCCCGCCAACCCGACAAC
ACGCATCGGCACTGATCGGC

Downstream 100 bases:

>100_bases
GCTGACCCAATGGACCACAGCATCGACGCGCTCGCGGTCGTGATCATGGGGCTGATGGTCGGCGTGGAGCTGGCGGTCGC
GGTGTTCTTCCACCCGCTCA

Product: hypothetical protein

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MLTLGLDIGGTKIAAALVDSVGTLVHTAVRPTPNPAPADDVWDVVHALIAEVVRAAGAPIAAVGIASAGPVDLPSGSVSP
INIAGWHRFPLRDKVAAAVPATPVVLGGDGLCMALGEQWLGAGRGARFLLGMVVSTGVGGGLVLDGAPYPGRTGNAGHVG
HVVVELDGRPCTCGGHGCVETVASGPSMVRWARENGWSAAPGAGARDLAAAAASDPLAQKAFHRSADALAAMIASVGAVC
DLDVVVIGGGVAQSGPLLFDPLRERLAHYAGLDFLSGLTVVPGELGGNAGLIGAARLATLARPAGS

Sequences:

>Translated_306_residues
MLTLGLDIGGTKIAAALVDSVGTLVHTAVRPTPNPAPADDVWDVVHALIAEVVRAAGAPIAAVGIASAGPVDLPSGSVSP
INIAGWHRFPLRDKVAAAVPATPVVLGGDGLCMALGEQWLGAGRGARFLLGMVVSTGVGGGLVLDGAPYPGRTGNAGHVG
HVVVELDGRPCTCGGHGCVETVASGPSMVRWARENGWSAAPGAGARDLAAAAASDPLAQKAFHRSADALAAMIASVGAVC
DLDVVVIGGGVAQSGPLLFDPLRERLAHYAGLDFLSGLTVVPGELGGNAGLIGAARLATLARPAGS
>Mature_306_residues
MLTLGLDIGGTKIAAALVDSVGTLVHTAVRPTPNPAPADDVWDVVHALIAEVVRAAGAPIAAVGIASAGPVDLPSGSVSP
INIAGWHRFPLRDKVAAAVPATPVVLGGDGLCMALGEQWLGAGRGARFLLGMVVSTGVGGGLVLDGAPYPGRTGNAGHVG
HVVVELDGRPCTCGGHGCVETVASGPSMVRWARENGWSAAPGAGARDLAAAAASDPLAQKAFHRSADALAAMIASVGAVC
DLDVVVIGGGVAQSGPLLFDPLRERLAHYAGLDFLSGLTVVPGELGGNAGLIGAARLATLARPAGS

Specific function: Required for glucose repression of many different genes [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI190014632, Length=196, Percent_Identity=32.1428571428571, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI298566325, Length=196, Percent_Identity=32.1428571428571, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4885285, Length=196, Percent_Identity=32.1428571428571, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI298566315, Length=196, Percent_Identity=32.1428571428571, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1787363, Length=278, Percent_Identity=30.9352517985612, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87081733, Length=263, Percent_Identity=29.6577946768061, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082230, Length=254, Percent_Identity=32.6771653543307, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786891, Length=276, Percent_Identity=25.3623188405797, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787878, Length=203, Percent_Identity=27.5862068965517, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790522, Length=251, Percent_Identity=25.4980079681275, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 30209; Mature: 30209

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLGLDIGGTKIAAALVDSVGTLVHTAVRPTPNPAPADDVWDVVHALIAEVVRAAGAPI
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCE
AAVGIASAGPVDLPSGSVSPINIAGWHRFPLRDKVAAAVPATPVVLGGDGLCMALGEQWL
EEEECCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCCCCCEEECCCCHHHHHHHHHH
GAGRGARFLLGMVVSTGVGGGLVLDGAPYPGRTGNAGHVGHVVVELDGRPCTCGGHGCVE
CCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHH
TVASGPSMVRWARENGWSAAPGAGARDLAAAAASDPLAQKAFHRSADALAAMIASVGAVC
HHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
DLDVVVIGGGVAQSGPLLFDPLRERLAHYAGLDFLSGLTVVPGELGGNAGLIGAARLATL
CEEEEEEECCCCCCCCCHHHHHHHHHHHHHCHHHHCCCEECCCCCCCCCCCHHHHHHHHH
ARPAGS
HCCCCC
>Mature Secondary Structure
MLTLGLDIGGTKIAAALVDSVGTLVHTAVRPTPNPAPADDVWDVVHALIAEVVRAAGAPI
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCE
AAVGIASAGPVDLPSGSVSPINIAGWHRFPLRDKVAAAVPATPVVLGGDGLCMALGEQWL
EEEECCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCCCCCEEECCCCHHHHHHHHHH
GAGRGARFLLGMVVSTGVGGGLVLDGAPYPGRTGNAGHVGHVVVELDGRPCTCGGHGCVE
CCCCCHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHHH
TVASGPSMVRWARENGWSAAPGAGARDLAAAAASDPLAQKAFHRSADALAAMIASVGAVC
HHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
DLDVVVIGGGVAQSGPLLFDPLRERLAHYAGLDFLSGLTVVPGELGGNAGLIGAARLATL
CEEEEEEECCCCCCCCCHHHHHHHHHHHHHCHHHHCCCEECCCCCCCCCCCHHHHHHHHH
ARPAGS
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1435260; 12000953 [H]