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The map label for this gene is udgA

Identifier: 41409923

GI number: 41409923

Start: 4276163

End: 4277488

Strand: Direct

Name: udgA

Synonym: MAP3825

Alternate gene names: 41409923

Gene position: 4276163-4277488 (Clockwise)

Preceding gene: 41409922

Following gene: 41409924

Centisome position: 88.54

GC content: 70.06

Gene sequence:

>1326_bases
ATGCGATGCACCGTGTTCGGCACGGGTTACCTGGGCGCCACCCACGCGGTGGGAATGGCGGAGCTGGGACACGACGTGCT
CGGGGTCGACATCGACCCGGGCAAGGTGGCCAAGCTCGCCGGGGGTGACATCCCCTTCTACGAGCCCGGCCTGCGAAAGC
TGTTGAACGAGAACCTGGCCGCGGGCCGGCTGCGCTTCACCACCGACTACGACATGGCGGCCGGCTTCGCCGACGTGCAC
TTCCTGGGTGTGGGCACCCCGCAGAAGAAGGGCGAATACGGCGCCGATCTGCGCCACGTGTACGCCGTCATCGACGAATT
GGTGCCCCGGTTGACGACGTCGGCGGTGCTGGTCGGCAAATCGACCGTCCCGGTGGGCACCGCGGCCGAGCTGAACCAGC
GGGCGGCGGCGCTGGCGCCGCGCGGTGTCGACGTCGAAATCGCGTGGAACCCGGAGTTTCTGCGCGAGGGCTATGCCGTG
CAGGACACCCTGCGGCCGGACCGGATTGTGCTTGGAATCAAACAGGATTCACCGCGCGCCCAGGCCGCCGTCCGGGAGCT
GTACGGGCCGCTGTTGGACGCCGGGGTGCCGTTCCTGGTGACGGATCTGCAGACCGCGGAGTTGGTCAAGGTGTCCGCCA
ATGCCTTTCTGGCGACCAAGATTTCGTTCATCAACGCGATCTCCGAGGTGTGCGAGGCCGCCGGCGCCGACGTCAGCCTG
CTGGCCGATGCGCTGGGCTACGACCCGCGCATCGGGCGCCAATTCCTCAACGCCGGTTTGGGTTTCGGCGGGGGCTGCCT
GCCCAAGGACATCCGGGCGTTCATGGCGCGCGCCGGCGAGCTGGGCGCCGATCAGGCGCTGACGTTCCTGCGCGAGGTGG
ACAGCATCAACATGCGCCGCCGCACCCGGATGGTGGAACTGGCCAGCGCGGCCTGCGGCGGCTCGCTGCTGGGCGCCAAC
GTCGCGGTGCTCGGCGCGGCGTTCAAGCCCGAATCCGACGACGTGCGCGACTCGCCGGCGCTCAATGTCGCCGGCCAGCT
GCAGCTCAACGGCGCCGCGGTCAACGTGTACGACCCGAAGGCCCTGGACAACGCGCAGCGGCTGTTCCCCACGCTGAACT
ACGCCGTCTCGGTCGAGGAGGCCTGCGAGCGCGCGGACGCGGTGCTGGTGCTCACCGAGTGGCGCCAGTTCGTCGAGATG
GACCCCGACGACCTGGCCGACCGGGTGCGGGCCCGCGTCGTCGTCGACGGCCGCAACTGCCTGGACGTCACCCGTTGGCA
GCGGGCCGGCTGGCGGGTCTACCGCCTGGGCGCGCCGCGACCCTGA

Upstream 100 bases:

>100_bases
CCGGGCAGTGTCGGCGCCATCGGCCAGCTGTCATCCGCCGTTTGCCTGACGCTTAGCCCAGCGATGCAATCAGCTCATCG
GGGCCACCTACACCGGTTGT

Downstream 100 bases:

>100_bases
GCGCGCCGGCCGAGCGTCACGCCAGCGTGGCGCCGGCCCGCGAGCGCCACGCTGGCGTGACGCTCGGCGCCGAACGGGAG
CGTAGCCTGACCGGCGTGGA

Product: UdgA

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MRCTVFGTGYLGATHAVGMAELGHDVLGVDIDPGKVAKLAGGDIPFYEPGLRKLLNENLAAGRLRFTTDYDMAAGFADVH
FLGVGTPQKKGEYGADLRHVYAVIDELVPRLTTSAVLVGKSTVPVGTAAELNQRAAALAPRGVDVEIAWNPEFLREGYAV
QDTLRPDRIVLGIKQDSPRAQAAVRELYGPLLDAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSL
LADALGYDPRIGRQFLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREVDSINMRRRTRMVELASAACGGSLLGAN
VAVLGAAFKPESDDVRDSPALNVAGQLQLNGAAVNVYDPKALDNAQRLFPTLNYAVSVEEACERADAVLVLTEWRQFVEM
DPDDLADRVRARVVVDGRNCLDVTRWQRAGWRVYRLGAPRP

Sequences:

>Translated_441_residues
MRCTVFGTGYLGATHAVGMAELGHDVLGVDIDPGKVAKLAGGDIPFYEPGLRKLLNENLAAGRLRFTTDYDMAAGFADVH
FLGVGTPQKKGEYGADLRHVYAVIDELVPRLTTSAVLVGKSTVPVGTAAELNQRAAALAPRGVDVEIAWNPEFLREGYAV
QDTLRPDRIVLGIKQDSPRAQAAVRELYGPLLDAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSL
LADALGYDPRIGRQFLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREVDSINMRRRTRMVELASAACGGSLLGAN
VAVLGAAFKPESDDVRDSPALNVAGQLQLNGAAVNVYDPKALDNAQRLFPTLNYAVSVEEACERADAVLVLTEWRQFVEM
DPDDLADRVRARVVVDGRNCLDVTRWQRAGWRVYRLGAPRP
>Mature_441_residues
MRCTVFGTGYLGATHAVGMAELGHDVLGVDIDPGKVAKLAGGDIPFYEPGLRKLLNENLAAGRLRFTTDYDMAAGFADVH
FLGVGTPQKKGEYGADLRHVYAVIDELVPRLTTSAVLVGKSTVPVGTAAELNQRAAALAPRGVDVEIAWNPEFLREGYAV
QDTLRPDRIVLGIKQDSPRAQAAVRELYGPLLDAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSL
LADALGYDPRIGRQFLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREVDSINMRRRTRMVELASAACGGSLLGAN
VAVLGAAFKPESDDVRDSPALNVAGQLQLNGAAVNVYDPKALDNAQRLFPTLNYAVSVEEACERADAVLVLTEWRQFVEM
DPDDLADRVRARVVVDGRNCLDVTRWQRAGWRVYRLGAPRP

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=464, Percent_Identity=31.4655172413793, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI296040438, Length=366, Percent_Identity=32.2404371584699, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI296040443, Length=317, Percent_Identity=33.4384858044164, Blast_Score=169, Evalue=4e-42,
Organism=Escherichia coli, GI1788340, Length=362, Percent_Identity=29.2817679558011, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI48994968, Length=432, Percent_Identity=27.5462962962963, Blast_Score=143, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17560350, Length=461, Percent_Identity=34.4902386117137, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI17136908, Length=468, Percent_Identity=32.6923076923077, Blast_Score=226, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 47292; Mature: 47292

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCTVFGTGYLGATHAVGMAELGHDVLGVDIDPGKVAKLAGGDIPFYEPGLRKLLNENLA
CEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
AGRLRFTTDYDMAAGFADVHFLGVGTPQKKGEYGADLRHVYAVIDELVPRLTTSAVLVGK
CCEEEEECCCHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEC
STVPVGTAAELNQRAAALAPRGVDVEIAWNPEFLREGYAVQDTLRPDRIVLGIKQDSPRA
CCCCCCCHHHHHHHHHHCCCCCCEEEEEECHHHHHCCCCCHHCCCCCEEEEEECCCCCHH
QAAVRELYGPLLDAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSL
HHHHHHHHHHHHHCCCCEEEECCCHHHHEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHH
LADALGYDPRIGRQFLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREVDSINMRR
HHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHH
RTRMVELASAACGGSLLGANVAVLGAAFKPESDDVRDSPALNVAGQLQLNGAAVNVYDPK
HHHHHHHHHHHCCCHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCEEEEEECCH
ALDNAQRLFPTLNYAVSVEEACERADAVLVLTEWRQFVEMDPDDLADRVRARVVVDGRNC
HHCCHHHHHHHHHHEEEHHHHHHHCCEEEEHHHHHHHHCCCHHHHHHHHHEEEEECCCCC
LDVTRWQRAGWRVYRLGAPRP
HHHHHHHHCCCEEEECCCCCC
>Mature Secondary Structure
MRCTVFGTGYLGATHAVGMAELGHDVLGVDIDPGKVAKLAGGDIPFYEPGLRKLLNENLA
CEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
AGRLRFTTDYDMAAGFADVHFLGVGTPQKKGEYGADLRHVYAVIDELVPRLTTSAVLVGK
CCEEEEECCCHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEC
STVPVGTAAELNQRAAALAPRGVDVEIAWNPEFLREGYAVQDTLRPDRIVLGIKQDSPRA
CCCCCCCHHHHHHHHHHCCCCCCEEEEEECHHHHHCCCCCHHCCCCCEEEEEECCCCCHH
QAAVRELYGPLLDAGVPFLVTDLQTAELVKVSANAFLATKISFINAISEVCEAAGADVSL
HHHHHHHHHHHHHCCCCEEEECCCHHHHEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHH
LADALGYDPRIGRQFLNAGLGFGGGCLPKDIRAFMARAGELGADQALTFLREVDSINMRR
HHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHH
RTRMVELASAACGGSLLGANVAVLGAAFKPESDDVRDSPALNVAGQLQLNGAAVNVYDPK
HHHHHHHHHHHCCCHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCEEEEEECCH
ALDNAQRLFPTLNYAVSVEEACERADAVLVLTEWRQFVEMDPDDLADRVRARVVVDGRNC
HHCCHHHHHHHHHHEEEHHHHHHHCCEEEEHHHHHHHHCCCHHHHHHHHHEEEEECCCCC
LDVTRWQRAGWRVYRLGAPRP
HHHHHHHHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]