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The map label for this gene is limC [H]

Identifier: 41409847

GI number: 41409847

Start: 4185029

End: 4185889

Strand: Direct

Name: limC [H]

Synonym: MAP3749

Alternate gene names: 41409847

Gene position: 4185029-4185889 (Clockwise)

Preceding gene: 41409844

Following gene: 41409848

Centisome position: 86.65

GC content: 61.21

Gene sequence:

>861_bases
ATGGGCCGACTGGCCGGCAAGGTTGCGCTCGTGACAGGTGGAGGTCGCGGCCAGGGCCGCAGCCATGCGGTGCACTTGGC
CGATGAAGGCGCCGACCTCATCGTCGTGGACATCGGCGAGGACATTCCCAGCAATCAGTACGCACTGGCCACACGGGCTG
ACTTGGACGACACCGCGAAGCTCGTCGAGAAGGCCGGTCGCCGCGTTGTCGCCGCACAGGTGGATGTCCGCGACCGGGTC
GGTCTGAAGGCGCTCCTCGATGAAGCGGTCACTCAACTCGGCGGCCTGCACGTCATTGTGGCTAATGCCGGAATCTGCCC
GCTTGGCAACGACATTCCCGTCCAAGGCTTCGTCGATGCCTTTGACGTCGACTTCATCGGTGTCGTCAACACCGTCCATA
GCGGACTACCACACCTCAACGCCGGTGCTTCGATCATTGTGACCGGATCAGTAGCCGGGCTGGTGCCGCAAGCTGGCGGC
GTTAGCGGTCAGGGCGGGCTGCAGGGACCCGGCGGCGACGGTTATGGCCTGGCGAAGAAGGTGATTCGTGATTACACCCG
GTCGCTGGCTCTGACATTGGGTCCACAGCAGATCAGAGTCAACGCGATACATCCGACAAACGTCAACACCGAGATGCTGC
ACAACCCGGCCATGTACCAAACCTTTCGTCCCGATCTAACCAATCCGAGTCGCGAAGACGCCGAAGTAACTTTTCCCTTC
ATGCAGGCCATGCCGATTCCCTACATCGATCCTTGCGATGTGTCGCATGCCGTGGTGTATCTGGCAGCCGACGAATCGCG
TTACGTCACCGGGCAGCAGCTCTTTGTCGATGCCGGGGCTTCACTGAAGCTCGGCATGTAA

Upstream 100 bases:

>100_bases
ACTAGGCCGGCAAGACACATGCAGCCTCACCCGACCCACCCGGGTTGCAGCACAACGTAACAACACGAAGTAACTGCACC
TACGAACTTAAGGAGGATCC

Downstream 100 bases:

>100_bases
GGGTTATGTCCTGGTTCGGCATGAGTGGAACACGACCGGCGTGGGCAATGCGGGCCTACCACGGCGATCTCGAGACTCGT
CGATCCGTTGTCCGAAGGTG

Product: hypothetical protein

Products: NA

Alternate protein names: (4R,6S)-carveol dehydrogenase; CDH; Carveol dehydrogenase [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MGRLAGKVALVTGGGRGQGRSHAVHLADEGADLIVVDIGEDIPSNQYALATRADLDDTAKLVEKAGRRVVAAQVDVRDRV
GLKALLDEAVTQLGGLHVIVANAGICPLGNDIPVQGFVDAFDVDFIGVVNTVHSGLPHLNAGASIIVTGSVAGLVPQAGG
VSGQGGLQGPGGDGYGLAKKVIRDYTRSLALTLGPQQIRVNAIHPTNVNTEMLHNPAMYQTFRPDLTNPSREDAEVTFPF
MQAMPIPYIDPCDVSHAVVYLAADESRYVTGQQLFVDAGASLKLGM

Sequences:

>Translated_286_residues
MGRLAGKVALVTGGGRGQGRSHAVHLADEGADLIVVDIGEDIPSNQYALATRADLDDTAKLVEKAGRRVVAAQVDVRDRV
GLKALLDEAVTQLGGLHVIVANAGICPLGNDIPVQGFVDAFDVDFIGVVNTVHSGLPHLNAGASIIVTGSVAGLVPQAGG
VSGQGGLQGPGGDGYGLAKKVIRDYTRSLALTLGPQQIRVNAIHPTNVNTEMLHNPAMYQTFRPDLTNPSREDAEVTFPF
MQAMPIPYIDPCDVSHAVVYLAADESRYVTGQQLFVDAGASLKLGM
>Mature_285_residues
GRLAGKVALVTGGGRGQGRSHAVHLADEGADLIVVDIGEDIPSNQYALATRADLDDTAKLVEKAGRRVVAAQVDVRDRVG
LKALLDEAVTQLGGLHVIVANAGICPLGNDIPVQGFVDAFDVDFIGVVNTVHSGLPHLNAGASIIVTGSVAGLVPQAGGV
SGQGGLQGPGGDGYGLAKKVIRDYTRSLALTLGPQQIRVNAIHPTNVNTEMLHNPAMYQTFRPDLTNPSREDAEVTFPFM
QAMPIPYIDPCDVSHAVVYLAADESRYVTGQQLFVDAGASLKLGM

Specific function: Catalyzes the oxidation of carveol to carvone, with a strong stereoselectivity since it efficiently converts only the (6S)-stereoisomers, of which (-)-(4R,6S)-trans-carveol is the better substrate. Displays a broad substrate specificity with a preference

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=287, Percent_Identity=22.9965156794425, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI59889578, Length=217, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI31542939, Length=217, Percent_Identity=29.9539170506912, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI87082100, Length=288, Percent_Identity=32.9861111111111, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1789378, Length=275, Percent_Identity=29.0909090909091, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1789208, Length=279, Percent_Identity=27.2401433691756, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787905, Length=286, Percent_Identity=26.5734265734266, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87082160, Length=279, Percent_Identity=26.5232974910394, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=297, Percent_Identity=30.3030303030303, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17560150, Length=301, Percent_Identity=26.578073089701, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193204405, Length=300, Percent_Identity=27.3333333333333, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17551412, Length=301, Percent_Identity=26.578073089701, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=301, Percent_Identity=27.5747508305648, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560220, Length=300, Percent_Identity=27.3333333333333, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=298, Percent_Identity=27.5167785234899, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562990, Length=297, Percent_Identity=26.2626262626263, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=297, Percent_Identity=26.5993265993266, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=302, Percent_Identity=27.4834437086093, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=302, Percent_Identity=26.4900662251656, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=297, Percent_Identity=25.9259259259259, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=288, Percent_Identity=27.0833333333333, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=305, Percent_Identity=26.5573770491803, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=300, Percent_Identity=25.6666666666667, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=297, Percent_Identity=26.9360269360269, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=281, Percent_Identity=25.2669039145907, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=293, Percent_Identity=25.5972696245734, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=283, Percent_Identity=23.321554770318, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=149, Percent_Identity=27.5167785234899, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=302, Percent_Identity=25.4966887417219, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI23397609, Length=283, Percent_Identity=27.5618374558304, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24643142, Length=286, Percent_Identity=28.6713286713287, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28571526, Length=286, Percent_Identity=26.9230769230769, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21357041, Length=283, Percent_Identity=25.4416961130742, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24644339, Length=282, Percent_Identity=26.241134751773, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 29877; Mature: 29746

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRLAGKVALVTGGGRGQGRSHAVHLADEGADLIVVDIGEDIPSNQYALATRADLDDTAK
CCCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCEEEEEECCCHHHHH
LVEKAGRRVVAAQVDVRDRVGLKALLDEAVTQLGGLHVIVANAGICPLGNDIPVQGFVDA
HHHHCCCEEEEEEECCHHHCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCHHH
FDVDFIGVVNTVHSGLPHLNAGASIIVTGSVAGLVPQAGGVSGQGGLQGPGGDGYGLAKK
HCCHHHHHHHHHHHCCCCCCCCCEEEEECCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
VIRDYTRSLALTLGPQQIRVNAIHPTNVNTEMLHNPAMYQTFRPDLTNPSREDAEVTFPF
HHHHHHHHEEEEECCCEEEEEEECCCCCCHHHHCCCHHHHCCCCCCCCCCCCCCEEEEHH
MQAMPIPYIDPCDVSHAVVYLAADESRYVTGQQLFVDAGASLKLGM
HHCCCCCCCCCCCCCEEEEEEEECCCCEEECCEEEEECCCEEEECC
>Mature Secondary Structure 
GRLAGKVALVTGGGRGQGRSHAVHLADEGADLIVVDIGEDIPSNQYALATRADLDDTAK
CCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCEEEEEECCCHHHHH
LVEKAGRRVVAAQVDVRDRVGLKALLDEAVTQLGGLHVIVANAGICPLGNDIPVQGFVDA
HHHHCCCEEEEEEECCHHHCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCHHH
FDVDFIGVVNTVHSGLPHLNAGASIIVTGSVAGLVPQAGGVSGQGGLQGPGGDGYGLAKK
HCCHHHHHHHHHHHCCCCCCCCCEEEEECCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
VIRDYTRSLALTLGPQQIRVNAIHPTNVNTEMLHNPAMYQTFRPDLTNPSREDAEVTFPF
HHHHHHHHEEEEECCCEEEEEEECCCCCCHHHHCCCHHHHCCCCCCCCCCCCCCEEEEHH
MQAMPIPYIDPCDVSHAVVYLAADESRYVTGQQLFVDAGASLKLGM
HHCCCCCCCCCCCCCEEEEEEEECCCCEEECCEEEEECCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10473585 [H]