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The map label for this gene is nirB

Identifier: 41409800

GI number: 41409800

Start: 4117914

End: 4120481

Strand: Direct

Name: nirB

Synonym: MAP3702

Alternate gene names: 41409800

Gene position: 4117914-4120481 (Clockwise)

Preceding gene: 41409794

Following gene: 41409801

Centisome position: 85.26

GC content: 69.16

Gene sequence:

>2568_bases
ATGTCTGCAGACGGGATTTCGCGCGACGGCTGTGCGCCGCGTCACATCATCGTAGTCGGACATGGCATGGTCGGACACCG
GTTCGTGGAGGCGCTGCGCGCCCGCGACACCGAGGGCCGTTGGCGCATCACGGTTTTCGCCGAGGAGGCTGACGCCGCCT
ACGACCGGGTGGGGCTGACTTCGTACACCGAGAGCTGGGACCGCGCGCTGCTGGCGTTGCCCGGCAACGACTACCAGGGT
GACCCGCAGGTCCGGCTGGTGCTCAACCAGCGGGTCACCGAAATAGACCGCGCGACAAAGTCAGTGGTGACCGCCGACGG
TCAGCGGCACCACTACGACACCCTGGTCCTGGCCACCGGTTCCTACGCCTTCGTGCCGCCCGTGCCCGGCCACGAGCTGC
CTGCCTGCCACGTCTACCGCACCCTCGACGACCTCGACGCCATCCGCGCCGACGCCCAGCGTGCGGCGCAGACCGCCCAT
GCTCGCGCCGGCGTGGTCATCGGCGGCGGCCTGCTCGGGCTGGAGGCCGCTAATGCGCTGCGCCAGTTCGGCTTAGCGAC
CCATGTGGTCGAGATGATGCCGCGGTTGATGGCCCAGCAGATCGACGAGGCCGGCGGCGCGCTGCTGGCCCGGATGATCG
GCGACCTGGGCATCTCGGTGCACGTCGGCACCGGCACCGAGGCGATCGAACCGGTCGAGGGCCCCGACGGGTCCACGACG
GTGCGGGTGCGCCTGAGCGACGGCCAGGTGATCGACGCCGGCCTGGTCATCTTCGCGGCCGGCATCCGGCCGCGCGACGA
GCTGGCGGTCGCCGCCGGCCTCGCCCGCGCCGAGCGGGGCGGGGTGCTCACCGACTTGTCCTGCCGGACAAGCGATCCCG
ACATCTACGCGATCGGCGAGGTGGCCGCGATCGACGGCCGGTGCTACGGCCTGGTGGGGCCGGGCTACACCTCCGCCGAA
GTGGTGGCCGACCGGCTGCTGGACGGCAGCGCGGAGTTCGGCGAGGCGGACCTGTCCACCAAGCTCAAACTGCTGGGCGT
CGACGTGGCCAGCTTCGGCGACGCGATGGGGACGACCGAGAACTGCCTCGAGGTCGCGATCAACGACGCGGTCAACCGCA
CCTACGCCAAACTGGTGCTCTCCGATGACGCCAAGACCCTGCTCGGCGGTGTGCTGGTCGGCGACGCCTCGTCCTACGGG
GTGCTGCGGCCCATGGTCGGGAGCGAGCTGCCGGGCGACCCGCTGGCGCTGATCGCGCCGGCCTCCTCCGGCGGCGGAAC
GGCGTTGGGCGTTGGGGCGCTTCCCGATTCGGCGCAGATCTGCTCCTGCAACAACGTCACCAAGGGCGACCTGAAATGCG
CGATCGCCGACGGCTGCGCCGACGTCGCTGCGCTCAAGTCGTGCACCTCGGCCGGCACCTCGTGCGGGTCGTGCGTGCCG
CTGCTCAAGCAGCTGCTGGAAGCCGAGGGGGTGGAGCAGTCCAAGGCGCTGTGCGAGCACTTCAGCCAGTCGCGGGCCGA
GCTGTTCGAGATCATCTCGGCCACCGAGATCCGCACCTTCTCCGGCCTGCTGGAGCGCTTCGGCCGCGGAAAGGGTTGCG
ACATCTGCAAACCCGTGGTCGCCTCGATCCTGGCGTCCACCGGGTCGGAGCACATCCTGGAGGGTGAGCAGGCCTCGCTG
CAGGATTCCAACGACCACTTCCTGGCCAACATCCAAAAGAACGGCAGCTACTCGGTGGTGCCCTGGGTGCCCGGCGGCGA
CATCAAGCCCGAGCACCTGATCCTGATCGGCCAGATCGCCCAGGACTTCGGCCTTTACACCAAGATCACCGGCGGCCAGC
GGATCGACATGTTCGGCGCCCGGGTGGACCAGCTGCCGGCGATCTGGAAGCGGCTGGTCGACGGCGGCATGGAGTCCGGC
CACGCCTACGGCAAAGCGCTGCGCACCGTGAAGAGCTGCGTGGGCACCGACTGGTGCCGGTACGGGCAGCAGGACTCGGT
GCAGCTGGCCATCGACCTGGAGCTGCGCTACCGCGGGTTGCGGGCGCCGCACAAGATCAAGATGGGCGTCTCGGGCTGCG
CGCGCGAGTGCGCGGAGGCGCGGTCCAAGGACGTCGGCGTCATCGCCACCGAGAAGGGCTGGAACCTCTACGTCGGCGGC
AACGGCGGTATGACGCCCAAGCACGCGCAGCTGCTCGCCAGTGACCTGGACACCGAGACGCTGGTCCGCTACATCGACCG
GTTCGTCATGTACTACATCCGCACGGCCGACCGGCTGCAGCGCACCGCGCCGTGGGTCGAGTCGCTGGACGGCGGTCTGG
ACCACGTCCGCGAGGTGGTGTGCGAGGACTCGCTGGGGCTGGCCGAGGAATTCGAGGCCGCAATGGAGCGGCATGTGCGC
AACTACAAGTGCGAATGGAAGGGCGTGCTGGACGATCCGGACAAGCTGTCGCGGTTCGTGTCGTTCGTCAACGCCCCCGA
CGCCGTCGATTCGACGGTGGCGTTCACCGAGCATGCCGGCCGCAAAATCCCTGTGTCCATTGGCATGCCGAAGATCCGTC
AGGGGTAG

Upstream 100 bases:

>100_bases
ACGATCAATCACAGCCGTTCCTGTGAGTTGTGAGATCCTCGTCATAGGACCGTCACATTGGGCGAAAAAGGCGTAATTTC
TCGCCGTTACTCTCAAAGCC

Downstream 100 bases:

>100_bases
TTCCGGAGGAACTGGGAGATAACATGACACTTCTCAACGACATTCAGGTGTGGACGAGCGCATGCTCCTACGACCACCTC
ATCCCCGGCCGCGGTGTCGG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 855; Mature: 854

Protein sequence:

>855_residues
MSADGISRDGCAPRHIIVVGHGMVGHRFVEALRARDTEGRWRITVFAEEADAAYDRVGLTSYTESWDRALLALPGNDYQG
DPQVRLVLNQRVTEIDRATKSVVTADGQRHHYDTLVLATGSYAFVPPVPGHELPACHVYRTLDDLDAIRADAQRAAQTAH
ARAGVVIGGGLLGLEAANALRQFGLATHVVEMMPRLMAQQIDEAGGALLARMIGDLGISVHVGTGTEAIEPVEGPDGSTT
VRVRLSDGQVIDAGLVIFAAGIRPRDELAVAAGLARAERGGVLTDLSCRTSDPDIYAIGEVAAIDGRCYGLVGPGYTSAE
VVADRLLDGSAEFGEADLSTKLKLLGVDVASFGDAMGTTENCLEVAINDAVNRTYAKLVLSDDAKTLLGGVLVGDASSYG
VLRPMVGSELPGDPLALIAPASSGGGTALGVGALPDSAQICSCNNVTKGDLKCAIADGCADVAALKSCTSAGTSCGSCVP
LLKQLLEAEGVEQSKALCEHFSQSRAELFEIISATEIRTFSGLLERFGRGKGCDICKPVVASILASTGSEHILEGEQASL
QDSNDHFLANIQKNGSYSVVPWVPGGDIKPEHLILIGQIAQDFGLYTKITGGQRIDMFGARVDQLPAIWKRLVDGGMESG
HAYGKALRTVKSCVGTDWCRYGQQDSVQLAIDLELRYRGLRAPHKIKMGVSGCARECAEARSKDVGVIATEKGWNLYVGG
NGGMTPKHAQLLASDLDTETLVRYIDRFVMYYIRTADRLQRTAPWVESLDGGLDHVREVVCEDSLGLAEEFEAAMERHVR
NYKCEWKGVLDDPDKLSRFVSFVNAPDAVDSTVAFTEHAGRKIPVSIGMPKIRQG

Sequences:

>Translated_855_residues
MSADGISRDGCAPRHIIVVGHGMVGHRFVEALRARDTEGRWRITVFAEEADAAYDRVGLTSYTESWDRALLALPGNDYQG
DPQVRLVLNQRVTEIDRATKSVVTADGQRHHYDTLVLATGSYAFVPPVPGHELPACHVYRTLDDLDAIRADAQRAAQTAH
ARAGVVIGGGLLGLEAANALRQFGLATHVVEMMPRLMAQQIDEAGGALLARMIGDLGISVHVGTGTEAIEPVEGPDGSTT
VRVRLSDGQVIDAGLVIFAAGIRPRDELAVAAGLARAERGGVLTDLSCRTSDPDIYAIGEVAAIDGRCYGLVGPGYTSAE
VVADRLLDGSAEFGEADLSTKLKLLGVDVASFGDAMGTTENCLEVAINDAVNRTYAKLVLSDDAKTLLGGVLVGDASSYG
VLRPMVGSELPGDPLALIAPASSGGGTALGVGALPDSAQICSCNNVTKGDLKCAIADGCADVAALKSCTSAGTSCGSCVP
LLKQLLEAEGVEQSKALCEHFSQSRAELFEIISATEIRTFSGLLERFGRGKGCDICKPVVASILASTGSEHILEGEQASL
QDSNDHFLANIQKNGSYSVVPWVPGGDIKPEHLILIGQIAQDFGLYTKITGGQRIDMFGARVDQLPAIWKRLVDGGMESG
HAYGKALRTVKSCVGTDWCRYGQQDSVQLAIDLELRYRGLRAPHKIKMGVSGCARECAEARSKDVGVIATEKGWNLYVGG
NGGMTPKHAQLLASDLDTETLVRYIDRFVMYYIRTADRLQRTAPWVESLDGGLDHVREVVCEDSLGLAEEFEAAMERHVR
NYKCEWKGVLDDPDKLSRFVSFVNAPDAVDSTVAFTEHAGRKIPVSIGMPKIRQG
>Mature_854_residues
SADGISRDGCAPRHIIVVGHGMVGHRFVEALRARDTEGRWRITVFAEEADAAYDRVGLTSYTESWDRALLALPGNDYQGD
PQVRLVLNQRVTEIDRATKSVVTADGQRHHYDTLVLATGSYAFVPPVPGHELPACHVYRTLDDLDAIRADAQRAAQTAHA
RAGVVIGGGLLGLEAANALRQFGLATHVVEMMPRLMAQQIDEAGGALLARMIGDLGISVHVGTGTEAIEPVEGPDGSTTV
RVRLSDGQVIDAGLVIFAAGIRPRDELAVAAGLARAERGGVLTDLSCRTSDPDIYAIGEVAAIDGRCYGLVGPGYTSAEV
VADRLLDGSAEFGEADLSTKLKLLGVDVASFGDAMGTTENCLEVAINDAVNRTYAKLVLSDDAKTLLGGVLVGDASSYGV
LRPMVGSELPGDPLALIAPASSGGGTALGVGALPDSAQICSCNNVTKGDLKCAIADGCADVAALKSCTSAGTSCGSCVPL
LKQLLEAEGVEQSKALCEHFSQSRAELFEIISATEIRTFSGLLERFGRGKGCDICKPVVASILASTGSEHILEGEQASLQ
DSNDHFLANIQKNGSYSVVPWVPGGDIKPEHLILIGQIAQDFGLYTKITGGQRIDMFGARVDQLPAIWKRLVDGGMESGH
AYGKALRTVKSCVGTDWCRYGQQDSVQLAIDLELRYRGLRAPHKIKMGVSGCARECAEARSKDVGVIATEKGWNLYVGGN
GGMTPKHAQLLASDLDTETLVRYIDRFVMYYIRTADRLQRTAPWVESLDGGLDHVREVVCEDSLGLAEEFEAAMERHVRN
YKCEWKGVLDDPDKLSRFVSFVNAPDAVDSTVAFTEHAGRKIPVSIGMPKIRQG

Specific function: Nitrate assimilation (denitrification); second step. [C]

COG id: COG1251

COG function: function code C; NAD(P)H-nitrite reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=286, Percent_Identity=24.4755244755245, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI226437568, Length=286, Percent_Identity=24.4755244755245, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI65787454, Length=286, Percent_Identity=24.4755244755245, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1789765, Length=838, Percent_Identity=49.6420047732697, Blast_Score=813, Evalue=0.0,
Organism=Escherichia coli, GI1789065, Length=396, Percent_Identity=28.5353535353535, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI1788892, Length=291, Percent_Identity=27.8350515463918, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17559934, Length=293, Percent_Identity=21.5017064846416, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585130, Length=289, Percent_Identity=22.8373702422145, Blast_Score=74, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281359715, Length=291, Percent_Identity=27.8350515463918, Blast_Score=69, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281359713, Length=291, Percent_Identity=27.8350515463918, Blast_Score=69, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639250, Length=291, Percent_Identity=27.8350515463918, Blast_Score=69, Evalue=2e-11,
Organism=Drosophila melanogaster, GI18543267, Length=291, Percent_Identity=27.8350515463918, Blast_Score=69, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639252, Length=291, Percent_Identity=27.8350515463918, Blast_Score=69, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639257, Length=291, Percent_Identity=27.8350515463918, Blast_Score=68, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007419
- InterPro:   IPR013027
- InterPro:   IPR005117
- InterPro:   IPR012744
- InterPro:   IPR012748
- InterPro:   IPR017881
- InterPro:   IPR006067
- InterPro:   IPR006066
- InterPro:   IPR001327
- InterPro:   IPR017941 [H]

Pfam domain/function: PF04324 Fer2_BFD; PF01077 NIR_SIR; PF03460 NIR_SIR_ferr; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.7.1.4 [H]

Molecular weight: Translated: 91059; Mature: 90928

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00365 NIR_SIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADGISRDGCAPRHIIVVGHGMVGHRFVEALRARDTEGRWRITVFAEEADAAYDRVGLT
CCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHCCCC
SYTESWDRALLALPGNDYQGDPQVRLVLNQRVTEIDRATKSVVTADGQRHHYDTLVLATG
HHHHCCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEC
SYAFVPPVPGHELPACHVYRTLDDLDAIRADAQRAAQTAHARAGVVIGGGLLGLEAANAL
CEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHH
RQFGLATHVVEMMPRLMAQQIDEAGGALLARMIGDLGISVHVGTGTEAIEPVEGPDGSTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCEE
VRVRLSDGQVIDAGLVIFAAGIRPRDELAVAAGLARAERGGVLTDLSCRTSDPDIYAIGE
EEEEECCCCEEECCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEECC
VAAIDGRCYGLVGPGYTSAEVVADRLLDGSAEFGEADLSTKLKLLGVDVASFGDAMGTTE
EEEECCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHCCCCCCHH
NCLEVAINDAVNRTYAKLVLSDDAKTLLGGVLVGDASSYGVLRPMVGSELPGDPLALIAP
HHHHHHHHHHHHHHHHHEEECCCHHHHHCEEEEECCCCCCCCCCHHCCCCCCCCEEEEEE
ASSGGGTALGVGALPDSAQICSCNNVTKGDLKCAIADGCADVAALKSCTSAGTSCGSCVP
CCCCCCCEEEECCCCCCCCEECCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCHHHH
LLKQLLEAEGVEQSKALCEHFSQSRAELFEIISATEIRTFSGLLERFGRGKGCDICKPVV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ASILASTGSEHILEGEQASLQDSNDHFLANIQKNGSYSVVPWVPGGDIKPEHLILIGQIA
HHHHHHCCCHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCEEEEEEHHH
QDFGLYTKITGGQRIDMFGARVDQLPAIWKRLVDGGMESGHAYGKALRTVKSCVGTDWCR
HHCCCEEEECCCCEEEHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHH
YGQQDSVQLAIDLELRYRGLRAPHKIKMGVSGCARECAEARSKDVGVIATEKGWNLYVGG
CCCCCCEEEEEEEEEEECCCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCEEEECC
NGGMTPKHAQLLASDLDTETLVRYIDRFVMYYIRTADRLQRTAPWVESLDGGLDHVREVV
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHH
CEDSLGLAEEFEAAMERHVRNYKCEWKGVLDDPDKLSRFVSFVNAPDAVDSTVAFTEHAG
HCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCC
RKIPVSIGMPKIRQG
CEEEEECCCCCCCCC
>Mature Secondary Structure 
SADGISRDGCAPRHIIVVGHGMVGHRFVEALRARDTEGRWRITVFAEEADAAYDRVGLT
CCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHCCCC
SYTESWDRALLALPGNDYQGDPQVRLVLNQRVTEIDRATKSVVTADGQRHHYDTLVLATG
HHHHCCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEC
SYAFVPPVPGHELPACHVYRTLDDLDAIRADAQRAAQTAHARAGVVIGGGLLGLEAANAL
CEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHH
RQFGLATHVVEMMPRLMAQQIDEAGGALLARMIGDLGISVHVGTGTEAIEPVEGPDGSTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCEE
VRVRLSDGQVIDAGLVIFAAGIRPRDELAVAAGLARAERGGVLTDLSCRTSDPDIYAIGE
EEEEECCCCEEECCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEECC
VAAIDGRCYGLVGPGYTSAEVVADRLLDGSAEFGEADLSTKLKLLGVDVASFGDAMGTTE
EEEECCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHCCCCCCHH
NCLEVAINDAVNRTYAKLVLSDDAKTLLGGVLVGDASSYGVLRPMVGSELPGDPLALIAP
HHHHHHHHHHHHHHHHHEEECCCHHHHHCEEEEECCCCCCCCCCHHCCCCCCCCEEEEEE
ASSGGGTALGVGALPDSAQICSCNNVTKGDLKCAIADGCADVAALKSCTSAGTSCGSCVP
CCCCCCCEEEECCCCCCCCEECCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCHHHH
LLKQLLEAEGVEQSKALCEHFSQSRAELFEIISATEIRTFSGLLERFGRGKGCDICKPVV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ASILASTGSEHILEGEQASLQDSNDHFLANIQKNGSYSVVPWVPGGDIKPEHLILIGQIA
HHHHHHCCCHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCEEEEEEHHH
QDFGLYTKITGGQRIDMFGARVDQLPAIWKRLVDGGMESGHAYGKALRTVKSCVGTDWCR
HHCCCEEEECCCCEEEHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHH
YGQQDSVQLAIDLELRYRGLRAPHKIKMGVSGCARECAEARSKDVGVIATEKGWNLYVGG
CCCCCCEEEEEEEEEEECCCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCEEEECC
NGGMTPKHAQLLASDLDTETLVRYIDRFVMYYIRTADRLQRTAPWVESLDGGLDHVREVV
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHH
CEDSLGLAEEFEAAMERHVRNYKCEWKGVLDDPDKLSRFVSFVNAPDAVDSTVAFTEHAG
HCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCC
RKIPVSIGMPKIRQG
CEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8468296 [H]