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The map label for this gene is ilvD

Identifier: 41409729

GI number: 41409729

Start: 4026807

End: 4028534

Strand: Reverse

Name: ilvD

Synonym: MAP3631c

Alternate gene names: 41409729

Gene position: 4028534-4026807 (Counterclockwise)

Preceding gene: 41409735

Following gene: 41409727

Centisome position: 83.41

GC content: 71.47

Gene sequence:

>1728_bases
ATGCCCACCACCGATTCGGCGCGCGCCGCCGACATCAAGCAGCCCGACATCAAGCCGCGCAGTCGTGACGTCACCGACGG
CCTGGAGAAGGCCGCCGCCCGGGGGATGCTGCGGGCGGTAGGCATGGGCGACGAGGACTTCGCCAAGCCGCAGATCGGGG
TGGCGTCGTCCTGGAACGAGATCACGCCGTGCAACCTGTCGCTGGACCGGCTGGCCAAGGCGGTCAAGGAAGGCGTCTTC
GCCGCGGGCGGCTACCCGCTGGAGTTCGGCACCATCTCGGTGTCCGACGGCATCTCGATGGGCCACGAGGGCATGCACTT
CTCGCTGGTGAGCCGCGAGGTGATCGCCGACAGCGTCGAGACGGTGATGCAGGCCGAGCGCCTGGACGGCTCGGTGCTGC
TGGCCGGCTGCGACAAGTCGCTGCCCGGCATGCTGATGGCCGCGGCCCGCCTGGACCTGGCCTCGGTGTTCCTCTACGCC
GGCTCGATCCTGCCCGGGGTGGCCAAGCTGTCCGACGGCAGCGAGCGCGAGGTGACGATCATCGACGCGTTCGAGGCCGT
CGGCGCGTGCGCGCGCGGGCTGATGCCGCGCGAGGACGTCGACGCCATCGAGCGGGCCATCTGTCCCGGCGAGGGCGCCT
GCGGCGGCATGTACACGGCCAACACCATGGCCAGCGCCGCCGAGGCGCTGGGGATGTCGCTGCCGGGCAGCGCGGCCCCG
CCGGCCACCGACCGCCGCCGCGACGGCTTCGCCCGGCGCAGCGGCCAGGCCGTCGTCGAGCTGCTGCGCCGCGGCATCAC
CGCCCGCGACATCCTCACCAAGGAGGCGTTCGAGAACGCGATCGCGGTGGTGATGGCGTTCGGCGGCTCCACCAACGCGG
TGCTGCACCTGCTGGCCATCGCCCACGAGGCCGACGTGGCGCTGTCGCTCGACGACTTCAGCCGGATCGGGTCGAAGGTG
CCGCACCTGGCCGACGTCAAGCCGTTCGGCCGGCACGTGATGACCGACGTCGACCACATCGGCGGCGTGCCGGTGATGAT
GAAGGCGCTGCTGGACGCCGGGCTGCTGAACGGCGACTGCCTGACGGTGACCGGTGCGACGGTGGCGCAGAACCTGGCCG
CGATCGCCCCGCCCGACCCGGACGGCAAGGTGCTGCGGGCACTCAGCGATCCGTTGCACCCGACCGGCGGCATCACCATC
CTGCGCGGGTCGCTGGCGCCCGAGGGCGCGGTGGTCAAGTCCGCCGGCTTCGATTCCGACGTGTTCGAAGGCACCGCAAG
GGTTTTCGACGGCGAGCGGGCCGCGCTGGACGCGCTGGAGGACGGCACCATCACCAAGGGCGACGCGGTGGTGATCCGGT
ACGAGGGCCCCAAGGGCGGGCCCGGGATGCGCGAGATGCTCGCCATCACCGGCGCGATCAAGGGCGCCGGGCTGGGTAAG
GACGTGCTGTTACTCACCGACGGCCGCTTCTCCGGCGGGACGACGGGACTGTGTGTCGGCCACATCGCGCCCGAGGCGGT
GGACGCAGGGCCGATCGCCTTTCTGCGCGACGGCGACCGCATCCGCCTGGACGTCGCCAACCGGGTTCTGGACGTACTCG
TCGATCCGGCCGAATTCGACTCTCGGCGAACAGGTTTCACCCCGCCGCCGCCCCGCTACAAGACCGGGGTGCTGGCCAAG
TACGTCAAGCTCGTCGGTTCCGCGGCGATCGGCGCCGTCTGCGGCTAG

Upstream 100 bases:

>100_bases
TGGCTGCCCCGCGGCGGCATCACACCCGGCCCCAGCTTATACCCCGCCCCGGTATAACCCCGGGAGCTGGTATCGCGACT
GGCCAGCGCATACTTGAACG

Downstream 100 bases:

>100_bases
CCTGGCCGCCTTGCGCTTTCGGCCTTCGGCGCGAGCGTGCCGTGGGCGACCACGCACGCTCGCGACCGAAAGTGGATCAG
CCGGCCGACGCGCGGGTGCG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MPTTDSARAADIKQPDIKPRSRDVTDGLEKAAARGMLRAVGMGDEDFAKPQIGVASSWNEITPCNLSLDRLAKAVKEGVF
AAGGYPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLASVFLYA
GSILPGVAKLSDGSEREVTIIDAFEAVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLPGSAAP
PATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVMAFGGSTNAVLHLLAIAHEADVALSLDDFSRIGSKV
PHLADVKPFGRHVMTDVDHIGGVPVMMKALLDAGLLNGDCLTVTGATVAQNLAAIAPPDPDGKVLRALSDPLHPTGGITI
LRGSLAPEGAVVKSAGFDSDVFEGTARVFDGERAALDALEDGTITKGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGK
DVLLLTDGRFSGGTTGLCVGHIAPEAVDAGPIAFLRDGDRIRLDVANRVLDVLVDPAEFDSRRTGFTPPPPRYKTGVLAK
YVKLVGSAAIGAVCG

Sequences:

>Translated_575_residues
MPTTDSARAADIKQPDIKPRSRDVTDGLEKAAARGMLRAVGMGDEDFAKPQIGVASSWNEITPCNLSLDRLAKAVKEGVF
AAGGYPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLASVFLYA
GSILPGVAKLSDGSEREVTIIDAFEAVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLPGSAAP
PATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVMAFGGSTNAVLHLLAIAHEADVALSLDDFSRIGSKV
PHLADVKPFGRHVMTDVDHIGGVPVMMKALLDAGLLNGDCLTVTGATVAQNLAAIAPPDPDGKVLRALSDPLHPTGGITI
LRGSLAPEGAVVKSAGFDSDVFEGTARVFDGERAALDALEDGTITKGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGK
DVLLLTDGRFSGGTTGLCVGHIAPEAVDAGPIAFLRDGDRIRLDVANRVLDVLVDPAEFDSRRTGFTPPPPRYKTGVLAK
YVKLVGSAAIGAVCG
>Mature_574_residues
PTTDSARAADIKQPDIKPRSRDVTDGLEKAAARGMLRAVGMGDEDFAKPQIGVASSWNEITPCNLSLDRLAKAVKEGVFA
AGGYPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLASVFLYAG
SILPGVAKLSDGSEREVTIIDAFEAVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLPGSAAPP
ATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVMAFGGSTNAVLHLLAIAHEADVALSLDDFSRIGSKVP
HLADVKPFGRHVMTDVDHIGGVPVMMKALLDAGLLNGDCLTVTGATVAQNLAAIAPPDPDGKVLRALSDPLHPTGGITIL
RGSLAPEGAVVKSAGFDSDVFEGTARVFDGERAALDALEDGTITKGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGKD
VLLLTDGRFSGGTTGLCVGHIAPEAVDAGPIAFLRDGDRIRLDVANRVLDVLVDPAEFDSRRTGFTPPPPRYKTGVLAKY
VKLVGSAAIGAVCG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=610, Percent_Identity=40, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI2367371, Length=501, Percent_Identity=35.1297405189621, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1786464, Length=488, Percent_Identity=35.8606557377049, Blast_Score=222, Evalue=6e-59,
Organism=Escherichia coli, GI1788157, Length=540, Percent_Identity=29.6296296296296, Blast_Score=196, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6322476, Length=562, Percent_Identity=47.3309608540925, Blast_Score=508, Evalue=1e-145,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59562; Mature: 59431

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTTDSARAADIKQPDIKPRSRDVTDGLEKAAARGMLRAVGMGDEDFAKPQIGVASSWNE
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCC
ITPCNLSLDRLAKAVKEGVFAAGGYPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVE
CCCCCCCHHHHHHHHHHCCEECCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
TVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTI
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEE
IDAFEAVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLPGSAAP
EHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
PATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVMAFGGSTNAVLHLLAI
CCCCHHHCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHH
AHEADVALSLDDFSRIGSKVPHLADVKPFGRHVMTDVDHIGGVPVMMKALLDAGLLNGDC
HHHCCEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCE
LTVTGATVAQNLAAIAPPDPDGKVLRALSDPLHPTGGITILRGSLAPEGAVVKSAGFDSD
EEEECHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEECCCCCHH
VFEGTARVFDGERAALDALEDGTITKGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGK
HHHHHHHHHCCCHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCC
DVLLLTDGRFSGGTTGLCVGHIAPEAVDAGPIAFLRDGDRIRLDVANRVLDVLVDPAEFD
CEEEEECCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCEEEEHHHHHHHHHHCCCHHHC
SRRTGFTPPPPRYKTGVLAKYVKLVGSAAIGAVCG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PTTDSARAADIKQPDIKPRSRDVTDGLEKAAARGMLRAVGMGDEDFAKPQIGVASSWNE
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCC
ITPCNLSLDRLAKAVKEGVFAAGGYPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVE
CCCCCCCHHHHHHHHHHCCEECCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
TVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLASVFLYAGSILPGVAKLSDGSEREVTI
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEE
IDAFEAVGACARGLMPREDVDAIERAICPGEGACGGMYTANTMASAAEALGMSLPGSAAP
EHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
PATDRRRDGFARRSGQAVVELLRRGITARDILTKEAFENAIAVVMAFGGSTNAVLHLLAI
CCCCHHHCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHH
AHEADVALSLDDFSRIGSKVPHLADVKPFGRHVMTDVDHIGGVPVMMKALLDAGLLNGDC
HHHCCEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCE
LTVTGATVAQNLAAIAPPDPDGKVLRALSDPLHPTGGITILRGSLAPEGAVVKSAGFDSD
EEEECHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEECCCCCHH
VFEGTARVFDGERAALDALEDGTITKGDAVVIRYEGPKGGPGMREMLAITGAIKGAGLGK
HHHHHHHHHCCCHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCC
DVLLLTDGRFSGGTTGLCVGHIAPEAVDAGPIAFLRDGDRIRLDVANRVLDVLVDPAEFD
CEEEEECCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCEEEEHHHHHHHHHHCCCHHHC
SRRTGFTPPPPRYKTGVLAKYVKLVGSAAIGAVCG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA