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The map label for this gene is mdmC [H]

Identifier: 41409725

GI number: 41409725

Start: 4024484

End: 4025137

Strand: Direct

Name: mdmC [H]

Synonym: MAP3627

Alternate gene names: 41409725

Gene position: 4024484-4025137 (Clockwise)

Preceding gene: 41409723

Following gene: 41409728

Centisome position: 83.33

GC content: 70.34

Gene sequence:

>654_bases
ATGACCGAGAAACCAACGCCCAAAGACGTCGACGCATTCTTGGACAGCACGGTGGTCGGCGGCGACCCGTCGGTGATCGA
CGCGCTCGAGGCCAGCAGCGCCGCCGGACTACCGCCGATCGCGGTGTCGGTGCAGCAGGGGAAGTTCCTCAGCCTGCTGG
CCACCGCCATGGGTGCGCGACGCATCCTCGAGCTCGGCACGCTGGGCGGGTTCAGCACCATCTGGCTGGCCCGCGGTGCC
GGCCCGCAGGGCCGGGTGGTGACGTTGGAATACGAGCCCAAGCACGCCGAGGTCGCCCGCGCCAACCTGCAGCGGGCCGG
CCTGGCCGATCGGGTGGAGGTGATCGTCGGCGCCGCGCTGGACACCCTGCCGTCGGTGACCGGTCCGTTCGATCTGGTGT
TCATCGACGCCGACAAGGAGAACTATCCCGCGTACCTGGACTGGGCGGTGCGGCTGGCCCGCCCGGGCGCGGTCATCGTG
GCGGACAACGTGATTCGTCAGGGCCAGATCCTCAAGCCGGAGGCCGACGCCCAAGCGCGGGCGGTGCGCCAAACGCTGCA
GGCGATGGGCGAGCACCCGCGGCTGGACACCGCGGTGATCCAGACGGTCGGCGCCAAGCACTGGGACGGCTTCGCGTTTG
CGGTGGTGCGCTAG

Upstream 100 bases:

>100_bases
GGTCGACCGCACCTACACTATATACCCCCCACGGGTATATAGTAAACGGCCGGATCGACCGGCCCGGCGAACCGTCGCGG
GTGCGGCTAGCGTTGGACGC

Downstream 100 bases:

>100_bases
GCCTCAGCGCGGGGTGAGGTCGGCGACGGCCTGGCGCGCGGAGGTGAGTTCGCCGATGCGCGAGGCGGTTTCGCCGGCGT
AGAGCGCGGCGCTGTCCAGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MTEKPTPKDVDAFLDSTVVGGDPSVIDALEASSAAGLPPIAVSVQQGKFLSLLATAMGARRILELGTLGGFSTIWLARGA
GPQGRVVTLEYEPKHAEVARANLQRAGLADRVEVIVGAALDTLPSVTGPFDLVFIDADKENYPAYLDWAVRLARPGAVIV
ADNVIRQGQILKPEADAQARAVRQTLQAMGEHPRLDTAVIQTVGAKHWDGFAFAVVR

Sequences:

>Translated_217_residues
MTEKPTPKDVDAFLDSTVVGGDPSVIDALEASSAAGLPPIAVSVQQGKFLSLLATAMGARRILELGTLGGFSTIWLARGA
GPQGRVVTLEYEPKHAEVARANLQRAGLADRVEVIVGAALDTLPSVTGPFDLVFIDADKENYPAYLDWAVRLARPGAVIV
ADNVIRQGQILKPEADAQARAVRQTLQAMGEHPRLDTAVIQTVGAKHWDGFAFAVVR
>Mature_216_residues
TEKPTPKDVDAFLDSTVVGGDPSVIDALEASSAAGLPPIAVSVQQGKFLSLLATAMGARRILELGTLGGFSTIWLARGAG
PQGRVVTLEYEPKHAEVARANLQRAGLADRVEVIVGAALDTLPSVTGPFDLVFIDADKENYPAYLDWAVRLARPGAVIVA
DNVIRQGQILKPEADAQARAVRQTLQAMGEHPRLDTAVIQTVGAKHWDGFAFAVVR

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=164, Percent_Identity=32.3170731707317, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI6466450, Length=156, Percent_Identity=30.1282051282051, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI205830453, Length=156, Percent_Identity=30.1282051282051, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI205830451, Length=156, Percent_Identity=30.1282051282051, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI4502969, Length=156, Percent_Identity=30.1282051282051, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI72001127, Length=168, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25148771, Length=167, Percent_Identity=26.9461077844311, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 23017; Mature: 22885

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKPTPKDVDAFLDSTVVGGDPSVIDALEASSAAGLPPIAVSVQQGKFLSLLATAMGAR
CCCCCCCCHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
RILELGTLGGFSTIWLARGAGPQGRVVTLEYEPKHAEVARANLQRAGLADRVEVIVGAAL
HHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHH
DTLPSVTGPFDLVFIDADKENYPAYLDWAVRLARPGAVIVADNVIRQGQILKPEADAQAR
HHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEEEEECCHHCCCEEECCCCCHHHH
AVRQTLQAMGEHPRLDTAVIQTVGAKHWDGFAFAVVR
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure 
TEKPTPKDVDAFLDSTVVGGDPSVIDALEASSAAGLPPIAVSVQQGKFLSLLATAMGAR
CCCCCCCHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
RILELGTLGGFSTIWLARGAGPQGRVVTLEYEPKHAEVARANLQRAGLADRVEVIVGAAL
HHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHH
DTLPSVTGPFDLVFIDADKENYPAYLDWAVRLARPGAVIVADNVIRQGQILKPEADAQAR
HHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEEEEECCHHCCCEEECCCCCHHHH
AVRQTLQAMGEHPRLDTAVIQTVGAKHWDGFAFAVVR
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]