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The map label for this gene is ytpA [H]

Identifier: 41409720

GI number: 41409720

Start: 4019833

End: 4020666

Strand: Direct

Name: ytpA [H]

Synonym: MAP3622

Alternate gene names: 41409720

Gene position: 4019833-4020666 (Clockwise)

Preceding gene: 41409717

Following gene: 41409721

Centisome position: 83.23

GC content: 71.1

Gene sequence:

>834_bases
GTGAACCGGACCGAACGTAGTTTCGACGGCGTCGGCGGTGTGCGCATCGTCTATGACGTCTGGACGCCGGAGGTCGCGCC
GCGCGCGGTGCTGGTGCTGTCCCACGGCTTCGGCGAGCATGCCCGCCGCTACGACCACGTCGCCCGGCGCTTCGGTGCGG
CCGGCCTGGTCACCTACGCGCTGGACCATCGCGGGCACGGCCGTTCCGGCGGCAAGCGGGTGCTGGTGCGCGACATCCAC
GAATACACCACCGACTTCGACACCCTGGTCGGCATCGCCACCCGGGAGCATCACGGCCTCAAGTGCATCGTGGTCGGGCA
CAGCATGGGCGGCGGGATCGTGTTCGCCTACGGCGTCGAGCGCCCCGACAACTACGACCTGATGGTGCTGTCCGGTCCCG
CGGTGGCGGCCCAGGACCAGGTGTCGCCGCTGCTGGCGCTGGCCGCCAAGGTGCTCGGCGTGATCGTGCCCGGGCTGCCC
GCGCAGGAACTCGACGCCGACGCCGTCTCCCGGGACCCCGAGGTGGTGGCCGCCTACCGCAACGATCCCCTGGTGTACCA
CGGCAAGGTCCCGGCCGGCGTGGGCCGCGCGTTGTTGCAGGTGGGTGAGACGATGCCGCAGCGGGCCCCGGCGCTGACGG
CGCCGCTGCTGGTCGTGCACGGCTCGGACGACCGGTTGATCCCGGTCGCCGGCAGCCGGCGCTTGGTCGAATGCGTGGGC
TCGGCCGACGTCGAGTTGAAGGTCTACCCGGGGCTCTACCACGAGGTGTTCAACGAGCCCGAGCGCGAGCAGGTGCTCGA
CGATGTGGTCGGCTGGATCACCGCTCGGCTGTGA

Upstream 100 bases:

>100_bases
GTTTGCGCGAGCAGGCTCACCCGCATGAGCGTACGCAGTGTCTGCAAGCGCGGCGCGGACCCGCAGCCATTACGCTGCCG
GTAATGATGAGGGACCCGCA

Downstream 100 bases:

>100_bases
GGCCGCCCGTGTCGGACCCCTCCCGTAAGTTGGCGCGTATGACTTCCGCTGGCGATGAGGAGGAGCGGCGCGGGTGATTT
CCGCCGGCGACGATGCAGAG

Product: hypothetical protein

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MNRTERSFDGVGGVRIVYDVWTPEVAPRAVLVLSHGFGEHARRYDHVARRFGAAGLVTYALDHRGHGRSGGKRVLVRDIH
EYTTDFDTLVGIATREHHGLKCIVVGHSMGGGIVFAYGVERPDNYDLMVLSGPAVAAQDQVSPLLALAAKVLGVIVPGLP
AQELDADAVSRDPEVVAAYRNDPLVYHGKVPAGVGRALLQVGETMPQRAPALTAPLLVVHGSDDRLIPVAGSRRLVECVG
SADVELKVYPGLYHEVFNEPEREQVLDDVVGWITARL

Sequences:

>Translated_277_residues
MNRTERSFDGVGGVRIVYDVWTPEVAPRAVLVLSHGFGEHARRYDHVARRFGAAGLVTYALDHRGHGRSGGKRVLVRDIH
EYTTDFDTLVGIATREHHGLKCIVVGHSMGGGIVFAYGVERPDNYDLMVLSGPAVAAQDQVSPLLALAAKVLGVIVPGLP
AQELDADAVSRDPEVVAAYRNDPLVYHGKVPAGVGRALLQVGETMPQRAPALTAPLLVVHGSDDRLIPVAGSRRLVECVG
SADVELKVYPGLYHEVFNEPEREQVLDDVVGWITARL
>Mature_277_residues
MNRTERSFDGVGGVRIVYDVWTPEVAPRAVLVLSHGFGEHARRYDHVARRFGAAGLVTYALDHRGHGRSGGKRVLVRDIH
EYTTDFDTLVGIATREHHGLKCIVVGHSMGGGIVFAYGVERPDNYDLMVLSGPAVAAQDQVSPLLALAAKVLGVIVPGLP
AQELDADAVSRDPEVVAAYRNDPLVYHGKVPAGVGRALLQVGETMPQRAPALTAPLLVVHGSDDRLIPVAGSRRLVECVG
SADVELKVYPGLYHEVFNEPEREQVLDDVVGWITARL

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=259, Percent_Identity=35.9073359073359, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI6005786, Length=259, Percent_Identity=35.9073359073359, Blast_Score=164, Evalue=9e-41,
Organism=Escherichia coli, GI1787678, Length=277, Percent_Identity=24.5487364620939, Blast_Score=72, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322756, Length=296, Percent_Identity=25.3378378378378, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 29928; Mature: 29928

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTERSFDGVGGVRIVYDVWTPEVAPRAVLVLSHGFGEHARRYDHVARRFGAAGLVTYA
CCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHEEEE
LDHRGHGRSGGKRVLVRDIHEYTTDFDTLVGIATREHHGLKCIVVGHSMGGGIVFAYGVE
ECCCCCCCCCCCEEHHHHHHHHHCCHHHHHEEEECCCCCEEEEEEECCCCCCEEEEEECC
RPDNYDLMVLSGPAVAAQDQVSPLLALAAKVLGVIVPGLPAQELDADAVSRDPEVVAAYR
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHCCCCCEEEEEC
NDPLVYHGKVPAGVGRALLQVGETMPQRAPALTAPLLVVHGSDDRLIPVAGSRRLVECVG
CCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEECCCCHHHHHHC
SADVELKVYPGLYHEVFNEPEREQVLDDVVGWITARL
CCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNRTERSFDGVGGVRIVYDVWTPEVAPRAVLVLSHGFGEHARRYDHVARRFGAAGLVTYA
CCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHEEEE
LDHRGHGRSGGKRVLVRDIHEYTTDFDTLVGIATREHHGLKCIVVGHSMGGGIVFAYGVE
ECCCCCCCCCCCEEHHHHHHHHHCCHHHHHEEEECCCCCEEEEEEECCCCCCEEEEEECC
RPDNYDLMVLSGPAVAAQDQVSPLLALAAKVLGVIVPGLPAQELDADAVSRDPEVVAAYR
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHCCCCCEEEEEC
NDPLVYHGKVPAGVGRALLQVGETMPQRAPALTAPLLVVHGSDDRLIPVAGSRRLVECVG
CCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEECCCCHHHHHHC
SADVELKVYPGLYHEVFNEPEREQVLDDVVGWITARL
CCCEEEEECCCHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]