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The map label for this gene is lip2 [H]

Identifier: 41409693

GI number: 41409693

Start: 3992440

End: 3993357

Strand: Direct

Name: lip2 [H]

Synonym: MAP3595

Alternate gene names: 41409693

Gene position: 3992440-3993357 (Clockwise)

Preceding gene: 41409692

Following gene: 41409695

Centisome position: 82.66

GC content: 75.16

Gene sequence:

>918_bases
GTGACGGCGCTGGACGGCGCCGAGCGCCTCGACCCGGCGCTGCGCGCGGTCGCCACCACCCGGACCGACTTCTCGCCCGC
CGCAATCGAACTCACCCGGGCGCCGTTCAACGAGCGCCGCCGGCTGGCCGCCGCGCAGACCGACACCGCCGGCGTGCGGA
TCGTCGACGACGACGCGAACGGCGTCGGCGTGCGCATCTATCGCGGCGGGCCCGAACCGGCGCCCGCCGTGATCTACTGC
CACGCCGGCGGATTCGCGCTGGGCAACCTGGACACCGACCACCGCCAGTGCGTGGAGCTGGCCCGGCGCGGCCGCTGCAC
GGTGGTGTCGGTCGACTACCGGCTGGCCCCCGAGCACCCCTACCCGGCCGCGCTGCAGGACGCGGGCACGGTGTTGCGGT
GGGTGCACGCCGAAGCCGCCGCCCTCGGCGTGGACCCGGCCCGGCTCGCCGTCGCGGGCAGCAGTGCCGGCGCCGCCCTG
GCCGCCTGCCTGGCGCACCCCGACGGGTCGTTGCCGGCCGTGGTGTTCCAGCTGCTGCACCAGCCGGTGCTCGACGACCG
GGCCACCGGGTCGAAGGCGCGGTTCCGGACCAGCCCGGCCTTCGACGGCGAGGCCGCCGAGCTGATGTGGCGCTACTACC
TGGGCCCGACCGTCGGGTCCGCGGCCGCCGTACCCGCGCGGCGGCCCGAATTAGCCGGGCTGCCACCGGCTTTGATCACC
TGCGCCGAGATCGACCCGTTCCGCGACGAGGCCATCGACTACGCCCGGCGGCTACTGGACGCCGGGGTCTGCACCGAGCT
GCACGTGTTCGCTCGTGCCTGCCACGGCTTCGACTCGCTGCTGCCGGACTGGCCGGGCTCGCAGCGATTGTTCGCGCTGC
AGGGCGAGGTGCTGTCGGCGGCGTTGCACCGCGATTAG

Upstream 100 bases:

>100_bases
GCGCCTTCTGGTCGATGACGCGCCGGTTCAGGCCGGCCGACTACCGGTTCCAGGCGCCGGCGATGCGCGTCCCGGCCCCG
GCCTCCGAGGCGGACGCGCG

Downstream 100 bases:

>100_bases
GCGTCGAACCGGATCAGCTGGCGCACCGCGGTGCCGTCGGCCAGATGATCCATCGCCTCGTTGATGTCTTCCAGCCGGAT
CGTGGACGACACCAGCGATT

Product: hypothetical protein

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MTALDGAERLDPALRAVATTRTDFSPAAIELTRAPFNERRRLAAAQTDTAGVRIVDDDANGVGVRIYRGGPEPAPAVIYC
HAGGFALGNLDTDHRQCVELARRGRCTVVSVDYRLAPEHPYPAALQDAGTVLRWVHAEAAALGVDPARLAVAGSSAGAAL
AACLAHPDGSLPAVVFQLLHQPVLDDRATGSKARFRTSPAFDGEAAELMWRYYLGPTVGSAAAVPARRPELAGLPPALIT
CAEIDPFRDEAIDYARRLLDAGVCTELHVFARACHGFDSLLPDWPGSQRLFALQGEVLSAALHRD

Sequences:

>Translated_305_residues
MTALDGAERLDPALRAVATTRTDFSPAAIELTRAPFNERRRLAAAQTDTAGVRIVDDDANGVGVRIYRGGPEPAPAVIYC
HAGGFALGNLDTDHRQCVELARRGRCTVVSVDYRLAPEHPYPAALQDAGTVLRWVHAEAAALGVDPARLAVAGSSAGAAL
AACLAHPDGSLPAVVFQLLHQPVLDDRATGSKARFRTSPAFDGEAAELMWRYYLGPTVGSAAAVPARRPELAGLPPALIT
CAEIDPFRDEAIDYARRLLDAGVCTELHVFARACHGFDSLLPDWPGSQRLFALQGEVLSAALHRD
>Mature_304_residues
TALDGAERLDPALRAVATTRTDFSPAAIELTRAPFNERRRLAAAQTDTAGVRIVDDDANGVGVRIYRGGPEPAPAVIYCH
AGGFALGNLDTDHRQCVELARRGRCTVVSVDYRLAPEHPYPAALQDAGTVLRWVHAEAAALGVDPARLAVAGSSAGAALA
ACLAHPDGSLPAVVFQLLHQPVLDDRATGSKARFRTSPAFDGEAAELMWRYYLGPTVGSAAAVPARRPELAGLPPALITC
AEIDPFRDEAIDYARRLLDAGVCTELHVFARACHGFDSLLPDWPGSQRLFALQGEVLSAALHRD

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI68051721, Length=335, Percent_Identity=26.2686567164179, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI157041239, Length=319, Percent_Identity=24.1379310344828, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI226423947, Length=343, Percent_Identity=25.6559766763848, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786682, Length=152, Percent_Identity=32.2368421052632, Blast_Score=78, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17540028, Length=223, Percent_Identity=27.8026905829596, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI72001146, Length=218, Percent_Identity=30.2752293577982, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71996133, Length=260, Percent_Identity=26.1538461538462, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 32429; Mature: 32298

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALDGAERLDPALRAVATTRTDFSPAAIELTRAPFNERRRLAAAQTDTAGVRIVDDDAN
CCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEECCCC
GVGVRIYRGGPEPAPAVIYCHAGGFALGNLDTDHRQCVELARRGRCTVVSVDYRLAPEHP
CEEEEEEECCCCCCCEEEEEECCCEEECCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCC
YPAALQDAGTVLRWVHAEAAALGVDPARLAVAGSSAGAALAACLAHPDGSLPAVVFQLLH
CCHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHH
QPVLDDRATGSKARFRTSPAFDGEAAELMWRYYLGPTVGSAAAVPARRPELAGLPPALIT
CCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHEE
CAEIDPFRDEAIDYARRLLDAGVCTELHVFARACHGFDSLLPDWPGSQRLFALQGEVLSA
ECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHH
ALHRD
HHCCC
>Mature Secondary Structure 
TALDGAERLDPALRAVATTRTDFSPAAIELTRAPFNERRRLAAAQTDTAGVRIVDDDAN
CCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEECCCC
GVGVRIYRGGPEPAPAVIYCHAGGFALGNLDTDHRQCVELARRGRCTVVSVDYRLAPEHP
CEEEEEEECCCCCCCEEEEEECCCEEECCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCC
YPAALQDAGTVLRWVHAEAAALGVDPARLAVAGSSAGAALAACLAHPDGSLPAVVFQLLH
CCHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHH
QPVLDDRATGSKARFRTSPAFDGEAAELMWRYYLGPTVGSAAAVPARRPELAGLPPALIT
CCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHEE
CAEIDPFRDEAIDYARRLLDAGVCTELHVFARACHGFDSLLPDWPGSQRLFALQGEVLSA
ECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHH
ALHRD
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]