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The map label for this gene is fadE2

Identifier: 41409668

GI number: 41409668

Start: 3968832

End: 3970064

Strand: Reverse

Name: fadE2

Synonym: MAP3570c

Alternate gene names: 41409668

Gene position: 3970064-3968832 (Counterclockwise)

Preceding gene: 41409677

Following gene: 41409667

Centisome position: 82.2

GC content: 69.59

Gene sequence:

>1233_bases
ATGGACTTCGCGATGTCGGCCAAAGCCAGCGACTACCACAAGCGGCTGACCGATTTCATGACCGAGCACGTCTTCGCGGC
CGAGGCCGAATACGACAAGTACCGGCACGAGGCCGGCCCGCACGACCACACCGTCCCGCCGGTGGTGGAACAGCTCAAGG
TCAAGGCCAAGCAGCAGGGGCTGTGGAACCTGTTCCTGCCCGCCGAGTCGGGTCTGACCAACCTGGAATACGCGCCGCTG
GCCGAGATCACCGGCTGGAGCCTGGAGATCGCGCCCGAGGCGCTCAACTGCGCGGCGCCCGACACCGGCAACATGGAGAC
GCTGCACCTGTTCGCCACCGAGGAGCAGCGCAAGCAGTGGCTGGAGCCGTTGCTGGCCGGCGAGATCCGCAGCGCCTTCT
CCATGACCGAGCCCGCCGTCGCGTCCAGCGACGCCCGCAACATCGAGACCTCCATCGTGCGCGACGGCGGCGACTACGTG
ATCAACGGCCGCAAGTGGTGGACGTCGGGCGCGGCGGACCCGCGCTGCAAGATCCTGATCGTGATGGGCCGCACCAACCC
CGACGCGGCCAGCCACCAACAACAGTCGATGGTGCTGGTGCCGATGGACACCCCGGGGGTGACGGTGGTGCGCTCCACCC
CGGTGTTCGGCTGGCAGGACCAGCACGGCCACTGCGAGATCGTCTACGACAACGTGCGGGTGCCGGTCACCAACCTGCTC
GGCGAGGAGGGCTCGGGCTTCGCGATCGCCCAGGCCCGGCTCGGTCCCGGCCGCATCCACCACTGCATGCGCGCCCTCGG
CGGGGCCGAGCGGGCGCTGGCGCTGATGGTCAACCGGGCCCAAAAGCGGGTGGCGTTCGGCCGCCCGCTGGCCGAGCAGG
GCGTGGTCCGGGAGTCGATTGCCAAGTCCCGCAACGAAATCGACCAGGCGCGGCTGCTCTGCGAGAAGGCGGCGTGGACC
ATCGACCAGCACGGCAACAAGGCCGCGCATCTGCTGGTCTCCCAGATCAAGGCGGTGGCGCCGAAGGTGGCCTGTGACGT
CATCGACCGGGCCATCCAGGTGCACGGCGCCGCCGGGGTCAGCGACGACACGGTGCTGGCCCGGCTGTACGGCTGGCATC
GCGCCATGCGGATCTTCGACGGCCCGGACGAGGTGCACATGCGGACCATCGCCCGCGCCGAACTGGGCCGGGAAAAGTCT
GCGCTCGCCGCGGCGGTCACCGCGCATGCCTGA

Upstream 100 bases:

>100_bases
TCTACCGCGAGCAGACACAAAAGCCCATTCCCAGCGGCGTGTCGGGGGGCTTTTGCGTCTGCTCGCGGTGGGCGGCGACC
CGTGTCCTATGGTGACGGGC

Downstream 100 bases:

>100_bases
GGCGCTGCGAGAACTGTCCGGCGCGTGGAACTTTCGTGACGTCGCCGACGGTGCGCCCATGCTGCGGCCGGGCCGGCTGT
TCCGGTCCGGCGAGCTGAGC

Product: FadE2

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MDFAMSAKASDYHKRLTDFMTEHVFAAEAEYDKYRHEAGPHDHTVPPVVEQLKVKAKQQGLWNLFLPAESGLTNLEYAPL
AEITGWSLEIAPEALNCAAPDTGNMETLHLFATEEQRKQWLEPLLAGEIRSAFSMTEPAVASSDARNIETSIVRDGGDYV
INGRKWWTSGAADPRCKILIVMGRTNPDAASHQQQSMVLVPMDTPGVTVVRSTPVFGWQDQHGHCEIVYDNVRVPVTNLL
GEEGSGFAIAQARLGPGRIHHCMRALGGAERALALMVNRAQKRVAFGRPLAEQGVVRESIAKSRNEIDQARLLCEKAAWT
IDQHGNKAAHLLVSQIKAVAPKVACDVIDRAIQVHGAAGVSDDTVLARLYGWHRAMRIFDGPDEVHMRTIARAELGREKS
ALAAAVTAHA

Sequences:

>Translated_410_residues
MDFAMSAKASDYHKRLTDFMTEHVFAAEAEYDKYRHEAGPHDHTVPPVVEQLKVKAKQQGLWNLFLPAESGLTNLEYAPL
AEITGWSLEIAPEALNCAAPDTGNMETLHLFATEEQRKQWLEPLLAGEIRSAFSMTEPAVASSDARNIETSIVRDGGDYV
INGRKWWTSGAADPRCKILIVMGRTNPDAASHQQQSMVLVPMDTPGVTVVRSTPVFGWQDQHGHCEIVYDNVRVPVTNLL
GEEGSGFAIAQARLGPGRIHHCMRALGGAERALALMVNRAQKRVAFGRPLAEQGVVRESIAKSRNEIDQARLLCEKAAWT
IDQHGNKAAHLLVSQIKAVAPKVACDVIDRAIQVHGAAGVSDDTVLARLYGWHRAMRIFDGPDEVHMRTIARAELGREKS
ALAAAVTAHA
>Mature_410_residues
MDFAMSAKASDYHKRLTDFMTEHVFAAEAEYDKYRHEAGPHDHTVPPVVEQLKVKAKQQGLWNLFLPAESGLTNLEYAPL
AEITGWSLEIAPEALNCAAPDTGNMETLHLFATEEQRKQWLEPLLAGEIRSAFSMTEPAVASSDARNIETSIVRDGGDYV
INGRKWWTSGAADPRCKILIVMGRTNPDAASHQQQSMVLVPMDTPGVTVVRSTPVFGWQDQHGHCEIVYDNVRVPVTNLL
GEEGSGFAIAQARLGPGRIHHCMRALGGAERALALMVNRAQKRVAFGRPLAEQGVVRESIAKSRNEIDQARLLCEKAAWT
IDQHGNKAAHLLVSQIKAVAPKVACDVIDRAIQVHGAAGVSDDTVLARLYGWHRAMRIFDGPDEVHMRTIARAELGREKS
ALAAAVTAHA

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI48976061, Length=401, Percent_Identity=53.6159600997506, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI211971008, Length=401, Percent_Identity=53.6159600997506, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI38505218, Length=409, Percent_Identity=51.1002444987775, Blast_Score=407, Evalue=1e-114,
Organism=Homo sapiens, GI4557233, Length=384, Percent_Identity=29.4270833333333, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI7656849, Length=399, Percent_Identity=28.0701754385965, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI21361497, Length=399, Percent_Identity=26.5664160401003, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI4557231, Length=405, Percent_Identity=24.6913580246914, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI187960098, Length=405, Percent_Identity=24.6913580246914, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4557235, Length=369, Percent_Identity=29.2682926829268, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI76496475, Length=369, Percent_Identity=29.2682926829268, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI4501859, Length=336, Percent_Identity=26.1904761904762, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4501857, Length=394, Percent_Identity=25.1269035532995, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI226958414, Length=283, Percent_Identity=23.321554770318, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI226958412, Length=283, Percent_Identity=23.321554770318, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI87081958, Length=308, Percent_Identity=28.5714285714286, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786223, Length=343, Percent_Identity=25.9475218658892, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17562446, Length=403, Percent_Identity=50.6203473945409, Blast_Score=378, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17534899, Length=348, Percent_Identity=29.5977011494253, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71985184, Length=342, Percent_Identity=30.4093567251462, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17569725, Length=357, Percent_Identity=26.890756302521, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17570075, Length=404, Percent_Identity=25.990099009901, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17505929, Length=319, Percent_Identity=28.2131661442006, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17551932, Length=358, Percent_Identity=27.6536312849162, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17533517, Length=292, Percent_Identity=27.3972602739726, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17508101, Length=283, Percent_Identity=27.9151943462898, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17538396, Length=348, Percent_Identity=27.5862068965517, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17506239, Length=372, Percent_Identity=25, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71985192, Length=253, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71990804, Length=215, Percent_Identity=30.6976744186047, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI32563615, Length=188, Percent_Identity=28.1914893617021, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21356377, Length=389, Percent_Identity=29.0488431876607, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24646207, Length=407, Percent_Identity=28.7469287469287, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI281363737, Length=344, Percent_Identity=28.4883720930233, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24660351, Length=398, Percent_Identity=27.8894472361809, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24666513, Length=284, Percent_Identity=28.8732394366197, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21355753, Length=282, Percent_Identity=24.113475177305, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 44937; Mature: 44937

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFAMSAKASDYHKRLTDFMTEHVFAAEAEYDKYRHEAGPHDHTVPPVVEQLKVKAKQQG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
LWNLFLPAESGLTNLEYAPLAEITGWSLEIAPEALNCAAPDTGNMETLHLFATEEQRKQW
CEEEEEECCCCCCCCCCCCCHHHCCCEEEECCCHHCCCCCCCCCCEEEEEEECHHHHHHH
LEPLLAGEIRSAFSMTEPAVASSDARNIETSIVRDGGDYVINGRKWWTSGAADPRCKILI
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEECCCCEEECCEEEECCCCCCCCEEEEE
VMGRTNPDAASHQQQSMVLVPMDTPGVTVVRSTPVFGWQDQHGHCEIVYDNVRVPVTNLL
EEECCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCHHHHC
GEEGSGFAIAQARLGPGRIHHCMRALGGAERALALMVNRAQKRVAFGRPLAEQGVVRESI
CCCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AKSRNEIDQARLLCEKAAWTIDQHGNKAAHLLVSQIKAVAPKVACDVIDRAIQVHGAAGV
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SDDTVLARLYGWHRAMRIFDGPDEVHMRTIARAELGREKSALAAAVTAHA
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure
MDFAMSAKASDYHKRLTDFMTEHVFAAEAEYDKYRHEAGPHDHTVPPVVEQLKVKAKQQG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
LWNLFLPAESGLTNLEYAPLAEITGWSLEIAPEALNCAAPDTGNMETLHLFATEEQRKQW
CEEEEEECCCCCCCCCCCCCHHHCCCEEEECCCHHCCCCCCCCCCEEEEEEECHHHHHHH
LEPLLAGEIRSAFSMTEPAVASSDARNIETSIVRDGGDYVINGRKWWTSGAADPRCKILI
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHEEECCCCEEECCEEEECCCCCCCCEEEEE
VMGRTNPDAASHQQQSMVLVPMDTPGVTVVRSTPVFGWQDQHGHCEIVYDNVRVPVTNLL
EEECCCCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCHHHHC
GEEGSGFAIAQARLGPGRIHHCMRALGGAERALALMVNRAQKRVAFGRPLAEQGVVRESI
CCCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AKSRNEIDQARLLCEKAAWTIDQHGNKAAHLLVSQIKAVAPKVACDVIDRAIQVHGAAGV
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SDDTVLARLYGWHRAMRIFDGPDEVHMRTIARAELGREKSALAAAVTAHA
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]