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The map label for this gene is ilvB [H]

Identifier: 41409610

GI number: 41409610

Start: 3910341

End: 3912047

Strand: Direct

Name: ilvB [H]

Synonym: MAP3512

Alternate gene names: 41409610

Gene position: 3910341-3912047 (Clockwise)

Preceding gene: 41409609

Following gene: 41409611

Centisome position: 80.96

GC content: 69.6

Gene sequence:

>1707_bases
ATGGGTGTGCCGGTTTATCAGCGGATCCTCGATCTCTTCCAGGCCGAGGGGGTGAATACCCTGTTCGGCATCCCGGACCC
CAACTTCGTGCGCATGTTCTTAGAGGCCGAATCCCGGGGCTGGTCGGTGGTCTCGCCGCACCACGAGCTGAGCGCGGGAT
TCATGGCCGAGGCGGCGTCGCGGATGACCGGCAAGCCCGGCCTGTGCATCGGGACGCTCGGCCCGGGCATGGCCAACATC
GCCGGTGCCATCCAGTGCGCGCTGGTGGAGAACTCGCCGGTGATCTTTCTCGGCGGCCAGCGGGCCCGCGTCACCGAACG
CCGGGTGCGCCGCGGACGCATCCAATTCGTGCGCCAGGAGCCACTTTTCGCGCCGTCGGTCAAATACAGCGCGTCCATCG
AATACGCCGACCAGACCGACGAGATCATCCACGAGGCGCTGCGCCGGGCCATGTCCGGCACGCCCGGCCCGGCCTACATC
GAATACCCCTCCCACGTGATCCTCTCCGAGCTCGACGTGCCCGACCCGCTGCCGCCGCACCGGTACCGGCTGGTCAACCA
GACCGCCGGGGAGCGCGAGGTGGCCGAGGCGGTGCGGCTGATCCGCGCCGCCGAGAGCCCGATCCTGCTGGTCGGGCACG
GGGTGCACACCTCGCGCACCGGCGCCGCGGTCCGGGAGCTGGCCGAGCTGATGGCCTGCCCGGTAATCCAGACCTCCGGC
GGCACCTCTTTCATCGACGGTCTGCAGGACCGCACCTTCGCCTACGGGTTCTCCCCCGCCGCCGTGGAGGCGGTGGTGAC
CTCCGACCTGTGCCTGGCGTTGGGCACCGAGCTCGGCGAACCGAGCCACTACGGCCGCACCCGGCACTGGGCGCAGAACG
ACGCCACGCGCAAATGGATTCTGGTGGAACAGGATCCGGCCGCCATCGGCGTCAACCGTCCCATCGACGTGCCGCTGGTC
GGTGACCTGCGCGGGGTGGTGCCGCAGCTGGTGGCGGCGCTGCGGGACACCCCGCGCAAGCCCTCGCCGGATCTGGACCG
CTGGATCGAGCAGGACGCGGCGGAGCTGGCGCAGCTCGCCGAGAACGCGCCGACGGGCCGCACCCCGATCCACCCGGCCC
GGTTCGTCGTCGAGGCCACCCGGGCCTTTCCCGACGACGGCATCATGGTGCGCGACGGCGGCGCCACCGTCATCTTCGGC
TGGACCTACTCGCAGGCCAAGCCGCGCGACGTGATCTGGAACCAGAACTTCGGCCACCTGGGCACCGGCCTGCCGTATGC
GGTCGGGGCGTCCATCGCCGAGGGCGGCAAGCGGCCGGTGATGCTGTTGACCAGCGACTCGGCCTTCCTCTTCCACATCG
CCGAGCTGGAAACCGCTGCGCGGCAAGGACTTCCACTGGTCTGCGTGGTGGGCGTCGACCACCAGTGGGGCCTCGAGGTG
GGCGTCTACAAGCGCACCTTCTCTCAGCCGTCGCCGCAGCCCGGCGTGCACTGGAGCAAGGACGTGCGGCTGGACAAGGT
CGCCGAGGGCTTCGGCTGCCACGGCGAGTACGTGGAGAAGGAGGACGAGATCGGCCCGGCGATCCAGCGGTCCTACGCCA
GCGGCAAGCCCGCCGTCGTGCACGTCTGCATCGATCCGAAGGCCAATTCCGAGGAGATGCCCAAGTACGACGAATTCCGC
ACCTGGTATGCCGAGGGCACCCAGTAA

Upstream 100 bases:

>100_bases
CGAAGTGCTCGCCGAAATCGGCGCGAGCAGACGCAAAAGCTCCCGAAACGCCGTGCCGGAGGCGGATTTTGCGTCTGCTC
GCGAGGGAAAGGAACTGTAA

Downstream 100 bases:

>100_bases
GAGAAGGATGATCTGATGCGCGAATACCTGAAGTTCTACATCGACGGACAATGGGTCGACCCGGTGCGGCCCAACACGTT
CGACGTGGAAAACCCGGCGA

Product: hypothetical protein

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MGVPVYQRILDLFQAEGVNTLFGIPDPNFVRMFLEAESRGWSVVSPHHELSAGFMAEAASRMTGKPGLCIGTLGPGMANI
AGAIQCALVENSPVIFLGGQRARVTERRVRRGRIQFVRQEPLFAPSVKYSASIEYADQTDEIIHEALRRAMSGTPGPAYI
EYPSHVILSELDVPDPLPPHRYRLVNQTAGEREVAEAVRLIRAAESPILLVGHGVHTSRTGAAVRELAELMACPVIQTSG
GTSFIDGLQDRTFAYGFSPAAVEAVVTSDLCLALGTELGEPSHYGRTRHWAQNDATRKWILVEQDPAAIGVNRPIDVPLV
GDLRGVVPQLVAALRDTPRKPSPDLDRWIEQDAAELAQLAENAPTGRTPIHPARFVVEATRAFPDDGIMVRDGGATVIFG
WTYSQAKPRDVIWNQNFGHLGTGLPYAVGASIAEGGKRPVMLLTSDSAFLFHIAELETAARQGLPLVCVVGVDHQWGLEV
GVYKRTFSQPSPQPGVHWSKDVRLDKVAEGFGCHGEYVEKEDEIGPAIQRSYASGKPAVVHVCIDPKANSEEMPKYDEFR
TWYAEGTQ

Sequences:

>Translated_568_residues
MGVPVYQRILDLFQAEGVNTLFGIPDPNFVRMFLEAESRGWSVVSPHHELSAGFMAEAASRMTGKPGLCIGTLGPGMANI
AGAIQCALVENSPVIFLGGQRARVTERRVRRGRIQFVRQEPLFAPSVKYSASIEYADQTDEIIHEALRRAMSGTPGPAYI
EYPSHVILSELDVPDPLPPHRYRLVNQTAGEREVAEAVRLIRAAESPILLVGHGVHTSRTGAAVRELAELMACPVIQTSG
GTSFIDGLQDRTFAYGFSPAAVEAVVTSDLCLALGTELGEPSHYGRTRHWAQNDATRKWILVEQDPAAIGVNRPIDVPLV
GDLRGVVPQLVAALRDTPRKPSPDLDRWIEQDAAELAQLAENAPTGRTPIHPARFVVEATRAFPDDGIMVRDGGATVIFG
WTYSQAKPRDVIWNQNFGHLGTGLPYAVGASIAEGGKRPVMLLTSDSAFLFHIAELETAARQGLPLVCVVGVDHQWGLEV
GVYKRTFSQPSPQPGVHWSKDVRLDKVAEGFGCHGEYVEKEDEIGPAIQRSYASGKPAVVHVCIDPKANSEEMPKYDEFR
TWYAEGTQ
>Mature_567_residues
GVPVYQRILDLFQAEGVNTLFGIPDPNFVRMFLEAESRGWSVVSPHHELSAGFMAEAASRMTGKPGLCIGTLGPGMANIA
GAIQCALVENSPVIFLGGQRARVTERRVRRGRIQFVRQEPLFAPSVKYSASIEYADQTDEIIHEALRRAMSGTPGPAYIE
YPSHVILSELDVPDPLPPHRYRLVNQTAGEREVAEAVRLIRAAESPILLVGHGVHTSRTGAAVRELAELMACPVIQTSGG
TSFIDGLQDRTFAYGFSPAAVEAVVTSDLCLALGTELGEPSHYGRTRHWAQNDATRKWILVEQDPAAIGVNRPIDVPLVG
DLRGVVPQLVAALRDTPRKPSPDLDRWIEQDAAELAQLAENAPTGRTPIHPARFVVEATRAFPDDGIMVRDGGATVIFGW
TYSQAKPRDVIWNQNFGHLGTGLPYAVGASIAEGGKRPVMLLTSDSAFLFHIAELETAARQGLPLVCVVGVDHQWGLEVG
VYKRTFSQPSPQPGVHWSKDVRLDKVAEGFGCHGEYVEKEDEIGPAIQRSYASGKPAVVHVCIDPKANSEEMPKYDEFRT
WYAEGTQ

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=556, Percent_Identity=24.1007194244604, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI21361361, Length=595, Percent_Identity=24.8739495798319, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1788716, Length=554, Percent_Identity=26.3537906137184, Blast_Score=149, Evalue=6e-37,
Organism=Escherichia coli, GI1790104, Length=558, Percent_Identity=24.5519713261649, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1786717, Length=566, Percent_Identity=25.4416961130742, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI87081685, Length=494, Percent_Identity=24.6963562753036, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1787096, Length=511, Percent_Identity=23.2876712328767, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17542570, Length=560, Percent_Identity=24.8214285714286, Blast_Score=135, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17531299, Length=583, Percent_Identity=24.5283018867925, Blast_Score=128, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17531301, Length=583, Percent_Identity=24.5283018867925, Blast_Score=128, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320816, Length=570, Percent_Identity=24.3859649122807, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6323755, Length=564, Percent_Identity=23.2269503546099, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI19922626, Length=575, Percent_Identity=25.2173913043478, Blast_Score=149, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 61930; Mature: 61799

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVPVYQRILDLFQAEGVNTLFGIPDPNFVRMFLEAESRGWSVVSPHHELSAGFMAEAAS
CCCHHHHHHHHHHHHCCCCEEECCCCCHHEEEEEECCCCCCEEECCCHHHHHHHHHHHHH
RMTGKPGLCIGTLGPGMANIAGAIQCALVENSPVIFLGGQRARVTERRVRRGRIQFVRQE
HHCCCCCEEEECCCCCHHHHHHEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHCC
PLFAPSVKYSASIEYADQTDEIIHEALRRAMSGTPGPAYIEYPSHVILSELDVPDPLPPH
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCEEEEECCCCCCCCCCH
RYRLVNQTAGEREVAEAVRLIRAAESPILLVGHGVHTSRTGAAVRELAELMACPVIQTSG
HHEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEECC
GTSFIDGLQDRTFAYGFSPAAVEAVVTSDLCLALGTELGEPSHYGRTRHWAQNDATRKWI
CCHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEE
LVEQDPAAIGVNRPIDVPLVGDLRGVVPQLVAALRDTPRKPSPDLDRWIEQDAAELAQLA
EEECCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
ENAPTGRTPIHPARFVVEATRAFPDDGIMVRDGGATVIFGWTYSQAKPRDVIWNQNFGHL
HCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCCCCCCCEEECCCCCCC
GTGLPYAVGASIAEGGKRPVMLLTSDSAFLFHIAELETAARQGLPLVCVVGVDHQWGLEV
CCCCCHHHCCHHHCCCCCCEEEEECCCEEEEEHHHHHHHHHCCCCEEEEEECCCCCCCEE
GVYKRTFSQPSPQPGVHWSKDVRLDKVAEGFGCHGEYVEKEDEIGPAIQRSYASGKPAVV
EHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHCCHHHHHHHCCCCCEEE
HVCIDPKANSEEMPKYDEFRTWYAEGTQ
EEEECCCCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
GVPVYQRILDLFQAEGVNTLFGIPDPNFVRMFLEAESRGWSVVSPHHELSAGFMAEAAS
CCHHHHHHHHHHHHCCCCEEECCCCCHHEEEEEECCCCCCEEECCCHHHHHHHHHHHHH
RMTGKPGLCIGTLGPGMANIAGAIQCALVENSPVIFLGGQRARVTERRVRRGRIQFVRQE
HHCCCCCEEEECCCCCHHHHHHEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHCC
PLFAPSVKYSASIEYADQTDEIIHEALRRAMSGTPGPAYIEYPSHVILSELDVPDPLPPH
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCEEEEECCCCCCCCCCH
RYRLVNQTAGEREVAEAVRLIRAAESPILLVGHGVHTSRTGAAVRELAELMACPVIQTSG
HHEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEECC
GTSFIDGLQDRTFAYGFSPAAVEAVVTSDLCLALGTELGEPSHYGRTRHWAQNDATRKWI
CCHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEE
LVEQDPAAIGVNRPIDVPLVGDLRGVVPQLVAALRDTPRKPSPDLDRWIEQDAAELAQLA
EEECCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
ENAPTGRTPIHPARFVVEATRAFPDDGIMVRDGGATVIFGWTYSQAKPRDVIWNQNFGHL
HCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCCCCCCCEEECCCCCCC
GTGLPYAVGASIAEGGKRPVMLLTSDSAFLFHIAELETAARQGLPLVCVVGVDHQWGLEV
CCCCCHHHCCHHHCCCCCCEEEEECCCEEEEEHHHHHHHHHCCCCEEEEEECCCCCCCEE
GVYKRTFSQPSPQPGVHWSKDVRLDKVAEGFGCHGEYVEKEDEIGPAIQRSYASGKPAVV
EHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHCCHHHHHHHCCCCCEEE
HVCIDPKANSEEMPKYDEFRTWYAEGTQ
EEEECCCCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]