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The map label for this gene is fadD12_2

Identifier: 41409595

GI number: 41409595

Start: 3889728

End: 3891293

Strand: Direct

Name: fadD12_2

Synonym: MAP3497

Alternate gene names: 41409595

Gene position: 3889728-3891293 (Clockwise)

Preceding gene: 41409594

Following gene: 41409599

Centisome position: 80.54

GC content: 72.41

Gene sequence:

>1566_bases
GTGAGCGCTGAACGGGTGGCGCCCACCGCCGCCCGGGCGCTGGTGCGCTCCGGTCTGCTCAACCCGCCCTCGCCGCGGGC
GGTTCTGCGGCTGCTTCGCGAGGCGAGCCGCGGCGGCACCAACCCCTACACGCTGTTGGCGGTCACCGCGGCCCGCTGGC
CGGGCCGCACCGCGATCATCGACGACGACGGCGCGCTGTCCTACCGCGAGCTGCAGCGCGCCACCGAATCGCTGGCGCGG
CGGTTGATCCGCGACGGCGTCGCGCCCGGCCGGGCGGTCGGGGTCATGTGCCGCAACGGACGCGGTTTTGTCACAGCGGT
TTTCGCGGTTGCCCTGCTCGGCGCCGACGTCGTCCCGATCAGCACCGAGTTCCGCAGTGACGCGCTGGCGGTCGCGCTGC
GCGCCCACCACATCTCGACGGTGGTGGCCGACAACGAATTCGCCGAGCGGATCGCGGGCGCCGACGACGCGGTCGCCGTC
ATCGACCCGGCCACCGCCGGCGCCGAGGAGAGCGGCGGGCGACCGGCCGTCGCCGCGCCCGGCCGCATCGTGCTGCTGAC
CTCGGGGACCACCGGGAAACCCAAGGGGGTGCCGCGCGCCCCGCAGCTGCGCTCCGCGGTGGGGGTGTGGGTGACCATCC
TGGACCGCACCCGGCTGCGCACCGGATCGCGAATCTCGGTGGCAATGCCGATGTTTCACGGGTTGGGCCTGGGCATGCTG
ATGCTCACCATCGCCCTGGGCGGCACGGTGCTGACCCATCGCCATTTCGACGCTGAAGCCGCGCTGGCCCAGGCCTCGCT
GCACCGGGCCGACGCCTTCACCGCGGTTCCGGTGGTGCTGGCCCGCATCCTCGAGCTGCCGCCGCGGGTGCGGGCGCGAA
ATCCGTTGCCGCAGTTGCGGGTCGTGATGTCCAGCGGCGACCGGCTCGATCCCACGCTGGGACAGCGGTTCATGGACACC
TACGGCAACATCCTCTACAACGGCTACGGTTCCACCGAGGTGGGCATCGGGGCGCTGGCGACACCGGCGGACCTGCGCGA
CGCCCCGGAAACCGTCGGGAAACCCGTCGCCGGCTGCCCGGTGCGGATCCTGGACCGCAACAACCGGCCGGTCGGCCCAC
GGGTGACCGGGCGCATCTTCGTCGGCGGCGAGCTGGCCGGCACTCGCTACACCGACGGCGGCGGGAAGACCGTCGTCGAC
GGCATGACCAGCACCGGCGACATGGGCTACCTGGACAACGCCGGCCGACTGTTCATCGTCGGCCGGGAGGACGACATGAT
CATCTCCGGCGGGGAGAACGTCTACCCGCGCGCGGTGGAGAACGCGCTCGCCGCGCACCCCGCCGTCGCCGACAACGCGG
TGATCGGCGTTCCCGACGAGCGGTTCGGCCACCGCCTGGCAGCGTTCGTGGTGCTGCACCCCGGCAGCGGCGTCGACGCG
GCGCAGCTGCGCGACTACCTCAAGGACCGGGTCTCGCGGTTCGAGCAGCCGCGCGACATCAACATCGTGTCGAGCATTCC
GCGCAACCCGACCGGCAAGGTGCTGCGCAAGGAACTGCCCGGTTAG

Upstream 100 bases:

>100_bases
CTGCCGGCCGAGCTGGCCTCGGTGCTGCTGGCCGGCCCGGCCGACCGCGCCGCACGGCTGTGGCATCGCCGGTTCTTCAG
CGACGCCGAGGAGGCCGGCC

Downstream 100 bases:

>100_bases
GAACCGTTAGGCATCCTGCTGGCCGGGCTCGAGGGCGGCGACCTGTTTGGCCAGCCAGTTGGGGGCCAGCGCCGAGATCG
CGGTGGCGCCCGCGGTGGAA

Product: acyl-CoA synthetase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MSAERVAPTAARALVRSGLLNPPSPRAVLRLLREASRGGTNPYTLLAVTAARWPGRTAIIDDDGALSYRELQRATESLAR
RLIRDGVAPGRAVGVMCRNGRGFVTAVFAVALLGADVVPISTEFRSDALAVALRAHHISTVVADNEFAERIAGADDAVAV
IDPATAGAEESGGRPAVAAPGRIVLLTSGTTGKPKGVPRAPQLRSAVGVWVTILDRTRLRTGSRISVAMPMFHGLGLGML
MLTIALGGTVLTHRHFDAEAALAQASLHRADAFTAVPVVLARILELPPRVRARNPLPQLRVVMSSGDRLDPTLGQRFMDT
YGNILYNGYGSTEVGIGALATPADLRDAPETVGKPVAGCPVRILDRNNRPVGPRVTGRIFVGGELAGTRYTDGGGKTVVD
GMTSTGDMGYLDNAGRLFIVGREDDMIISGGENVYPRAVENALAAHPAVADNAVIGVPDERFGHRLAAFVVLHPGSGVDA
AQLRDYLKDRVSRFEQPRDINIVSSIPRNPTGKVLRKELPG

Sequences:

>Translated_521_residues
MSAERVAPTAARALVRSGLLNPPSPRAVLRLLREASRGGTNPYTLLAVTAARWPGRTAIIDDDGALSYRELQRATESLAR
RLIRDGVAPGRAVGVMCRNGRGFVTAVFAVALLGADVVPISTEFRSDALAVALRAHHISTVVADNEFAERIAGADDAVAV
IDPATAGAEESGGRPAVAAPGRIVLLTSGTTGKPKGVPRAPQLRSAVGVWVTILDRTRLRTGSRISVAMPMFHGLGLGML
MLTIALGGTVLTHRHFDAEAALAQASLHRADAFTAVPVVLARILELPPRVRARNPLPQLRVVMSSGDRLDPTLGQRFMDT
YGNILYNGYGSTEVGIGALATPADLRDAPETVGKPVAGCPVRILDRNNRPVGPRVTGRIFVGGELAGTRYTDGGGKTVVD
GMTSTGDMGYLDNAGRLFIVGREDDMIISGGENVYPRAVENALAAHPAVADNAVIGVPDERFGHRLAAFVVLHPGSGVDA
AQLRDYLKDRVSRFEQPRDINIVSSIPRNPTGKVLRKELPG
>Mature_520_residues
SAERVAPTAARALVRSGLLNPPSPRAVLRLLREASRGGTNPYTLLAVTAARWPGRTAIIDDDGALSYRELQRATESLARR
LIRDGVAPGRAVGVMCRNGRGFVTAVFAVALLGADVVPISTEFRSDALAVALRAHHISTVVADNEFAERIAGADDAVAVI
DPATAGAEESGGRPAVAAPGRIVLLTSGTTGKPKGVPRAPQLRSAVGVWVTILDRTRLRTGSRISVAMPMFHGLGLGMLM
LTIALGGTVLTHRHFDAEAALAQASLHRADAFTAVPVVLARILELPPRVRARNPLPQLRVVMSSGDRLDPTLGQRFMDTY
GNILYNGYGSTEVGIGALATPADLRDAPETVGKPVAGCPVRILDRNNRPVGPRVTGRIFVGGELAGTRYTDGGGKTVVDG
MTSTGDMGYLDNAGRLFIVGREDDMIISGGENVYPRAVENALAAHPAVADNAVIGVPDERFGHRLAAFVVLHPGSGVDAA
QLRDYLKDRVSRFEQPRDINIVSSIPRNPTGKVLRKELPG

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=525, Percent_Identity=26.6666666666667, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI187761343, Length=525, Percent_Identity=26.6666666666667, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI122937307, Length=356, Percent_Identity=29.7752808988764, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI42544132, Length=361, Percent_Identity=26.8698060941828, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI156151445, Length=544, Percent_Identity=23.8970588235294, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI115511026, Length=366, Percent_Identity=27.8688524590164, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI38505220, Length=484, Percent_Identity=25.2066115702479, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI58082049, Length=381, Percent_Identity=27.5590551181102, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI157311624, Length=381, Percent_Identity=26.509186351706, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI157311622, Length=381, Percent_Identity=26.509186351706, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI13375727, Length=383, Percent_Identity=26.1096605744125, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI28416953, Length=518, Percent_Identity=23.7451737451737, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI221142682, Length=487, Percent_Identity=27.3100616016427, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI1786810, Length=498, Percent_Identity=27.710843373494, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI145693145, Length=511, Percent_Identity=26.027397260274, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788107, Length=525, Percent_Identity=23.2380952380952, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788595, Length=446, Percent_Identity=29.1479820627803, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786801, Length=513, Percent_Identity=25.1461988304094, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1790505, Length=530, Percent_Identity=22.4528301886792, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786529, Length=417, Percent_Identity=24.9400479616307, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17557194, Length=501, Percent_Identity=26.9461077844311, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17538037, Length=499, Percent_Identity=26.0521042084168, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17558820, Length=509, Percent_Identity=27.7013752455796, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17559526, Length=353, Percent_Identity=28.8951841359773, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI71994694, Length=521, Percent_Identity=25.7197696737044, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17560140, Length=492, Percent_Identity=23.1707317073171, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71994690, Length=521, Percent_Identity=25.7197696737044, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71994703, Length=521, Percent_Identity=25.7197696737044, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32563687, Length=508, Percent_Identity=27.1653543307087, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17531443, Length=499, Percent_Identity=22.2444889779559, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71996755, Length=496, Percent_Identity=21.5725806451613, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI25141359, Length=484, Percent_Identity=23.9669421487603, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71985884, Length=234, Percent_Identity=30.7692307692308, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17560308, Length=366, Percent_Identity=26.775956284153, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319699, Length=346, Percent_Identity=28.9017341040462, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6323182, Length=292, Percent_Identity=25.6849315068493, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319264, Length=387, Percent_Identity=25.0645994832041, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24581924, Length=507, Percent_Identity=25.2465483234714, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI18859661, Length=358, Percent_Identity=28.4916201117318, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI21355181, Length=503, Percent_Identity=24.6520874751491, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24653035, Length=384, Percent_Identity=25.2604166666667, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI161076582, Length=391, Percent_Identity=24.8081841432225, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24648260, Length=346, Percent_Identity=29.7687861271676, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24648257, Length=350, Percent_Identity=28.2857142857143, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI20130357, Length=344, Percent_Identity=24.4186046511628, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19922652, Length=509, Percent_Identity=22.9862475442043, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24648255, Length=469, Percent_Identity=24.7334754797441, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24648253, Length=469, Percent_Identity=24.3070362473348, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21356441, Length=490, Percent_Identity=23.265306122449, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21358303, Length=462, Percent_Identity=22.0779220779221, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356947, Length=346, Percent_Identity=25.7225433526012, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281365686, Length=173, Percent_Identity=28.3236994219653, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656500, Length=491, Percent_Identity=21.1812627291242, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21355225, Length=383, Percent_Identity=24.8041775456919, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648676, Length=561, Percent_Identity=25.3119429590018, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 55071; Mature: 54940

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAERVAPTAARALVRSGLLNPPSPRAVLRLLREASRGGTNPYTLLAVTAARWPGRTAII
CCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEEEE
DDDGALSYRELQRATESLARRLIRDGVAPGRAVGVMCRNGRGFVTAVFAVALLGADVVPI
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEC
STEFRSDALAVALRAHHISTVVADNEFAERIAGADDAVAVIDPATAGAEESGGRPAVAAP
CHHHCCHHHHHHHHHHHHEEEEECCHHHHHHCCCCCCEEEECCCCCCCCCCCCCCEEECC
GRIVLLTSGTTGKPKGVPRAPQLRSAVGVWVTILDRTRLRTGSRISVAMPMFHGLGLGML
CEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHH
MLTIALGGTVLTHRHFDAEAALAQASLHRADAFTAVPVVLARILELPPRVRARNPLPQLR
HHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
VVMSSGDRLDPTLGQRFMDTYGNILYNGYGSTEVGIGALATPADLRDAPETVGKPVAGCP
HEECCCCCCCHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCHHHCCCHHHHCCCCCCCC
VRILDRNNRPVGPRVTGRIFVGGELAGTRYTDGGGKTVVDGMTSTGDMGYLDNAGRLFIV
EEEEECCCCCCCCCEEEEEEECCEECCCEEECCCCCEEECCCCCCCCCCCCCCCCEEEEE
GREDDMIISGGENVYPRAVENALAAHPAVADNAVIGVPDERFGHRLAAFVVLHPGSGVDA
ECCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCEEECCCHHHCCEEEEEEEEECCCCCCH
AQLRDYLKDRVSRFEQPRDINIVSSIPRNPTGKVLRKELPG
HHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHCCC
>Mature Secondary Structure 
SAERVAPTAARALVRSGLLNPPSPRAVLRLLREASRGGTNPYTLLAVTAARWPGRTAII
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEEEE
DDDGALSYRELQRATESLARRLIRDGVAPGRAVGVMCRNGRGFVTAVFAVALLGADVVPI
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEC
STEFRSDALAVALRAHHISTVVADNEFAERIAGADDAVAVIDPATAGAEESGGRPAVAAP
CHHHCCHHHHHHHHHHHHEEEEECCHHHHHHCCCCCCEEEECCCCCCCCCCCCCCEEECC
GRIVLLTSGTTGKPKGVPRAPQLRSAVGVWVTILDRTRLRTGSRISVAMPMFHGLGLGML
CEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHH
MLTIALGGTVLTHRHFDAEAALAQASLHRADAFTAVPVVLARILELPPRVRARNPLPQLR
HHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
VVMSSGDRLDPTLGQRFMDTYGNILYNGYGSTEVGIGALATPADLRDAPETVGKPVAGCP
HEECCCCCCCHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCHHHCCCHHHHCCCCCCCC
VRILDRNNRPVGPRVTGRIFVGGELAGTRYTDGGGKTVVDGMTSTGDMGYLDNAGRLFIV
EEEEECCCCCCCCCEEEEEEECCEECCCEEECCCCCEEECCCCCCCCCCCCCCCCEEEEE
GREDDMIISGGENVYPRAVENALAAHPAVADNAVIGVPDERFGHRLAAFVVLHPGSGVDA
ECCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCEEECCCHHHCCEEEEEEEEECCCCCCH
AQLRDYLKDRVSRFEQPRDINIVSSIPRNPTGKVLRKELPG
HHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]