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The map label for this gene is rmlD

Identifier: 41409478

GI number: 41409478

Start: 3753585

End: 3754508

Strand: Reverse

Name: rmlD

Synonym: MAP3380c

Alternate gene names: 41409478

Gene position: 3754508-3753585 (Counterclockwise)

Preceding gene: 41409485

Following gene: 41409477

Centisome position: 77.74

GC content: 75.97

Gene sequence:

>924_bases
ATGTCAGGCAGGATCGTGATCGCCGGCGCCGGTGGGCAGCTGGGCGGCTATTTGAGCGCGCTGGCGGCTGGTCAGGGCCG
TGACGTGGTGGCGCTGACGTCCGCGCAGTGGGACATCACCGACCCGGCGGCGGCCGAACACATCGTGCGGCCCGGCGACG
TGGTGATCAACTGCGCGGCCTACACCGACGTCGACGGCGCCGAGAGCGACGAGGCGGGCGCCTTCGCGGTCAACGAGGCC
GGCCCCGGGCATATCGCGCGGGCCTGCGCGCGCGCCGGCGCCCGGCTGCTCCACGTCTCCACCGACTACGTGTTCGGCGG
CGAGTCCCCGGCCGGTGCCCCGGACCGGCCGCGCCCCTACGAGCCCGGCGACCCCGTCGCCCCGCAGGGCGTGTACGCCC
GCAGCAAGGTCGCGGGGGAGCGGGCAGTGCTGGCGGCGCTGCCGGATCCCGCGCAGGGCGTCGTGGTGCGCACCGCCTGG
GTCTACACCGGCGGCACCGGCAAGGACTTCGTCGCCGTCATGCGCCGGCTGGCCGCGGGGGAGGGCCCGGTGCAGGTGGT
CGACGACCAGATCGGGTCGCCGACCTACGTCGGCGACCTGGCGGCCGCGTTGCTGCAGATCGTCGACGACCGGGTGCCCG
GGCCGGTCCTGCACGCCGCCAATGAGGGCGCGGTGTCCCGCTTCGAGCAGGCCCGCGCGGTCTTCGAGGAATGCGGCGCC
GACCCGGCGCGGGTGCGGCCGGTGGGCACCGAGCACTTTCCCCGGCCGGCGCCGCGGCCGACCTACTCGGCGCTGGGCAG
CCGCGAGTCCGCCGCGGCCGGGCTGCGCCCGCTAAGGCCCTGGCGCCCTGCGCTTGTCGCCGCGCTCACCAACGCTGGTA
GCCCGGCCGCGGCGGATCGACCGTTACCCTCTACGCGTGACTGA

Upstream 100 bases:

>100_bases
ATCCCACTACATTACTTGCGACACACTGGCTTCACGGGTAGCCGGCGCCCGCGTGCCCCGGCCGTCCCGGCGGCCCGAGG
CCTCATGCCAAACTCGAACC

Downstream 100 bases:

>100_bases
CGTGCTGCCGGTGGTGACGGTGACCTATTCACCGGGCCCGCACCTGGAGCGCTTCCTGGCGTCGCTGTCGCTGGCCACCG
AACGCGAGGTGTGCGTGCTG

Product: RmlD

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSGRIVIAGAGGQLGGYLSALAAGQGRDVVALTSAQWDITDPAAAEHIVRPGDVVINCAAYTDVDGAESDEAGAFAVNEA
GPGHIARACARAGARLLHVSTDYVFGGESPAGAPDRPRPYEPGDPVAPQGVYARSKVAGERAVLAALPDPAQGVVVRTAW
VYTGGTGKDFVAVMRRLAAGEGPVQVVDDQIGSPTYVGDLAAALLQIVDDRVPGPVLHAANEGAVSRFEQARAVFEECGA
DPARVRPVGTEHFPRPAPRPTYSALGSRESAAAGLRPLRPWRPALVAALTNAGSPAAADRPLPSTRD

Sequences:

>Translated_307_residues
MSGRIVIAGAGGQLGGYLSALAAGQGRDVVALTSAQWDITDPAAAEHIVRPGDVVINCAAYTDVDGAESDEAGAFAVNEA
GPGHIARACARAGARLLHVSTDYVFGGESPAGAPDRPRPYEPGDPVAPQGVYARSKVAGERAVLAALPDPAQGVVVRTAW
VYTGGTGKDFVAVMRRLAAGEGPVQVVDDQIGSPTYVGDLAAALLQIVDDRVPGPVLHAANEGAVSRFEQARAVFEECGA
DPARVRPVGTEHFPRPAPRPTYSALGSRESAAAGLRPLRPWRPALVAALTNAGSPAAADRPLPSTRD
>Mature_306_residues
SGRIVIAGAGGQLGGYLSALAAGQGRDVVALTSAQWDITDPAAAEHIVRPGDVVINCAAYTDVDGAESDEAGAFAVNEAG
PGHIARACARAGARLLHVSTDYVFGGESPAGAPDRPRPYEPGDPVAPQGVYARSKVAGERAVLAALPDPAQGVVVRTAWV
YTGGTGKDFVAVMRRLAAGEGPVQVVDDQIGSPTYVGDLAAALLQIVDDRVPGPVLHAANEGAVSRFEQARAVFEECGAD
PARVRPVGTEHFPRPAPRPTYSALGSRESAAAGLRPLRPWRPALVAALTNAGSPAAADRPLPSTRD

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galacta

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=302, Percent_Identity=25.8278145695364, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI11034825, Length=302, Percent_Identity=25.8278145695364, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1788352, Length=281, Percent_Identity=32.3843416370107, Blast_Score=113, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 31486; Mature: 31355

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGRIVIAGAGGQLGGYLSALAAGQGRDVVALTSAQWDITDPAAAEHIVRPGDVVINCAA
CCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCEEEEEEE
YTDVDGAESDEAGAFAVNEAGPGHIARACARAGARLLHVSTDYVFGGESPAGAPDRPRPY
ECCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCEEEEEECCEEECCCCCCCCCCCCCCC
EPGDPVAPQGVYARSKVAGERAVLAALPDPAQGVVVRTAWVYTGGTGKDFVAVMRRLAAG
CCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHCC
EGPVQVVDDQIGSPTYVGDLAAALLQIVDDRVPGPVLHAANEGAVSRFEQARAVFEECGA
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHCC
DPARVRPVGTEHFPRPAPRPTYSALGSRESAAAGLRPLRPWRPALVAALTNAGSPAAADR
CHHHCCCCCCCCCCCCCCCCHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCC
PLPSTRD
CCCCCCC
>Mature Secondary Structure 
SGRIVIAGAGGQLGGYLSALAAGQGRDVVALTSAQWDITDPAAAEHIVRPGDVVINCAA
CCCEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCEEEEEEE
YTDVDGAESDEAGAFAVNEAGPGHIARACARAGARLLHVSTDYVFGGESPAGAPDRPRPY
ECCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCEEEEEECCEEECCCCCCCCCCCCCCC
EPGDPVAPQGVYARSKVAGERAVLAALPDPAQGVVVRTAWVYTGGTGKDFVAVMRRLAAG
CCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHCC
EGPVQVVDDQIGSPTYVGDLAAALLQIVDDRVPGPVLHAANEGAVSRFEQARAVFEECGA
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHCC
DPARVRPVGTEHFPRPAPRPTYSALGSRESAAAGLRPLRPWRPALVAALTNAGSPAAADR
CHHHCCCCCCCCCCCCCCCCHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCC
PLPSTRD
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]