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The map label for this gene is manA

Identifier: 41409465

GI number: 41409465

Start: 3741385

End: 3742611

Strand: Reverse

Name: manA

Synonym: MAP3367c

Alternate gene names: 41409465

Gene position: 3742611-3741385 (Counterclockwise)

Preceding gene: 41409466

Following gene: 41409463

Centisome position: 77.49

GC content: 70.58

Gene sequence:

>1227_bases
GTGGAGCTGCTTCGCGGGGCTTTGAGAACATACGCATGGGGTTCGCGTACCGCCATCGCCGAATTCACCGAACGACCGGT
GCCGGCGGCGCATCCGGAGGCCGAACTCTGGTTCGGCGCCCACCCGGGCGACCCGGCCTGGCTGGAGACCGACAACGGCG
AGATCACGTTGCTCGACGCGCTGCGCGCCGACCCGGAGGGACAGCTCGGTCCGGGGTCGCGGGCCCGGTTCGGTGACGTG
CTGCCGTTTTTGGTCAAGGTGCTGGCCGCCGACGAGCCGCTGTCGCTGCAGGCACACCCGAGCGCCGAGCAGGCGGCCGA
GGGCTACCTGCGCGAGGAGCGGCTCGGCATCCCGCTGAACTCGCCGGTGCGCAACTACCGCGACACCTCGCACAAGCCGG
AGTTGCTGGTCGCGCTGTATCCGTTCGAGGCGCTGGCCGGGTTCCGCCCGGCGTCGCGCACCGTCGAGCTGCTGCGGGCG
CTGGCCGTCTCGGATCTCGATCCCTTCATCGAGTTGCTGGGCGACCAGTCCGACGCCGACGGCCTGCGCGCGCTGTTCAC
CACCTGGATCACCGCCCCGCAGCCCGACATCGACGTGCTGGTGCCCGCCGTGCTGGACGGCGCAATCGCCTATCTCAGTT
CGGGCGCAACGGAATTCGCGGCCGAGGCCAAGACCGTGCTCGAGCTGGGCGAGCGCTATCCCGGCGACGCCGGGGTGCTG
GCTGCGTTGCTGCTCAACCGGGTCAGCCTGGCCCCGGGCGAGGCCATCTTCGTCTCGGCCGGCAACCTGCACACCTATCT
GCGGGGCTTCGCCGTGGAGGTGATGGCCAACTCCGACAACGTGTTACGCGGCGGCCTGACCCCCAAGCACGTCGACGTGC
CCGAGCTGCTGCGGGTGCTCGACTTCGCGCCCACCACCGAGGACCAGCTGCGCCCGCGCGTGCGGCGCGAGGGCTTCGGG
CGGATCTATGAGACCCCGACCGACGAGTTCGCCGTCGCGCTGTTGGAGCTGGAGGACGAGTACGTCGGCCACGAGGTGGA
CGCCACCTGCAGCCACGACGGCCCGCAGATCCTGCTGTGCATCCAGGGCTGCACGACCGTGCACGGCAAATCCGGCTCGC
TGCGGCTCAAGCGCGGCATGGCCGCCTGGGTGGCCGCCGACGATGCCCCGATCCGGCTGGTCGCCCACGAACCCACCAAG
CTGTTCAGGGCGACGGTCGGGCTGTAG

Upstream 100 bases:

>100_bases
TCGGCGGGCCCGGGCGGACCGAGCAGCAGCTGGCGGTGCTGGCCGTCCGGCTGGAGATGGCCGCCGTTTACATGCGACTG
GTGCGGGGATAGATAGAACA

Downstream 100 bases:

>100_bases
CGGTCCCCGGCCGGCCCGCCCGGCGGCGCTGCCCCAGCCACAGCCGCATGTTGTGCCCGACGGCGCGCCCGACGATGCGG
GGCGGCGGGATCAGGTAGAG

Product: hypothetical protein

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MELLRGALRTYAWGSRTAIAEFTERPVPAAHPEAELWFGAHPGDPAWLETDNGEITLLDALRADPEGQLGPGSRARFGDV
LPFLVKVLAADEPLSLQAHPSAEQAAEGYLREERLGIPLNSPVRNYRDTSHKPELLVALYPFEALAGFRPASRTVELLRA
LAVSDLDPFIELLGDQSDADGLRALFTTWITAPQPDIDVLVPAVLDGAIAYLSSGATEFAAEAKTVLELGERYPGDAGVL
AALLLNRVSLAPGEAIFVSAGNLHTYLRGFAVEVMANSDNVLRGGLTPKHVDVPELLRVLDFAPTTEDQLRPRVRREGFG
RIYETPTDEFAVALLELEDEYVGHEVDATCSHDGPQILLCIQGCTTVHGKSGSLRLKRGMAAWVAADDAPIRLVAHEPTK
LFRATVGL

Sequences:

>Translated_408_residues
MELLRGALRTYAWGSRTAIAEFTERPVPAAHPEAELWFGAHPGDPAWLETDNGEITLLDALRADPEGQLGPGSRARFGDV
LPFLVKVLAADEPLSLQAHPSAEQAAEGYLREERLGIPLNSPVRNYRDTSHKPELLVALYPFEALAGFRPASRTVELLRA
LAVSDLDPFIELLGDQSDADGLRALFTTWITAPQPDIDVLVPAVLDGAIAYLSSGATEFAAEAKTVLELGERYPGDAGVL
AALLLNRVSLAPGEAIFVSAGNLHTYLRGFAVEVMANSDNVLRGGLTPKHVDVPELLRVLDFAPTTEDQLRPRVRREGFG
RIYETPTDEFAVALLELEDEYVGHEVDATCSHDGPQILLCIQGCTTVHGKSGSLRLKRGMAAWVAADDAPIRLVAHEPTK
LFRATVGL
>Mature_408_residues
MELLRGALRTYAWGSRTAIAEFTERPVPAAHPEAELWFGAHPGDPAWLETDNGEITLLDALRADPEGQLGPGSRARFGDV
LPFLVKVLAADEPLSLQAHPSAEQAAEGYLREERLGIPLNSPVRNYRDTSHKPELLVALYPFEALAGFRPASRTVELLRA
LAVSDLDPFIELLGDQSDADGLRALFTTWITAPQPDIDVLVPAVLDGAIAYLSSGATEFAAEAKTVLELGERYPGDAGVL
AALLLNRVSLAPGEAIFVSAGNLHTYLRGFAVEVMANSDNVLRGGLTPKHVDVPELLRVLDFAPTTEDQLRPRVRREGFG
RIYETPTDEFAVALLELEDEYVGHEVDATCSHDGPQILLCIQGCTTVHGKSGSLRLKRGMAAWVAADDAPIRLVAHEPTK
LFRATVGL

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=439, Percent_Identity=32.1184510250569, Blast_Score=191, Evalue=2e-48,
Organism=Escherichia coli, GI1787899, Length=398, Percent_Identity=38.6934673366834, Blast_Score=265, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI71997620, Length=401, Percent_Identity=30.6733167082294, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17557650, Length=353, Percent_Identity=28.328611898017, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320839, Length=418, Percent_Identity=28.4688995215311, Blast_Score=154, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21356061, Length=411, Percent_Identity=29.1970802919708, Blast_Score=141, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 44159; Mature: 44159

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLRGALRTYAWGSRTAIAEFTERPVPAAHPEAELWFGAHPGDPAWLETDNGEITLLDA
CHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCEEECCCCCCCCEEECCCCCEEEEEE
LRADPEGQLGPGSRARFGDVLPFLVKVLAADEPLSLQAHPSAEQAAEGYLREERLGIPLN
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHCCCCCC
SPVRNYRDTSHKPELLVALYPFEALAGFRPASRTVELLRALAVSDLDPFIELLGDQSDAD
CCHHHHCCCCCCCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCH
GLRALFTTWITAPQPDIDVLVPAVLDGAIAYLSSGATEFAAEAKTVLELGERYPGDAGVL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHH
AALLLNRVSLAPGEAIFVSAGNLHTYLRGFAVEVMANSDNVLRGGLTPKHVDVPELLRVL
HHHHHHHHCCCCCCEEEEECCCHHHHHHHEEEEEEECCCCEEECCCCCCCCCHHHHHHHH
DFAPTTEDQLRPRVRREGFGRIYETPTDEFAVALLELEDEYVGHEVDATCSHDGPQILLC
HCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHEEHHHHHHHHCCCCCCCCCCCCCCEEEEE
IQGCTTVHGKSGSLRLKRGMAAWVAADDAPIRLVAHEPTKLFRATVGL
EECCCEEECCCCCEEEECCCEEEEECCCCCEEEEECCCHHHHHHHCCC
>Mature Secondary Structure
MELLRGALRTYAWGSRTAIAEFTERPVPAAHPEAELWFGAHPGDPAWLETDNGEITLLDA
CHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCEEECCCCCCCCEEECCCCCEEEEEE
LRADPEGQLGPGSRARFGDVLPFLVKVLAADEPLSLQAHPSAEQAAEGYLREERLGIPLN
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHCCCCCC
SPVRNYRDTSHKPELLVALYPFEALAGFRPASRTVELLRALAVSDLDPFIELLGDQSDAD
CCHHHHCCCCCCCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCH
GLRALFTTWITAPQPDIDVLVPAVLDGAIAYLSSGATEFAAEAKTVLELGERYPGDAGVL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHH
AALLLNRVSLAPGEAIFVSAGNLHTYLRGFAVEVMANSDNVLRGGLTPKHVDVPELLRVL
HHHHHHHHCCCCCCEEEEECCCHHHHHHHEEEEEEECCCCEEECCCCCCCCCHHHHHHHH
DFAPTTEDQLRPRVRREGFGRIYETPTDEFAVALLELEDEYVGHEVDATCSHDGPQILLC
HCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHEEHHHHHHHHCCCCCCCCCCCCCCEEEEE
IQGCTTVHGKSGSLRLKRGMAAWVAADDAPIRLVAHEPTKLFRATVGL
EECCCEEECCCCCEEEECCCEEEEECCCCCEEEEECCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6397402; 9097039; 9278503 [H]