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The map label for this gene is ubiB [C]

Identifier: 41409393

GI number: 41409393

Start: 3661456

End: 3662799

Strand: Direct

Name: ubiB [C]

Synonym: MAP3295

Alternate gene names: 41409393

Gene position: 3661456-3662799 (Clockwise)

Preceding gene: 41409392

Following gene: 41409396

Centisome position: 75.81

GC content: 67.93

Gene sequence:

>1344_bases
ATGGATGATGGTTACGTGTCGGATATCAAACGGGGACGTGCCGCGCGCAACGCGAAGCTGGCCAGCATTCCGGTCGGATT
CGCCGGCCGGGCGGCGATCGGATTCGGTAAACGCCTGACCGGTAAGTCCAGGGACGAGGTCCAGGCCGAGCTCCTGGAAA
AGGCCGCCAACCAGTTGTTCACCGTGCTGGGTGAGCTCAAGGGCGGCGCGATGAAGGTGGGTCAGGCGCTGTCGGTGCTC
GAGGCCGCGGTTCCCGAGGAATTCGGCGAGCCCTACCGCGAGGCGCTGACCAAGCTGCAGAAGGACGCCCCGCCGCTGCC
CGCGGCGAAGGTGCACCGGGTGCTCGACGCGCAGCTGGGCACCAAGTGGCGGGAGCGGTTCAGTTCGTTCGACGACACCC
CGGTGGCCTCGGCCAGCATCGGCCAGGTGCACAAGGGGGTGTGGTCCGACGGCCGCGAGGTCGCCGTCAAGATCCAGTAC
CCGGGCGCCGACGAGGCGCTGCGGGCCGACCTCAAGACCATGCAGCGCCTGGTCGGGGTGTTCAAGCAGCTCGCGCCCGG
CGCCGACGTCCAAGGCGTGGTCGACGAGCTGATCGAGCGCACCGAGATGGAGCTGGACTACCGGCTGGAGGCCGAGAACC
AGCGCGCCTTCGCGAAGGCGTACCAGGACCACCCGCACTTCGCGGTGCCGCGGATCGTGGCCAGCGCACCCAAGGTGGTG
ATCCAGGAGTGGATGCAGGGCATCCCGATGGCCGAGATCATCCGGCACGGCACCACCGAGCAGCGCGACCTGATGGGCAC
CCGGCTGCTGGAGCTCACCTTCGACGCGCCGCGGCGGCTGGGCATGCTGCACGGCGACGCGCACCCGGGCAACTTCATGC
TGCTGCCCGACGGCCGGATGGGCGTGATCGACTTCGGCGCCGTCGCGCCACTGCCCGACGGCTTGCCCGTCGAACTCGGC
ATGACGATCCGGTTGGCCCGCGACAAGAACTACGACCTGCTGTTGCCGACGATGGAGAAGGCCGGGTTCATCCAGAAGGG
CCAGCAGGTGTCCGTGCGCGACATCGACGACATGCTGCGTCAGTACGTCGAGCCCGTCGAGGTCGAGGTGTTCCACTACA
CCCGCAAGTGGCTGCAGAAGATGTCCGCCATCGAGATCGACCGGTCGGTGTCGCAGATCCGCACCGCCCGGCAGATGGAC
CTGCCGCCCAAGCTCGTGATCCCGATGCGGGTGATCATGTCGGTGGCCGCCATCCTGTGCCAGCTGGACGCCCACGTGCC
GATCAAGGCGCTGTCCGAAGAGCTGGTGCCCGGCTTCGCCGAACCCGACAACGCCATCGTCTAG

Upstream 100 bases:

>100_bases
TTGATGCGGGCGCACTCGTGCCGGCCCTATCGCGCTGACCTGCGCCACCGGGGTGTGACAACCTCCGTTGTCGCCGTCTC
TCCCCATCGCGCTGGCCATC

Downstream 100 bases:

>100_bases
GAACGCTGGCTGCTAGGCCGCCGCCCCGGCGCGCCGGCCGTCCTTGCGGGGACGCCCGCGGGGTCGTTTGAAGCCCAGCA
CCGCGCCGCGATCGAGGATT

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MDDGYVSDIKRGRAARNAKLASIPVGFAGRAAIGFGKRLTGKSRDEVQAELLEKAANQLFTVLGELKGGAMKVGQALSVL
EAAVPEEFGEPYREALTKLQKDAPPLPAAKVHRVLDAQLGTKWRERFSSFDDTPVASASIGQVHKGVWSDGREVAVKIQY
PGADEALRADLKTMQRLVGVFKQLAPGADVQGVVDELIERTEMELDYRLEAENQRAFAKAYQDHPHFAVPRIVASAPKVV
IQEWMQGIPMAEIIRHGTTEQRDLMGTRLLELTFDAPRRLGMLHGDAHPGNFMLLPDGRMGVIDFGAVAPLPDGLPVELG
MTIRLARDKNYDLLLPTMEKAGFIQKGQQVSVRDIDDMLRQYVEPVEVEVFHYTRKWLQKMSAIEIDRSVSQIRTARQMD
LPPKLVIPMRVIMSVAAILCQLDAHVPIKALSEELVPGFAEPDNAIV

Sequences:

>Translated_447_residues
MDDGYVSDIKRGRAARNAKLASIPVGFAGRAAIGFGKRLTGKSRDEVQAELLEKAANQLFTVLGELKGGAMKVGQALSVL
EAAVPEEFGEPYREALTKLQKDAPPLPAAKVHRVLDAQLGTKWRERFSSFDDTPVASASIGQVHKGVWSDGREVAVKIQY
PGADEALRADLKTMQRLVGVFKQLAPGADVQGVVDELIERTEMELDYRLEAENQRAFAKAYQDHPHFAVPRIVASAPKVV
IQEWMQGIPMAEIIRHGTTEQRDLMGTRLLELTFDAPRRLGMLHGDAHPGNFMLLPDGRMGVIDFGAVAPLPDGLPVELG
MTIRLARDKNYDLLLPTMEKAGFIQKGQQVSVRDIDDMLRQYVEPVEVEVFHYTRKWLQKMSAIEIDRSVSQIRTARQMD
LPPKLVIPMRVIMSVAAILCQLDAHVPIKALSEELVPGFAEPDNAIV
>Mature_447_residues
MDDGYVSDIKRGRAARNAKLASIPVGFAGRAAIGFGKRLTGKSRDEVQAELLEKAANQLFTVLGELKGGAMKVGQALSVL
EAAVPEEFGEPYREALTKLQKDAPPLPAAKVHRVLDAQLGTKWRERFSSFDDTPVASASIGQVHKGVWSDGREVAVKIQY
PGADEALRADLKTMQRLVGVFKQLAPGADVQGVVDELIERTEMELDYRLEAENQRAFAKAYQDHPHFAVPRIVASAPKVV
IQEWMQGIPMAEIIRHGTTEQRDLMGTRLLELTFDAPRRLGMLHGDAHPGNFMLLPDGRMGVIDFGAVAPLPDGLPVELG
MTIRLARDKNYDLLLPTMEKAGFIQKGQQVSVRDIDDMLRQYVEPVEVEVFHYTRKWLQKMSAIEIDRSVSQIRTARQMD
LPPKLVIPMRVIMSVAAILCQLDAHVPIKALSEELVPGFAEPDNAIV

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI34147522, Length=401, Percent_Identity=26.1845386533666, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI40254938, Length=264, Percent_Identity=31.0606060606061, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI27363457, Length=299, Percent_Identity=27.4247491638796, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI217416386, Length=253, Percent_Identity=26.8774703557312, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI217035081, Length=192, Percent_Identity=33.8541666666667, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI41393593, Length=271, Percent_Identity=27.3062730627306, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI2367309, Length=245, Percent_Identity=27.7551020408163, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI32565180, Length=316, Percent_Identity=29.1139240506329, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17559152, Length=327, Percent_Identity=26.9113149847095, Blast_Score=102, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6321319, Length=314, Percent_Identity=26.7515923566879, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323282, Length=236, Percent_Identity=25.4237288135593, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18859849, Length=282, Percent_Identity=29.7872340425532, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI22024280, Length=267, Percent_Identity=30.3370786516854, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24662575, Length=286, Percent_Identity=27.972027972028, Blast_Score=102, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 49408; Mature: 49408

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDGYVSDIKRGRAARNAKLASIPVGFAGRAAIGFGKRLTGKSRDEVQAELLEKAANQLF
CCCCHHHHHHHHHHHCCCEEEECCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
TVLGELKGGAMKVGQALSVLEAAVPEEFGEPYREALTKLQKDAPPLPAAKVHRVLDAQLG
HHHHHHCCCHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
TKWRERFSSFDDTPVASASIGQVHKGVWSDGREVAVKIQYPGADEALRADLKTMQRLVGV
HHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHH
FKQLAPGADVQGVVDELIERTEMELDYRLEAENQRAFAKAYQDHPHFAVPRIVASAPKVV
HHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHCHHHH
IQEWMQGIPMAEIIRHGTTEQRDLMGTRLLELTFDAPRRLGMLHGDAHPGNFMLLPDGRM
HHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHEECCCHHHHCCCCCCCCCCCEEEECCCCC
GVIDFGAVAPLPDGLPVELGMTIRLARDKNYDLLLPTMEKAGFIQKGQQVSVRDIDDMLR
CEEECCCCCCCCCCCCEEECCEEEEECCCCCEEEECCHHHCCHHHCCCCCCHHHHHHHHH
QYVEPVEVEVFHYTRKWLQKMSAIEIDRSVSQIRTARQMDLPPKLVIPMRVIMSVAAILC
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
QLDAHVPIKALSEELVPGFAEPDNAIV
HHCCCCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MDDGYVSDIKRGRAARNAKLASIPVGFAGRAAIGFGKRLTGKSRDEVQAELLEKAANQLF
CCCCHHHHHHHHHHHCCCEEEECCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
TVLGELKGGAMKVGQALSVLEAAVPEEFGEPYREALTKLQKDAPPLPAAKVHRVLDAQLG
HHHHHHCCCHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
TKWRERFSSFDDTPVASASIGQVHKGVWSDGREVAVKIQYPGADEALRADLKTMQRLVGV
HHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHH
FKQLAPGADVQGVVDELIERTEMELDYRLEAENQRAFAKAYQDHPHFAVPRIVASAPKVV
HHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHCHHHH
IQEWMQGIPMAEIIRHGTTEQRDLMGTRLLELTFDAPRRLGMLHGDAHPGNFMLLPDGRM
HHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHEECCCHHHHCCCCCCCCCCCEEEECCCCC
GVIDFGAVAPLPDGLPVELGMTIRLARDKNYDLLLPTMEKAGFIQKGQQVSVRDIDDMLR
CEEECCCCCCCCCCCCEEECCEEEEECCCCCEEEECCHHHCCHHHCCCCCCHHHHHHHHH
QYVEPVEVEVFHYTRKWLQKMSAIEIDRSVSQIRTARQMDLPPKLVIPMRVIMSVAAILC
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
QLDAHVPIKALSEELVPGFAEPDNAIV
HHCCCCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA