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The map label for this gene is devS [H]

Identifier: 41409368

GI number: 41409368

Start: 3629834

End: 3631489

Strand: Reverse

Name: devS [H]

Synonym: MAP3270c

Alternate gene names: 41409368

Gene position: 3631489-3629834 (Counterclockwise)

Preceding gene: 41409369

Following gene: 41409365

Centisome position: 75.19

GC content: 71.38

Gene sequence:

>1656_bases
GTGACCGGGAACCGGTTCGACGAACTGGCGGCCGCGCGCGATCAAACCGAGAAACTGCTGCGGGTGATCGCCGAGATCGG
CGCGGGCCTGGATCTCGACGCGACGCTGCACCGGATCATCAGCGCGGCAAGGGAATTGACGTCGGCCCCGTACGGTGCCC
TGGCCGTGCGCGACCGGCATGCCAACCTGATCTCCTTTGTGCACGAAGGCATGGACGCCGAGACGGTGCGGCGCATCGGG
CACCACCCGGTCGGCAAGGGGCTGCTCAGTCTGTCCCTGCTGGACACCCCGGCGCTGCGGATGGACGACCTGACCGCCCA
CCCCGCCGCCGCCGGATTCCCCGAGCACCATCCGGCGATGCGGGCCTTTCTCGCGGTGCCGATCACCATCCGCGGCGCGG
TGTTCGGCAACCTGTATCTGACCCACGTCGATGAGGCGCGGGTGTTCTCCGACGCCGACGAGATGGCCGCGCGCGCCCTG
GCCTTCGCGGCGGCGGTCGCCATCGACAACGCGCAGGTCTTCGAGCGCGAGCGGATGTCGGTGAAATGGATCGAAGCCAG
CCGCGAGATCACCACCGCGCTGCTGTCGCGCACCGAGCCGCACCGGCGCCCGATGCAGCTGATCGCCGAACGCGCCTGCG
CGTTGACCGACGCCGAACAGGCCATCGTGCTGGTGCCCGCCGACCCCGAGCAGCCCGGCAACCCGGAGGTGGACACCCTG
GTGGTCTTGGCGGCGGTGGGCCTGCCCGCCGCCGACGTGCTCGGGCAGCGGGTCCCGGTGCGCGGCTCCACCAGCGGCGC
GGTCTTCAAGTCCGGCGAACCGCTGATCACCGACGAATTCCGTTATCCCATCCAGGCTTTCACCGATGCCGGGCGGCGAC
CGGCGATCGTGATGCCGCTGCGCGCCCGCGACGAAGTGGTCGGGGTGATCGCGATCGCCCGCGGCACCGAGCAGCCGCCG
TTCGACGAGAGCTATCTGGACCTGGTGCGCGACTTCGCCACCCACGCCGCCATCGCGCTGGTGCTCGCCGCGGCGCGCGA
GGACGCGCGGCAGCTGGCCGTTTTGGCCGAGCGGGAGCGCATCGCGCACGACCTGCACGACCACGTCATCCAGCGGCTGT
TCGCCGCCGGCATGGATCTGCAGGGCACGCTGGCCCGGGCGCGGTCGCCGGAGGTGGCCGACCGGCTCAACCGGACGCTC
GACGACCTGCAGACGATCATCGAGGAGATCCGCACCACGATCTTCGCGCTGCGCTCCCCGGCGGCCGTCGCCGGCGACTT
CCGGCACCGCATTCAGCGGGTCATCGCCGAGCTGACCGAGAATCGCGACCTGGTCACCACGGTGCGCATGGACGGTCCGA
TGACGGCGGTCGGCGCCGAGCTCGCCGAGCACGCCGAGGCGGTGACCGCCGAAGCCGTCAGCAACGCCGTCCGCCACTCG
GGCGCGTCGCGGCTGACGGTGCAGATCGGTGTCGCCGACATGTTCACCCTGGACGTGATCGACAACGGCCGCGGCATCGC
GTCCGGCAACACCCGTCGCAGCGGGCTGGCCAACATGACACGGCGGGCCGAGCAACTCGGCGGCAGCTGCGAGATCAGCA
GCCCGCCCGGCGGCGGCACCCGGGTGCATTGGACCGCCCCGCTGCTCGACCACTGA

Upstream 100 bases:

>100_bases
TGGCCAAACTCGGCATGGAGCGCCGGACCCAGGCGGCGGTGTTCGCGTCGAAACTCAACCAGCAGGCCGGCCGTCCGCCG
ACCCCACCGGACTGGCCGGG

Downstream 100 bases:

>100_bases
GCACCAAAAGCCTTGGCCCGCAACCGATCAGCTGCGGGTGTCGGAAGCCTTCAGGCGTTGGTGCGCGGTCAGCAGAAGGT
GGTCGAATTCCGACCGCGTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MTGNRFDELAAARDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVRDRHANLISFVHEGMDAETVRRIG
HHPVGKGLLSLSLLDTPALRMDDLTAHPAAAGFPEHHPAMRAFLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAARAL
AFAAAVAIDNAQVFERERMSVKWIEASREITTALLSRTEPHRRPMQLIAERACALTDAEQAIVLVPADPEQPGNPEVDTL
VVLAAVGLPAADVLGQRVPVRGSTSGAVFKSGEPLITDEFRYPIQAFTDAGRRPAIVMPLRARDEVVGVIAIARGTEQPP
FDESYLDLVRDFATHAAIALVLAAAREDARQLAVLAERERIAHDLHDHVIQRLFAAGMDLQGTLARARSPEVADRLNRTL
DDLQTIIEEIRTTIFALRSPAAVAGDFRHRIQRVIAELTENRDLVTTVRMDGPMTAVGAELAEHAEAVTAEAVSNAVRHS
GASRLTVQIGVADMFTLDVIDNGRGIASGNTRRSGLANMTRRAEQLGGSCEISSPPGGGTRVHWTAPLLDH

Sequences:

>Translated_551_residues
MTGNRFDELAAARDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVRDRHANLISFVHEGMDAETVRRIG
HHPVGKGLLSLSLLDTPALRMDDLTAHPAAAGFPEHHPAMRAFLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAARAL
AFAAAVAIDNAQVFERERMSVKWIEASREITTALLSRTEPHRRPMQLIAERACALTDAEQAIVLVPADPEQPGNPEVDTL
VVLAAVGLPAADVLGQRVPVRGSTSGAVFKSGEPLITDEFRYPIQAFTDAGRRPAIVMPLRARDEVVGVIAIARGTEQPP
FDESYLDLVRDFATHAAIALVLAAAREDARQLAVLAERERIAHDLHDHVIQRLFAAGMDLQGTLARARSPEVADRLNRTL
DDLQTIIEEIRTTIFALRSPAAVAGDFRHRIQRVIAELTENRDLVTTVRMDGPMTAVGAELAEHAEAVTAEAVSNAVRHS
GASRLTVQIGVADMFTLDVIDNGRGIASGNTRRSGLANMTRRAEQLGGSCEISSPPGGGTRVHWTAPLLDH
>Mature_550_residues
TGNRFDELAAARDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVRDRHANLISFVHEGMDAETVRRIGH
HPVGKGLLSLSLLDTPALRMDDLTAHPAAAGFPEHHPAMRAFLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAARALA
FAAAVAIDNAQVFERERMSVKWIEASREITTALLSRTEPHRRPMQLIAERACALTDAEQAIVLVPADPEQPGNPEVDTLV
VLAAVGLPAADVLGQRVPVRGSTSGAVFKSGEPLITDEFRYPIQAFTDAGRRPAIVMPLRARDEVVGVIAIARGTEQPPF
DESYLDLVRDFATHAAIALVLAAAREDARQLAVLAERERIAHDLHDHVIQRLFAAGMDLQGTLARARSPEVADRLNRTLD
DLQTIIEEIRTTIFALRSPAAVAGDFRHRIQRVIAELTENRDLVTTVRMDGPMTAVGAELAEHAEAVTAEAVSNAVRHSG
ASRLTVQIGVADMFTLDVIDNGRGIASGNTRRSGLANMTRRAEQLGGSCEISSPPGGGTRVHWTAPLLDH

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaer

COG id: COG2203

COG function: function code T; FOG: GAF domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=261, Percent_Identity=28.3524904214559, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1787474, Length=225, Percent_Identity=28, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016030
- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 59505; Mature: 59374

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGNRFDELAAARDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVRDRH
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHH
ANLISFVHEGMDAETVRRIGHHPVGKGLLSLSLLDTPALRMDDLTAHPAAAGFPEHHPAM
HHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHH
RAFLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAARALAFAAAVAIDNAQVFERERMS
HHHHHCCEEEECEEECCEEEEECCHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCE
VKWIEASREITTALLSRTEPHRRPMQLIAERACALTDAEQAIVLVPADPEQPGNPEVDTL
EEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHH
VVLAAVGLPAADVLGQRVPVRGSTSGAVFKSGEPLITDEFRYPIQAFTDAGRRPAIVMPL
HHHHHHCCCHHHHHCCCCCCCCCCCCCEEECCCCCEECCCCCCHHHHHCCCCCCEEEEEC
RARDEVVGVIAIARGTEQPPFDESYLDLVRDFATHAAIALVLAAAREDARQLAVLAERER
CCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAHDLHDHVIQRLFAAGMDLQGTLARARSPEVADRLNRTLDDLQTIIEEIRTTIFALRSP
HHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AAVAGDFRHRIQRVIAELTENRDLVTTVRMDGPMTAVGAELAEHAEAVTAEAVSNAVRHS
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GASRLTVQIGVADMFTLDVIDNGRGIASGNTRRSGLANMTRRAEQLGGSCEISSPPGGGT
CCCEEEEEEECCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCC
RVHWTAPLLDH
EEEEECCCCCC
>Mature Secondary Structure 
TGNRFDELAAARDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVRDRH
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHH
ANLISFVHEGMDAETVRRIGHHPVGKGLLSLSLLDTPALRMDDLTAHPAAAGFPEHHPAM
HHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHH
RAFLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAARALAFAAAVAIDNAQVFERERMS
HHHHHCCEEEECEEECCEEEEECCHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCE
VKWIEASREITTALLSRTEPHRRPMQLIAERACALTDAEQAIVLVPADPEQPGNPEVDTL
EEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHH
VVLAAVGLPAADVLGQRVPVRGSTSGAVFKSGEPLITDEFRYPIQAFTDAGRRPAIVMPL
HHHHHHCCCHHHHHCCCCCCCCCCCCCEEECCCCCEECCCCCCHHHHHCCCCCCEEEEEC
RARDEVVGVIAIARGTEQPPFDESYLDLVRDFATHAAIALVLAAAREDARQLAVLAERER
CCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAHDLHDHVIQRLFAAGMDLQGTLARARSPEVADRLNRTLDDLQTIIEEIRTTIFALRSP
HHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AAVAGDFRHRIQRVIAELTENRDLVTTVRMDGPMTAVGAELAEHAEAVTAEAVSNAVRHS
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GASRLTVQIGVADMFTLDVIDNGRGIASGNTRRSGLANMTRRAEQLGGSCEISSPPGGGT
CCCEEEEEEECCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCC
RVHWTAPLLDH
EEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]