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The map label for this gene is acbB [H]

Identifier: 41409346

GI number: 41409346

Start: 3603820

End: 3604896

Strand: Direct

Name: acbB [H]

Synonym: MAP3248

Alternate gene names: 41409346

Gene position: 3603820-3604896 (Clockwise)

Preceding gene: 41409344

Following gene: 41409347

Centisome position: 74.62

GC content: 70.66

Gene sequence:

>1077_bases
ATGACCGGGGCGACTACCCCGAAGGGCAACGGTGAAACGGGGTTTCACCCCAGACCTGACGGGTACCAGAGCCCGATGCG
ATCACTGACCCGGGTGCTGATCACCGGCGGCGCCGGCTTTTTGGGCGCGCACCTGTGTGCGCGGCTGCTCGACGACGGCG
TCGAGGTGGTCAGCGTGGACGACCTGTCCACCAGCGGGCCTGCGGTCCGATTCGGCGACCGGCCCGGATACCGGTTCGTG
CAGCGCGACGTCTGCGAGCCCGGGTTGATCGACGAGGTCGGCAGCGGCTTCGACGCCGTATTCCATTTGGCCTCAGCGGC
TTCCCCGGTCGACTACCAGCGCCGCCCGATCCAGACGCTGTGCACCGGCTCGGCGGGCACCGCGACTGCGCTGGAGATCG
CCGAGCGCGCCGGCGCCCGGTTCGTGTTGGCGTCCACCAGCGAGGTGTACGGCGACCCCGAGTCGCATCCGCAGCGCGAA
AGCTATTGGGGCAACGTCAATCCGGCGGGCCCGCGCAGCGTATACGACGAAGCCAAGCGGTTCGCCGAAGCGTTGACGTT
CGCCTATCACCGCCTCGGCCGCGCCGATGTCGGGGCGGCCCGGATCTTCAACACGTACGGGCCCGGCATGCGGGCGGACG
ACGGCCGGATGGTGCCGACGTTCTGCTTGCAGGCGCTGCGCGGCGATCCGCTGACGGTGTCCGGCACCGGGCTGCAGACC
CGGTCGCTGTGCTACGTCGACGACACCATCACCGGGCTGATCGCGTTGGCGCACAGCGACTTCGCCGGCCCGGTGAACAT
CGGCAATCCGACCGAGCTGACCGTGCTGTCCGCCGCCGAGTTGATCCGGGAGCTGGCCGGCAGCACGTCGACCATCCAGT
TCACCCCGCCGGCCGCCGACGACCCGCAGCGCCGCTGCCCGGACATCCGGCTGGCCCGCAAAAGGCTGGGCTGGCGGCCG
CGGGTCGACTATCGCACCGGCTTGAGCACCACCCTGGCGTGGTTCGCCGAGCGGGCCGGGCGCACCGGTGAGTCGGCGCA
ACAGCTCGTCGCGACCACTGACCGGCGGACCCGGTAG

Upstream 100 bases:

>100_bases
CGGGCACTCGGTGGTGTCCAGCAGGCGGGTCAGCGTGCCGGTCAGCTCCGCCGAGCGGTCCCGGGTGGCGATGACGAAGG
AGGTGCGCGGCATGGTCGAC

Downstream 100 bases:

>100_bases
GAGGCAGCAGAGTGCGAATTCTCGGAGTCAATGCGGTATTTCACGATCCGGCCGCCGCGCTGGTGATCGACGGCCGGGTG
GTGGCGGCCGCCGAGGAAGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MTGATTPKGNGETGFHPRPDGYQSPMRSLTRVLITGGAGFLGAHLCARLLDDGVEVVSVDDLSTSGPAVRFGDRPGYRFV
QRDVCEPGLIDEVGSGFDAVFHLASAASPVDYQRRPIQTLCTGSAGTATALEIAERAGARFVLASTSEVYGDPESHPQRE
SYWGNVNPAGPRSVYDEAKRFAEALTFAYHRLGRADVGAARIFNTYGPGMRADDGRMVPTFCLQALRGDPLTVSGTGLQT
RSLCYVDDTITGLIALAHSDFAGPVNIGNPTELTVLSAAELIRELAGSTSTIQFTPPAADDPQRRCPDIRLARKRLGWRP
RVDYRTGLSTTLAWFAERAGRTGESAQQLVATTDRRTR

Sequences:

>Translated_358_residues
MTGATTPKGNGETGFHPRPDGYQSPMRSLTRVLITGGAGFLGAHLCARLLDDGVEVVSVDDLSTSGPAVRFGDRPGYRFV
QRDVCEPGLIDEVGSGFDAVFHLASAASPVDYQRRPIQTLCTGSAGTATALEIAERAGARFVLASTSEVYGDPESHPQRE
SYWGNVNPAGPRSVYDEAKRFAEALTFAYHRLGRADVGAARIFNTYGPGMRADDGRMVPTFCLQALRGDPLTVSGTGLQT
RSLCYVDDTITGLIALAHSDFAGPVNIGNPTELTVLSAAELIRELAGSTSTIQFTPPAADDPQRRCPDIRLARKRLGWRP
RVDYRTGLSTTLAWFAERAGRTGESAQQLVATTDRRTR
>Mature_357_residues
TGATTPKGNGETGFHPRPDGYQSPMRSLTRVLITGGAGFLGAHLCARLLDDGVEVVSVDDLSTSGPAVRFGDRPGYRFVQ
RDVCEPGLIDEVGSGFDAVFHLASAASPVDYQRRPIQTLCTGSAGTATALEIAERAGARFVLASTSEVYGDPESHPQRES
YWGNVNPAGPRSVYDEAKRFAEALTFAYHRLGRADVGAARIFNTYGPGMRADDGRMVPTFCLQALRGDPLTVSGTGLQTR
SLCYVDDTITGLIALAHSDFAGPVNIGNPTELTVLSAAELIRELAGSTSTIQFTPPAADDPQRRCPDIRLARKRLGWRPR
VDYRTGLSTTLAWFAERAGRTGESAQQLVATTDRRTR

Specific function: Probably involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose. Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4- hexulose via a three-step process involving oxidation, dehydration and re

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=307, Percent_Identity=50.4885993485342, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI7657641, Length=327, Percent_Identity=26.9113149847095, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1788589, Length=343, Percent_Identity=27.4052478134111, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI48994969, Length=337, Percent_Identity=28.7833827893175, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788353, Length=336, Percent_Identity=28.2738095238095, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786974, Length=319, Percent_Identity=25.705329153605, Blast_Score=81, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17539532, Length=315, Percent_Identity=46.031746031746, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI115532424, Length=324, Percent_Identity=28.0864197530864, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17568069, Length=332, Percent_Identity=28.3132530120482, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982035, Length=364, Percent_Identity=24.4505494505494, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71982038, Length=366, Percent_Identity=24.3169398907104, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356223, Length=331, Percent_Identity=45.0151057401813, Blast_Score=300, Evalue=1e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 38480; Mature: 38349

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGATTPKGNGETGFHPRPDGYQSPMRSLTRVLITGGAGFLGAHLCARLLDDGVEVVSVD
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEC
DLSTSGPAVRFGDRPGYRFVQRDVCEPGLIDEVGSGFDAVFHLASAASPVDYQRRPIQTL
CCCCCCCEEEECCCCCHHHHHHHCCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHCCHHHH
CTGSAGTATALEIAERAGARFVLASTSEVYGDPESHPQRESYWGNVNPAGPRSVYDEAKR
HCCCCCHHHHHHHHHHCCCEEEEECCHHHCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHH
FAEALTFAYHRLGRADVGAARIFNTYGPGMRADDGRMVPTFCLQALRGDPLTVSGTGLQT
HHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCC
RSLCYVDDTITGLIALAHSDFAGPVNIGNPTELTVLSAAELIRELAGSTSTIQFTPPAAD
CEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCC
DPQRRCPDIRLARKRLGWRPRVDYRTGLSTTLAWFAERAGRTGESAQQLVATTDRRTR
CHHHHCCHHHHHHHHCCCCCCCCHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TGATTPKGNGETGFHPRPDGYQSPMRSLTRVLITGGAGFLGAHLCARLLDDGVEVVSVD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEC
DLSTSGPAVRFGDRPGYRFVQRDVCEPGLIDEVGSGFDAVFHLASAASPVDYQRRPIQTL
CCCCCCCEEEECCCCCHHHHHHHCCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHCCHHHH
CTGSAGTATALEIAERAGARFVLASTSEVYGDPESHPQRESYWGNVNPAGPRSVYDEAKR
HCCCCCHHHHHHHHHHCCCEEEEECCHHHCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHH
FAEALTFAYHRLGRADVGAARIFNTYGPGMRADDGRMVPTFCLQALRGDPLTVSGTGLQT
HHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCC
RSLCYVDDTITGLIALAHSDFAGPVNIGNPTELTVLSAAELIRELAGSTSTIQFTPPAAD
CEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCC
DPQRRCPDIRLARKRLGWRPRVDYRTGLSTTLAWFAERAGRTGESAQQLVATTDRRTR
CHHHHCCHHHHHHHHCCCCCCCCHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10196166 [H]