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The map label for this gene is fprA

Identifier: 41409274

GI number: 41409274

Start: 3526975

End: 3528342

Strand: Direct

Name: fprA

Synonym: MAP3176

Alternate gene names: 41409274

Gene position: 3526975-3528342 (Clockwise)

Preceding gene: 41409263

Following gene: 41409275

Centisome position: 73.03

GC content: 70.69

Gene sequence:

>1368_bases
ATGCGCCCATACCACGTTGCAATCGTCGGCTCCGGACCGTCCGGCTTCTTCGCCGCGGCCTCGCTGCTGAAGGCGGCCGA
CGGGTCCGAGCACCCCGACGTCGCCGTCGACATGCTCGAAATGCTGCCCACCCCGTGGGGGCTGGTGCGCTCCGGGGTGG
CGCCCGATCATCCCAAGATCAAGTCGATCAGCAAGCAGTTCGAGAAGACGGCCGCCGATCCCCGCTTCCGTTTCTTCGGC
AACGTCTCGGTCGGCGAACACGTGCAGGCCAGCGAGCTCGCCGAGCGCTACGACGCGGTCATCTACGCCGTCGGGGCGCA
GTCCGACCGGGCGCTGAACATCCCCGGCGAGGACCTGCCGGGCAGCATCGCCGCCGTCGATTTCGTGGGCTGGTACAACG
CGCACCCCAACTTCGAGGAGGCCACCCCCGACCTGTCCGGTTCGCGGGCGGTGGTCGTGGGCAACGGCAACGTCGCACTC
GACGTCGCCCGCATCCTGGTCACCGACCCCGACGTGCTGGGCCTGACCGACATCGCCGACCACGCCCTGGAGTCGCTGCG
GCCGTGCGGGGTCGACGAGGTGGTGGTGATCGGCCGGCGCGGGCCGCTGCAGACCGCCTTCACCACGCTCGAGCTGCGTG
AGCTCGGCGAGCTGGACAACGTCGACGTGATCGTCGACCCGGCCCAGCTGGAGGGCGTGACCGACGAGGACGCGGCCGCG
GCCGGCAAGACGGCCAAGCAGAACATCAGCGTGCTGCGCGATTACGCGAAACGCTCGCCGCGTCCCGGGCACCGCCGGAT
CGTGCTGCGGTTCATGACCTCGCCGATCGAGATCAAGGGCGACGGCCGGGTGGAAAGCATCGTGCTGGGCCGCAACGAGT
TGGTCACCGACGAGACCGGGCGGGTGTCGGCCCGCGACACCGGCGAGCGCGAGGAACTGCCGGTCCAACTGGTGGTGCGC
TCGGTCGGCTACCGCGGCGTGCCCACCCCCGGGCTGCCGTTCGACGAGAAGACGGCGACCATCCCCAACACCGGCGGCCG
GGTCGAGGGCAGCCGCAACGAGTACGTGGTGGGGTGGATCAAGCGCGGGCCGACCGGCGTCATCGGCACCAATAAGAAGG
ACTCCCAGGACACCGTGGACACGCTGCTCGCCGACCTGGCCAACGCCGGCCCGGACGGGCTGGCCGACTTTCCGGACGAC
CACGCCGACCGGCTGGCCGACTGGCTGGCGTCACGTCAGCCGAAGCTGGTCACCACCGCGCATTGGGAGCTCATCGACGC
GCACGAGCGGGCGGCCGGCGAGGCGCGCGGGCGCCCCCGCGTCAAGCTGCCCAGTTTGGCCAAGTTGCTGCGGGTCAGCC
ACGGCTGA

Upstream 100 bases:

>100_bases
TGCGTTTAGAGTCGAGTCACGATCATGTGCGCCCGCGTTGCGCGCCCGCCAATCCTGGCAGCCCCCGGCGCGCGAACCGG
GCCCGAATAGAAGGTCGAGA

Downstream 100 bases:

>100_bases
GCGGCCGTCGTCGCCGCCGAGAGGACGAACGGCTCTACTGATTCGCGGTGATTCTCCGTAGCTTTGAGGGCGTGGGTAGC
GACGAGCCGGTGCAGGTGCT

Product: FprA

Products: NA

Alternate protein names: NFR [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MRPYHVAIVGSGPSGFFAAASLLKAADGSEHPDVAVDMLEMLPTPWGLVRSGVAPDHPKIKSISKQFEKTAADPRFRFFG
NVSVGEHVQASELAERYDAVIYAVGAQSDRALNIPGEDLPGSIAAVDFVGWYNAHPNFEEATPDLSGSRAVVVGNGNVAL
DVARILVTDPDVLGLTDIADHALESLRPCGVDEVVVIGRRGPLQTAFTTLELRELGELDNVDVIVDPAQLEGVTDEDAAA
AGKTAKQNISVLRDYAKRSPRPGHRRIVLRFMTSPIEIKGDGRVESIVLGRNELVTDETGRVSARDTGEREELPVQLVVR
SVGYRGVPTPGLPFDEKTATIPNTGGRVEGSRNEYVVGWIKRGPTGVIGTNKKDSQDTVDTLLADLANAGPDGLADFPDD
HADRLADWLASRQPKLVTTAHWELIDAHERAAGEARGRPRVKLPSLAKLLRVSHG

Sequences:

>Translated_455_residues
MRPYHVAIVGSGPSGFFAAASLLKAADGSEHPDVAVDMLEMLPTPWGLVRSGVAPDHPKIKSISKQFEKTAADPRFRFFG
NVSVGEHVQASELAERYDAVIYAVGAQSDRALNIPGEDLPGSIAAVDFVGWYNAHPNFEEATPDLSGSRAVVVGNGNVAL
DVARILVTDPDVLGLTDIADHALESLRPCGVDEVVVIGRRGPLQTAFTTLELRELGELDNVDVIVDPAQLEGVTDEDAAA
AGKTAKQNISVLRDYAKRSPRPGHRRIVLRFMTSPIEIKGDGRVESIVLGRNELVTDETGRVSARDTGEREELPVQLVVR
SVGYRGVPTPGLPFDEKTATIPNTGGRVEGSRNEYVVGWIKRGPTGVIGTNKKDSQDTVDTLLADLANAGPDGLADFPDD
HADRLADWLASRQPKLVTTAHWELIDAHERAAGEARGRPRVKLPSLAKLLRVSHG
>Mature_455_residues
MRPYHVAIVGSGPSGFFAAASLLKAADGSEHPDVAVDMLEMLPTPWGLVRSGVAPDHPKIKSISKQFEKTAADPRFRFFG
NVSVGEHVQASELAERYDAVIYAVGAQSDRALNIPGEDLPGSIAAVDFVGWYNAHPNFEEATPDLSGSRAVVVGNGNVAL
DVARILVTDPDVLGLTDIADHALESLRPCGVDEVVVIGRRGPLQTAFTTLELRELGELDNVDVIVDPAQLEGVTDEDAAA
AGKTAKQNISVLRDYAKRSPRPGHRRIVLRFMTSPIEIKGDGRVESIVLGRNELVTDETGRVSARDTGEREELPVQLVVR
SVGYRGVPTPGLPFDEKTATIPNTGGRVEGSRNEYVVGWIKRGPTGVIGTNKKDSQDTVDTLLADLANAGPDGLADFPDD
HADRLADWLASRQPKLVTTAHWELIDAHERAAGEARGRPRVKLPSLAKLLRVSHG

Specific function: May serve as electron transfer protein and supply electrons to P450 systems [H]

COG id: COG0493

COG function: function code ER; NADPH-dependent glutamate synthase beta chain and related oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferredoxin--NADP reductase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI111118981, Length=463, Percent_Identity=43.4125269978402, Blast_Score=311, Evalue=8e-85,
Organism=Homo sapiens, GI111118983, Length=469, Percent_Identity=42.6439232409382, Blast_Score=305, Evalue=4e-83,
Organism=Escherichia coli, GI87082180, Length=168, Percent_Identity=29.7619047619048, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17543860, Length=456, Percent_Identity=32.2368421052632, Blast_Score=229, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6320584, Length=487, Percent_Identity=31.8275154004107, Blast_Score=214, Evalue=3e-56,
Organism=Drosophila melanogaster, GI17137178, Length=457, Percent_Identity=36.980306345733, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR021163
- InterPro:   IPR016040 [H]

Pfam domain/function: PF07992 Pyr_redox_2 [H]

EC number: =1.18.1.2 [H]

Molecular weight: Translated: 48868; Mature: 48868

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPYHVAIVGSGPSGFFAAASLLKAADGSEHPDVAVDMLEMLPTPWGLVRSGVAPDHPKI
CCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCHH
KSISKQFEKTAADPRFRFFGNVSVGEHVQASELAERYDAVIYAVGAQSDRALNIPGEDLP
HHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHCEEEEEECCCCCCEECCCCCCCC
GSIAAVDFVGWYNAHPNFEEATPDLSGSRAVVVGNGNVALDVARILVTDPDVLGLTDIAD
CCEEEEEEEEEECCCCCHHHCCCCCCCCEEEEEECCCEEEEEEEEEECCCCCCCHHHHHH
HALESLRPCGVDEVVVIGRRGPLQTAFTTLELRELGELDNVDVIVDPAQLEGVTDEDAAA
HHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHCCCCCHHHHH
AGKTAKQNISVLRDYAKRSPRPGHRRIVLRFMTSPIEIKGDGRVESIVLGRNELVTDETG
CCCHHHHHHHHHHHHHHCCCCCCHHEEEEEEECCCEEEECCCCEEEEEECCCCEECCCCC
RVSARDTGEREELPVQLVVRSVGYRGVPTPGLPFDEKTATIPNTGGRVEGSRNEYVVGWI
CCCCCCCCCCHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
KRGPTGVIGTNKKDSQDTVDTLLADLANAGPDGLADFPDDHADRLADWLASRQPKLVTTA
ECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEC
HWELIDAHERAAGEARGRPRVKLPSLAKLLRVSHG
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MRPYHVAIVGSGPSGFFAAASLLKAADGSEHPDVAVDMLEMLPTPWGLVRSGVAPDHPKI
CCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCHH
KSISKQFEKTAADPRFRFFGNVSVGEHVQASELAERYDAVIYAVGAQSDRALNIPGEDLP
HHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHCEEEEEECCCCCCEECCCCCCCC
GSIAAVDFVGWYNAHPNFEEATPDLSGSRAVVVGNGNVALDVARILVTDPDVLGLTDIAD
CCEEEEEEEEEECCCCCHHHCCCCCCCCEEEEEECCCEEEEEEEEEECCCCCCCHHHHHH
HALESLRPCGVDEVVVIGRRGPLQTAFTTLELRELGELDNVDVIVDPAQLEGVTDEDAAA
HHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHCCCCCHHHHH
AGKTAKQNISVLRDYAKRSPRPGHRRIVLRFMTSPIEIKGDGRVESIVLGRNELVTDETG
CCCHHHHHHHHHHHHHHCCCCCCHHEEEEEEECCCEEEECCCCEEEEEECCCCEECCCCC
RVSARDTGEREELPVQLVVRSVGYRGVPTPGLPFDEKTATIPNTGGRVEGSRNEYVVGWI
CCCCCCCCCCHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
KRGPTGVIGTNKKDSQDTVDTLLADLANAGPDGLADFPDDHADRLADWLASRQPKLVTTA
ECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEC
HWELIDAHERAAGEARGRPRVKLPSLAKLLRVSHG
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]