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The map label for this gene is emrE

Identifier: 41409225

GI number: 41409225

Start: 3478052

End: 3478456

Strand: Direct

Name: emrE

Synonym: MAP3127

Alternate gene names: 41409225

Gene position: 3478052-3478456 (Clockwise)

Preceding gene: 41409220

Following gene: 41409226

Centisome position: 72.01

GC content: 63.46

Gene sequence:

>405_bases
GTGCCCGGTACCGGCCATAACCTGCGCTTCCTTTCCTGTCCTGTACACACATACCTGTACATGCGTGCGCGAGGAGGCGT
CTTGACCTATCTGTTCTTGATCTGCGCGATTTTGGCCGAGGTGGTCGCGACCAGCCTGCTCAAGAGCACCCAGGGTTTCA
CCCGGCTGTGGCCCACCGTGATCTGTCTGCTCGGCTACGCCGTGTCCTTCGCGCTGCTGGCCGTGTCGATTTCGCGCGGC
ATGCAGACCGACGTCGCCTACGCGTTGTGGTCGGCCATCGGCACGGCGCTGATCGTGCTGATCGCCGTGCTGTTCCTTGG
CTCGCCGATATCGGTGACCAAGGTCGTCGGTGTCGGGCTGATCATCGCCGGCGTGGTGACGCTGAACCTGACCGGGGCGC
ACTGA

Upstream 100 bases:

>100_bases
AGACCAGCACCGCGGCCGCCGTGCCGCCGCGCGCCGGATAGTAGGTCGCCGCCAGCGACGCCCGCTCCCCGACCGCGCTG
CTGACGTCGAAGCGGACCGG

Downstream 100 bases:

>100_bases
CCGGGTCCGGCGCCGGGCCGAAGGTGCCGTCTCGAGTGGACGATTCGCCGGTGCGCCGCAAGGATCGACAGCACAACTCG
TGGCAGGGAGGGAAGTGACA

Product: EmrE

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 134; Mature: 133

Protein sequence:

>134_residues
MPGTGHNLRFLSCPVHTYLYMRARGGVLTYLFLICAILAEVVATSLLKSTQGFTRLWPTVICLLGYAVSFALLAVSISRG
MQTDVAYALWSAIGTALIVLIAVLFLGSPISVTKVVGVGLIIAGVVTLNLTGAH

Sequences:

>Translated_134_residues
MPGTGHNLRFLSCPVHTYLYMRARGGVLTYLFLICAILAEVVATSLLKSTQGFTRLWPTVICLLGYAVSFALLAVSISRG
MQTDVAYALWSAIGTALIVLIAVLFLGSPISVTKVVGVGLIIAGVVTLNLTGAH
>Mature_133_residues
PGTGHNLRFLSCPVHTYLYMRARGGVLTYLFLICAILAEVVATSLLKSTQGFTRLWPTVICLLGYAVSFALLAVSISRGM
QTDVAYALWSAIGTALIVLIAVLFLGSPISVTKVVGVGLIIAGVVTLNLTGAH

Specific function: Multidrug efflux pump. Confers resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O and pyronin Y [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family. Mmr (TC 2.A.7.1.2) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=101, Percent_Identity=44.5544554455446, Blast_Score=83, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 14152; Mature: 14021

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGTGHNLRFLSCPVHTYLYMRARGGVLTYLFLICAILAEVVATSLLKSTQGFTRLWPTV
CCCCCCCCEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ICLLGYAVSFALLAVSISRGMQTDVAYALWSAIGTALIVLIAVLFLGSPISVTKVVGVGL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IIAGVVTLNLTGAH
HHHHHHHHCCCCCC
>Mature Secondary Structure 
PGTGHNLRFLSCPVHTYLYMRARGGVLTYLFLICAILAEVVATSLLKSTQGFTRLWPTV
CCCCCCCEEEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ICLLGYAVSFALLAVSISRGMQTDVAYALWSAIGTALIVLIAVLFLGSPISVTKVVGVGL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IIAGVVTLNLTGAH
HHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA