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The map label for this gene is fgd1 [H]

Identifier: 41409218

GI number: 41409218

Start: 3470894

End: 3471850

Strand: Reverse

Name: fgd1 [H]

Synonym: MAP3120c

Alternate gene names: 41409218

Gene position: 3471850-3470894 (Counterclockwise)

Preceding gene: 41409221

Following gene: 41409214

Centisome position: 71.88

GC content: 70.53

Gene sequence:

>957_bases
ATGACCAAGATCGGATACTTTCTTTCCTGCGAGCAGTTCGGGCCGAAGGAACTCGTCGACCAGGCCAAGCGGGCGCAGGA
CGCCGGGTTCGAGGCGCTGTGGATCTCCGACCACTTCCATCCCTGGAACGACGAGCAGGGCCAGAGCCCGTTCGTGTGGT
CGGTGATCGGCGCGCTCTCCGAGGCGACGTCGCTGCCGGTCAGCACCGCCGTCACCTGCCCGACCATCCGGATACACCCG
GCGATCATCGCGCAGGCGGCGGCCACCGCGGCCGTGCAGCTGCAGGGCCGGTTCGTGCTGGGGGTGGGCAGCGGCGAGGC
CCTCAACGAGCACATCCTGGGCGATCCCTGGCCGTCCGCCGGGGTCCGGCTTCAGATGCTCGAGGAGGCCGTCGAGGTCA
TCCGCAAGCTGCACCAGGGCGGCGAGGTGAGCCACCACGGCAAGCACTACGAGGTGCAGGAAGCCCGGATCTACACCCGG
CCCGAGCAGCCGGTGCCCATCTACGGCTCGGCGTTCGGGCCGCAGGCGGTGCGGCTGGCCGCCCGGATCGGCGACGGATA
CAGCATCTCCATGCCCGACGGCGAGCTGGTCAAACAGTTCCGGGAGGCCGGCGGCGGCGACAAGCCGGTGCAGGGCGGCA
CCAAGGTGTGCTGGGACGCCGACGCCGACGCCGCGCTGAAAACCGCGCACCGGCTGTGGGGCAACGAGGGGCTGCCCGGC
CAGACGTCCCAAATCCTGCCCCGCCCCAAGGATTTCGCCGCGCTGATGCCGCTGGTGCCGCCGGACACCGTCGCCCAGAG
CGTCGCCTGCGGGCCCGACCCCGACCGGCACATCGCCCAGTTGCGCCGCTACATCGACGCCGACATCGACGAGGTCTACG
TGCAGCAGATCGGCCCGGACATGGACGGGTTCTTCGCGGCCTGGGAGCAGGCCGTGCTGCCCGCGGTCCGCAACTAG

Upstream 100 bases:

>100_bases
CTCTCGGTTATCGAGAACTGTCTTCTCCCGAATTGGCCGGCGTGTTCTCGCGGGTGCTGCCTAATGCTTAAGCGACCGCC
GAGCGGGTAGCCGGGGCGCC

Downstream 100 bases:

>100_bases
CGGCCGCGGCTCAGCTCGCCGATGCGCACCGCTCCAGCCGGAAGGTGCGTTCGAAGCCGGCCGGCTGCGTCGTCAACGTC
ACCTCCACCGCACCGCTGGG

Product: hypothetical protein

Products: NA

Alternate protein names: F420_G6P_DH [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MTKIGYFLSCEQFGPKELVDQAKRAQDAGFEALWISDHFHPWNDEQGQSPFVWSVIGALSEATSLPVSTAVTCPTIRIHP
AIIAQAAATAAVQLQGRFVLGVGSGEALNEHILGDPWPSAGVRLQMLEEAVEVIRKLHQGGEVSHHGKHYEVQEARIYTR
PEQPVPIYGSAFGPQAVRLAARIGDGYSISMPDGELVKQFREAGGGDKPVQGGTKVCWDADADAALKTAHRLWGNEGLPG
QTSQILPRPKDFAALMPLVPPDTVAQSVACGPDPDRHIAQLRRYIDADIDEVYVQQIGPDMDGFFAAWEQAVLPAVRN

Sequences:

>Translated_318_residues
MTKIGYFLSCEQFGPKELVDQAKRAQDAGFEALWISDHFHPWNDEQGQSPFVWSVIGALSEATSLPVSTAVTCPTIRIHP
AIIAQAAATAAVQLQGRFVLGVGSGEALNEHILGDPWPSAGVRLQMLEEAVEVIRKLHQGGEVSHHGKHYEVQEARIYTR
PEQPVPIYGSAFGPQAVRLAARIGDGYSISMPDGELVKQFREAGGGDKPVQGGTKVCWDADADAALKTAHRLWGNEGLPG
QTSQILPRPKDFAALMPLVPPDTVAQSVACGPDPDRHIAQLRRYIDADIDEVYVQQIGPDMDGFFAAWEQAVLPAVRN
>Mature_317_residues
TKIGYFLSCEQFGPKELVDQAKRAQDAGFEALWISDHFHPWNDEQGQSPFVWSVIGALSEATSLPVSTAVTCPTIRIHPA
IIAQAAATAAVQLQGRFVLGVGSGEALNEHILGDPWPSAGVRLQMLEEAVEVIRKLHQGGEVSHHGKHYEVQEARIYTRP
EQPVPIYGSAFGPQAVRLAARIGDGYSISMPDGELVKQFREAGGGDKPVQGGTKVCWDADADAALKTAHRLWGNEGLPGQ
TSQILPRPKDFAALMPLVPPDTVAQSVACGPDPDRHIAQLRRYIDADIDEVYVQQIGPDMDGFFAAWEQAVLPAVRN

Specific function: Involved in the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to

COG id: COG2141

COG function: function code C; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019945
- InterPro:   IPR019944
- InterPro:   IPR011251
- InterPro:   IPR016048 [H]

Pfam domain/function: PF00296 Bac_luciferase [H]

EC number: =1.1.99.34 [H]

Molecular weight: Translated: 34500; Mature: 34369

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIGYFLSCEQFGPKELVDQAKRAQDAGFEALWISDHFHPWNDEQGQSPFVWSVIGALS
CCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
EATSLPVSTAVTCPTIRIHPAIIAQAAATAAVQLQGRFVLGVGSGEALNEHILGDPWPSA
HHHCCCCCCEEECCEEEECHHHHHHHHHHHEEEECCEEEEEECCCCHHHHCCCCCCCCCC
GVRLQMLEEAVEVIRKLHQGGEVSHHGKHYEVQEARIYTRPEQPVPIYGSAFGPQAVRLA
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHEEEECCCCCCCCCCCCCCHHHHHHH
ARIGDGYSISMPDGELVKQFREAGGGDKPVQGGTKVCWDADADAALKTAHRLWGNEGLPG
HHCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCC
QTSQILPRPKDFAALMPLVPPDTVAQSVACGPDPDRHIAQLRRYIDADIDEVYVQQIGPD
CCHHCCCCCHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCC
MDGFFAAWEQAVLPAVRN
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKIGYFLSCEQFGPKELVDQAKRAQDAGFEALWISDHFHPWNDEQGQSPFVWSVIGALS
CCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHH
EATSLPVSTAVTCPTIRIHPAIIAQAAATAAVQLQGRFVLGVGSGEALNEHILGDPWPSA
HHHCCCCCCEEECCEEEECHHHHHHHHHHHEEEECCEEEEEECCCCHHHHCCCCCCCCCC
GVRLQMLEEAVEVIRKLHQGGEVSHHGKHYEVQEARIYTRPEQPVPIYGSAFGPQAVRLA
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHEEEECCCCCCCCCCCCCCHHHHHHH
ARIGDGYSISMPDGELVKQFREAGGGDKPVQGGTKVCWDADADAALKTAHRLWGNEGLPG
HHCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCC
QTSQILPRPKDFAALMPLVPPDTVAQSVACGPDPDRHIAQLRRYIDADIDEVYVQQIGPD
CCHHCCCCCHHHHHHCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCC
MDGFFAAWEQAVLPAVRN
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]