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The map label for this gene is phr

Identifier: 41409179

GI number: 41409179

Start: 3427758

End: 3429086

Strand: Direct

Name: phr

Synonym: MAP3081

Alternate gene names: 41409179

Gene position: 3427758-3429086 (Clockwise)

Preceding gene: 41409178

Following gene: 41409181

Centisome position: 70.97

GC content: 70.43

Gene sequence:

>1329_bases
ATGCCCGCGCTGTTGTGGTTCCGCCGCGACCTTCGCCTGCACGATCATCCGGCGCTGTCGGCCGCGGCGGACAGTGACGA
GGTGCTCGCCTGCTTCGTGCTCGATCCGCGGCTGCAGAGGTCGTCCGGGCCGCGCCGGCTGCAGTTCCTGGGCGACTCGC
TGCGGGTGCTGCGCGACGAGCTCGACGGTCGGCTGCTGGTCACCCGCGGGCGGCCCGACATCCGAATTCCCGAAATCGCC
AAGGCAATCGGCGCCTCGTCGGTGCACGTCTCGGAGGACTTCACGCCGTTCGGGAAGCGCCGGGACGCGCGGGTGCGCGC
GGCGCTGGCGTCGGTCCCGCTGGTGGCGACCGGATCGCCGTACCTCGTCGCGCCGGGCCGCGTCACCAAGCCGGACGGCT
CGCCCTACCAGGTGTTCACCCCGTTTCTGCGGCGGTGGCGCGACACCGGCTGGCGACCACCGGTCAAAACCGGCGCCGCA
TCCGCGCGCTGGCTCGACCCGGCGCGGCTCGGCATCACCGACTGCGAAATCCCCGACCCCGGCGCCACGCTCGACCTGGC
GGCCGGCGAGGAGGCGGCGCGAAACAAGTGGAAGTCCTTCGTGGACAACGGGTTAGCGAACTACGCCGACGATCGCCACC
GGCCCGACATCGAGGGCACCAGCCGGATGTCGGCGCACCTGAAGTTCGGCACCATCCATCCGCGCACGCTGGTCGCCGAT
CTCGACCTACGCGCCGCCGCAGCGCGAGCGTACCTGCGGGAGTTGGCCTTTCGCGACTTCTATGCCGACGTGCTGCATCA
CCGGCCGGCCAGCGCGTGGCGCAACTGGAACAGCGCCTTCGACGCCATCCGCACCGACACCGGCGCCGAGGCCGGCCGCC
GCTTCGCGGCCTGGAAGGCCGGCGAAACCGGTTTTCCGTTCGTCGACGCCGGAATGCGCCAGCTGCGCCAGACCGGATTC
ATGCACAACCGGGTGCGCATGACCGTTGCCTCTTTCCTGGTGAAGGACCTTCACCTGCCCTGGCAGTGGGGCGCGCACTG
GTTTCTGCAGCAGTTGGTGGACGGCGACCTGGCGAACAACCAGCATGGCTGGCAATGGTGTGCGGGCTGCGGGACCGACG
CCGCACCCTACTTCCGGGTGTTCAACCCCGCCGCCCAGGGCGAAAAATTCGATCCCTCCGGCGACTACATCCGCCGCTGG
GTGCCCGAATTGCGGTGCGCCGACGACCCACACCTGCGCACCGGCGAGCGACCGCCCGGTTACCCGGCGCCGATCGTCGA
CCACGCGACCGAACGCGCCGAAGCGCTGCGCCGCTATCGGAGCATGTGA

Upstream 100 bases:

>100_bases
CGCCACCGCCCTGGCGTTGTCGCCCTATCCGTTGTGGTGCGGCTTCGCCACCGTGTTGTCCACCCACATCTGGCGCCTCA
ACCGTTAGCCCGCACCGCCG

Downstream 100 bases:

>100_bases
ACCGCCGTCCGGGCACCCGACGTCGACGCGGGCGACGTCAACTTCCATTTCAAGGTGGACGAGCAGCCGCAACCAAAAAG
CTAGCGGGAGGCCTTCTTTC

Product: Phr

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MPALLWFRRDLRLHDHPALSAAADSDEVLACFVLDPRLQRSSGPRRLQFLGDSLRVLRDELDGRLLVTRGRPDIRIPEIA
KAIGASSVHVSEDFTPFGKRRDARVRAALASVPLVATGSPYLVAPGRVTKPDGSPYQVFTPFLRRWRDTGWRPPVKTGAA
SARWLDPARLGITDCEIPDPGATLDLAAGEEAARNKWKSFVDNGLANYADDRHRPDIEGTSRMSAHLKFGTIHPRTLVAD
LDLRAAAARAYLRELAFRDFYADVLHHRPASAWRNWNSAFDAIRTDTGAEAGRRFAAWKAGETGFPFVDAGMRQLRQTGF
MHNRVRMTVASFLVKDLHLPWQWGAHWFLQQLVDGDLANNQHGWQWCAGCGTDAAPYFRVFNPAAQGEKFDPSGDYIRRW
VPELRCADDPHLRTGERPPGYPAPIVDHATERAEALRRYRSM

Sequences:

>Translated_442_residues
MPALLWFRRDLRLHDHPALSAAADSDEVLACFVLDPRLQRSSGPRRLQFLGDSLRVLRDELDGRLLVTRGRPDIRIPEIA
KAIGASSVHVSEDFTPFGKRRDARVRAALASVPLVATGSPYLVAPGRVTKPDGSPYQVFTPFLRRWRDTGWRPPVKTGAA
SARWLDPARLGITDCEIPDPGATLDLAAGEEAARNKWKSFVDNGLANYADDRHRPDIEGTSRMSAHLKFGTIHPRTLVAD
LDLRAAAARAYLRELAFRDFYADVLHHRPASAWRNWNSAFDAIRTDTGAEAGRRFAAWKAGETGFPFVDAGMRQLRQTGF
MHNRVRMTVASFLVKDLHLPWQWGAHWFLQQLVDGDLANNQHGWQWCAGCGTDAAPYFRVFNPAAQGEKFDPSGDYIRRW
VPELRCADDPHLRTGERPPGYPAPIVDHATERAEALRRYRSM
>Mature_441_residues
PALLWFRRDLRLHDHPALSAAADSDEVLACFVLDPRLQRSSGPRRLQFLGDSLRVLRDELDGRLLVTRGRPDIRIPEIAK
AIGASSVHVSEDFTPFGKRRDARVRAALASVPLVATGSPYLVAPGRVTKPDGSPYQVFTPFLRRWRDTGWRPPVKTGAAS
ARWLDPARLGITDCEIPDPGATLDLAAGEEAARNKWKSFVDNGLANYADDRHRPDIEGTSRMSAHLKFGTIHPRTLVADL
DLRAAAARAYLRELAFRDFYADVLHHRPASAWRNWNSAFDAIRTDTGAEAGRRFAAWKAGETGFPFVDAGMRQLRQTGFM
HNRVRMTVASFLVKDLHLPWQWGAHWFLQQLVDGDLANNQHGWQWCAGCGTDAAPYFRVFNPAAQGEKFDPSGDYIRRWV
PELRCADDPHLRTGERPPGYPAPIVDHATERAEALRRYRSM

Specific function: Involved in repair of UV radiation-induced DNA damage. Exhibits specific, light-dependent repair activity for a cyclobutyl pyrimidine dimer by catalyzing the light-dependent monomerization (300-600 nm) of the dimers (in cis-syn configuration), which are f

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=488, Percent_Identity=29.5081967213115, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI4758072, Length=490, Percent_Identity=27.1428571428571, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI188536103, Length=441, Percent_Identity=28.1179138321995, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1786926, Length=492, Percent_Identity=36.1788617886179, Blast_Score=252, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6324962, Length=507, Percent_Identity=27.810650887574, Blast_Score=189, Evalue=7e-49,
Organism=Drosophila melanogaster, GI17137248, Length=492, Percent_Identity=30.2845528455285, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24585455, Length=492, Percent_Identity=30.2845528455285, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24648152, Length=493, Percent_Identity=26.9776876267748, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR019947
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 49655; Mature: 49523

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPALLWFRRDLRLHDHPALSAAADSDEVLACFVLDPRLQRSSGPRRLQFLGDSLRVLRDE
CCCHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHCCCCCCHHHHHHHHHHHHHH
LDGRLLVTRGRPDIRIPEIAKAIGASSVHVSEDFTPFGKRRDARVRAALASVPLVATGSP
CCCEEEEECCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHCCEEECCCC
YLVAPGRVTKPDGSPYQVFTPFLRRWRDTGWRPPVKTGAASARWLDPARLGITDCEIPDP
EEECCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCC
GATLDLAAGEEAARNKWKSFVDNGLANYADDRHRPDIEGTSRMSAHLKFGTIHPRTLVAD
CCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHEEEEEECCCCCCCEEEC
LDLRAAAARAYLRELAFRDFYADVLHHRPASAWRNWNSAFDAIRTDTGAEAGRRFAAWKA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHCCCCHHHHCEEEEECC
GETGFPFVDAGMRQLRQTGFMHNRVRMTVASFLVKDLHLPWQWGAHWFLQQLVDGDLANN
CCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
QHGWQWCAGCGTDAAPYFRVFNPAAQGEKFDPSGDYIRRWVPELRCADDPHLRTGERPPG
CCCCHHCCCCCCCCCCHHEEECHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
YPAPIVDHATERAEALRRYRSM
CCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PALLWFRRDLRLHDHPALSAAADSDEVLACFVLDPRLQRSSGPRRLQFLGDSLRVLRDE
CCHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHCCCCCCHHHHHHHHHHHHHH
LDGRLLVTRGRPDIRIPEIAKAIGASSVHVSEDFTPFGKRRDARVRAALASVPLVATGSP
CCCEEEEECCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHCCEEECCCC
YLVAPGRVTKPDGSPYQVFTPFLRRWRDTGWRPPVKTGAASARWLDPARLGITDCEIPDP
EEECCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCC
GATLDLAAGEEAARNKWKSFVDNGLANYADDRHRPDIEGTSRMSAHLKFGTIHPRTLVAD
CCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHEEEEEECCCCCCCEEEC
LDLRAAAARAYLRELAFRDFYADVLHHRPASAWRNWNSAFDAIRTDTGAEAGRRFAAWKA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHCCCCHHHHCEEEEECC
GETGFPFVDAGMRQLRQTGFMHNRVRMTVASFLVKDLHLPWQWGAHWFLQQLVDGDLANN
CCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
QHGWQWCAGCGTDAAPYFRVFNPAAQGEKFDPSGDYIRRWVPELRCADDPHLRTGERPPG
CCCCHHCCCCCCCCCCHHEEECHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
YPAPIVDHATERAEALRRYRSM
CCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11254140; 8905231; 10896222; 10871367 [H]