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The map label for this gene is crtT

Identifier: 41409172

GI number: 41409172

Start: 3418845

End: 3419570

Strand: Direct

Name: crtT

Synonym: MAP3074

Alternate gene names: 41409172

Gene position: 3418845-3419570 (Clockwise)

Preceding gene: 41409171

Following gene: 41409173

Centisome position: 70.79

GC content: 73.14

Gene sequence:

>726_bases
GTGCGCGCCGGTGACACGCGCCCCGCCCCGGGCAACCTGGCGGCCGCGTTCGACGCCGGCGCCGCGACCTACGACCGGCT
GGTCGGCGCCAGCCCGGGCTACCATGCGCAGCTGCTGCTGTCGGCGCGCAGGATGCGAATACCGCACGACGGCAAGGGCT
TACGCCTGCTCGATGCCGGCTGCGGAACCGGTGCGTCGACGGCCGCGCTGCTCGCCGTCGCGCCGGCGGCCGACATCGTC
GCCGTCGACGCGTCGCGCGGCATGCTGGAGGTGGCGCTGGCCAAGCGGTGGCCGGCCTCGGTCCGGTTCGTGCACGCTCC
CGTCCAACGACTGGCAGAACACGGGATCAGCGGGCCGTTCGACGGCGTGCTGGCCGCCTACCTGATCCGCAACGTCGCCG
ACCGCGACGAGCAGCTACGGCGGTTCCGCACCCTGCTGCGGCCCGGCGCAACCCTTGCGGTGCACGAATATTCGGTGCGC
GACTCCGCCGCCGCCACGCTTGCCTGGCACGCCCTCTGCTGGGGCATCATCATTCCGGCCGGGTGGTGGCGCAGCGGGGA
TACCGCGCTGTACCGCTACCTGTGGCGCAGCGTGCTCGCATTCGACGGCGCCACCCGGTTCCGGGCCCGACTGGCCGACG
CCGGCTTCACCGCCGTCCACAGCGAGACCATGCCCGGCTGGGAAGCCGGCATCGTGCACACCTTCCTCGCGGACGCACCC
TCATGA

Upstream 100 bases:

>100_bases
CAGATCAGCGGGTTGCGTTTCCCGTTCGACATCCCGGTGGAGGATTTTCTGTTCGGCTTCGCGATGGTCACCGCGGTGCT
GCTGCTCTGGGAACGACGAC

Downstream 100 bases:

>100_bases
CCGCGGGTGCCACCGACCGCCGCCGTCGGATACTGCCTGCGCCAACCGGATTGCCGGATGCCGGTGCGCTGCCGTCCCGC
CCACGGGTGGCGGTGGTGGG

Product: CrtT

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MRAGDTRPAPGNLAAAFDAGAATYDRLVGASPGYHAQLLLSARRMRIPHDGKGLRLLDAGCGTGASTAALLAVAPAADIV
AVDASRGMLEVALAKRWPASVRFVHAPVQRLAEHGISGPFDGVLAAYLIRNVADRDEQLRRFRTLLRPGATLAVHEYSVR
DSAAATLAWHALCWGIIIPAGWWRSGDTALYRYLWRSVLAFDGATRFRARLADAGFTAVHSETMPGWEAGIVHTFLADAP
S

Sequences:

>Translated_241_residues
MRAGDTRPAPGNLAAAFDAGAATYDRLVGASPGYHAQLLLSARRMRIPHDGKGLRLLDAGCGTGASTAALLAVAPAADIV
AVDASRGMLEVALAKRWPASVRFVHAPVQRLAEHGISGPFDGVLAAYLIRNVADRDEQLRRFRTLLRPGATLAVHEYSVR
DSAAATLAWHALCWGIIIPAGWWRSGDTALYRYLWRSVLAFDGATRFRARLADAGFTAVHSETMPGWEAGIVHTFLADAP
S
>Mature_241_residues
MRAGDTRPAPGNLAAAFDAGAATYDRLVGASPGYHAQLLLSARRMRIPHDGKGLRLLDAGCGTGASTAALLAVAPAADIV
AVDASRGMLEVALAKRWPASVRFVHAPVQRLAEHGISGPFDGVLAAYLIRNVADRDEQLRRFRTLLRPGATLAVHEYSVR
DSAAATLAWHALCWGIIIPAGWWRSGDTALYRYLWRSVLAFDGATRFRARLADAGFTAVHSETMPGWEAGIVHTFLADAP
S

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Escherichia coli, GI48994983, Length=173, Percent_Identity=28.3236994219653, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 25779; Mature: 25779

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAGDTRPAPGNLAAAFDAGAATYDRLVGASPGYHAQLLLSARRMRIPHDGKGLRLLDAG
CCCCCCCCCCCCEEEHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECC
CGTGASTAALLAVAPAADIVAVDASRGMLEVALAKRWPASVRFVHAPVQRLAEHGISGPF
CCCCCHHHHHHHCCCCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCH
DGVLAAYLIRNVADRDEQLRRFRTLLRPGATLAVHEYSVRDSAAATLAWHALCWGIIIPA
HHHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCC
GWWRSGDTALYRYLWRSVLAFDGATRFRARLADAGFTAVHSETMPGWEAGIVHTFLADAP
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHCCC
S
C
>Mature Secondary Structure
MRAGDTRPAPGNLAAAFDAGAATYDRLVGASPGYHAQLLLSARRMRIPHDGKGLRLLDAG
CCCCCCCCCCCCEEEHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECC
CGTGASTAALLAVAPAADIVAVDASRGMLEVALAKRWPASVRFVHAPVQRLAEHGISGPF
CCCCCHHHHHHHCCCCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCH
DGVLAAYLIRNVADRDEQLRRFRTLLRPGATLAVHEYSVRDSAAATLAWHALCWGIIIPA
HHHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCC
GWWRSGDTALYRYLWRSVLAFDGATRFRARLADAGFTAVHSETMPGWEAGIVHTFLADAP
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA