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The map label for this gene is mrdA [H]

Identifier: 41409034

GI number: 41409034

Start: 3269906

End: 3271768

Strand: Reverse

Name: mrdA [H]

Synonym: MAP2936c

Alternate gene names: 41409034

Gene position: 3271768-3269906 (Counterclockwise)

Preceding gene: 41409035

Following gene: 41409033

Centisome position: 67.74

GC content: 70.75

Gene sequence:

>1863_bases
GTGTCGACGCCGCTGTTCAGGCCGCAGTTCTTAACATCAGCACCGATGGTAACTACAAGAACAGTGGCCACATCCGCCTC
GGGCTTGCTGCTGGTCGCGGTGATCGCCCTGTCCGGATGCACACCGCGGCCCGACGGGCCCGGACCGGCCGCGGAGAAGT
TCTTCCGCGCCCTGGCCGTCGGCGACACCGCGACGGCCGCCCAGCTCAGCGACAACCCCAACGAGGCCCGCGAAGCCCTC
AACGCGGCCTGGTCGGGTCTGCAGGCCAGCCACCTGGACGCGCAGATCCTCAACGCCAAGTACGCCGAGGACACCGGCAC
GGTCGGCTATCGCTTCACCTGGCACCTGCCCAAGAACCGCACCTGGACCTACGACGGCCAGCTGAAGATGGCGCGCGACG
AGGGCCGCTGGGAGGTGCGCTGGACCACCACCGCGCTGCACGCCAAGCTCGGCGAGCACCAGACCTTCGCGTTGCGCGCG
GACCGGCCGCGCCGCGCCTCGGTCAACGAACTCGGCGGCAGCGACGTGCTGGTGCCGGGCTACCTGTACCACTACACGCT
GGACGCCACCCAGGCCGGCAACGGCGCCGCGCTGTTCGGCACCGCGCACGCGGTGGTCGACGTGCTGCGCCCGTTCAACG
GCGCGCTCGCCGACCCGCAGCTGCTCGCCGAGCAGGCCAGCTCGTCGACCCAGCCGGTGGACCTGGTCACGCTGCACCCC
GACGACAACGACAAGGTGTTCCCGGCCATCGGCAGGCTGCCCGGCATCGTGGTCACCCCGCAGCCCGAAATGCTGCCCAC
CGACCCGCATTTCGCGCCGGCCGTCGTCGCCGCGGTGAAGAAGGCGGTGATCGACCAGCTCGACGGCCAGGCGGGCTGGC
GGGTGGTCAGCGTCAACCAGAACGGTGTTGAGGTGGAGGTGCTGCACGAGGTGGAGGGGTCGCCGGCGCCGTCGGTGTCG
CTCACCATCGACCGGGCGGTGCAGAACGCGGCCCAGCACGCGGTGGACACCCGCGGCGGCAAGGCAATGATCGTGGTGAT
CAAGCCGTCGACCGGGGAGATCCTGGCGATCGCGCAGAACGGCGGCGCCGACGCCGACGGCCTGCCGGCCACCAACGGAC
TCTTCCCGCCCGGGTCGACGTTCAAGATGATCACCGCCGGCGCGGCCGTCGACCGCGACATGGCCACCCCCAACACCATG
CTGGGCTGCCCCGGCCATCTCGACATCGGGCATCGCACCATCCCCAACTACGGTGGCTTCGATCTGGGCGTGGTGCCGAT
GTCGCGGGCGTTCGCCAGCTCCTGCAACACCACCTTCGCCGAGCTCAGCAGCAAGATGCCGCCGCGCGGCCTGACCCAGG
CGGCCACCCGGTACGGCATCGGCCTGGACTACCAGATCGACGGCATCACCACGGTCACCGGCTCGGTGCCGCCGACCGTG
GACCTGGCTGAGCGCACCGAGGACGGCTTCGGCCAGGGCAAGGTGCTGGCCAGCCCGTTCGGCATGGCGCTGGTGGCCGC
GACGGTGGCCGCCGGCAAGACGCCGGTGCCGCAGCTGATCGTGGGCCGGCAGACCGCGGTCCAGGGCGACACCACCCCGA
TCAGCCCGAAGATGGTCGACGCGCTGCGGCCGATGATGCGGCTGGTGGTCACCAACGGGACCGCCAAGGAGATCGCCGGC
TGCGGCGCGGTGTACGGCAAGACCGGTGAGGCCGAGTTCCCCGGCGGGTCGCACTCGTGGTTCGCCGGCTACCGCGGCGA
CCTGGCCTTCGCGGCGCTGATCGTCGGGGGCGGCAGCTCGGAATACGCGGTCCGGATGACCAAGGTGATGTTCGAGTCGC
TGCCGCCGGACTTTTTGGCCTGA

Upstream 100 bases:

>100_bases
CGGTCCTGCTCGACTGATGGACCCCGGGCCGAAGTCACGCTGGCGTGACGCTCGGCGGACGAGATAGTCCGCAATCGGCA
CATCACGATCCGGTCTCGGT

Downstream 100 bases:

>100_bases
CCAACACGCCCGCTCACAGGGCGCGCGCGGCGGTAAATTGCAAGCGTGGGCGAGTCCGGGGAAGAGATGGTCGCGCTACG
GGTCTCCGACGCCGACCGCA

Product: hypothetical protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MSTPLFRPQFLTSAPMVTTRTVATSASGLLLVAVIALSGCTPRPDGPGPAAEKFFRALAVGDTATAAQLSDNPNEAREAL
NAAWSGLQASHLDAQILNAKYAEDTGTVGYRFTWHLPKNRTWTYDGQLKMARDEGRWEVRWTTTALHAKLGEHQTFALRA
DRPRRASVNELGGSDVLVPGYLYHYTLDATQAGNGAALFGTAHAVVDVLRPFNGALADPQLLAEQASSSTQPVDLVTLHP
DDNDKVFPAIGRLPGIVVTPQPEMLPTDPHFAPAVVAAVKKAVIDQLDGQAGWRVVSVNQNGVEVEVLHEVEGSPAPSVS
LTIDRAVQNAAQHAVDTRGGKAMIVVIKPSTGEILAIAQNGGADADGLPATNGLFPPGSTFKMITAGAAVDRDMATPNTM
LGCPGHLDIGHRTIPNYGGFDLGVVPMSRAFASSCNTTFAELSSKMPPRGLTQAATRYGIGLDYQIDGITTVTGSVPPTV
DLAERTEDGFGQGKVLASPFGMALVAATVAAGKTPVPQLIVGRQTAVQGDTTPISPKMVDALRPMMRLVVTNGTAKEIAG
CGAVYGKTGEAEFPGGSHSWFAGYRGDLAFAALIVGGGSSEYAVRMTKVMFESLPPDFLA

Sequences:

>Translated_620_residues
MSTPLFRPQFLTSAPMVTTRTVATSASGLLLVAVIALSGCTPRPDGPGPAAEKFFRALAVGDTATAAQLSDNPNEAREAL
NAAWSGLQASHLDAQILNAKYAEDTGTVGYRFTWHLPKNRTWTYDGQLKMARDEGRWEVRWTTTALHAKLGEHQTFALRA
DRPRRASVNELGGSDVLVPGYLYHYTLDATQAGNGAALFGTAHAVVDVLRPFNGALADPQLLAEQASSSTQPVDLVTLHP
DDNDKVFPAIGRLPGIVVTPQPEMLPTDPHFAPAVVAAVKKAVIDQLDGQAGWRVVSVNQNGVEVEVLHEVEGSPAPSVS
LTIDRAVQNAAQHAVDTRGGKAMIVVIKPSTGEILAIAQNGGADADGLPATNGLFPPGSTFKMITAGAAVDRDMATPNTM
LGCPGHLDIGHRTIPNYGGFDLGVVPMSRAFASSCNTTFAELSSKMPPRGLTQAATRYGIGLDYQIDGITTVTGSVPPTV
DLAERTEDGFGQGKVLASPFGMALVAATVAAGKTPVPQLIVGRQTAVQGDTTPISPKMVDALRPMMRLVVTNGTAKEIAG
CGAVYGKTGEAEFPGGSHSWFAGYRGDLAFAALIVGGGSSEYAVRMTKVMFESLPPDFLA
>Mature_619_residues
STPLFRPQFLTSAPMVTTRTVATSASGLLLVAVIALSGCTPRPDGPGPAAEKFFRALAVGDTATAAQLSDNPNEAREALN
AAWSGLQASHLDAQILNAKYAEDTGTVGYRFTWHLPKNRTWTYDGQLKMARDEGRWEVRWTTTALHAKLGEHQTFALRAD
RPRRASVNELGGSDVLVPGYLYHYTLDATQAGNGAALFGTAHAVVDVLRPFNGALADPQLLAEQASSSTQPVDLVTLHPD
DNDKVFPAIGRLPGIVVTPQPEMLPTDPHFAPAVVAAVKKAVIDQLDGQAGWRVVSVNQNGVEVEVLHEVEGSPAPSVSL
TIDRAVQNAAQHAVDTRGGKAMIVVIKPSTGEILAIAQNGGADADGLPATNGLFPPGSTFKMITAGAAVDRDMATPNTML
GCPGHLDIGHRTIPNYGGFDLGVVPMSRAFASSCNTTFAELSSKMPPRGLTQAATRYGIGLDYQIDGITTVTGSVPPTVD
LAERTEDGFGQGKVLASPFGMALVAATVAAGKTPVPQLIVGRQTAVQGDTTPISPKMVDALRPMMRLVVTNGTAKEIAGC
GAVYGKTGEAEFPGGSHSWFAGYRGDLAFAALIVGGGSSEYAVRMTKVMFESLPPDFLA

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=290, Percent_Identity=25.1724137931034, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786272, Length=255, Percent_Identity=23.5294117647059, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 65042; Mature: 64911

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPLFRPQFLTSAPMVTTRTVATSASGLLLVAVIALSGCTPRPDGPGPAAEKFFRALAV
CCCCCCCCHHHCCCCCEEEEEHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHC
GDTATAAQLSDNPNEAREALNAAWSGLQASHLDAQILNAKYAEDTGTVGYRFTWHLPKNR
CCCCCCHHCCCCHHHHHHHHHHHHCCCCHHHCCHHHHCCEECCCCCCEEEEEEEECCCCC
TWTYDGQLKMARDEGRWEVRWTTTALHAKLGEHQTFALRADRPRRASVNELGGSDVLVPG
EEEECCEEEEECCCCCEEEEEEEHHHHHHCCCCEEEEEECCCCCCCCHHHCCCCCEEECC
YLYHYTLDATQAGNGAALFGTAHAVVDVLRPFNGALADPQLLAEQASSSTQPVDLVTLHP
EEEEEEEECCCCCCCEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEEECC
DDNDKVFPAIGRLPGIVVTPQPEMLPTDPHFAPAVVAAVKKAVIDQLDGQAGWRVVSVNQ
CCCCCCCHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
NGVEVEVLHEVEGSPAPSVSLTIDRAVQNAAQHAVDTRGGKAMIVVIKPSTGEILAIAQN
CCCEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEEC
GGADADGLPATNGLFPPGSTFKMITAGAAVDRDMATPNTMLGCPGHLDIGHRTIPNYGGF
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCC
DLGVVPMSRAFASSCNTTFAELSSKMPPRGLTQAATRYGIGLDYQIDGITTVTGSVPPTV
EEEHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEEECCEEEEECCCCCCC
DLAERTEDGFGQGKVLASPFGMALVAATVAAGKTPVPQLIVGRQTAVQGDTTPISPKMVD
CHHHHCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCHHHHH
ALRPMMRLVVTNGTAKEIAGCGAVYGKTGEAEFPGGSHSWFAGYRGDLAFAALIVGGGSS
HHHHHHHHEECCCCHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCC
EYAVRMTKVMFESLPPDFLA
CHHHHHHHHHHHHCCCHHCC
>Mature Secondary Structure 
STPLFRPQFLTSAPMVTTRTVATSASGLLLVAVIALSGCTPRPDGPGPAAEKFFRALAV
CCCCCCCHHHCCCCCEEEEEHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHC
GDTATAAQLSDNPNEAREALNAAWSGLQASHLDAQILNAKYAEDTGTVGYRFTWHLPKNR
CCCCCCHHCCCCHHHHHHHHHHHHCCCCHHHCCHHHHCCEECCCCCCEEEEEEEECCCCC
TWTYDGQLKMARDEGRWEVRWTTTALHAKLGEHQTFALRADRPRRASVNELGGSDVLVPG
EEEECCEEEEECCCCCEEEEEEEHHHHHHCCCCEEEEEECCCCCCCCHHHCCCCCEEECC
YLYHYTLDATQAGNGAALFGTAHAVVDVLRPFNGALADPQLLAEQASSSTQPVDLVTLHP
EEEEEEEECCCCCCCEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEEEEECC
DDNDKVFPAIGRLPGIVVTPQPEMLPTDPHFAPAVVAAVKKAVIDQLDGQAGWRVVSVNQ
CCCCCCCHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
NGVEVEVLHEVEGSPAPSVSLTIDRAVQNAAQHAVDTRGGKAMIVVIKPSTGEILAIAQN
CCCEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEEC
GGADADGLPATNGLFPPGSTFKMITAGAAVDRDMATPNTMLGCPGHLDIGHRTIPNYGGF
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCC
DLGVVPMSRAFASSCNTTFAELSSKMPPRGLTQAATRYGIGLDYQIDGITTVTGSVPPTV
EEEHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEEECCEEEEECCCCCCC
DLAERTEDGFGQGKVLASPFGMALVAATVAAGKTPVPQLIVGRQTAVQGDTTPISPKMVD
CHHHHCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCHHHHH
ALRPMMRLVVTNGTAKEIAGCGAVYGKTGEAEFPGGSHSWFAGYRGDLAFAALIVGGGSS
HHHHHHHHEECCCCHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCC
EYAVRMTKVMFESLPPDFLA
CHHHHHHHHHHHHCCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]