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The map label for this gene is hemE

Identifier: 41408897

GI number: 41408897

Start: 3129164

End: 3130237

Strand: Reverse

Name: hemE

Synonym: MAP2799c

Alternate gene names: 41408897

Gene position: 3130237-3129164 (Counterclockwise)

Preceding gene: 41408901

Following gene: 41408896

Centisome position: 64.81

GC content: 71.79

Gene sequence:

>1074_bases
ATGAACAGCAGCGCGCGTACCCGCCGCGACCTTCCCGAGTCGCCGTATCTGGCCGCGGTGAACGGCCGCAAACCCCACCG
GGTTCCGGTGTGGTTCATGCGGCAGGCCGGCCGGTCGCTGCCCGAATACCGGGCGCTGCGGGCTCAGCACGACATGCTGT
CGGCCTGTTTCGACGCCGAGCTGGTCTGCGAGATCACGCTGCAGCCGGTGCGCCGGCACGACGTCGACGCGGCGATCCTG
TTCTCCGACATCGTGGTCCCGCTGCTGGGCGCCGGCATCGACCTGGACATCGTGGCGGGCGTCGGGCCGGTGATCGCGTC
GCCGGTGCGCACCGCCGCGGACGTGGCCGCGATGAAACCGCTTGAGCGGCAACGGGTTCAGCCGATCGCCGATGCGGTGC
GGCTGCTGGTGTCCGCGCTCGTTGAGGTTCCGCTGATCGGCTTCGCGGGTGCGCCGTTCACGCTGGCGTCCTATCTGATC
GAGGGCGGGCCCAGCCGCCACCACGCCCGCACCAAGGCGATGATGCTGGCCGACCCGGACAGCTGGCACGCCCTGATGGA
GAAGCTGACCGACATCACCGTGGGCTTCCTGCGGGTGCAACTGGACGCCGGGGTGGACGCCGTCCAGGTGTTCGACTCGT
GGGCCGGGGCGCTGTCGCTGGCCAACTACCGCAGCTACGTGCAGCCGCACAGCGCCCGGGTGTTCGCGGCGCTGGCCGAT
TACGGCGTGCCGATGACACACTTCGGGGTGGGCACCGCCGAACTGTTGGGGGCGATGTCGGCCGCCCTCAAACCGGCGCC
CGCGACGGTGGTGGGCGTGGACTGGCGCACCGCGCTCGCCGACGCGGCGACCCGGGTGATGCCCGGCACCGCGCTGCAGG
GCAACCTCGATCCGGTGGTGCTGCTGGCCGGGTGGCCGGTGGTGGAGACGGCGGCGCGGGCGGTGGTGGACGACGGGCGG
CGCGCCGTCGACGCCGGCGCGGCCGGGCACGTGTTCAACCTCGGCCACGGGGTGCTGCCCGAAACCGATCCCGGTGTGCT
GACCGAGCTGGTGTCACTGGTCCACTCGCTATGA

Upstream 100 bases:

>100_bases
CAGCGCAGGCTGGGGAAGTCGTGGTAATCGACCGGCGGGTGGCTGACTGGCACGGTCGTCGATACTACGCAGCGACGCCG
TCATGGCAGCATTGAGCCCG

Downstream 100 bases:

>100_bases
CGGCCCGCTCGTATTGTGTTGTGGGCGGCGGTATTTCAGGGCTGACGGCGGCCTACCGGCTGCGGGTGGCGGCCGGCGAC
GACGCGGTGATCACGCTGCT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MNSSARTRRDLPESPYLAAVNGRKPHRVPVWFMRQAGRSLPEYRALRAQHDMLSACFDAELVCEITLQPVRRHDVDAAIL
FSDIVVPLLGAGIDLDIVAGVGPVIASPVRTAADVAAMKPLERQRVQPIADAVRLLVSALVEVPLIGFAGAPFTLASYLI
EGGPSRHHARTKAMMLADPDSWHALMEKLTDITVGFLRVQLDAGVDAVQVFDSWAGALSLANYRSYVQPHSARVFAALAD
YGVPMTHFGVGTAELLGAMSAALKPAPATVVGVDWRTALADAATRVMPGTALQGNLDPVVLLAGWPVVETAARAVVDDGR
RAVDAGAAGHVFNLGHGVLPETDPGVLTELVSLVHSL

Sequences:

>Translated_357_residues
MNSSARTRRDLPESPYLAAVNGRKPHRVPVWFMRQAGRSLPEYRALRAQHDMLSACFDAELVCEITLQPVRRHDVDAAIL
FSDIVVPLLGAGIDLDIVAGVGPVIASPVRTAADVAAMKPLERQRVQPIADAVRLLVSALVEVPLIGFAGAPFTLASYLI
EGGPSRHHARTKAMMLADPDSWHALMEKLTDITVGFLRVQLDAGVDAVQVFDSWAGALSLANYRSYVQPHSARVFAALAD
YGVPMTHFGVGTAELLGAMSAALKPAPATVVGVDWRTALADAATRVMPGTALQGNLDPVVLLAGWPVVETAARAVVDDGR
RAVDAGAAGHVFNLGHGVLPETDPGVLTELVSLVHSL
>Mature_357_residues
MNSSARTRRDLPESPYLAAVNGRKPHRVPVWFMRQAGRSLPEYRALRAQHDMLSACFDAELVCEITLQPVRRHDVDAAIL
FSDIVVPLLGAGIDLDIVAGVGPVIASPVRTAADVAAMKPLERQRVQPIADAVRLLVSALVEVPLIGFAGAPFTLASYLI
EGGPSRHHARTKAMMLADPDSWHALMEKLTDITVGFLRVQLDAGVDAVQVFDSWAGALSLANYRSYVQPHSARVFAALAD
YGVPMTHFGVGTAELLGAMSAALKPAPATVVGVDWRTALADAATRVMPGTALQGNLDPVVLLAGWPVVETAARAVVDDGR
RAVDAGAAGHVFNLGHGVLPETDPGVLTELVSLVHSL

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=357, Percent_Identity=36.9747899159664, Blast_Score=198, Evalue=6e-51,
Organism=Escherichia coli, GI2367337, Length=355, Percent_Identity=40.5633802816901, Blast_Score=233, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6320252, Length=359, Percent_Identity=33.983286908078, Blast_Score=199, Evalue=6e-52,
Organism=Drosophila melanogaster, GI221330099, Length=355, Percent_Identity=36.3380281690141, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI19921920, Length=349, Percent_Identity=36.676217765043, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 37894; Mature: 37894

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSARTRRDLPESPYLAAVNGRKPHRVPVWFMRQAGRSLPEYRALRAQHDMLSACFDAE
CCCCCCHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
LVCEITLQPVRRHDVDAAILFSDIVVPLLGAGIDLDIVAGVGPVIASPVRTAADVAAMKP
EEEEEEHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEHHHCCCHHHHHHHHHHHHHHHHCC
LERQRVQPIADAVRLLVSALVEVPLIGFAGAPFTLASYLIEGGPSRHHARTKAMMLADPD
HHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCHHHHHHHHHHCCCCHHHHHHHEEEEECCH
SWHALMEKLTDITVGFLRVQLDAGVDAVQVFDSWAGALSLANYRSYVQPHSARVFAALAD
HHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YGVPMTHFGVGTAELLGAMSAALKPAPATVVGVDWRTALADAATRVMPGTALQGNLDPVV
CCCCHHHCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEE
LLAGWPVVETAARAVVDDGRRAVDAGAAGHVFNLGHGVLPETDPGVLTELVSLVHSL
EEECCCHHHHHHHHHHHCCCHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNSSARTRRDLPESPYLAAVNGRKPHRVPVWFMRQAGRSLPEYRALRAQHDMLSACFDAE
CCCCCCHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
LVCEITLQPVRRHDVDAAILFSDIVVPLLGAGIDLDIVAGVGPVIASPVRTAADVAAMKP
EEEEEEHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEHHHCCCHHHHHHHHHHHHHHHHCC
LERQRVQPIADAVRLLVSALVEVPLIGFAGAPFTLASYLIEGGPSRHHARTKAMMLADPD
HHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCHHHHHHHHHHCCCCHHHHHHHEEEEECCH
SWHALMEKLTDITVGFLRVQLDAGVDAVQVFDSWAGALSLANYRSYVQPHSARVFAALAD
HHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YGVPMTHFGVGTAELLGAMSAALKPAPATVVGVDWRTALADAATRVMPGTALQGNLDPVV
CCCCHHHCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCEE
LLAGWPVVETAARAVVDDGRRAVDAGAAGHVFNLGHGVLPETDPGVLTELVSLVHSL
EEECCCHHHHHHHHHHHCCCHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA