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The map label for this gene is glyA

Identifier: 41408797

GI number: 41408797

Start: 3035471

End: 3036751

Strand: Reverse

Name: glyA

Synonym: MAP2699c

Alternate gene names: 41408797

Gene position: 3036751-3035471 (Counterclockwise)

Preceding gene: 41408799

Following gene: 41408796

Centisome position: 62.88

GC content: 71.98

Gene sequence:

>1281_bases
ATGTCGGCGCCGCTCGCCGACATCGACCCCGACATCGCCGGGTTGCTGGGTCAGGAGCTGGGCCGCCAGCGCGACACGCT
GGAGATGATCGCCTCGGAGAACTTCGTCCCGCGCGCGGTGCTGCAGGCCCAGGGCAGCGTGCTGACCAACAAGTACGCCG
AGGGGCTGCCCGGCCGCCGCTACTACGGCGGCTGCGAGTACGTCGACGTGGTGGAGAACATCGCCCGGGATCGGGCCAAG
GCCCTCTTCGACGCCGACTTCGCCAACGTGCAGCCGCATTCGGGTGCCCAGGCCAACGCGGCCGTGCTGCACGCGCTGAT
GACGCCGGGGGAGCGGCTGCTGGGTCTGGACCTGGCCAACGGCGGGCACCTGACGCACGGCATGAAGCTGAACTTCTCCG
GCAAGCTCTACGACGTCGGCTTCTACGGCGTCGACCCGACCACGCACCTGATCGACATGGACGCGGTGCGGGCCAAGGCC
CTCGAGTTCCGTCCCAAGGTCATCATCGCCGGCTGGTCGGCCTACCCGCGGGTGCTGGACTTCGCGGCGTTCGCGTCGAT
CGCCGACGAGGTCGGCGCCAAGCTGTGGGTCGACATGGCACACTTCGCGGGCCTGGTCGCCGCCGGGCTGCACCCGTCCC
CGGTTCCGCACGCCGACGTGGTGTCCACCACCGTGCACAAGACGCTCGGCGGCCCGCGCTCCGGCCTGATCCTGGGCAAG
CAGGAGTACGCCAAGTCGATCAACTCCGCGGTGTTCCCCGGCCAGCAGGGCGGGCCGCTCATGCACGTCATCGCCGCCAA
GGCCGTCGCGCTCAAGATCGCCGGCACGGAAGAGTTCGCCGACCGGCAGCGGCGCACCCTGTCCGGGGCGCGCATCCTCG
CCGAGCGGCTGTCGGGCGCCGACGTGGCGGCCGCCGGCGTGTCGGTGGTCAGCGGCGGCACCGACGTCCACCTGGTGCTG
GTCGACCTGCGCAACTCGGAGCTCGACGGCCAGGCCGCCGAGGACCTGCTGCACGAGATCGGCATCACCGTGAACCGCAA
CGCCGTGCCCAACGATCCCCGGCCGCCGATGGTCACCTCCGGGTTGCGGGTGGGCACGCCGGCCCTGGCCACCCGGGGCT
TCGGGGGCGCCGAGTTCAGTGAGGTCGCCGACGTCATCGCCACCGCGCTGGCGGGCGGCCGCGGGGCCGATCTGGCGGCG
CTGCGGGACCGGGTCACCCGGCTGGCCAGGGATTTCCCGCTGTACGAGGGCCTCGAAGACTGGGCGCTGGTCGGCCGGTA
G

Upstream 100 bases:

>100_bases
CGCCCGACGGCAGGGCCGGCGAAAAGCCGGCCCTGGATAGACTGGCGCCGTGACTGCTGCACCTGACGCTCGCCCCACCG
CATCCGACACGGCGTCGCTG

Downstream 100 bases:

>100_bases
CCGGCCGCTGGGGACCAAAGTCACCACTTTGCCCGCGGCGGCGCGGACGATTTCACGAACCTGTGTACGCAAGTTACAGT
TATCTCCATGGCCGAAAGAC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSAPLADIDPDIAGLLGQELGRQRDTLEMIASENFVPRAVLQAQGSVLTNKYAEGLPGRRYYGGCEYVDVVENIARDRAK
ALFDADFANVQPHSGAQANAAVLHALMTPGERLLGLDLANGGHLTHGMKLNFSGKLYDVGFYGVDPTTHLIDMDAVRAKA
LEFRPKVIIAGWSAYPRVLDFAAFASIADEVGAKLWVDMAHFAGLVAAGLHPSPVPHADVVSTTVHKTLGGPRSGLILGK
QEYAKSINSAVFPGQQGGPLMHVIAAKAVALKIAGTEEFADRQRRTLSGARILAERLSGADVAAAGVSVVSGGTDVHLVL
VDLRNSELDGQAAEDLLHEIGITVNRNAVPNDPRPPMVTSGLRVGTPALATRGFGGAEFSEVADVIATALAGGRGADLAA
LRDRVTRLARDFPLYEGLEDWALVGR

Sequences:

>Translated_426_residues
MSAPLADIDPDIAGLLGQELGRQRDTLEMIASENFVPRAVLQAQGSVLTNKYAEGLPGRRYYGGCEYVDVVENIARDRAK
ALFDADFANVQPHSGAQANAAVLHALMTPGERLLGLDLANGGHLTHGMKLNFSGKLYDVGFYGVDPTTHLIDMDAVRAKA
LEFRPKVIIAGWSAYPRVLDFAAFASIADEVGAKLWVDMAHFAGLVAAGLHPSPVPHADVVSTTVHKTLGGPRSGLILGK
QEYAKSINSAVFPGQQGGPLMHVIAAKAVALKIAGTEEFADRQRRTLSGARILAERLSGADVAAAGVSVVSGGTDVHLVL
VDLRNSELDGQAAEDLLHEIGITVNRNAVPNDPRPPMVTSGLRVGTPALATRGFGGAEFSEVADVIATALAGGRGADLAA
LRDRVTRLARDFPLYEGLEDWALVGR
>Mature_425_residues
SAPLADIDPDIAGLLGQELGRQRDTLEMIASENFVPRAVLQAQGSVLTNKYAEGLPGRRYYGGCEYVDVVENIARDRAKA
LFDADFANVQPHSGAQANAAVLHALMTPGERLLGLDLANGGHLTHGMKLNFSGKLYDVGFYGVDPTTHLIDMDAVRAKAL
EFRPKVIIAGWSAYPRVLDFAAFASIADEVGAKLWVDMAHFAGLVAAGLHPSPVPHADVVSTTVHKTLGGPRSGLILGKQ
EYAKSINSAVFPGQQGGPLMHVIAAKAVALKIAGTEEFADRQRRTLSGARILAERLSGADVAAAGVSVVSGGTDVHLVLV
DLRNSELDGQAAEDLLHEIGITVNRNAVPNDPRPPMVTSGLRVGTPALATRGFGGAEFSEVADVIATALAGGRGADLAAL
RDRVTRLARDFPLYEGLEDWALVGR

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=456, Percent_Identity=44.7368421052632, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI261862352, Length=456, Percent_Identity=44.7368421052632, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI261862350, Length=456, Percent_Identity=44.7368421052632, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI261862348, Length=456, Percent_Identity=44.7368421052632, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI261862346, Length=451, Percent_Identity=44.3458980044346, Blast_Score=321, Evalue=7e-88,
Organism=Homo sapiens, GI22547186, Length=469, Percent_Identity=43.4968017057569, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI22547189, Length=454, Percent_Identity=41.6299559471366, Blast_Score=285, Evalue=7e-77,
Organism=Escherichia coli, GI1788902, Length=415, Percent_Identity=54.6987951807229, Blast_Score=415, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI25144732, Length=405, Percent_Identity=45.4320987654321, Blast_Score=322, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI25144729, Length=405, Percent_Identity=45.4320987654321, Blast_Score=322, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6319739, Length=414, Percent_Identity=45.6521739130435, Blast_Score=347, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6323087, Length=436, Percent_Identity=40.5963302752294, Blast_Score=317, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24640005, Length=466, Percent_Identity=43.9914163090129, Blast_Score=352, Evalue=2e-97,
Organism=Drosophila melanogaster, GI221329721, Length=466, Percent_Identity=43.9914163090129, Blast_Score=352, Evalue=3e-97,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44956; Mature: 44824

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPLADIDPDIAGLLGQELGRQRDTLEMIASENFVPRAVLQAQGSVLTNKYAEGLPGRR
CCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHCCCCCCC
YYGGCEYVDVVENIARDRAKALFDADFANVQPHSGAQANAAVLHALMTPGERLLGLDLAN
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECC
GGHLTHGMKLNFSGKLYDVGFYGVDPTTHLIDMDAVRAKALEFRPKVIIAGWSAYPRVLD
CCCEECCEEEECCCEEEEEEEECCCCCHHEEEHHHHHHHHHHCCCCEEEECCCHHHHHHH
FAAFASIADEVGAKLWVDMAHFAGLVAAGLHPSPVPHADVVSTTVHKTLGGPRSGLILGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECH
QEYAKSINSAVFPGQQGGPLMHVIAAKAVALKIAGTEEFADRQRRTLSGARILAERLSGA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
DVAAAGVSVVSGGTDVHLVLVDLRNSELDGQAAEDLLHEIGITVNRNAVPNDPRPPMVTS
HHHHHCHHEECCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCEEC
GLRVGTPALATRGFGGAEFSEVADVIATALAGGRGADLAALRDRVTRLARDFPLYEGLED
CCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHCCCHH
WALVGR
HHHCCC
>Mature Secondary Structure 
SAPLADIDPDIAGLLGQELGRQRDTLEMIASENFVPRAVLQAQGSVLTNKYAEGLPGRR
CCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHCCCCCCC
YYGGCEYVDVVENIARDRAKALFDADFANVQPHSGAQANAAVLHALMTPGERLLGLDLAN
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECC
GGHLTHGMKLNFSGKLYDVGFYGVDPTTHLIDMDAVRAKALEFRPKVIIAGWSAYPRVLD
CCCEECCEEEECCCEEEEEEEECCCCCHHEEEHHHHHHHHHHCCCCEEEECCCHHHHHHH
FAAFASIADEVGAKLWVDMAHFAGLVAAGLHPSPVPHADVVSTTVHKTLGGPRSGLILGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECH
QEYAKSINSAVFPGQQGGPLMHVIAAKAVALKIAGTEEFADRQRRTLSGARILAERLSGA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
DVAAAGVSVVSGGTDVHLVLVDLRNSELDGQAAEDLLHEIGITVNRNAVPNDPRPPMVTS
HHHHHCHHEECCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCEEC
GLRVGTPALATRGFGGAEFSEVADVIATALAGGRGADLAALRDRVTRLARDFPLYEGLED
CCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHCCCHH
WALVGR
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA