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The map label for this gene is zwf

Identifier: 41408769

GI number: 41408769

Start: 3008144

End: 3009553

Strand: Reverse

Name: zwf

Synonym: MAP2671c

Alternate gene names: 41408769

Gene position: 3009553-3008144 (Counterclockwise)

Preceding gene: 41408772

Following gene: 41408768

Centisome position: 62.31

GC content: 66.95

Gene sequence:

>1410_bases
TTGGCCGACGATGACAGCCATCCATCCGACCTGCTGGTGATCTTCGGAATCACCGGGGACTTGGCGCGCAAGATGACGTT
CCGCGCGCTCTACCGGCTGGAGCGCCGCGAGGAGCTCGAGCACCCGATCATCGGCGTGGCCAGCGACGACATCACCCTCG
ACCAGCTGCTGGACCGCGCCCGGGAGGCGATCAAGGCCACCGGTGAGACGTTCGACGACGCGGTGTTCGACCGCTTGGCG
GGCCGGCTGTCCTACCTGTCGGGCGACGTCACCGACGCCGGGCTCTACAGCGAGCTCGCCAAGAAGATCGGTGGCGATTC
GCGTCCGCTGTACTACCTGGAGATGCCGCCGTCGTTGTTCGCGCCGATCGTGGAGAACCTGGCCAAGGCCGACCTACTGG
AACGCGCCAGGGTGGCGGTGGAAAAGCCGTTCGGCCACGACCTGGAATCTGCGCGCGACCTCAACGCCCGGCTGCGCGCG
GTGCTCGACGAAGACCAAATCCTGCGCGTAGACCACTTTTTGGGCAAACAGCCGGTCGAAGAACTGCAATACCTGCGGTT
CGCCAACAACGCCCTGGCCAAGCTGTGGGACCGCGACAGCATCTCCGAAATCCACATCACCATGGCCGAGGACTTCGGCA
TCGAGGACCGCGGCAAGTTCTATGACGCCGTGGGGGCGGTGCGCGACGTCGTGCAAAACCATCTGCTGCAGGTGCTCGCG
CTGGTCGCCATGGAACCCCCGGTGGGGGCGGGCGCCGACGACCTCAACGACAAGAAGGCCGAGGTGTTCCGGGCCATGCC
GTCGCTGGACCCGGAGCACTGCGTGCGTGGCCAGTATCGCGGCTACACCGAAGTCCCCGGTGTGGCAAAGGATTCCACCA
CCGAGACCTACGTCGCGCTGAGGGCCGAGATCGACAACTGGCGCTGGGCCGGGGTGCCGATCTTCCTGCGCGCCGGCAAG
GCGTTGCCGCACAAGGTCACCGAGGTCCGGATGTTCCTGCATCACGTGCCCGGCTTCTCCTTCCTGCCCAACCGCCGCCC
GCCCGAGCCCAACCAGATCGTGCTGCGCATCGACCCCGATCCCGGGATGCGCCTGCAGCTGTCCGCTCAGGTCGGCGACT
CGTGGCACGACGTGCACCTGGACTCCTCGTTCGCGGTGGACCTCGGCGAACCGGTGCGGCCCTACGAACGGCTGCTCTAC
GCCGCGTTCAACGGCGACCGCCAGCTGTTTGCCCGCGAGGACGCCATCGAAGAGACCTGGCGGATCGTGCAGCCGGTGCT
GGACAAGCCGAGCCGCATCCACCAATACGAGCAAGGCTCCTGGGGACCCGAGGCCGCGCAGGCGCTGGTGCACGGTCGCC
ACGCCTGGCAGCAACCGTGGCTGCCGCAGAGCACGTCCACGAAACGATAA

Upstream 100 bases:

>100_bases
GGGCTGGCGCCCCTGCCGGGCTGTGTCTAGTGTTGAGTCCGCCGGCCGCGGGTAGTGAGTCTCAAGGGAGCCGATCGGGT
GACTTTCGGGAGGAGCGGTC

Downstream 100 bases:

>100_bases
GGAGGCTCGAGACACGATGCAGCTGGGGATGATCGGCCTGGGCCGGATGGGTGCCAACATCGTCCGACGGGTGGTCAAGG
GCGGACACGAATGCGTTGTC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MADDDSHPSDLLVIFGITGDLARKMTFRALYRLERREELEHPIIGVASDDITLDQLLDRAREAIKATGETFDDAVFDRLA
GRLSYLSGDVTDAGLYSELAKKIGGDSRPLYYLEMPPSLFAPIVENLAKADLLERARVAVEKPFGHDLESARDLNARLRA
VLDEDQILRVDHFLGKQPVEELQYLRFANNALAKLWDRDSISEIHITMAEDFGIEDRGKFYDAVGAVRDVVQNHLLQVLA
LVAMEPPVGAGADDLNDKKAEVFRAMPSLDPEHCVRGQYRGYTEVPGVAKDSTTETYVALRAEIDNWRWAGVPIFLRAGK
ALPHKVTEVRMFLHHVPGFSFLPNRRPPEPNQIVLRIDPDPGMRLQLSAQVGDSWHDVHLDSSFAVDLGEPVRPYERLLY
AAFNGDRQLFAREDAIEETWRIVQPVLDKPSRIHQYEQGSWGPEAAQALVHGRHAWQQPWLPQSTSTKR

Sequences:

>Translated_469_residues
MADDDSHPSDLLVIFGITGDLARKMTFRALYRLERREELEHPIIGVASDDITLDQLLDRAREAIKATGETFDDAVFDRLA
GRLSYLSGDVTDAGLYSELAKKIGGDSRPLYYLEMPPSLFAPIVENLAKADLLERARVAVEKPFGHDLESARDLNARLRA
VLDEDQILRVDHFLGKQPVEELQYLRFANNALAKLWDRDSISEIHITMAEDFGIEDRGKFYDAVGAVRDVVQNHLLQVLA
LVAMEPPVGAGADDLNDKKAEVFRAMPSLDPEHCVRGQYRGYTEVPGVAKDSTTETYVALRAEIDNWRWAGVPIFLRAGK
ALPHKVTEVRMFLHHVPGFSFLPNRRPPEPNQIVLRIDPDPGMRLQLSAQVGDSWHDVHLDSSFAVDLGEPVRPYERLLY
AAFNGDRQLFAREDAIEETWRIVQPVLDKPSRIHQYEQGSWGPEAAQALVHGRHAWQQPWLPQSTSTKR
>Mature_468_residues
ADDDSHPSDLLVIFGITGDLARKMTFRALYRLERREELEHPIIGVASDDITLDQLLDRAREAIKATGETFDDAVFDRLAG
RLSYLSGDVTDAGLYSELAKKIGGDSRPLYYLEMPPSLFAPIVENLAKADLLERARVAVEKPFGHDLESARDLNARLRAV
LDEDQILRVDHFLGKQPVEELQYLRFANNALAKLWDRDSISEIHITMAEDFGIEDRGKFYDAVGAVRDVVQNHLLQVLAL
VAMEPPVGAGADDLNDKKAEVFRAMPSLDPEHCVRGQYRGYTEVPGVAKDSTTETYVALRAEIDNWRWAGVPIFLRAGKA
LPHKVTEVRMFLHHVPGFSFLPNRRPPEPNQIVLRIDPDPGMRLQLSAQVGDSWHDVHLDSSFAVDLGEPVRPYERLLYA
AFNGDRQLFAREDAIEETWRIVQPVLDKPSRIHQYEQGSWGPEAAQALVHGRHAWQQPWLPQSTSTKR

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=506, Percent_Identity=33.7944664031621, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI109389365, Length=506, Percent_Identity=33.7944664031621, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI52145310, Length=349, Percent_Identity=31.8051575931232, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1788158, Length=470, Percent_Identity=37.0212765957447, Blast_Score=298, Evalue=5e-82,
Organism=Caenorhabditis elegans, GI17538218, Length=493, Percent_Identity=34.8884381338742, Blast_Score=270, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6324088, Length=485, Percent_Identity=34.020618556701, Blast_Score=253, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24643350, Length=465, Percent_Identity=33.5483870967742, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24643352, Length=465, Percent_Identity=33.5483870967742, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI221513548, Length=468, Percent_Identity=29.4871794871795, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 52934; Mature: 52803

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADDDSHPSDLLVIFGITGDLARKMTFRALYRLERREELEHPIIGVASDDITLDQLLDRA
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHH
REAIKATGETFDDAVFDRLAGRLSYLSGDVTDAGLYSELAKKIGGDSRPLYYLEMPPSLF
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHH
APIVENLAKADLLERARVAVEKPFGHDLESARDLNARLRAVLDEDQILRVDHFLGKQPVE
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEHHHHHHCCCHHH
ELQYLRFANNALAKLWDRDSISEIHITMAEDFGIEDRGKFYDAVGAVRDVVQNHLLQVLA
HHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LVAMEPPVGAGADDLNDKKAEVFRAMPSLDPEHCVRGQYRGYTEVPGVAKDSTTETYVAL
HHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCEEEEE
RAEIDNWRWAGVPIFLRAGKALPHKVTEVRMFLHHVPGFSFLPNRRPPEPNQIVLRIDPD
EEECCCCEECCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCC
PGMRLQLSAQVGDSWHDVHLDSSFAVDLGEPVRPYERLLYAAFNGDRQLFAREDAIEETW
CCCEEEEEECCCCCEEEEECCCCEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
RIVQPVLDKPSRIHQYEQGSWGPEAAQALVHGRHAWQQPWLPQSTSTKR
HHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
ADDDSHPSDLLVIFGITGDLARKMTFRALYRLERREELEHPIIGVASDDITLDQLLDRA
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHH
REAIKATGETFDDAVFDRLAGRLSYLSGDVTDAGLYSELAKKIGGDSRPLYYLEMPPSLF
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHH
APIVENLAKADLLERARVAVEKPFGHDLESARDLNARLRAVLDEDQILRVDHFLGKQPVE
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEHHHHHHCCCHHH
ELQYLRFANNALAKLWDRDSISEIHITMAEDFGIEDRGKFYDAVGAVRDVVQNHLLQVLA
HHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LVAMEPPVGAGADDLNDKKAEVFRAMPSLDPEHCVRGQYRGYTEVPGVAKDSTTETYVAL
HHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCEEEEE
RAEIDNWRWAGVPIFLRAGKALPHKVTEVRMFLHHVPGFSFLPNRRPPEPNQIVLRIDPD
EEECCCCEECCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCC
PGMRLQLSAQVGDSWHDVHLDSSFAVDLGEPVRPYERLLYAAFNGDRQLFAREDAIEETW
CCCEEEEEECCCCCEEEEECCCCEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
RIVQPVLDKPSRIHQYEQGSWGPEAAQALVHGRHAWQQPWLPQSTSTKR
HHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]