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The map label for this gene is thrB

Identifier: 41408564

GI number: 41408564

Start: 2770240

End: 2771187

Strand: Reverse

Name: thrB

Synonym: MAP2466c

Alternate gene names: 41408564

Gene position: 2771187-2770240 (Counterclockwise)

Preceding gene: 41408565

Following gene: 41408563

Centisome position: 57.38

GC content: 70.36

Gene sequence:

>948_bases
TTGGTGACCTCCATGCTGCCCGCCGGGCTGGTGGCCTCCGCCGTCGTGTCGGCGTCCAGTGCCAATCTCGGTCCCGGCTT
CGACAGCATCGGCCTGGCACTGAGCCTCATCGACGAGATCACCGTCGAGACAACCGATTCCGGCCTGGTAGTGCAGGTCG
AGGGCGAGGGCGCCGACCAGGTGCCGCTCGGCCCGGAACACCTGGTGGTGCGCGCCGTGGAGTGCGGCCTGCGCGCCGTC
GGCGTCCGCGCGGCGGGCCTGGTGGTGCGCTGCCGCAACGCCATCCCGCACTCCCGTGGCCTGGGCTCGTCCGCCGCGGC
GGTAGTCGGCGGCCTCGCAGCGGCGAACGGCCTTGTCGCACAAGCGAATTGCCAACCGCTGAGTGATGCTGCGCTGATCC
AGCTGTCCTCGGAGTTCGAGGGGCATCCGGACAACGCCGCGGCCGCCGTGTTTGGTGGCGCGATCGTTTCGTGGATCGAC
CGCGGCGGACAGCACCCCCGGTACGCGGCGGCGCCGCTGCGGCTGCACCCCGATATCCACCTGTACTGCGCGATTCCCCA
GGAACGCTCGCTGACCGCGGAGACCCGGGTGCTGCTGCCCGCGCAGGTCAGCCACGAGGACGCACGCTTCAACGTGAGCC
GGGCCGCGTTGCTGGTGGTCGCGCTCACCGAACGCCCGGATCTGCTGATGGCGGCCACCGAGGACGTGCTGCATCAGCCG
CAGCGGGCGCCGGCCATGCCCGCCTCGGCGGAATATTTGCGGCTGCTGCGGCGTCATAACGTGGCAGCGACGCTTTCCGG
GGCCGGTCCCTCGTTGATCGCACTGACCACAGCGTCGGCGTTGCCCCCGGAAGTGATGGAGTACGGGGCGGCGAACGGAT
TCACCCTCGCCGAAATGACCGCCGGCGAAGGAGTTCGCTGGAGCCCGGGAGTCACCGTCGTCGGTTGA

Upstream 100 bases:

>100_bases
GGGACATGCCGGCCGTGACGCCGCTGCCGGTCGACCCGGTCCTGGTGGTCGAGAAGCTCGGGCTGGCCTGACGAATGGGC
GCGCTCGCAACGAAAGGCTG

Downstream 100 bases:

>100_bases
TCCACAGCGTGGCCGGAGGGTTTGCTTGCTTCCGGCAGGGATGGGGGCTATCCTCGGAGCCGTCCAGCAATCGCAGCATC
TGCATCTGCATACATACTGC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MVTSMLPAGLVASAVVSASSANLGPGFDSIGLALSLIDEITVETTDSGLVVQVEGEGADQVPLGPEHLVVRAVECGLRAV
GVRAAGLVVRCRNAIPHSRGLGSSAAAVVGGLAAANGLVAQANCQPLSDAALIQLSSEFEGHPDNAAAAVFGGAIVSWID
RGGQHPRYAAAPLRLHPDIHLYCAIPQERSLTAETRVLLPAQVSHEDARFNVSRAALLVVALTERPDLLMAATEDVLHQP
QRAPAMPASAEYLRLLRRHNVAATLSGAGPSLIALTTASALPPEVMEYGAANGFTLAEMTAGEGVRWSPGVTVVG

Sequences:

>Translated_315_residues
MVTSMLPAGLVASAVVSASSANLGPGFDSIGLALSLIDEITVETTDSGLVVQVEGEGADQVPLGPEHLVVRAVECGLRAV
GVRAAGLVVRCRNAIPHSRGLGSSAAAVVGGLAAANGLVAQANCQPLSDAALIQLSSEFEGHPDNAAAAVFGGAIVSWID
RGGQHPRYAAAPLRLHPDIHLYCAIPQERSLTAETRVLLPAQVSHEDARFNVSRAALLVVALTERPDLLMAATEDVLHQP
QRAPAMPASAEYLRLLRRHNVAATLSGAGPSLIALTTASALPPEVMEYGAANGFTLAEMTAGEGVRWSPGVTVVG
>Mature_315_residues
MVTSMLPAGLVASAVVSASSANLGPGFDSIGLALSLIDEITVETTDSGLVVQVEGEGADQVPLGPEHLVVRAVECGLRAV
GVRAAGLVVRCRNAIPHSRGLGSSAAAVVGGLAAANGLVAQANCQPLSDAALIQLSSEFEGHPDNAAAAVFGGAIVSWID
RGGQHPRYAAAPLRLHPDIHLYCAIPQERSLTAETRVLLPAQVSHEDARFNVSRAALLVVALTERPDLLMAATEDVLHQP
QRAPAMPASAEYLRLLRRHNVAATLSGAGPSLIALTTASALPPEVMEYGAANGFTLAEMTAGEGVRWSPGVTVVG

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=295, Percent_Identity=29.8305084745763, Blast_Score=78, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6321814, Length=342, Percent_Identity=32.4561403508772, Blast_Score=122, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_MYCPA (Q73X44)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_961400.1
- ProteinModelPortal:   Q73X44
- SMR:   Q73X44
- EnsemblBacteria:   EBMYCT00000037684
- GeneID:   2720689
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP2466c
- NMPDR:   fig|262316.1.peg.2466
- GeneTree:   EBGT00050000016145
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- ProtClustDB:   PRK01212
- BRENDA:   2.7.1.39
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 32337; Mature: 32337

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTSMLPAGLVASAVVSASSANLGPGFDSIGLALSLIDEITVETTDSGLVVQVEGEGADQ
CCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCEEEEECCCCCCC
VPLGPEHLVVRAVECGLRAVGVRAAGLVVRCRNAIPHSRGLGSSAAAVVGGLAAANGLVA
CCCCHHHHHHHHHHHCHHHCCHHHHHHEEEEHHCCCCCCCCCCHHHHHHHHHHHHCCEEE
QANCQPLSDAALIQLSSEFEGHPDNAAAAVFGGAIVSWIDRGGQHPRYAAAPLRLHPDIH
ECCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCEEECCCEE
LYCAIPQERSLTAETRVLLPAQVSHEDARFNVSRAALLVVALTERPDLLMAATEDVLHQP
EEEECCCCCCCCCCCEEEECCCCCCCCCCEEHHHEEEEEEEECCCCCEEEEECHHHHCCC
QRAPAMPASAEYLRLLRRHNVAATLSGAGPSLIALTTASALPPEVMEYGAANGFTLAEMT
CCCCCCCCCHHHHHHHHHCCCEEEECCCCCCEEEEEECCCCCHHHHHHCCCCCCEEEEEC
AGEGVRWSPGVTVVG
CCCCEEECCCEEEEC
>Mature Secondary Structure
MVTSMLPAGLVASAVVSASSANLGPGFDSIGLALSLIDEITVETTDSGLVVQVEGEGADQ
CCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCEEEEECCCCCCC
VPLGPEHLVVRAVECGLRAVGVRAAGLVVRCRNAIPHSRGLGSSAAAVVGGLAAANGLVA
CCCCHHHHHHHHHHHCHHHCCHHHHHHEEEEHHCCCCCCCCCCHHHHHHHHHHHHCCEEE
QANCQPLSDAALIQLSSEFEGHPDNAAAAVFGGAIVSWIDRGGQHPRYAAAPLRLHPDIH
ECCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCEEECCCEE
LYCAIPQERSLTAETRVLLPAQVSHEDARFNVSRAALLVVALTERPDLLMAATEDVLHQP
EEEECCCCCCCCCCCEEEECCCCCCCCCCEEHHHEEEEEEEECCCCCEEEEECHHHHCCC
QRAPAMPASAEYLRLLRRHNVAATLSGAGPSLIALTTASALPPEVMEYGAANGFTLAEMT
CCCCCCCCCHHHHHHHHHCCCEEEECCCCCCEEEEEECCCCCHHHHHHCCCCCCEEEEEC
AGEGVRWSPGVTVVG
CCCCEEECCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA