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The map label for this gene is hemK

Identifier: 41408559

GI number: 41408559

Start: 2765680

End: 2766582

Strand: Reverse

Name: hemK

Synonym: MAP2461c

Alternate gene names: 41408559

Gene position: 2766582-2765680 (Counterclockwise)

Preceding gene: 41408560

Following gene: 41408558

Centisome position: 57.28

GC content: 71.98

Gene sequence:

>903_bases
ATGCACACGATGAGCAGCGAGACGATCCGGCTCAGCCTGCGGCGCGCGATCGACGACGCGACGGCCACCCTCGCCGAAGC
CGGAATCGCTTCCGCGCGTTGGGATGCCGAGCAGCTGGCCGCGCACCTGGCGGGCGTCGACCGCGGCCGGCTGGGCTTGC
TCGAGCCGCCGGGTCAAGAGTTCTTCCAGCGGTACCGCGACGCGGTGTCGGCCCGCGCCCGGCGGGTGCCGTTGCAGCAT
TTGTTGGGGACGGCGGCCTTCGGTCCGGTCCTTTTGCACGTCGGACCCGGGGTCTTCGTCCCGCGTCCCGAAACCGAGGC
GCTGCTGGAATGGGCCACCGCGCAACAACTTCCACCGCGGCCCGTCATCGTGGACCTGTGCACCGGGTCGGGCGCCCTGG
CGGTAGCGCTGGCTCACCATTGCGCCGGCCGGGGCCTACCGGCGCGCATCGTCGGCGTCGACAACTCCGATGCGGCCCTG
GAATATGCGCGCCGCAATGCCGCGGGCACGACGGTCGAGCTGGTGCGCGCCGACGTCATCGAGCTGGCCCGTGTGCCCGG
CTCGGCGCCCGACCTGGACGGGCGGGTGGATCTGGTCGTGGCCAACCCGCCCTATGTTCCCGACGGTGCCGTGCTGGAAC
CCGAAGTCGCCCAGCACGATCCGCACCACGCGGTGTTCGGCGGGCCCGACGGCCTGGCGGTGATCGCCCCCATCGTCGAA
CTGGCCGGCCGGTGGCTGCGGCCGGGCGGACTGATCGGCATCGAGCACGACGACACCACCTCGCACCAGACCGTCGAATT
GTTCGACCGCACCGGGCTTTTCGACGACGTGCGGGCGCGCCGGGACCTGACCGGCCGGCCACGGTTCGTGACCGCCCGCA
GGAGGAGCGGCGCTGATGTCTGA

Upstream 100 bases:

>100_bases
CTCGACCAGGTGCTCGACGGCGACCTGGACGCGTTGTTCGACGCGCTGGCCGCCGCCGACAAGCAGTCGCGGTTACAGCA
GGCATGACCTCCCGGCGACG

Downstream 100 bases:

>100_bases
CTTCTTCGACTGCGCCGACCCCGATCAGCGTTCCCGCGGCATCGCGGCGGCGGCCGCGGCCGTCAAGGGCGGCCGGCTGG
TCGTCATGCCGACCGACACC

Product: hypothetical protein

Products: NA

Alternate protein names: M.MtuHHemKP [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MHTMSSETIRLSLRRAIDDATATLAEAGIASARWDAEQLAAHLAGVDRGRLGLLEPPGQEFFQRYRDAVSARARRVPLQH
LLGTAAFGPVLLHVGPGVFVPRPETEALLEWATAQQLPPRPVIVDLCTGSGALAVALAHHCAGRGLPARIVGVDNSDAAL
EYARRNAAGTTVELVRADVIELARVPGSAPDLDGRVDLVVANPPYVPDGAVLEPEVAQHDPHHAVFGGPDGLAVIAPIVE
LAGRWLRPGGLIGIEHDDTTSHQTVELFDRTGLFDDVRARRDLTGRPRFVTARRRSGADV

Sequences:

>Translated_300_residues
MHTMSSETIRLSLRRAIDDATATLAEAGIASARWDAEQLAAHLAGVDRGRLGLLEPPGQEFFQRYRDAVSARARRVPLQH
LLGTAAFGPVLLHVGPGVFVPRPETEALLEWATAQQLPPRPVIVDLCTGSGALAVALAHHCAGRGLPARIVGVDNSDAAL
EYARRNAAGTTVELVRADVIELARVPGSAPDLDGRVDLVVANPPYVPDGAVLEPEVAQHDPHHAVFGGPDGLAVIAPIVE
LAGRWLRPGGLIGIEHDDTTSHQTVELFDRTGLFDDVRARRDLTGRPRFVTARRRSGADV
>Mature_300_residues
MHTMSSETIRLSLRRAIDDATATLAEAGIASARWDAEQLAAHLAGVDRGRLGLLEPPGQEFFQRYRDAVSARARRVPLQH
LLGTAAFGPVLLHVGPGVFVPRPETEALLEWATAQQLPPRPVIVDLCTGSGALAVALAHHCAGRGLPARIVGVDNSDAAL
EYARRNAAGTTVELVRADVIELARVPGSAPDLDGRVDLVVANPPYVPDGAVLEPEVAQHDPHHAVFGGPDGLAVIAPIVE
LAGRWLRPGGLIGIEHDDTTSHQTVELFDRTGLFDDVRARRDLTGRPRFVTARRRSGADV

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=299, Percent_Identity=32.4414715719064, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1787463, Length=293, Percent_Identity=31.3993174061433, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082085, Length=196, Percent_Identity=29.5918367346939, Blast_Score=62, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24582226, Length=287, Percent_Identity=28.9198606271777, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 32048; Mature: 32048

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTMSSETIRLSLRRAIDDATATLAEAGIASARWDAEQLAAHLAGVDRGRLGLLEPPGQE
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHCCCCCCCCCCCCCHHH
FFQRYRDAVSARARRVPLQHLLGTAAFGPVLLHVGPGVFVPRPETEALLEWATAQQLPPR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHCCCCC
PVIVDLCTGSGALAVALAHHCAGRGLPARIVGVDNSDAALEYARRNAAGTTVELVRADVI
CEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHH
ELARVPGSAPDLDGRVDLVVANPPYVPDGAVLEPEVAQHDPHHAVFGGPDGLAVIAPIVE
HHHHCCCCCCCCCCCEEEEECCCCCCCCCCEECCHHHCCCCCCEECCCCCCHHHHHHHHH
LAGRWLRPGGLIGIEHDDTTSHQTVELFDRTGLFDDVRARRDLTGRPRFVTARRRSGADV
HHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCCCC
>Mature Secondary Structure
MHTMSSETIRLSLRRAIDDATATLAEAGIASARWDAEQLAAHLAGVDRGRLGLLEPPGQE
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHCCCCCCCCCCCCCHHH
FFQRYRDAVSARARRVPLQHLLGTAAFGPVLLHVGPGVFVPRPETEALLEWATAQQLPPR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHCCCCC
PVIVDLCTGSGALAVALAHHCAGRGLPARIVGVDNSDAALEYARRNAAGTTVELVRADVI
CEEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHH
ELARVPGSAPDLDGRVDLVVANPPYVPDGAVLEPEVAQHDPHHAVFGGPDGLAVIAPIVE
HHHHCCCCCCCCCCCEEEEECCCCCCCCCCEECCHHHCCCCCCEECCCCCCHHHHHHHHH
LAGRWLRPGGLIGIEHDDTTSHQTVELFDRTGLFDDVRARRDLTGRPRFVTARRRSGADV
HHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]