Click here to switch to the map view.

The map label for this gene is clpX

Identifier: 41408376

GI number: 41408376

Start: 2547371

End: 2548651

Strand: Reverse

Name: clpX

Synonym: MAP2278c

Alternate gene names: 41408376

Gene position: 2548651-2547371 (Counterclockwise)

Preceding gene: 41408378

Following gene: 41408375

Centisome position: 52.77

GC content: 65.11

Gene sequence:

>1281_bases
ATGGCGCGCATCGGAGACGGCGGTGACCTGCTGAAGTGCTCGTTCTGCGGAAAGAGCCAGAAACAGGTCAAGAAACTCAT
TGCTGGCCCCGGCGTGTACATCTGCGATGAGTGCATCGACCTCTGCAACGAGATCATCGAAGAGGAGCTCGCCGACGCCG
ACGACGTCAAGCTCGACGAGCTGCCCAAGCCGATCGAGATCCGGGAGTTCCTCGAGGGATACGTCATCGGGCAGGACACC
GCCAAGCGGACGCTGGCCGTGGCGGTCTACAACCACTACAAGCGCATCCAGGCCGGCGAGAAGGGCCGCGACTCGCGCCA
CGAACCGGTCGAGCTGACCAAGTCCAACATCTTGATGCTGGGGCCGACCGGATGCGGCAAGACCTACCTGGCCCAGACGC
TGGCCAAGATGCTCAACGTGCCGTTCGCCATCGCCGACGCCACCGCGCTCACCGAGGCCGGATACGTCGGTGAGGACGTG
GAGAACATCCTGCTGAAGCTGATCCAGGCCGCCGACTACGACGTCAAGCGCGCCGAGACCGGCATCATCTACATCGACGA
GGTGGACAAGATCGCGCGCAAGAGCGAGAACCCGTCGATCACCCGCGACGTGTCGGGGGAGGGCGTGCAGCAGGCCCTGC
TGAAGATCCTGGAGGGCACCCAGGCGTCGGTGCCGCCGCAGGGCGGCCGCAAGCACCCGCACCAGGAGTTCATCCAGATC
GACACCACCAACGTGTTGTTCATCGTCGCGGGCGCCTTCGCCGGGCTGGAGAAGATCATCTACGAGCGCGTCGGCAAGCG
GGGCCTGGGTTTTGGCGCCGAGGTGCGCTCCAAGGCCGAGATCGACACCACCGATCACTTCGCCGAGGTCATGCCCGAGG
ACCTGATCAAGTTCGGTCTGATCCCCGAGTTCATCGGCCGGTTGCCCGTGGTCGCCTCGGTCACCAACCTGGACCGCGAG
TCGCTGGTCAAGATCCTGTCCGAGCCGAAGAACGCTCTGGTCAAGCAGTACACCCGGCTGTTCGAGATGGACGGCGTGGA
GCTGGAGTTCACCGACGACGCGCTGGAGGCGATCGCCGATCAGGCCATCCACCGCGGCACCGGGGCCCGCGGCCTGCGCG
CGATCATGGAAGAAGTGCTGCTGCCGGTGATGTACGACATCCCGAGCCGCGACGACGTCGCCAAGGTCGTGGTGACCAAG
GAGACCGTGCAGGACAACGTGTTGCCGACGATCGTGCCGCGCAAGCCGTCGCGCACCGAGCGTCGCGACAAGAGCGCCTG
A

Upstream 100 bases:

>100_bases
GCGTTTATGGTCGCGGCGGGCCCGATCAAGCGGGTAGCGTCGGTGAATACATGCGGGACAGGCAAGACCAACGGCGAACA
GGAAGTAGGCCCTCAGCACC

Downstream 100 bases:

>100_bases
CGCGACGCCGCGCTCCTGGCTAAGCGCGGCGGTTAACGCTCACGACGTGACCAATAACACAGTTTGGTGCGGTTCGCGTC
GGCGCCACCACCCTGACTTG

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELADADDVKLDELPKPIEIREFLEGYVIGQDT
AKRTLAVAVYNHYKRIQAGEKGRDSRHEPVELTKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATALTEAGYVGEDV
ENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSITRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQI
DTTNVLFIVAGAFAGLEKIIYERVGKRGLGFGAEVRSKAEIDTTDHFAEVMPEDLIKFGLIPEFIGRLPVVASVTNLDRE
SLVKILSEPKNALVKQYTRLFEMDGVELEFTDDALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTK
ETVQDNVLPTIVPRKPSRTERRDKSA

Sequences:

>Translated_426_residues
MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELADADDVKLDELPKPIEIREFLEGYVIGQDT
AKRTLAVAVYNHYKRIQAGEKGRDSRHEPVELTKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATALTEAGYVGEDV
ENILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSITRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQI
DTTNVLFIVAGAFAGLEKIIYERVGKRGLGFGAEVRSKAEIDTTDHFAEVMPEDLIKFGLIPEFIGRLPVVASVTNLDRE
SLVKILSEPKNALVKQYTRLFEMDGVELEFTDDALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTK
ETVQDNVLPTIVPRKPSRTERRDKSA
>Mature_425_residues
ARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELADADDVKLDELPKPIEIREFLEGYVIGQDTA
KRTLAVAVYNHYKRIQAGEKGRDSRHEPVELTKSNILMLGPTGCGKTYLAQTLAKMLNVPFAIADATALTEAGYVGEDVE
NILLKLIQAADYDVKRAETGIIYIDEVDKIARKSENPSITRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQID
TTNVLFIVAGAFAGLEKIIYERVGKRGLGFGAEVRSKAEIDTTDHFAEVMPEDLIKFGLIPEFIGRLPVVASVTNLDRES
LVKILSEPKNALVKQYTRLFEMDGVELEFTDDALEAIADQAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTKE
TVQDNVLPTIVPRKPSRTERRDKSA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=346, Percent_Identity=49.7109826589595, Blast_Score=308, Evalue=5e-84,
Organism=Escherichia coli, GI1786642, Length=412, Percent_Identity=62.378640776699, Blast_Score=520, Evalue=1e-149,
Organism=Escherichia coli, GI1790366, Length=108, Percent_Identity=48.1481481481481, Blast_Score=101, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71982908, Length=310, Percent_Identity=44.8387096774194, Blast_Score=271, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI71982905, Length=312, Percent_Identity=45.1923076923077, Blast_Score=271, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI71988663, Length=413, Percent_Identity=36.8038740920097, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71988660, Length=251, Percent_Identity=38.6454183266932, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319704, Length=428, Percent_Identity=39.9532710280374, Blast_Score=280, Evalue=5e-76,
Organism=Drosophila melanogaster, GI24648291, Length=330, Percent_Identity=46.3636363636364, Blast_Score=290, Evalue=9e-79,
Organism=Drosophila melanogaster, GI24648289, Length=330, Percent_Identity=46.3636363636364, Blast_Score=290, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_MYCA1 (A0QDF5)

Other databases:

- EMBL:   CP000479
- RefSeq:   YP_880943.1
- ProteinModelPortal:   A0QDF5
- STRING:   A0QDF5
- EnsemblBacteria:   EBMYCT00000012900
- GeneID:   4529103
- GenomeReviews:   CP000479_GR
- KEGG:   mav:MAV_1716
- TIGR:   MAV_1716
- eggNOG:   COG1219
- GeneTree:   EBGT00050000016479
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- PhylomeDB:   A0QDF5
- ProtClustDB:   PRK05342
- BioCyc:   MAVI243243:MAV_1716-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 46903; Mature: 46772

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELADADDVKLDE
CCCCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LPKPIEIREFLEGYVIGQDTAKRTLAVAVYNHYKRIQAGEKGRDSRHEPVELTKSNILML
CCCCHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEE
GPTGCGKTYLAQTLAKMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKRAET
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHCCC
GIIYIDEVDKIARKSENPSITRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQI
CEEEEECHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEE
DTTNVLFIVAGAFAGLEKIIYERVGKRGLGFGAEVRSKAEIDTTDHFAEVMPEDLIKFGL
CCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHCC
IPEFIGRLPVVASVTNLDRESLVKILSEPKNALVKQYTRLFEMDGVELEFTDDALEAIAD
HHHHHCCCCHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHH
QAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTKETVQDNVLPTIVPRKPSRTE
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEHHHHHCCCCCCCCCCCCCCCC
RRDKSA
CCCCCC
>Mature Secondary Structure 
ARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELADADDVKLDE
CCCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LPKPIEIREFLEGYVIGQDTAKRTLAVAVYNHYKRIQAGEKGRDSRHEPVELTKSNILML
CCCCHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEE
GPTGCGKTYLAQTLAKMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKRAET
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHCCC
GIIYIDEVDKIARKSENPSITRDVSGEGVQQALLKILEGTQASVPPQGGRKHPHQEFIQI
CEEEEECHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEE
DTTNVLFIVAGAFAGLEKIIYERVGKRGLGFGAEVRSKAEIDTTDHFAEVMPEDLIKFGL
CCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHCC
IPEFIGRLPVVASVTNLDRESLVKILSEPKNALVKQYTRLFEMDGVELEFTDDALEAIAD
HHHHHCCCCHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHH
QAIHRGTGARGLRAIMEEVLLPVMYDIPSRDDVAKVVVTKETVQDNVLPTIVPRKPSRTE
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEHHHHHCCCCCCCCCCCCCCCC
RRDKSA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA