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The map label for this gene is rnz [H]

Identifier: 41408318

GI number: 41408318

Start: 2467845

End: 2468687

Strand: Direct

Name: rnz [H]

Synonym: MAP2220

Alternate gene names: 41408318

Gene position: 2467845-2468687 (Clockwise)

Preceding gene: 41408316

Following gene: 41408322

Centisome position: 51.1

GC content: 74.02

Gene sequence:

>843_bases
ATGATCGAGGTCACCCTGCTGGGCACCGGAAGCCCGATCCCCGACCCCAACCGCGCCGGGCCGTCGACCCTGGTGCGCGC
CGGCGGGCAGGTGTTCCTGGTCGACTGCGGACGCGGGGTGCTGCAGCGCGCCGCGGCGGGGGGGGTGGGCGCGGCCGGAT
TGTCGGCGCTGCTGCTCACCCACCTGCACAGCGACCACGTCGGCGACCTGGGCGACGTCCTGATCACGCGGTGGATCAGC
ACCTTCACCCCCGACCCGGTGCCGCTGCCCATCATCGGGCCGCCCGGCACGGCCGAGCTGGTGGCGGCGACGCTGAACGC
GCTGCGGCACGACATCGGTTACCGGATCGCCCATCACGCTGATCTCAACGCGCCCCCGGCGGTGGATGTGCGCGAGCACA
CCGACGGCCCGGTGTGGGACCGCGACGGCGTGTCGATCCGGGTGGCCCCCACCGACCACCGGCCGGTGGCCCCGACCATC
GGGTTCCGCGTCGAATACCAGGGTGCGTCGGTGGTGCTGGCCGGCGACACCGTGCCGTGCGCCGGGCTCGACGAGCTGGC
GGCCGGCGCCGGCGCGCTGGTGCACACCGTGATCCGCAAGGACATCGTGGCCACCATCCCGCAGCAGCGGCTGCAGGACA
TCTGCGACTACCACTCCTCGGTCGAGGAGGCCGCGGCGACCGCGGCCCGCGCCGGGGTGGGCACCCTCGTCATGACGCAC
TACGTGCCCGCGCTGGTGGCGGGCCAGGAAGAACAGTGGCGGGCGCTGGCGGCCCGCGAGTTCGCCGGACGCGTCGAACT
CGGCGACGACCTGCACCGGGTTCAGGTCGACGCGCCCTCCTGA

Upstream 100 bases:

>100_bases
GCTTCACACCAGGCTACGGCGAACTCGCGCGGCGCAAAAGCCACCAGGAGAACCTGCAAACAGATCGTGTCCAAGCTCCA
GGCCCTGCAAGATAGGCCCC

Downstream 100 bases:

>100_bases
GCTCGACCGCCCCGGTCACCATAACCCTTGTCCCGCAAAGCAATTCCCGCGACCACCAGCCAGGCCAGCGCCGCCACCCG
CGCGACCGGCAAGATCACGC

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MIEVTLLGTGSPIPDPNRAGPSTLVRAGGQVFLVDCGRGVLQRAAAGGVGAAGLSALLLTHLHSDHVGDLGDVLITRWIS
TFTPDPVPLPIIGPPGTAELVAATLNALRHDIGYRIAHHADLNAPPAVDVREHTDGPVWDRDGVSIRVAPTDHRPVAPTI
GFRVEYQGASVVLAGDTVPCAGLDELAAGAGALVHTVIRKDIVATIPQQRLQDICDYHSSVEEAAATAARAGVGTLVMTH
YVPALVAGQEEQWRALAAREFAGRVELGDDLHRVQVDAPS

Sequences:

>Translated_280_residues
MIEVTLLGTGSPIPDPNRAGPSTLVRAGGQVFLVDCGRGVLQRAAAGGVGAAGLSALLLTHLHSDHVGDLGDVLITRWIS
TFTPDPVPLPIIGPPGTAELVAATLNALRHDIGYRIAHHADLNAPPAVDVREHTDGPVWDRDGVSIRVAPTDHRPVAPTI
GFRVEYQGASVVLAGDTVPCAGLDELAAGAGALVHTVIRKDIVATIPQQRLQDICDYHSSVEEAAATAARAGVGTLVMTH
YVPALVAGQEEQWRALAAREFAGRVELGDDLHRVQVDAPS
>Mature_280_residues
MIEVTLLGTGSPIPDPNRAGPSTLVRAGGQVFLVDCGRGVLQRAAAGGVGAAGLSALLLTHLHSDHVGDLGDVLITRWIS
TFTPDPVPLPIIGPPGTAELVAATLNALRHDIGYRIAHHADLNAPPAVDVREHTDGPVWDRDGVSIRVAPTDHRPVAPTI
GFRVEYQGASVVLAGDTVPCAGLDELAAGAGALVHTVIRKDIVATIPQQRLQDICDYHSSVEEAAATAARAGVGTLVMTH
YVPALVAGQEEQWRALAAREFAGRVELGDDLHRVQVDAPS

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Escherichia coli, GI87082078, Length=280, Percent_Identity=25.3571428571429, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 29236; Mature: 29236

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEVTLLGTGSPIPDPNRAGPSTLVRAGGQVFLVDCGRGVLQRAAAGGVGAAGLSALLLT
CEEEEEEECCCCCCCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHCCCCCHHHHHHHHHH
HLHSDHVGDLGDVLITRWISTFTPDPVPLPIIGPPGTAELVAATLNALRHDIGYRIAHHA
HHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHEEEECC
DLNAPPAVDVREHTDGPVWDRDGVSIRVAPTDHRPVAPTIGFRVEYQGASVVLAGDTVPC
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCEEEEECCCCCC
AGLDELAAGAGALVHTVIRKDIVATIPQQRLQDICDYHSSVEEAAATAARAGVGTLVMTH
CCHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
YVPALVAGQEEQWRALAAREFAGRVELGDDLHRVQVDAPS
HHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure
MIEVTLLGTGSPIPDPNRAGPSTLVRAGGQVFLVDCGRGVLQRAAAGGVGAAGLSALLLT
CEEEEEEECCCCCCCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHCCCCCHHHHHHHHHH
HLHSDHVGDLGDVLITRWISTFTPDPVPLPIIGPPGTAELVAATLNALRHDIGYRIAHHA
HHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHEEEECC
DLNAPPAVDVREHTDGPVWDRDGVSIRVAPTDHRPVAPTIGFRVEYQGASVVLAGDTVPC
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCEEEEECCCCCC
AGLDELAAGAGALVHTVIRKDIVATIPQQRLQDICDYHSSVEEAAATAARAGVGTLVMTH
CCHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
YVPALVAGQEEQWRALAAREFAGRVELGDDLHRVQVDAPS
HHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA