Click here to switch to the map view.

The map label for this gene is fadK [H]

Identifier: 41408169

GI number: 41408169

Start: 2279549

End: 2281081

Strand: Reverse

Name: fadK [H]

Synonym: MAP2071c

Alternate gene names: 41408169

Gene position: 2281081-2279549 (Counterclockwise)

Preceding gene: 41408170

Following gene: 41408167

Centisome position: 47.23

GC content: 69.93

Gene sequence:

>1533_bases
GTGACGTTCTGGTCGCTGATTGCCGAGGCCGCACGACGCGGCTCACCCCGGCCACTTCTCGCCGACGAGCACGGTCGCAG
CATGACCGCACGTCAGCTCTACGACGCCGCATGCGTCGCCGCGGCCGCGCTGGCCGAGCGGGGAGTCCGCCGGGGCGCCG
TCGTGTCCTGGCAGTTGCCCACCACGCTGGAGACCATGGTGCTGATGGCCGCGCTGGCCCGGCTCGGTGCGGTGCAGAAC
CCGATCATCCCGGTCCTGCGGGAAAGCGAAGTCCGCTTCATCACCGGCCAGCTGAACACTGAATACTTTGTGGCGCCTGG
GCTTTGGCGCGGCTTCGATCACGGTGGGCTGGCTCGGGCACTGTCGGCCGAACGGGGCTTCGAGGTCATCACCGTCGACC
TGGCGGCGCCGCCGGCCGCCGGTGCGCTGCGCCTGCCCGGCGCCGATCCCGATTCCCTGCCGGCGCCGCCGCAATCCGCC
GACGAGGCGCGCTGGATCTACTACTCGTCGGGGACCACCGCCGCTCCCAAGGGGATTCGCCATACCGACAGCTCGGTCAT
CGCCGGCTCGGCGGGAGTGGTCGGCATGGTGGGGGCCACCAGCAGCGACGTCGATCCGATCGCCTTTCCGGTCGCACACA
TCGGCGGGGCCGCGATGCTGGCCACCGCACTGCTGACCGGCATGTGGTTAGTGCTGTTCGAGGCTTTCGACCCGGCCGCC
ACTCCGCTGGCCATCGCCGCACACAATCCGACGTTCCTGGGCACCGCGACGCCCTTCTTCGTCGCCTATCTCGAAGCCCA
ACGGGCCCAAGGGAATCGGCCACTGTTCCCGTCGCTGCGCGGATGCCTGGCCGGAGGCGCACCCATCACCGCCGAGTTGA
GTCGACGGGTCCGCGACACCTTCGGGGTGGCCGGCATCGCCAACGCCTGGGGAATGACCGAGTTCCCCTGCGCGACATCC
CCGTCGCTGACCGCGGCACCCGAGGTGCTCGACCATACCGTGGGGCCGCCGGTGCCCGGCGTCGAAGTCCGCGTGGTCGA
CGGCGCAGAGAATGAACTGGCTGCCGGGCAGGAGGGCGAGCTGCGGCTCAAGGGACCCCAGTGCTTCCTCGGCTACGCCG
ACCCAACGCTGGACGCCGACGCCTTCGACGACCAGGGCTGGCTGCGCACCGGCGATCTCGGCCTGATCGACGCCGACGGC
AACGTCCGCGTCACGGGCCGCACCAAAGACGCGATCATCCGCAATGCGGAGAACATCTCGGCCCTCGAGATCGAGAACGC
ACTTGCGGCGCATCCCGCCGTCGCCGACGTCGCCGTCATCGGGATCCCCGACCCGCGCACCGGCGAACGGGTCTGCGCCG
TCGTGGTACCCGCGACGGCCGACGGCGTCACGCTGGAATCCCTTGTGCAACACTGCCGATCACGCGGGCTGAGCCGCTAC
AAACACCCCGAGCGCCTGGTCGTCGTCGACACCCTCCCGCGCAACCAGTTCGGCAAGGTGATCAAGAAGGACCTGCGCGA
CGCCTTCGGGTGA

Upstream 100 bases:

>100_bases
GGTCGACACCGCGGGCCCGATCGGCACCGGACTGTCGGTTGCCATCGCGCACTCGGGATTTCGTCCGCCGTCCGCCGACC
CGTCGGCGGGGTGAGTTCCG

Downstream 100 bases:

>100_bases
AGCCGGACGCCTGGGCCCGGCACGCCTATTCGCGCGGATGTAACGCCACGGCGAGATTTCGCCCGGATTTCCGCCGTGGC
GTTACGAGCGCGGACAGACA

Product: hypothetical protein

Products: NA

Alternate protein names: Acyl-CoA synthetase [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MTFWSLIAEAARRGSPRPLLADEHGRSMTARQLYDAACVAAAALAERGVRRGAVVSWQLPTTLETMVLMAALARLGAVQN
PIIPVLRESEVRFITGQLNTEYFVAPGLWRGFDHGGLARALSAERGFEVITVDLAAPPAAGALRLPGADPDSLPAPPQSA
DEARWIYYSSGTTAAPKGIRHTDSSVIAGSAGVVGMVGATSSDVDPIAFPVAHIGGAAMLATALLTGMWLVLFEAFDPAA
TPLAIAAHNPTFLGTATPFFVAYLEAQRAQGNRPLFPSLRGCLAGGAPITAELSRRVRDTFGVAGIANAWGMTEFPCATS
PSLTAAPEVLDHTVGPPVPGVEVRVVDGAENELAAGQEGELRLKGPQCFLGYADPTLDADAFDDQGWLRTGDLGLIDADG
NVRVTGRTKDAIIRNAENISALEIENALAAHPAVADVAVIGIPDPRTGERVCAVVVPATADGVTLESLVQHCRSRGLSRY
KHPERLVVVDTLPRNQFGKVIKKDLRDAFG

Sequences:

>Translated_510_residues
MTFWSLIAEAARRGSPRPLLADEHGRSMTARQLYDAACVAAAALAERGVRRGAVVSWQLPTTLETMVLMAALARLGAVQN
PIIPVLRESEVRFITGQLNTEYFVAPGLWRGFDHGGLARALSAERGFEVITVDLAAPPAAGALRLPGADPDSLPAPPQSA
DEARWIYYSSGTTAAPKGIRHTDSSVIAGSAGVVGMVGATSSDVDPIAFPVAHIGGAAMLATALLTGMWLVLFEAFDPAA
TPLAIAAHNPTFLGTATPFFVAYLEAQRAQGNRPLFPSLRGCLAGGAPITAELSRRVRDTFGVAGIANAWGMTEFPCATS
PSLTAAPEVLDHTVGPPVPGVEVRVVDGAENELAAGQEGELRLKGPQCFLGYADPTLDADAFDDQGWLRTGDLGLIDADG
NVRVTGRTKDAIIRNAENISALEIENALAAHPAVADVAVIGIPDPRTGERVCAVVVPATADGVTLESLVQHCRSRGLSRY
KHPERLVVVDTLPRNQFGKVIKKDLRDAFG
>Mature_509_residues
TFWSLIAEAARRGSPRPLLADEHGRSMTARQLYDAACVAAAALAERGVRRGAVVSWQLPTTLETMVLMAALARLGAVQNP
IIPVLRESEVRFITGQLNTEYFVAPGLWRGFDHGGLARALSAERGFEVITVDLAAPPAAGALRLPGADPDSLPAPPQSAD
EARWIYYSSGTTAAPKGIRHTDSSVIAGSAGVVGMVGATSSDVDPIAFPVAHIGGAAMLATALLTGMWLVLFEAFDPAAT
PLAIAAHNPTFLGTATPFFVAYLEAQRAQGNRPLFPSLRGCLAGGAPITAELSRRVRDTFGVAGIANAWGMTEFPCATSP
SLTAAPEVLDHTVGPPVPGVEVRVVDGAENELAAGQEGELRLKGPQCFLGYADPTLDADAFDDQGWLRTGDLGLIDADGN
VRVTGRTKDAIIRNAENISALEIENALAAHPAVADVAVIGIPDPRTGERVCAVVVPATADGVTLESLVQHCRSRGLSRYK
HPERLVVVDTLPRNQFGKVIKKDLRDAFG

Specific function: Catalyzes the esterification, concomitant with transport, of exogenous fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It has a low activity on medium or long chain fatty acids and is ma

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Membrane; Peripheral membrane protein. Note=Partially membrane-associated [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=400, Percent_Identity=30.75, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI187761343, Length=400, Percent_Identity=30.75, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI156151445, Length=523, Percent_Identity=26.0038240917782, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI157311624, Length=369, Percent_Identity=30.8943089430894, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI157311622, Length=369, Percent_Identity=30.8943089430894, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI58082049, Length=368, Percent_Identity=29.8913043478261, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI42544132, Length=376, Percent_Identity=27.6595744680851, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI38505220, Length=355, Percent_Identity=29.5774647887324, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI122937307, Length=360, Percent_Identity=30.2777777777778, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI115511026, Length=362, Percent_Identity=27.9005524861878, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI28416953, Length=530, Percent_Identity=26.7924528301887, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI40807491, Length=373, Percent_Identity=27.8820375335121, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI13375727, Length=519, Percent_Identity=25.0481695568401, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI57165410, Length=357, Percent_Identity=26.0504201680672, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI57165412, Length=357, Percent_Identity=25.7703081232493, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI27477105, Length=175, Percent_Identity=31.4285714285714, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI145693145, Length=515, Percent_Identity=32.8155339805825, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1786810, Length=496, Percent_Identity=30.8467741935484, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1788107, Length=537, Percent_Identity=27.7467411545624, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI221142682, Length=480, Percent_Identity=26.25, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788595, Length=339, Percent_Identity=25.9587020648968, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1789201, Length=352, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790505, Length=381, Percent_Identity=26.246719160105, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1786529, Length=535, Percent_Identity=23.7383177570093, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786801, Length=459, Percent_Identity=23.5294117647059, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI32563687, Length=513, Percent_Identity=28.2651072124756, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17558820, Length=525, Percent_Identity=27.8095238095238, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17531443, Length=398, Percent_Identity=27.6381909547739, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71994703, Length=530, Percent_Identity=26.4150943396226, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17538037, Length=521, Percent_Identity=26.679462571977, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71994694, Length=530, Percent_Identity=26.4150943396226, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71994690, Length=530, Percent_Identity=26.4150943396226, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17557194, Length=486, Percent_Identity=26.1316872427983, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17559526, Length=359, Percent_Identity=28.9693593314763, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17560308, Length=519, Percent_Identity=26.9749518304432, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71985884, Length=371, Percent_Identity=28.0323450134771, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71996755, Length=524, Percent_Identity=25.381679389313, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17560140, Length=454, Percent_Identity=26.2114537444934, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17564090, Length=167, Percent_Identity=31.1377245508982, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17556552, Length=359, Percent_Identity=25.9052924791086, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17510401, Length=418, Percent_Identity=22.2488038277512, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319699, Length=459, Percent_Identity=24.1830065359477, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6319264, Length=533, Percent_Identity=23.827392120075, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323182, Length=537, Percent_Identity=25.1396648044693, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24581924, Length=534, Percent_Identity=26.2172284644195, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI18859661, Length=374, Percent_Identity=26.7379679144385, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21355181, Length=372, Percent_Identity=26.8817204301075, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281365686, Length=415, Percent_Identity=24.0963855421687, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24653035, Length=364, Percent_Identity=26.9230769230769, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21356441, Length=355, Percent_Identity=27.3239436619718, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19922652, Length=518, Percent_Identity=24.3243243243243, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356947, Length=346, Percent_Identity=25.7225433526012, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21358303, Length=394, Percent_Identity=25.1269035532995, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI20130357, Length=380, Percent_Identity=23.4210526315789, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24648253, Length=347, Percent_Identity=26.5129682997118, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24648255, Length=347, Percent_Identity=26.5129682997118, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24648260, Length=350, Percent_Identity=25.1428571428571, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281366413, Length=393, Percent_Identity=26.2086513994911, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24666501, Length=393, Percent_Identity=26.2086513994911, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24666497, Length=393, Percent_Identity=26.2086513994911, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24648257, Length=400, Percent_Identity=26.75, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI161076582, Length=372, Percent_Identity=25.5376344086022, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24656500, Length=507, Percent_Identity=24.8520710059172, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17933690, Length=139, Percent_Identity=34.5323741007194, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921316, Length=169, Percent_Identity=30.1775147928994, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 53620; Mature: 53488

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFWSLIAEAARRGSPRPLLADEHGRSMTARQLYDAACVAAAALAERGVRRGAVVSWQLP
CCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
TTLETMVLMAALARLGAVQNPIIPVLRESEVRFITGQLNTEYFVAPGLWRGFDHGGLARA
HHHHHHHHHHHHHHHCCCCCCCCHHEECCCEEEEEEECCCEEEECCCHHCCCCCCCHHHH
LSAERGFEVITVDLAAPPAAGALRLPGADPDSLPAPPQSADEARWIYYSSGTTAAPKGIR
HHHCCCCEEEEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
HTDSSVIAGSAGVVGMVGATSSDVDPIAFPVAHIGGAAMLATALLTGMWLVLFEAFDPAA
CCCCCEEECCCCEEEEECCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCC
TPLAIAAHNPTFLGTATPFFVAYLEAQRAQGNRPLFPSLRGCLAGGAPITAELSRRVRDT
CCEEEEECCCCEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHH
FGVAGIANAWGMTEFPCATSPSLTAAPEVLDHTVGPPVPGVEVRVVDGAENELAAGQEGE
HCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCC
LRLKGPQCFLGYADPTLDADAFDDQGWLRTGDLGLIDADGNVRVTGRTKDAIIRNAENIS
EEEECCEEEEECCCCCCCCCCCCCCCCEEECCEEEEECCCCEEEECCCHHHHHHCCCCCE
ALEIENALAAHPAVADVAVIGIPDPRTGERVCAVVVPATADGVTLESLVQHCRSRGLSRY
EEEHHHHHHCCCCHHCEEEEECCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCHHHH
KHPERLVVVDTLPRNQFGKVIKKDLRDAFG
CCCCEEEEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TFWSLIAEAARRGSPRPLLADEHGRSMTARQLYDAACVAAAALAERGVRRGAVVSWQLP
CHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
TTLETMVLMAALARLGAVQNPIIPVLRESEVRFITGQLNTEYFVAPGLWRGFDHGGLARA
HHHHHHHHHHHHHHHCCCCCCCCHHEECCCEEEEEEECCCEEEECCCHHCCCCCCCHHHH
LSAERGFEVITVDLAAPPAAGALRLPGADPDSLPAPPQSADEARWIYYSSGTTAAPKGIR
HHHCCCCEEEEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
HTDSSVIAGSAGVVGMVGATSSDVDPIAFPVAHIGGAAMLATALLTGMWLVLFEAFDPAA
CCCCCEEECCCCEEEEECCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCC
TPLAIAAHNPTFLGTATPFFVAYLEAQRAQGNRPLFPSLRGCLAGGAPITAELSRRVRDT
CCEEEEECCCCEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHH
FGVAGIANAWGMTEFPCATSPSLTAAPEVLDHTVGPPVPGVEVRVVDGAENELAAGQEGE
HCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCC
LRLKGPQCFLGYADPTLDADAFDDQGWLRTGDLGLIDADGNVRVTGRTKDAIIRNAENIS
EEEECCEEEEECCCCCCCCCCCCCCCCEEECCEEEEECCCCEEEECCCHHHHHHCCCCCE
ALEIENALAAHPAVADVAVIGIPDPRTGERVCAVVVPATADGVTLESLVQHCRSRGLSRY
EEEHHHHHHCCCCHHCEEEEECCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCHHHH
KHPERLVVVDTLPRNQFGKVIKKDLRDAFG
CCCCEEEEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 7984428; 12535077 [H]