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The map label for this gene is hsaA [H]

Identifier: 41408120

GI number: 41408120

Start: 2230008

End: 2231183

Strand: Direct

Name: hsaA [H]

Synonym: MAP2022

Alternate gene names: 41408120

Gene position: 2230008-2231183 (Clockwise)

Preceding gene: 41408118

Following gene: 41408124

Centisome position: 46.17

GC content: 72.02

Gene sequence:

>1176_bases
GTGCGCATGTCCGTGGTCGAACATCACCCCCTGCATGGCATCACCGACGAGTTCATGGCGCGGTTGGGCGAGCGCGCCGA
GGAGGCCGAGCGGCTGCGCCGGCTGCCGGCGGCGACGGTCGACGAGTTCCGGCAGACCGAGCTGTTCCGCCTGCTGTTGC
CGGCCCGGTTCGGTGGCCTGGAGGCCTCGTTTCCCGAACTGCTGCAACCGATTCGGCGGATGGCGCACGGCTGCGCGTCC
AGCGCCTGGACGCTGGGTTTCTATGCGCTGCACAACTGGATGCTGTCGTTGTTCGATCCGCGGGCGCAGCGGGAGGTCTT
CGCGTCCGGGCCGGTGCTGGCGCCGGCTCCCCTGGCGCCCACCGGCCGCGGCACACCGGCCGACGGCGGTGTGCGGCTGA
CCGGCAGGTGGTCCTGGGCGACGGGGGCGATGGAGGCCGATTGGCTGATCGTCGGCGCGTTGATCGAGCGCACCGACCGC
ATCGATCCGGCGTTGGTCGTGGTGCCCGCCGGGCAGGTCGAGGTCGTCGACACCTGGCACACCGCCGGCATGCGCGGCAC
GGGTTCGCATGACGTGGTGATCACCGACGTCTTCGTTCCCGAGCATCGGCTGGTGGCGGTGGCCGACATCTACGGCGGGA
CCGCGCCCGGCGCGCGCGAGCACGCCGCCGCCACCTATCGCTGGCCGATGGTGCCCGCGCTGGCGCTGACGGCGGCGATG
CCCGTGCTGGGGGCGGCGGAGCGGGTGGTGCAGCTGTTCGCCGACCGGCTCGGCGAGCGGGTGCTGGCGTATAGCGCAGT
GGCGCAAAAGGATCAGCCCGCCGCGCAGATCAGGCTGGGCGAGGCCCGGGTGCGGCTGGACGCGCTGCGGGCGTTGGTCG
CACAGACCGCCGACCGGATCGAGGCGATCGTCGCCGGCGGCGACCGGGTGAGCCGCTCGGTGCGGGCCGATGCCCGGCTG
GCGGCCGCGCGCACGGTGCACGAAAGCCGGGCGATCATCGCCGACGTCATGGAGGCGTCCGGCGCGAGCGCTCATTTCCT
GTCCAGCCCGATGCAGCGCGCCAAGCGCGACGTGGACATCGCCGCGGGGCATGTGGTGTTCGACTACGACACGAGCCGAG
AGTTGGCCGGGGCGTTGGCGATTGGGGCGAAGATCTCCCCGATCTCAATGATCTGA

Upstream 100 bases:

>100_bases
CAGGACGTCGCGGCGGGCCACGGACCGCGGCCCTCGGCGATCACTCACGGCGCGATGGTAACAACCGCGGGCTCTACATA
CTAAAAAGTATGTTACGGTC

Downstream 100 bases:

>100_bases
GGCCACGCCCGCCTCGGTCAGCATCAGGTCGAGGAATCGTTCGCGTTGGGCCAGCGATTGGGCCTGCTCGGCCGAGCCGG
TGAGGTGCAGCAGTCCGATG

Product: hypothetical protein

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MRMSVVEHHPLHGITDEFMARLGERAEEAERLRRLPAATVDEFRQTELFRLLLPARFGGLEASFPELLQPIRRMAHGCAS
SAWTLGFYALHNWMLSLFDPRAQREVFASGPVLAPAPLAPTGRGTPADGGVRLTGRWSWATGAMEADWLIVGALIERTDR
IDPALVVVPAGQVEVVDTWHTAGMRGTGSHDVVITDVFVPEHRLVAVADIYGGTAPGAREHAAATYRWPMVPALALTAAM
PVLGAAERVVQLFADRLGERVLAYSAVAQKDQPAAQIRLGEARVRLDALRALVAQTADRIEAIVAGGDRVSRSVRADARL
AAARTVHESRAIIADVMEASGASAHFLSSPMQRAKRDVDIAAGHVVFDYDTSRELAGALAIGAKISPISMI

Sequences:

>Translated_391_residues
MRMSVVEHHPLHGITDEFMARLGERAEEAERLRRLPAATVDEFRQTELFRLLLPARFGGLEASFPELLQPIRRMAHGCAS
SAWTLGFYALHNWMLSLFDPRAQREVFASGPVLAPAPLAPTGRGTPADGGVRLTGRWSWATGAMEADWLIVGALIERTDR
IDPALVVVPAGQVEVVDTWHTAGMRGTGSHDVVITDVFVPEHRLVAVADIYGGTAPGAREHAAATYRWPMVPALALTAAM
PVLGAAERVVQLFADRLGERVLAYSAVAQKDQPAAQIRLGEARVRLDALRALVAQTADRIEAIVAGGDRVSRSVRADARL
AAARTVHESRAIIADVMEASGASAHFLSSPMQRAKRDVDIAAGHVVFDYDTSRELAGALAIGAKISPISMI
>Mature_391_residues
MRMSVVEHHPLHGITDEFMARLGERAEEAERLRRLPAATVDEFRQTELFRLLLPARFGGLEASFPELLQPIRRMAHGCAS
SAWTLGFYALHNWMLSLFDPRAQREVFASGPVLAPAPLAPTGRGTPADGGVRLTGRWSWATGAMEADWLIVGALIERTDR
IDPALVVVPAGQVEVVDTWHTAGMRGTGSHDVVITDVFVPEHRLVAVADIYGGTAPGAREHAAATYRWPMVPALALTAAM
PVLGAAERVVQLFADRLGERVLAYSAVAQKDQPAAQIRLGEARVRLDALRALVAQTADRIEAIVAGGDRVSRSVRADARL
AAARTVHESRAIIADVMEASGASAHFLSSPMQRAKRDVDIAAGHVVFDYDTSRELAGALAIGAKISPISMI

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol. Also catalyzes the o-hydroxylation of a range of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 42156; Mature: 42156

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMSVVEHHPLHGITDEFMARLGERAEEAERLRRLPAATVDEFRQTELFRLLLPARFGGL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
EASFPELLQPIRRMAHGCASSAWTLGFYALHNWMLSLFDPRAQREVFASGPVLAPAPLAP
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCC
TGRGTPADGGVRLTGRWSWATGAMEADWLIVGALIERTDRIDPALVVVPAGQVEVVDTWH
CCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEHH
TAGMRGTGSHDVVITDVFVPEHRLVAVADIYGGTAPGAREHAAATYRWPMVPALALTAAM
CCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCHHHCCCEEECCCHHHHHHHHHH
PVLGAAERVVQLFADRLGERVLAYSAVAQKDQPAAQIRLGEARVRLDALRALVAQTADRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEECHHHHHHHHHHHHHHHHHHHH
EAIVAGGDRVSRSVRADARLAAARTVHESRAIIADVMEASGASAHFLSSPMQRAKRDVDI
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCE
AAGHVVFDYDTSRELAGALAIGAKISPISMI
EECEEEEECCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRMSVVEHHPLHGITDEFMARLGERAEEAERLRRLPAATVDEFRQTELFRLLLPARFGGL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
EASFPELLQPIRRMAHGCASSAWTLGFYALHNWMLSLFDPRAQREVFASGPVLAPAPLAP
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCC
TGRGTPADGGVRLTGRWSWATGAMEADWLIVGALIERTDRIDPALVVVPAGQVEVVDTWH
CCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEHH
TAGMRGTGSHDVVITDVFVPEHRLVAVADIYGGTAPGAREHAAATYRWPMVPALALTAAM
CCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCHHHCCCEEECCCHHHHHHHHHH
PVLGAAERVVQLFADRLGERVLAYSAVAQKDQPAAQIRLGEARVRLDALRALVAQTADRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEECHHHHHHHHHHHHHHHHHHHH
EAIVAGGDRVSRSVRADARLAAARTVHESRAIIADVMEASGASAHFLSSPMQRAKRDVDI
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCE
AAGHVVFDYDTSRELAGALAIGAKISPISMI
EECEEEEECCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]