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The map label for this gene is accD6

Identifier: 41408098

GI number: 41408098

Start: 2206608

End: 2208029

Strand: Direct

Name: accD6

Synonym: MAP2000

Alternate gene names: 41408098

Gene position: 2206608-2208029 (Clockwise)

Preceding gene: 41408097

Following gene: 41408102

Centisome position: 45.69

GC content: 69.76

Gene sequence:

>1422_bases
ATGACTATCACGGCCCCCGAGACGGTTGGCGAGTCGCTCGACCCCCGCGACCCGCTGTTGCGCCTGAGCAATTTCTTCGA
CGACGGCAGCGTCGCGCTGCTGCACGAACGTGACCGCTCGGGCGTGCTTGCCGCCGCGGGAACCGTGAACGGTGTGCGCA
CCATCGCGTTCTGCACCGACGGCACCGTGATGGGCGGCGCCATGGGCATCGAGGGCTGCTCGCACATCGTCGACGCCTAC
GACACCGCCATCGAGGAGCAGAGCCCGATCGTGGGCATCTGGCACTCCGGCGGTGCCCGGCTGGCCGAGGGCGTGAAGGC
GTTGCACGCCGTGGGCCTGGTGTTCGAGGCGATGATCCGCGCGTCCGGCTACATCCCGCAGATCTCGGTGGTGGTCGGCT
TCGCGGCCGGTGGCGCCGCCTACGGGCCGGCGCTGACCGACGTCGTGGTGATGGCGCCGGAGAGCCGGGTGTTCGTCACC
GGACCCGACGTGGTGCGCAGCGTCACCGGCGAGGACGTCGACATGGCCTCGCTCGGCGGCCCCGAGACCCACCACAAGAA
GTCCGGGGTGTGCCACATCGTCGCCGACGACGAGCTCGACGCCTACGAGCGCGGTCGCCGGTTGGTCGGATTGTTCTGCC
AGCAGGGCCATTTCGACCGCACCAAGGCCGAGGCCGGCGACACCGACATCCACGCGCTGCTGCCCGAGTCGCCCCGCCGC
GCCTACGACGTCCGCCCCATCGTGACCGCGATCCTCGACGACGAGACGCCGTTCGACGAGTTCCAGGCGAACTGGGCGCC
GTCGATGGTGATCGGGTTGGGCCGGCTGTCCGGTCGCACGGTCGGCGTGCTGGCCAACAACCCGCTGCGGCTGGGCGGTT
GCCTGAACTCCGAAAGTGCCGAGAAGGCAGCGCGTTTCGTGCGGCTGTGCGATGCCTTCGGCATTCCGCTGGTGGTGATC
GTCGACGTGCCGGGCTATCTGCCCGGTGTCGACCAGGAGTGGGGCGGTGTGGTGCGTCGCGGCGCCAAGCTGCTGCACGC
CTTCGGCGAGGCGACCGTTCCGCGGGTCACCCTGGTGACCCGAAAGACCTACGGCGGGGCCTACATTGCGATGAACTCCC
GTTCGCTGAACGCGACCAAGGTGTTCGCCTGGCCGGACGCCGAGGTCGCGGTGATGGGAGCCAAGGCCGCCGTCGGCATC
CTGCACAAGAAGAAGCTGGCCGCCGCCCCGGAGCACGAGCGCGAGGCGCTGCACGACCAGCTGGCCGCCGAGCACGAGAA
GATCGCCGGCGGTGTGGACAGTGCGATCGAGATCGGCGTGGTCGACGAGAAGATCGACCCGGCGCACACCCGCAGCAAGC
TCACCGAGGCGCTGGCCCAGGCGCCGGCACGCCGCGGCCGTCACAAGAACATCCCGCTGTAA

Upstream 100 bases:

>100_bases
CAACAACTCGTTCGGCTTCGGCGGCCACAACGTCGCCATCGCCTTCGGACGGTACTGAACCCACGGTCCCGAGCAGCACC
GGAATACAGGAGACCCTGCG

Downstream 100 bases:

>100_bases
CCCCACTTTTCCCGCGCGAGCAGACGCAAAAGCCCCGCGACACGCCGCGCATCAGGGGCTTTTGCGTCTGCTCGCGCCCT
AACGTGCCCGGCCCAGGCAC

Product: AccD6

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTITAPETVGESLDPRDPLLRLSNFFDDGSVALLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGIEGCSHIVDAY
DTAIEEQSPIVGIWHSGGARLAEGVKALHAVGLVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVT
GPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVADDELDAYERGRRLVGLFCQQGHFDRTKAEAGDTDIHALLPESPRR
AYDVRPIVTAILDDETPFDEFQANWAPSMVIGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVI
VDVPGYLPGVDQEWGGVVRRGAKLLHAFGEATVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGI
LHKKKLAAAPEHEREALHDQLAAEHEKIAGGVDSAIEIGVVDEKIDPAHTRSKLTEALAQAPARRGRHKNIPL

Sequences:

>Translated_473_residues
MTITAPETVGESLDPRDPLLRLSNFFDDGSVALLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGIEGCSHIVDAY
DTAIEEQSPIVGIWHSGGARLAEGVKALHAVGLVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVT
GPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVADDELDAYERGRRLVGLFCQQGHFDRTKAEAGDTDIHALLPESPRR
AYDVRPIVTAILDDETPFDEFQANWAPSMVIGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVI
VDVPGYLPGVDQEWGGVVRRGAKLLHAFGEATVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGI
LHKKKLAAAPEHEREALHDQLAAEHEKIAGGVDSAIEIGVVDEKIDPAHTRSKLTEALAQAPARRGRHKNIPL
>Mature_472_residues
TITAPETVGESLDPRDPLLRLSNFFDDGSVALLHERDRSGVLAAAGTVNGVRTIAFCTDGTVMGGAMGIEGCSHIVDAYD
TAIEEQSPIVGIWHSGGARLAEGVKALHAVGLVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTG
PDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVADDELDAYERGRRLVGLFCQQGHFDRTKAEAGDTDIHALLPESPRRA
YDVRPIVTAILDDETPFDEFQANWAPSMVIGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVIV
DVPGYLPGVDQEWGGVVRRGAKLLHAFGEATVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGIL
HKKKLAAAPEHEREALHDQLAAEHEKIAGGVDSAIEIGVVDEKIDPAHTRSKLTEALAQAPARRGRHKNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=489, Percent_Identity=39.8773006134969, Blast_Score=322, Evalue=3e-88,
Organism=Homo sapiens, GI295821216, Length=426, Percent_Identity=42.018779342723, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI11545863, Length=480, Percent_Identity=29.375, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI25147362, Length=445, Percent_Identity=41.123595505618, Blast_Score=327, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI25147359, Length=445, Percent_Identity=41.123595505618, Blast_Score=327, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI17552936, Length=430, Percent_Identity=30, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI71997163, Length=308, Percent_Identity=24.3506493506494, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24586065, Length=502, Percent_Identity=29.0836653386454, Blast_Score=179, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 50129; Mature: 49997

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITAPETVGESLDPRDPLLRLSNFFDDGSVALLHERDRSGVLAAAGTVNGVRTIAFCTD
CEECCCHHHCCCCCCCCHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCCCEEEEEEEEC
GTVMGGAMGIEGCSHIVDAYDTAIEEQSPIVGIWHSGGARLAEGVKALHAVGLVFEAMIR
CCEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPDVVRSVTGEDVDMASLGG
HCCCCCEEEEEEEEECCCCCCCCHHHCEEEECCCCEEEEECHHHHHHCCCCCCCHHHCCC
PETHHKKSGVCHIVADDELDAYERGRRLVGLFCQQGHFDRTKAEAGDTDIHALLPESPRR
CCCCCCCCCEEEEEECCCCCHHHHCCCEEEHHHCCCCCCCCCCCCCCCCEEEECCCCCCC
AYDVRPIVTAILDDETPFDEFQANWAPSMVIGLGRLSGRTVGVLANNPLRLGGCLNSESA
CCCCHHHHHHHCCCCCCHHHHHCCCCCHHEEEEECCCCCEEEEEECCCEEECCCCCCHHH
EKAARFVRLCDAFGIPLVVIVDVPGYLPGVDQEWGGVVRRGAKLLHAFGEATVPRVTLVT
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEE
RKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQ
EECCCCEEEEEECCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHH
LAAEHEKIAGGVDSAIEIGVVDEKIDPAHTRSKLTEALAQAPARRGRHKNIPL
HHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TITAPETVGESLDPRDPLLRLSNFFDDGSVALLHERDRSGVLAAAGTVNGVRTIAFCTD
EECCCHHHCCCCCCCCHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCCCEEEEEEEEC
GTVMGGAMGIEGCSHIVDAYDTAIEEQSPIVGIWHSGGARLAEGVKALHAVGLVFEAMIR
CCEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ASGYIPQISVVVGFAAGGAAYGPALTDVVVMAPESRVFVTGPDVVRSVTGEDVDMASLGG
HCCCCCEEEEEEEEECCCCCCCCHHHCEEEECCCCEEEEECHHHHHHCCCCCCCHHHCCC
PETHHKKSGVCHIVADDELDAYERGRRLVGLFCQQGHFDRTKAEAGDTDIHALLPESPRR
CCCCCCCCCEEEEEECCCCCHHHHCCCEEEHHHCCCCCCCCCCCCCCCCEEEECCCCCCC
AYDVRPIVTAILDDETPFDEFQANWAPSMVIGLGRLSGRTVGVLANNPLRLGGCLNSESA
CCCCHHHHHHHCCCCCCHHHHHCCCCCHHEEEEECCCCCEEEEEECCCEEECCCCCCHHH
EKAARFVRLCDAFGIPLVVIVDVPGYLPGVDQEWGGVVRRGAKLLHAFGEATVPRVTLVT
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEE
RKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQ
EECCCCEEEEEECCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHH
LAAEHEKIAGGVDSAIEIGVVDEKIDPAHTRSKLTEALAQAPARRGRHKNIPL
HHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]