Click here to switch to the map view.

The map label for this gene is kasA

Identifier: 41408096

GI number: 41408096

Start: 2203974

End: 2205224

Strand: Direct

Name: kasA

Synonym: MAP1998

Alternate gene names: 41408096

Gene position: 2203974-2205224 (Clockwise)

Preceding gene: 41408095

Following gene: 41408097

Centisome position: 45.63

GC content: 68.98

Gene sequence:

>1251_bases
GTGAGTAAGCCTTCCACTGCTAACGGCGGTTACCCCAGCGTTGTGGTAACCGCCGTCACGGCGACGACGTCGATCGCGCC
GGACGTCGAGAGCACGTGGAAGGGTCTACTCGCCGGCGAAAGCGGCATCCACGTCCTCGAAGACGACTACATCACCAAGT
GGGACCTGCCGGTCCGGATCGGTGGCCACCTCAAGGAGCCCATCGACGAGCGGATGAGCAGGCTCGACCTGCGCCGCATG
TCCTACGTCCAGCGGCTGGCCAAGCTGCTCAGCACCCAGCTGTGGGAGACCGCCGGCAACCCGGAGCTCGACCCCGACCG
GTTCTCGGTCGTGGTGGGCACCGGCCTCGGTGGTGCCGAGCGGATCGTGGAGAGCTACGACCTGATGAACGAGGGCGGGC
CCCGCAAGGTGTCGCCGCTGGCCGTGCAGATGATCATGCCCAACGGCGCCGCCGCCGTGGTGGGTCTGCAGCTCGGCGCC
CGCGCCGGGGTGATCACCCCGGTGTCAGCCTGTTCGTCGGGCTCGGAGGCGATCGCCCACGCGTGGCGCCAGATCGTCAT
GGGCGACGCCGATGTCGCCGTGTGCGGTGGTGTCGAGGGCCCTATCGACGCGCTGCCGATCGCGGCCTTCTCGATGATGC
GGGCCATGTCGACGCGCAACGACGAGCCCGAGCGGGCGTCGCGGCCGTTCGACAAGGACCGCGACGGGTTCGTGTTCGGC
GAGGCCGGCGCGCTGATGCTGATCGAGACCGAGGAGCACGCCAAGGCCCGCGGTGCCAAGCCGCTGGCCCGGTTGATGGG
TGCCGGCATCACGTCCGATGCGTTCCACATGGTGGCCCCGGCGGGCGACGGTGTGCGGGCGGGCCGGGCCATGACGCGGT
CGCTGGAGTTGGCGGGCCTGTCCCCGAAGGACGTCGACCACGTCAACGCGCACGGCACCGCGACGCCGATCGGTGACACC
GCCGAGGCCAACGCCATCCGGGTGGCCGGATGTCAGGAGGCGGCGGTGTATGCGCCGAAGTCCGCGCTGGGACACTCAAT
CGGCGCGGTCGGCGCGCTGGAATCGGTGCTCACGGTGCTGACCCTGCGCGACGGCGTCATTCCGCCCACCTTGAACTATG
AAACCCCGGACCCCGAAATCGATCTGGACATCGTGGCGGGCGAACCCCGCTACGGCGACTACCAATACGCGATCAACAAC
TCGTTCGGCTTCGGTGGCCACAACGTGGCACTGGCCTTCGGGCGCTACTGA

Upstream 100 bases:

>100_bases
AAGAGAACCCCGAGGCTGCCGAGGCGTTGCGCGCCAAGCTGGAGACCGAGAACCCCGAGGCGGTCGCCAACGTCAAGGCA
AGGCTGGAAGCGGACAGCAA

Downstream 100 bases:

>100_bases
GCACGACGTCCGGCGACGATGCGGGCCGCACCGGCCCGCAAAGTTGCCGGACAAGTTAGGGAAGGAATCTTCGCAAGACC
CATGACAGAGCTGGTTACCG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: Beta-ketoacyl-ACP synthase 1; KAS 1 [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSKPSTANGGYPSVVVTAVTATTSIAPDVESTWKGLLAGESGIHVLEDDYITKWDLPVRIGGHLKEPIDERMSRLDLRRM
SYVQRLAKLLSTQLWETAGNPELDPDRFSVVVGTGLGGAERIVESYDLMNEGGPRKVSPLAVQMIMPNGAAAVVGLQLGA
RAGVITPVSACSSGSEAIAHAWRQIVMGDADVAVCGGVEGPIDALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFG
EAGALMLIETEEHAKARGAKPLARLMGAGITSDAFHMVAPAGDGVRAGRAMTRSLELAGLSPKDVDHVNAHGTATPIGDT
AEANAIRVAGCQEAAVYAPKSALGHSIGAVGALESVLTVLTLRDGVIPPTLNYETPDPEIDLDIVAGEPRYGDYQYAINN
SFGFGGHNVALAFGRY

Sequences:

>Translated_416_residues
MSKPSTANGGYPSVVVTAVTATTSIAPDVESTWKGLLAGESGIHVLEDDYITKWDLPVRIGGHLKEPIDERMSRLDLRRM
SYVQRLAKLLSTQLWETAGNPELDPDRFSVVVGTGLGGAERIVESYDLMNEGGPRKVSPLAVQMIMPNGAAAVVGLQLGA
RAGVITPVSACSSGSEAIAHAWRQIVMGDADVAVCGGVEGPIDALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFG
EAGALMLIETEEHAKARGAKPLARLMGAGITSDAFHMVAPAGDGVRAGRAMTRSLELAGLSPKDVDHVNAHGTATPIGDT
AEANAIRVAGCQEAAVYAPKSALGHSIGAVGALESVLTVLTLRDGVIPPTLNYETPDPEIDLDIVAGEPRYGDYQYAINN
SFGFGGHNVALAFGRY
>Mature_415_residues
SKPSTANGGYPSVVVTAVTATTSIAPDVESTWKGLLAGESGIHVLEDDYITKWDLPVRIGGHLKEPIDERMSRLDLRRMS
YVQRLAKLLSTQLWETAGNPELDPDRFSVVVGTGLGGAERIVESYDLMNEGGPRKVSPLAVQMIMPNGAAAVVGLQLGAR
AGVITPVSACSSGSEAIAHAWRQIVMGDADVAVCGGVEGPIDALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFGE
AGALMLIETEEHAKARGAKPLARLMGAGITSDAFHMVAPAGDGVRAGRAMTRSLELAGLSPKDVDHVNAHGTATPIGDTA
EANAIRVAGCQEAAVYAPKSALGHSIGAVGALESVLTVLTLRDGVIPPTLNYETPDPEIDLDIVAGEPRYGDYQYAINNS
FGFGGHNVALAFGRY

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=34.8557692307692, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=41.0958904109589, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI41872631, Length=257, Percent_Identity=29.1828793774319, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1787337, Length=409, Percent_Identity=40.5867970660147, Blast_Score=264, Evalue=9e-72,
Organism=Escherichia coli, GI1788663, Length=406, Percent_Identity=34.2364532019704, Blast_Score=175, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI71983541, Length=409, Percent_Identity=34.718826405868, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71983535, Length=262, Percent_Identity=38.5496183206107, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI212642053, Length=253, Percent_Identity=30.0395256916996, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17550940, Length=256, Percent_Identity=25.390625, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=441, Percent_Identity=31.2925170068027, Blast_Score=207, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24644341, Length=431, Percent_Identity=37.3549883990719, Blast_Score=251, Evalue=6e-67,
Organism=Drosophila melanogaster, GI221330659, Length=256, Percent_Identity=27.734375, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI19920632, Length=256, Percent_Identity=27.734375, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24581345, Length=254, Percent_Identity=28.740157480315, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43746; Mature: 43615

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPSTANGGYPSVVVTAVTATTSIAPDVESTWKGLLAGESGIHVLEDDYITKWDLPVRI
CCCCCCCCCCCCEEEEEEEEHHCCCCCCHHHHHHHHHCCCCCCEEECCCCEEEECCCEEE
GGHLKEPIDERMSRLDLRRMSYVQRLAKLLSTQLWETAGNPELDPDRFSVVVGTGLGGAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHH
RIVESYDLMNEGGPRKVSPLAVQMIMPNGAAAVVGLQLGARAGVITPVSACSSGSEAIAH
HHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCHHHCCCCHHHHHH
AWRQIVMGDADVAVCGGVEGPIDALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFG
HHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEEE
EAGALMLIETEEHAKARGAKPLARLMGAGITSDAFHMVAPAGDGVRAGRAMTRSLELAGL
CCCEEEEEECHHHHHHCCCCHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHEEEECCC
SPKDVDHVNAHGTATPIGDTAEANAIRVAGCQEAAVYAPKSALGHSIGAVGALESVLTVL
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHEECCHHHHHHHHHHHHHHHHHHHHH
TLRDGVIPPTLNYETPDPEIDLDIVAGEPRYGDYQYAINNSFGFGGHNVALAFGRY
HHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
SKPSTANGGYPSVVVTAVTATTSIAPDVESTWKGLLAGESGIHVLEDDYITKWDLPVRI
CCCCCCCCCCCEEEEEEEEHHCCCCCCHHHHHHHHHCCCCCCEEECCCCEEEECCCEEE
GGHLKEPIDERMSRLDLRRMSYVQRLAKLLSTQLWETAGNPELDPDRFSVVVGTGLGGAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHH
RIVESYDLMNEGGPRKVSPLAVQMIMPNGAAAVVGLQLGARAGVITPVSACSSGSEAIAH
HHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCHHHCCCCHHHHHH
AWRQIVMGDADVAVCGGVEGPIDALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFG
HHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEEE
EAGALMLIETEEHAKARGAKPLARLMGAGITSDAFHMVAPAGDGVRAGRAMTRSLELAGL
CCCEEEEEECHHHHHHCCCCHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHEEEECCC
SPKDVDHVNAHGTATPIGDTAEANAIRVAGCQEAAVYAPKSALGHSIGAVGALESVLTVL
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHEECCHHHHHHHHHHHHHHHHHHHHH
TLRDGVIPPTLNYETPDPEIDLDIVAGEPRYGDYQYAINNSFGFGGHNVALAFGRY
HHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]