Click here to switch to the map view.

The map label for this gene is aceE

Identifier: 41408092

GI number: 41408092

Start: 2198143

End: 2200932

Strand: Direct

Name: aceE

Synonym: MAP1994

Alternate gene names: 41408092

Gene position: 2198143-2200932 (Clockwise)

Preceding gene: 41408088

Following gene: 41408093

Centisome position: 45.51

GC content: 67.92

Gene sequence:

>2790_bases
TTGACAACCGAATTCGTGCGCCACGATCTGGCCACAAACCCCACCGGCCCGGCCGAACCCGACCGCGTCCGGGTGATCCG
CGAGGGGGTCGCGTCCTACCTCCCCGACATCGACCCGGAAGAGACGTCGGAGTGGCTGGAGTCCTTCGACGAACTGCTGG
AGCGCTCCGGGCCGTCACGGGCCCGCTATCTGATGCTGCGGCTGCTGGAACGCGCCGGCGAGCAGCGGGTCGCCCTCCCG
TCGCTGACCTCCACCGACTACGTCAACACCATTCCCACCGAACTCGAGCCGTGGTTCCCCGGCGACGAGGACGTCGAACG
GCGCTACCGGGCGTGGATCCGGTGGAACGCCGCCATCATGGTGCACCGCGCGCAGCGGCCGGGAGTCGGTGTGGGCGGCC
ACATTTCGACCTACGCGTCGTCGGCGGCGCTGTACGAAGTCGGCTTCAACCACTTCTTCCGCGGCAAGTCGCATCCCGGC
GGCGGCGACCAGATCTTCATCCAGGGCCACGCCTCCCCGGGGATCTACGCGCGCGCCTTCCTGGAGGGCCGGTTGACCGC
CGACCAACTCGACGGCTTCCGCCAGGAGCACAGCCACGCCGGCGGCGGCCTGCCGTCCTACCCGCACCCACGGCTGATGC
CCGACTTCTGGGAATTCCCCACGGTGTCGATGGGCCTGGGCCCGCTGAACGCCATTTATCAGGCGCGGTTCAACCACTAC
CTGCATGACCGCGGCATCAAGGACACCTCCGATCAGCACGTGTGGTGCTTCTTGGGCGACGGCGAGATGGACGAGCCGGA
AAGCCGCGGTCTGATCCAGGTGGCCGCCAACGAGGCGCTGGACAACCTGACGTTCGTGATCAACTGCAACCTGCAGCGCC
TCGACGGCCCGGTGCGCGGCAACGGCAAGATCATTCAGGAACTGGAGTCGTTCTTCCGCGGCGCCGGCTGGAACGTCATC
AAGGTGGTCTGGGGCCGCGAGTGGGACGCCCTGCTGCACGCCGACCGGGACGGCGCGCTGGTGAACCTGATGAACACCAC
GCCCGACGGGGATTACCAGACCTACAAGGCCAACGACGGCGCCTACGTGCGCGACCATTTCTTCGGCCGCGACCCGCGCA
CCAAGGCGCTGGTGGAGAACATGACCGACGCCGAGATCTGGAACCTCAAGCGCGGCGGCCACGACTACCGCAAGGTGTAT
GCCGCCTACCGGGCCGCCGTCGACCACAAGGGCCAGCCCACGGTGATCTTGGCCAAGACCATCAAGGGCTACTCGCTGGG
CGCGCACTTCCAGGGCCGCAACGCCACGCATCAGATGAAAAAGCTTGCGCTGGAAGACCTCAAGCACTTCCGGGACGCGA
TGCGCATTCCGATCAGCGACGCCCAGCTGGACGAGAATCCCTATCTGCCGCCCTACTACCACCCCGGCTCCGATGCCCCC
GAGATCCGCTACATGCTCGACCGGCGCCGCACCCTGGGTGGCTTTCTGCCCGAACGCCGCACCAAGGCAAAGGCATTGAG
GCTTCCCGGCCGCGACATCTACGCCGCACTGAAGAAGGGGTCGGGCACCCAGGAGGTCGCCACCACCATGGCGACGGTGC
GCACCTTCAAAGAAGTATTGCGGGACAAGGAGATTGGCCCGCGGATCGTGCCGATCATTCCCGACGAGGCGCGCACCTTC
GGCATGGACTCCTGGTTCCCGTCGCTGAAGATCTACAACCGCAACGGCCAGCTGTACACCGCCGTGGACGCCGAATTGAT
GTTGGCGTACAAGGAAAGCGAAGTCGGGCAGATCCTGCACGAGGGCATCAACGAAGCCGGATCGGTGGGATCGTTCATCG
CGGCCGGGACGTCGTATGCCACGCACAACGAGCCGATGATCCCGATCTACATCTTCTATTCGATGTTCGGCTTCCAGCGC
ACCGGTGACGGGCTGTGGGCCGCCGCCGACCAGATGACACGCGGCTTCCTGCTCGGCGCGACGGCGGGGCGCACCACCCT
GACCGGCGAGGGCCTGCAACACGCCGACGGCCACTCGCTGCTGCTGGCCGCCACCAACCCGGCCGTGGTCGCCTACGACC
CGGCGTTCGCCTACGAGATCGCCTACATCGTGGAGAGCGGGCTGGCACGGATGTTCGGCGAGAACCCCGAGGACGTGTAC
TTCTACATCACCGTCTACAACGAGCCGTACGTGCAGCCGCCGGAGCCGGAGAACTTCGATCCCGAGGGCCTGCTGCGCGG
CCTCTACCGCTACCACGTGGCCACCGAACAGCGCGCCAACAAGGCGCAGATCCTGGCCTCCGGGGTGGCCATGCCGTCGG
CGCTGAACGCGGCGAAGATGCTGGCCGACGAGTGGGACGTGGCCGCCGACGTGTGGTCGGTGACCAGCTGGGGCGAGTTG
AACCGCGACGGCGTGGCGATCGACCGGGCCAGGCTGCGGCACCCGGACCGGCCCGCCGGCGTCCCCTACGTCACGCAGGC
GCTGTCGGATGCCAGCGGGCCGGTGGTCGCCGTGTCGGACTGGATGCGGGCGGTTCCCGAGCAGATCCGGCCGTGGGTGC
CGGGCACCTACGTGACGCTGGGCACCGACGGGTTCGGCTTCTCCGACACCCGGCCCGCGGCGCGGCGCTACTTCAACACC
GACGCGGAGTCGCAGGTGGTCGCGGTGCTCGAGGCGCTGGCGCGCGACGGCGAGATCGACCCGTCGGTGCCGGTCGCCGC
CGCACGCCAGTACCGCATCGACGACGTGCTGGCCGCCCCCGAGCAGACGTCCGACCCCGGCGTGGCCTAA

Upstream 100 bases:

>100_bases
CAGACGTCGACTATCCGCGTCGAACACCGGTGCGGCACGATGGTGGTCGGGGTGCGAACCACCCCATGGCACACATCCCG
CCAATTACAGGAGTAGTGGG

Downstream 100 bases:

>100_bases
CGGCACCCGGGGCGGGGCGCCCACGCTCCCACCACCCCGCCGCGCCCACGCCCACCGCGCCTCCGCCGAGCGTGAAGTTA
GCTTCACGGTCGGGGCCGAG

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 929; Mature: 928

Protein sequence:

>929_residues
MTTEFVRHDLATNPTGPAEPDRVRVIREGVASYLPDIDPEETSEWLESFDELLERSGPSRARYLMLRLLERAGEQRVALP
SLTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFNHFFRGKSHPG
GGDQIFIQGHASPGIYARAFLEGRLTADQLDGFRQEHSHAGGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHY
LHDRGIKDTSDQHVWCFLGDGEMDEPESRGLIQVAANEALDNLTFVINCNLQRLDGPVRGNGKIIQELESFFRGAGWNVI
KVVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDGAYVRDHFFGRDPRTKALVENMTDAEIWNLKRGGHDYRKVY
AAYRAAVDHKGQPTVILAKTIKGYSLGAHFQGRNATHQMKKLALEDLKHFRDAMRIPISDAQLDENPYLPPYYHPGSDAP
EIRYMLDRRRTLGGFLPERRTKAKALRLPGRDIYAALKKGSGTQEVATTMATVRTFKEVLRDKEIGPRIVPIIPDEARTF
GMDSWFPSLKIYNRNGQLYTAVDAELMLAYKESEVGQILHEGINEAGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQR
TGDGLWAAADQMTRGFLLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVAYDPAFAYEIAYIVESGLARMFGENPEDVY
FYITVYNEPYVQPPEPENFDPEGLLRGLYRYHVATEQRANKAQILASGVAMPSALNAAKMLADEWDVAADVWSVTSWGEL
NRDGVAIDRARLRHPDRPAGVPYVTQALSDASGPVVAVSDWMRAVPEQIRPWVPGTYVTLGTDGFGFSDTRPAARRYFNT
DAESQVVAVLEALARDGEIDPSVPVAAARQYRIDDVLAAPEQTSDPGVA

Sequences:

>Translated_929_residues
MTTEFVRHDLATNPTGPAEPDRVRVIREGVASYLPDIDPEETSEWLESFDELLERSGPSRARYLMLRLLERAGEQRVALP
SLTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFNHFFRGKSHPG
GGDQIFIQGHASPGIYARAFLEGRLTADQLDGFRQEHSHAGGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHY
LHDRGIKDTSDQHVWCFLGDGEMDEPESRGLIQVAANEALDNLTFVINCNLQRLDGPVRGNGKIIQELESFFRGAGWNVI
KVVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDGAYVRDHFFGRDPRTKALVENMTDAEIWNLKRGGHDYRKVY
AAYRAAVDHKGQPTVILAKTIKGYSLGAHFQGRNATHQMKKLALEDLKHFRDAMRIPISDAQLDENPYLPPYYHPGSDAP
EIRYMLDRRRTLGGFLPERRTKAKALRLPGRDIYAALKKGSGTQEVATTMATVRTFKEVLRDKEIGPRIVPIIPDEARTF
GMDSWFPSLKIYNRNGQLYTAVDAELMLAYKESEVGQILHEGINEAGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQR
TGDGLWAAADQMTRGFLLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVAYDPAFAYEIAYIVESGLARMFGENPEDVY
FYITVYNEPYVQPPEPENFDPEGLLRGLYRYHVATEQRANKAQILASGVAMPSALNAAKMLADEWDVAADVWSVTSWGEL
NRDGVAIDRARLRHPDRPAGVPYVTQALSDASGPVVAVSDWMRAVPEQIRPWVPGTYVTLGTDGFGFSDTRPAARRYFNT
DAESQVVAVLEALARDGEIDPSVPVAAARQYRIDDVLAAPEQTSDPGVA
>Mature_928_residues
TTEFVRHDLATNPTGPAEPDRVRVIREGVASYLPDIDPEETSEWLESFDELLERSGPSRARYLMLRLLERAGEQRVALPS
LTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFNHFFRGKSHPGG
GDQIFIQGHASPGIYARAFLEGRLTADQLDGFRQEHSHAGGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHYL
HDRGIKDTSDQHVWCFLGDGEMDEPESRGLIQVAANEALDNLTFVINCNLQRLDGPVRGNGKIIQELESFFRGAGWNVIK
VVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDGAYVRDHFFGRDPRTKALVENMTDAEIWNLKRGGHDYRKVYA
AYRAAVDHKGQPTVILAKTIKGYSLGAHFQGRNATHQMKKLALEDLKHFRDAMRIPISDAQLDENPYLPPYYHPGSDAPE
IRYMLDRRRTLGGFLPERRTKAKALRLPGRDIYAALKKGSGTQEVATTMATVRTFKEVLRDKEIGPRIVPIIPDEARTFG
MDSWFPSLKIYNRNGQLYTAVDAELMLAYKESEVGQILHEGINEAGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQRT
GDGLWAAADQMTRGFLLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVAYDPAFAYEIAYIVESGLARMFGENPEDVYF
YITVYNEPYVQPPEPENFDPEGLLRGLYRYHVATEQRANKAQILASGVAMPSALNAAKMLADEWDVAADVWSVTSWGELN
RDGVAIDRARLRHPDRPAGVPYVTQALSDASGPVVAVSDWMRAVPEQIRPWVPGTYVTLGTDGFGFSDTRPAARRYFNTD
AESQVVAVLEALARDGEIDPSVPVAAARQYRIDDVLAAPEQTSDPGVA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=882, Percent_Identity=52.4943310657596, Blast_Score=924, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 103375; Mature: 103244

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEFVRHDLATNPTGPAEPDRVRVIREGVASYLPDIDPEETSEWLESFDELLERSGPSR
CCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHH
ARYLMLRLLERAGEQRVALPSLTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIM
HHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECEEEE
VHRAQRPGVGVGGHISTYASSAALYEVGFNHFFRGKSHPGGGDQIFIQGHASPGIYARAF
EEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEHH
LEGRLTADQLDGFRQEHSHAGGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHY
HHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHH
LHDRGIKDTSDQHVWCFLGDGEMDEPESRGLIQVAANEALDNLTFVINCNLQRLDGPVRG
HHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEHHHHHCCEEEEEECCHHHCCCCCCC
NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDG
CCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCC
AYVRDHFFGRDPRTKALVENMTDAEIWNLKRGGHDYRKVYAAYRAAVDHKGQPTVILAKT
CEEHHHCCCCCCCHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEC
IKGYSLGAHFQGRNATHQMKKLALEDLKHFRDAMRIPISDAQLDENPYLPPYYHPGSDAP
CCCCEECCEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
EIRYMLDRRRTLGGFLPERRTKAKALRLPGRDIYAALKKGSGTQEVATTMATVRTFKEVL
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RDKEIGPRIVPIIPDEARTFGMDSWFPSLKIYNRNGQLYTAVDAELMLAYKESEVGQILH
HCCCCCCEEEEECCCCHHHCCCCCCCCCEEEECCCCCEEEEECCEEEEEECHHHHHHHHH
EGINEAGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGDGLWAAADQMTRGFLLGA
HHHHHHCCCCHHHHCCCCCCCCCCCEEHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEEC
TAGRTTLTGEGLQHADGHSLLLAATNPAVVAYDPAFAYEIAYIVESGLARMFGENPEDVY
CCCCCEECCCCCCCCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCEE
FYITVYNEPYVQPPEPENFDPEGLLRGLYRYHVATEQRANKAQILASGVAMPSALNAAKM
EEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHH
LADEWDVAADVWSVTSWGELNRDGVAIDRARLRHPDRPAGVPYVTQALSDASGPVVAVSD
HHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHCCCCCCCCCHHHHHHHHCCCCCEEEHHH
WMRAVPEQIRPWVPGTYVTLGTDGFGFSDTRPAARRYFNTDAESQVVAVLEALARDGEID
HHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
PSVPVAAARQYRIDDVLAAPEQTSDPGVA
CCCCHHHHHHHCHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TTEFVRHDLATNPTGPAEPDRVRVIREGVASYLPDIDPEETSEWLESFDELLERSGPSR
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHH
ARYLMLRLLERAGEQRVALPSLTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIM
HHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEECEEEE
VHRAQRPGVGVGGHISTYASSAALYEVGFNHFFRGKSHPGGGDQIFIQGHASPGIYARAF
EEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEHH
LEGRLTADQLDGFRQEHSHAGGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHY
HHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHH
LHDRGIKDTSDQHVWCFLGDGEMDEPESRGLIQVAANEALDNLTFVINCNLQRLDGPVRG
HHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEHHHHHCCEEEEEECCHHHCCCCCCC
NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDG
CCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCC
AYVRDHFFGRDPRTKALVENMTDAEIWNLKRGGHDYRKVYAAYRAAVDHKGQPTVILAKT
CEEHHHCCCCCCCHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEC
IKGYSLGAHFQGRNATHQMKKLALEDLKHFRDAMRIPISDAQLDENPYLPPYYHPGSDAP
CCCCEECCEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCH
EIRYMLDRRRTLGGFLPERRTKAKALRLPGRDIYAALKKGSGTQEVATTMATVRTFKEVL
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RDKEIGPRIVPIIPDEARTFGMDSWFPSLKIYNRNGQLYTAVDAELMLAYKESEVGQILH
HCCCCCCEEEEECCCCHHHCCCCCCCCCEEEECCCCCEEEEECCEEEEEECHHHHHHHHH
EGINEAGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGDGLWAAADQMTRGFLLGA
HHHHHHCCCCHHHHCCCCCCCCCCCEEHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEEC
TAGRTTLTGEGLQHADGHSLLLAATNPAVVAYDPAFAYEIAYIVESGLARMFGENPEDVY
CCCCCEECCCCCCCCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCEE
FYITVYNEPYVQPPEPENFDPEGLLRGLYRYHVATEQRANKAQILASGVAMPSALNAAKM
EEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHH
LADEWDVAADVWSVTSWGELNRDGVAIDRARLRHPDRPAGVPYVTQALSDASGPVVAVSD
HHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHCCCCCCCCCHHHHHHHHCCCCCEEEHHH
WMRAVPEQIRPWVPGTYVTLGTDGFGFSDTRPAARRYFNTDAESQVVAVLEALARDGEID
HHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCC
PSVPVAAARQYRIDDVLAAPEQTSDPGVA
CCCCHHHHHHHCHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]