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The map label for this gene is ahpE

Identifier: 41408089

GI number: 41408089

Start: 2196403

End: 2196864

Strand: Reverse

Name: ahpE

Synonym: MAP1991c

Alternate gene names: 41408089

Gene position: 2196864-2196403 (Counterclockwise)

Preceding gene: 41408090

Following gene: 41408087

Centisome position: 45.49

GC content: 67.75

Gene sequence:

>462_bases
ATGCTGTCGGTCGGCACCCCCGCCCCGGACTTCACCCTGCGCGACCAGAACCAGCAGCGCGTCACGCTGAGCTCCTACCG
CGGCTCCAAGAACGTGCTGCTGGTGTTCTTCCCGCTGGCGTTCACCGGGATTTGCCAGGGCGAGCTGGACCAGCTGCGCG
ACCACCTGCCCGAGTTCGAGAACGACGACAGCGCGGTGCTGGCCATCTCGGTGGGTCCACCACCCACACACCGGATTTGG
GCGCTGGAGAGCGGTTTCACCTTCCCGGTGCTGTCCGATTTCTGGCCGCACGGCGCGGTCAGCCAGAGCTACGGCGTGTT
CAACGACGAGGCCGGCTACTCCAACCGCGGGACGTTCGTGGTCGACCGGTCCGGGATCATTCGCTTCGCCGAGATGAAGC
AGCCCGGCGAGTCCCGCGACCAGCGGCTGTGGACCGACGCGCTGGCGGCGCTGAAGGCCTGA

Upstream 100 bases:

>100_bases
CCGCTCCCACCGCCGGGCTGATGCCGACCTCCTCGGTCAACCTGGGCGACTGGAGCGCCAGCCGGCTGGTGCAGCCCAAA
TCGCGCGCCGGGAAGCGTTG

Downstream 100 bases:

>100_bases
AAGTTTGGGGTCCCGGCCGACGGGCGTGTAGCCTGCGGCCTGCACAGGGGCGCGTAGCTCAGTGGTAGAGCTCTGGTTTT
ACACACCAGCGGTCGGCGGT

Product: AhpE

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MLSVGTPAPDFTLRDQNQQRVTLSSYRGSKNVLLVFFPLAFTGICQGELDQLRDHLPEFENDDSAVLAISVGPPPTHRIW
ALESGFTFPVLSDFWPHGAVSQSYGVFNDEAGYSNRGTFVVDRSGIIRFAEMKQPGESRDQRLWTDALAALKA

Sequences:

>Translated_153_residues
MLSVGTPAPDFTLRDQNQQRVTLSSYRGSKNVLLVFFPLAFTGICQGELDQLRDHLPEFENDDSAVLAISVGPPPTHRIW
ALESGFTFPVLSDFWPHGAVSQSYGVFNDEAGYSNRGTFVVDRSGIIRFAEMKQPGESRDQRLWTDALAALKA
>Mature_153_residues
MLSVGTPAPDFTLRDQNQQRVTLSSYRGSKNVLLVFFPLAFTGICQGELDQLRDHLPEFENDDSAVLAISVGPPPTHRIW
ALESGFTFPVLSDFWPHGAVSQSYGVFNDEAGYSNRGTFVVDRSGIIRFAEMKQPGESRDQRLWTDALAALKA

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG1225

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=137, Percent_Identity=32.8467153284672, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI32455266, Length=137, Percent_Identity=32.8467153284672, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI32455264, Length=137, Percent_Identity=32.8467153284672, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI32189392, Length=135, Percent_Identity=34.0740740740741, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI5453549, Length=136, Percent_Identity=32.3529411764706, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1786822, Length=125, Percent_Identity=31.2, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193204376, Length=135, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI32565831, Length=135, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17738015, Length=137, Percent_Identity=35.7664233576642, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24656348, Length=139, Percent_Identity=32.3741007194245, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17864676, Length=139, Percent_Identity=32.3741007194245, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357347, Length=149, Percent_Identity=31.5436241610738, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 16977; Mature: 16977

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVGTPAPDFTLRDQNQQRVTLSSYRGSKNVLLVFFPLAFTGICQGELDQLRDHLPEFE
CCCCCCCCCCCEECCCCCCEEEEECCCCCCCEEEEEECHHHHHCCCCHHHHHHHHCCCCC
NDDSAVLAISVGPPPTHRIWALESGFTFPVLSDFWPHGAVSQSYGVFNDEAGYSNRGTFV
CCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEE
VDRSGIIRFAEMKQPGESRDQRLWTDALAALKA
EECCCCEEEECCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLSVGTPAPDFTLRDQNQQRVTLSSYRGSKNVLLVFFPLAFTGICQGELDQLRDHLPEFE
CCCCCCCCCCCEECCCCCCEEEEECCCCCCCEEEEEECHHHHHCCCCHHHHHHHHCCCCC
NDDSAVLAISVGPPPTHRIWALESGFTFPVLSDFWPHGAVSQSYGVFNDEAGYSNRGTFV
CCCCEEEEEECCCCCCCEEEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEE
VDRSGIIRFAEMKQPGESRDQRLWTDALAALKA
EECCCCEEEECCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]