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The map label for this gene is cobC [C]

Identifier: 41408078

GI number: 41408078

Start: 2186416

End: 2187549

Strand: Reverse

Name: cobC [C]

Synonym: MAP1980c

Alternate gene names: 41408078

Gene position: 2187549-2186416 (Counterclockwise)

Preceding gene: 41408079

Following gene: 41408075

Centisome position: 45.29

GC content: 71.43

Gene sequence:

>1134_bases
GTGAAGGTCGTCATCGAAGCCGACGGGGGATCGCGCGGCAACCCCGGCCCGGCCGGGTACGGCGCCGTGGTGTGGACACC
GGACCGCGGCACCGTGCTGGCCGAGAACAAGCAGGCCATCGGGCGGGCCACCAACAACGTCGCCGAATATCGCGGCCTGC
TAGCCGGTTTGGGCGACGCGCTGAAGCTGGGCGCCACCGAGGCCGAGGTCTACCTGGATTCCAAACTGTTGGTGGAGCAG
ATGTCGGGGCGGTGGAAGGTCAAACACCCCGACCTGATCGAGCTGCACGCCCAGGCCCGAAGCCTGGCCGCGCGATTCGA
CAGGATCAGCTACACGTGGATCCCCCGCGAGCGCAACTCGCACGCCGACCGGCTGGCCAACGAGGCGATGGACGCGGCCG
CCGCGGCCACCGGCACGGCGGAAAAGCCCGGGCCGGCCGAACAATCCGATCCGACCGCCGCCGACGCCGGGAAAACCGCC
GCGGCGCCGTCACCCGCGGCGCCCGGGTGGACCGGCGCGCGCGGCACCCCGACCCGGCTGCTGTTGCTGCGACACGGGCA
GACCGAATTGTCGGTGCAGCGGCGCTATTCCGGGCGCGGCAACCCCGCACTCACCGAGACGGGACGGCGGCAGGCCGACG
CGGCGGCACGCTATCTGGCCGCGCGCGGCGGGATTTCGGCGGTGTTCGCCTCCCCGCTGCAACGGGCCTACGACACCGCG
GCGGTCGTCGCCAAGGCGCTGGGCCTGGACGTGACCGTCGACGACGACCTGATCGAAACCGATTTCGGGGCCTGGGAGGG
GTTGACGTTCGGCGAGGCCGCCGAGCGCGACCCCGGACTGCACCGGCGCTGGCTGCGTGACACCAGCACCGCCCCGCCCG
GCGGGGAGAGCTTCGACTCGGCGGCCGAGCGGGTGTCGCGGGTTCGCCAGAAGATCATCGCCGCACAGCAGGGCAGCACC
GTGCTGGTGGTGTCGCACGTGACGCCGATCAAGATGCTGCTGCGGGAGGCGCTGGACGCCGGGCCGGGCATCCTGTACCG
GTTGCATCTCGACCTCGCCTCGCTGAGCATCGCCGAGTTCTATTCCGACGGAGCCGCTTCGGTGCGGCTGGTCAACCAGA
CCGGATACCTGTAG

Upstream 100 bases:

>100_bases
ACCGCGGGGAGCTGTCCCGGATCTCGGCGGCCGCCGAGGACGACGTGGTGCGGTGCCCGGAATGCGGGGCGATTCTGCTG
CGGGTCAAGGGGTCCGGTCA

Downstream 100 bases:

>100_bases
GACGCCGGAAAGCCAGGCGGACGGGTTAGCCGTCGCCGGCGGGCGGGTGCACGGTGATGGCCTGCTCGGGGCAGTTCTGC
TCGCCGACGCCGGCCTGCAC

Product: bifunctional RNase H/acid phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKVVIEADGGSRGNPGPAGYGAVVWTPDRGTVLAENKQAIGRATNNVAEYRGLLAGLGDALKLGATEAEVYLDSKLLVEQ
MSGRWKVKHPDLIELHAQARSLAARFDRISYTWIPRERNSHADRLANEAMDAAAAATGTAEKPGPAEQSDPTAADAGKTA
AAPSPAAPGWTGARGTPTRLLLLRHGQTELSVQRRYSGRGNPALTETGRRQADAAARYLAARGGISAVFASPLQRAYDTA
AVVAKALGLDVTVDDDLIETDFGAWEGLTFGEAAERDPGLHRRWLRDTSTAPPGGESFDSAAERVSRVRQKIIAAQQGST
VLVVSHVTPIKMLLREALDAGPGILYRLHLDLASLSIAEFYSDGAASVRLVNQTGYL

Sequences:

>Translated_377_residues
MKVVIEADGGSRGNPGPAGYGAVVWTPDRGTVLAENKQAIGRATNNVAEYRGLLAGLGDALKLGATEAEVYLDSKLLVEQ
MSGRWKVKHPDLIELHAQARSLAARFDRISYTWIPRERNSHADRLANEAMDAAAAATGTAEKPGPAEQSDPTAADAGKTA
AAPSPAAPGWTGARGTPTRLLLLRHGQTELSVQRRYSGRGNPALTETGRRQADAAARYLAARGGISAVFASPLQRAYDTA
AVVAKALGLDVTVDDDLIETDFGAWEGLTFGEAAERDPGLHRRWLRDTSTAPPGGESFDSAAERVSRVRQKIIAAQQGST
VLVVSHVTPIKMLLREALDAGPGILYRLHLDLASLSIAEFYSDGAASVRLVNQTGYL
>Mature_377_residues
MKVVIEADGGSRGNPGPAGYGAVVWTPDRGTVLAENKQAIGRATNNVAEYRGLLAGLGDALKLGATEAEVYLDSKLLVEQ
MSGRWKVKHPDLIELHAQARSLAARFDRISYTWIPRERNSHADRLANEAMDAAAAATGTAEKPGPAEQSDPTAADAGKTA
AAPSPAAPGWTGARGTPTRLLLLRHGQTELSVQRRYSGRGNPALTETGRRQADAAARYLAARGGISAVFASPLQRAYDTA
AVVAKALGLDVTVDDDLIETDFGAWEGLTFGEAAERDPGLHRRWLRDTSTAPPGGESFDSAAERVSRVRQKIIAAQQGST
VLVVSHVTPIKMLLREALDAGPGILYRLHLDLASLSIAEFYSDGAASVRLVNQTGYL

Specific function: Converts N1-(5-Phospho-Alpha-D-Ribosyl)-5,6- Dimethylbenzimidazole Into N1-Alpha-D-Ribosyl-5,6- Dimethylbenzimidazole; Involved In The Assembly Of The Nucleotide Loop Of Cobalamin. [C]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=198, Percent_Identity=28.7878787878788, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790856, Length=183, Percent_Identity=29.5081967213115, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR012337
- InterPro:   IPR014636
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00300 PGAM; PF00075 RnaseH [H]

EC number: 3.1.3.73 [C]

Molecular weight: Translated: 39995; Mature: 39995

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVIEADGGSRGNPGPAGYGAVVWTPDRGTVLAENKQAIGRATNNVAEYRGLLAGLGDA
CEEEEECCCCCCCCCCCCCCCCEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCHH
LKLGATEAEVYLDSKLLVEQMSGRWKVKHPDLIELHAQARSLAARFDRISYTWIPRERNS
HHCCCCHHHEEECHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCC
HADRLANEAMDAAAAATGTAEKPGPAEQSDPTAADAGKTAAAPSPAAPGWTGARGTPTRL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
LLLRHGQTELSVQRRYSGRGNPALTETGRRQADAAARYLAARGGISAVFASPLQRAYDTA
EEEECCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AVVAKALGLDVTVDDDLIETDFGAWEGLTFGEAAERDPGLHRRWLRDTSTAPPGGESFDS
HHHHHHHCCCEEECCCHHHCCCCCCCCCCCCCHHCCCCCHHHHHHHCCCCCCCCCCHHHH
AAERVSRVRQKIIAAQQGSTVLVVSHVTPIKMLLREALDAGPGILYRLHLDLASLSIAEF
HHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHH
YSDGAASVRLVNQTGYL
HCCCCCEEEEECCCCCC
>Mature Secondary Structure
MKVVIEADGGSRGNPGPAGYGAVVWTPDRGTVLAENKQAIGRATNNVAEYRGLLAGLGDA
CEEEEECCCCCCCCCCCCCCCCEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCHH
LKLGATEAEVYLDSKLLVEQMSGRWKVKHPDLIELHAQARSLAARFDRISYTWIPRERNS
HHCCCCHHHEEECHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCC
HADRLANEAMDAAAAATGTAEKPGPAEQSDPTAADAGKTAAAPSPAAPGWTGARGTPTRL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
LLLRHGQTELSVQRRYSGRGNPALTETGRRQADAAARYLAARGGISAVFASPLQRAYDTA
EEEECCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AVVAKALGLDVTVDDDLIETDFGAWEGLTFGEAAERDPGLHRRWLRDTSTAPPGGESFDS
HHHHHHHCCCEEECCCHHHCCCCCCCCCCCCCHHCCCCCHHHHHHHCCCCCCCCCCHHHH
AAERVSRVRQKIIAAQQGSTVLVVSHVTPIKMLLREALDAGPGILYRLHLDLASLSIAEF
HHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHH
YSDGAASVRLVNQTGYL
HCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]