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The map label for this gene is cobH

Identifier: 41407909

GI number: 41407909

Start: 1987805

End: 1988431

Strand: Direct

Name: cobH

Synonym: MAP1811

Alternate gene names: 41407909

Gene position: 1987805-1988431 (Clockwise)

Preceding gene: 41407908

Following gene: 41407910

Centisome position: 41.16

GC content: 73.84

Gene sequence:

>627_bases
GTGCTCGACTACATCCGCGATGCGGCGGAGATCTATCGCCTGTCGTTCGCGACCATCCGCGCCGAAGCCGACTTGGCCCG
CTTCCCCGCCGATGTGGCCCGCGTGGTGGTGCGGCTGATCCACACCTGCGGGCAGGTCGACGTGGCCGAGCACGTCGCGT
TCACCGACGATGTCGTCGAGCGGGTGGGCACCGCCCTGCGCGCCGGCGCCCCGGTGTTATGCGATTCGTCGATGGTGGCC
GCCGGGATCACCGCGGCGCGGTTGCCGGCCGACAACGAGGTGGTGTCCCTGGTCGCCGATCCCCTGTCGGCCGAACTGGC
CGCCCGCCGGCAGACCACCCGCTCGGCGGCCGGGGTCGAGCTGTGGGCCGACCGGCTGCCGGGCGCCGTGCTGGCCATCG
GCAACGCGCCCACCGCGCTGTTCCGGCTGCTCGAGCTGGTCGACGACGGGGTGGACCCGCCGGCCGGGGTGCTGGGCGGG
CCGGTCGGATTCGTCGGGTCGGCGCAGTCCAAGCAGGAGCTCGTCGACAACCCGCGCGGCATGTCGTACCTGGTGGTGCG
GGGCCGCCGCGGGGGTAGCGCGATGGCCGCCGCGGCCGTCAACGCGATCGCGAGCGACCGCGAATGA

Upstream 100 bases:

>100_bases
CACCGTCATTTCGTCGGGTGCGAACGCGCCTGCGGCAGTCCGCTCGCCGGCGAGGTGCTGCTGGCGACCGGCGAGGGATA
CCGGCAGCTACGGTAATCGG

Downstream 100 bases:

>100_bases
CGGCACCGGCCAACCCGCGAGGGACGTTGTGGGGCGTCGGGCTGGGGCCCGGTGACCCGGAGTTGGTCACCGTCAAGGCC
GCCCGGGTGATCGGCGAGGC

Product: precorrin-8X methylmutase

Products: NA

Alternate protein names: HBA synthase; Precorrin isomerase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MLDYIRDAAEIYRLSFATIRAEADLARFPADVARVVVRLIHTCGQVDVAEHVAFTDDVVERVGTALRAGAPVLCDSSMVA
AGITAARLPADNEVVSLVADPLSAELAARRQTTRSAAGVELWADRLPGAVLAIGNAPTALFRLLELVDDGVDPPAGVLGG
PVGFVGSAQSKQELVDNPRGMSYLVVRGRRGGSAMAAAAVNAIASDRE

Sequences:

>Translated_208_residues
MLDYIRDAAEIYRLSFATIRAEADLARFPADVARVVVRLIHTCGQVDVAEHVAFTDDVVERVGTALRAGAPVLCDSSMVA
AGITAARLPADNEVVSLVADPLSAELAARRQTTRSAAGVELWADRLPGAVLAIGNAPTALFRLLELVDDGVDPPAGVLGG
PVGFVGSAQSKQELVDNPRGMSYLVVRGRRGGSAMAAAAVNAIASDRE
>Mature_208_residues
MLDYIRDAAEIYRLSFATIRAEADLARFPADVARVVVRLIHTCGQVDVAEHVAFTDDVVERVGTALRAGAPVLCDSSMVA
AGITAARLPADNEVVSLVADPLSAELAARRQTTRSAAGVELWADRLPGAVLAIGNAPTALFRLLELVDDGVDPPAGVLGG
PVGFVGSAQSKQELVDNPRGMSYLVVRGRRGGSAMAAAAVNAIASDRE

Specific function: Catalyzes the conversion of precorrin-8X to hydrogenobyrinic acid; a methyl migration reaction during the transformation of precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: =5.4.1.2 [H]

Molecular weight: Translated: 21674; Mature: 21674

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDYIRDAAEIYRLSFATIRAEADLARFPADVARVVVRLIHTCGQVDVAEHVAFTDDVVE
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RVGTALRAGAPVLCDSSMVAAGITAARLPADNEVVSLVADPLSAELAARRQTTRSAAGVE
HHHHHHHCCCCEEECCCHHHHCCHHHCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHH
LWADRLPGAVLAIGNAPTALFRLLELVDDGVDPPAGVLGGPVGFVGSAQSKQELVDNPRG
HHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCHHHHHHCCCCC
MSYLVVRGRRGGSAMAAAAVNAIASDRE
CEEEEEECCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDYIRDAAEIYRLSFATIRAEADLARFPADVARVVVRLIHTCGQVDVAEHVAFTDDVVE
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RVGTALRAGAPVLCDSSMVAAGITAARLPADNEVVSLVADPLSAELAARRQTTRSAAGVE
HHHHHHHCCCCEEECCCHHHHCCHHHCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHH
LWADRLPGAVLAIGNAPTALFRLLELVDDGVDPPAGVLGGPVGFVGSAQSKQELVDNPRG
HHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCHHHHHHCCCCC
MSYLVVRGRRGGSAMAAAAVNAIASDRE
CEEEEEECCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]