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The map label for this gene is aceAb

Identifier: 41407741

GI number: 41407741

Start: 1795784

End: 1798072

Strand: Direct

Name: aceAb

Synonym: MAP1643

Alternate gene names: 41407741

Gene position: 1795784-1798072 (Clockwise)

Preceding gene: 41407740

Following gene: 41407742

Centisome position: 37.18

GC content: 67.85

Gene sequence:

>2289_bases
ATGGCGATCATCGACAAAGAGACGCAAGTCCGGCCATCGTTCGACGACGAGGTAGCCGCCACGCAGCGCTACTTCGACGA
CCCCCGCTTCGCCCGCATCACGCGCCTCTACACCGCTCGGCAGGTGGCCGAGCAGCGCGGCACCATCCGCACCGACTACA
CCGTGGCACGCGACGCGGCGGCCGCGTTCTACGAACGGCTGCGCGAGCTGTTCGCCCAGAAGAAGAGCATCACCACCTTC
GGCCCGTACTCGCCCGGCCAGGCGGTCACCATGAAGCGGATGGGCATCGAGGGCATCTACCTCGGCGGGTGGGCCACCTC
GGCCAAGGGCTCCACCACCGAGGACCCGGGGCCCGACCTCGCCAGCTACCCGCTGAGCCAGGTGCCCGACGACGCCGCGG
TGTTGGTGCGCGCGCTGCTCACCGCCGACCGCAACCAGCAGTACCTGCGGCTGCAGATGAGCGAACAGCAGCGCGCCGCC
ACCAAGGAGTACGACTACCGGCCGTTCATCATCGCCGACGCCGACACCGGCCACGGGGGAGACCCGCACGTGCGGAACCT
GATCCGCCGTTTCGTCGAGGTCGGGGTGCCCGGCTACCACATCGAGGACCAGCGGCCCGGCACCAAGAAGTGTGGCCACC
AGGGCGGCAAGGTCTTGGTGCCCTCCGACGAGCAGATCAAGCGGCTCAACGCCGCGCGCTTCCAGCTCGACATCATGCGG
GTGCCCGGGATCATCGTCGCCCGCACCGACGCCGAGGCCGCCAACCTGCTGGACAGCCGCGCCGACGAGCGCGACCAGCC
GTTCCTGCTGGGTGCCACCAACCTCGACATCCCGTCGTACAAGGCGTGCTTCCTGGCGATGGTGCGCCGCTTCTACGAGC
TGGGTGTCAAGGACCTCAACGGCCACCTGCTCTACGCGCTGCCGGAGGCGGAGTACGCCGAGGCCACCGCCTGGCTCGAG
CGTCAGGGCATCCAGGGCGTCATCTCCGACGCCGTCAACGCCTGGCGCGAGAACGGGCAACAGTCCATCGACGACCTGTT
CGACCAGGTGGAGTCGCGGTTCGTGGCGGCCTGGGAGGACGACGCCGGGCTGATGACCTACGGCGAGGCCGTCGCCGAGG
TGCTGGAGTTCGCCGCGAGCGAGGGCGAGCCGGCTGACATGAGCGCCGACGAGTGGCGGGCCTTCGCGGCGCGCGCCTCG
CTCTACTCCGCCAAGGCCAAGGCGAAGGAGCTGGGCTTCGACCCGGGCTGGGACTGCGAGCTGGCCAAGACCCCCGAGGG
CTACTACCAGATCCGGGGCGGCATCCCGTACGCCATCGCCAAGTCGCTGGCCGCCGCGCCGTTCGCCGACATCCTGTGGA
TGGAGACCAAGACCGCCGACCTGGCCGACGCCAAGCAGTTCGCCGACGCTATCCACGCCGAGTTCCCCGACCAGATGCTG
GCCTACAACCTGTCGCCGTCGTTCAACTGGGACACCACCGGCATGACCGACGAGCAGATGAAGCAGTTCCCCGAGGAACT
CGGCAAGATGGGCTTCGTCTTCAACTTCATCACCTACGGCGGACACCAGATCGACGGCGTGGCCGCCGAGGAGTTCGCCA
CCTCGCTGCAACAGGACGGCATGCTGGCGCTGGCCCGCTTGCAGCGCAAGATGCGTCTGGTCGAATCCCCTTACCGCACA
CCGCAAACGCTCGTCGGTGGGCCCCGCAGCGATGCCGCACTGGCCGCCTCGTCGGGCCGCACCGCGACCACCAAGGCGAT
GGGCGAGGGCTCGACCCAGCATCAGCATCTGGTGCAGACCGAGGTGCCCAAGAAGCTGCTCGAGGAGTGGCTGGCGATGT
GGAGCGAGAACTACCACCTCGGCGAGAAGCTCCGCGTGCAGTTGCGGCCCCGCCGGGCGGGTTCGGACGTGCTGGAACTC
GGCATCTACGGCGACGGCGACGAGCAACTGGCCAATGTCGTCGTCGACCCGATCAAGGACCGGCACGGCCGCAGCATCCT
TCAGGTGCGCGACCAGAACACCTTCGCCGAAAAGCTCCGGCAGAAGCGGCTGATGACGTTGATCCACCTGTGGCTGGTGC
ACCGCTTCAAGGCCGACGCGGTGATCTACGTGACGCCGACCGAGGACAACCTGTACCAGACCTCGAAGATGAAGTCGCAC
GGCATCTTCAGCGAGGTGTACCAGGAGGTCGGCGAGATCATCGTCGCCGAGGTGAACCGGCCCCGCATCGCCGAACTGCT
GCAGCCCGACCGGGTGGCGCTGCGCAAGCTGATCACCAAAGAGGGTTAG

Upstream 100 bases:

>100_bases
GGCAACAGCTTTGGTTCAACTCCTGCGACTCCTGATTGAACGGCCCTTTCCGGGGATAGACTCGCGGTCAGGGGAATCGT
GCCGAGAGGAGCGTAAGACC

Downstream 100 bases:

>100_bases
CCGCCGGCCCGGACCGGAGTTTGCACGCCCGCGCCCCCGGGTAAGAAACAGGGGGCGTCGCGGCGCGGCGCCCCTTCGAG
ATTGGGGTTGCGATGAGATC

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 762; Mature: 761

Protein sequence:

>762_residues
MAIIDKETQVRPSFDDEVAATQRYFDDPRFARITRLYTARQVAEQRGTIRTDYTVARDAAAAFYERLRELFAQKKSITTF
GPYSPGQAVTMKRMGIEGIYLGGWATSAKGSTTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQQYLRLQMSEQQRAA
TKEYDYRPFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQLDIMR
VPGIIVARTDAEAANLLDSRADERDQPFLLGATNLDIPSYKACFLAMVRRFYELGVKDLNGHLLYALPEAEYAEATAWLE
RQGIQGVISDAVNAWRENGQQSIDDLFDQVESRFVAAWEDDAGLMTYGEAVAEVLEFAASEGEPADMSADEWRAFAARAS
LYSAKAKAKELGFDPGWDCELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADAKQFADAIHAEFPDQML
AYNLSPSFNWDTTGMTDEQMKQFPEELGKMGFVFNFITYGGHQIDGVAAEEFATSLQQDGMLALARLQRKMRLVESPYRT
PQTLVGGPRSDAALAASSGRTATTKAMGEGSTQHQHLVQTEVPKKLLEEWLAMWSENYHLGEKLRVQLRPRRAGSDVLEL
GIYGDGDEQLANVVVDPIKDRHGRSILQVRDQNTFAEKLRQKRLMTLIHLWLVHRFKADAVIYVTPTEDNLYQTSKMKSH
GIFSEVYQEVGEIIVAEVNRPRIAELLQPDRVALRKLITKEG

Sequences:

>Translated_762_residues
MAIIDKETQVRPSFDDEVAATQRYFDDPRFARITRLYTARQVAEQRGTIRTDYTVARDAAAAFYERLRELFAQKKSITTF
GPYSPGQAVTMKRMGIEGIYLGGWATSAKGSTTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQQYLRLQMSEQQRAA
TKEYDYRPFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQLDIMR
VPGIIVARTDAEAANLLDSRADERDQPFLLGATNLDIPSYKACFLAMVRRFYELGVKDLNGHLLYALPEAEYAEATAWLE
RQGIQGVISDAVNAWRENGQQSIDDLFDQVESRFVAAWEDDAGLMTYGEAVAEVLEFAASEGEPADMSADEWRAFAARAS
LYSAKAKAKELGFDPGWDCELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADAKQFADAIHAEFPDQML
AYNLSPSFNWDTTGMTDEQMKQFPEELGKMGFVFNFITYGGHQIDGVAAEEFATSLQQDGMLALARLQRKMRLVESPYRT
PQTLVGGPRSDAALAASSGRTATTKAMGEGSTQHQHLVQTEVPKKLLEEWLAMWSENYHLGEKLRVQLRPRRAGSDVLEL
GIYGDGDEQLANVVVDPIKDRHGRSILQVRDQNTFAEKLRQKRLMTLIHLWLVHRFKADAVIYVTPTEDNLYQTSKMKSH
GIFSEVYQEVGEIIVAEVNRPRIAELLQPDRVALRKLITKEG
>Mature_761_residues
AIIDKETQVRPSFDDEVAATQRYFDDPRFARITRLYTARQVAEQRGTIRTDYTVARDAAAAFYERLRELFAQKKSITTFG
PYSPGQAVTMKRMGIEGIYLGGWATSAKGSTTEDPGPDLASYPLSQVPDDAAVLVRALLTADRNQQYLRLQMSEQQRAAT
KEYDYRPFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQLDIMRV
PGIIVARTDAEAANLLDSRADERDQPFLLGATNLDIPSYKACFLAMVRRFYELGVKDLNGHLLYALPEAEYAEATAWLER
QGIQGVISDAVNAWRENGQQSIDDLFDQVESRFVAAWEDDAGLMTYGEAVAEVLEFAASEGEPADMSADEWRAFAARASL
YSAKAKAKELGFDPGWDCELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADAKQFADAIHAEFPDQMLA
YNLSPSFNWDTTGMTDEQMKQFPEELGKMGFVFNFITYGGHQIDGVAAEEFATSLQQDGMLALARLQRKMRLVESPYRTP
QTLVGGPRSDAALAASSGRTATTKAMGEGSTQHQHLVQTEVPKKLLEEWLAMWSENYHLGEKLRVQLRPRRAGSDVLELG
IYGDGDEQLANVVVDPIKDRHGRSILQVRDQNTFAEKLRQKRLMTLIHLWLVHRFKADAVIYVTPTEDNLYQTSKMKSHG
IFSEVYQEVGEIIVAEVNRPRIAELLQPDRVALRKLITKEG

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=256, Percent_Identity=37.890625, Blast_Score=160, Evalue=3e-40,
Organism=Escherichia coli, GI1786525, Length=227, Percent_Identity=28.6343612334802, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561814, Length=241, Percent_Identity=39.0041493775934, Blast_Score=165, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71982926, Length=241, Percent_Identity=39.0041493775934, Blast_Score=164, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320908, Length=597, Percent_Identity=33.500837520938, Blast_Score=292, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6325263, Length=620, Percent_Identity=29.6774193548387, Blast_Score=250, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 85214; Mature: 85083

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIIDKETQVRPSFDDEVAATQRYFDDPRFARITRLYTARQVAEQRGTIRTDYTVARDAA
CCEECCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHH
AAFYERLRELFAQKKSITTFGPYSPGQAVTMKRMGIEGIYLGGWATSAKGSTTEDPGPDL
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHCCCCEEEECCEECCCCCCCCCCCCCCH
ASYPLSQVPDDAAVLVRALLTADRNQQYLRLQMSEQQRAATKEYDYRPFIIADADTGHGG
HCCCHHHCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHCCCCCCEEEEECCCCCCC
DPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQLDIMR
CHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCEEECCCHHHHHHHHHHHHEEEEEE
VPGIIVARTDAEAANLLDSRADERDQPFLLGATNLDIPSYKACFLAMVRRFYELGVKDLN
CCCEEEEECCHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCC
GHLLYALPEAEYAEATAWLERQGIQGVISDAVNAWRENGQQSIDDLFDQVESRFVAAWED
CCEEEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECC
DAGLMTYGEAVAEVLEFAASEGEPADMSADEWRAFAARASLYSAKAKAKELGFDPGWDCE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
LAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADAKQFADAIHAEFPDQML
ECCCCCCCEEEECCCCHHHHHHHHHCCHHHHHEEECCCCHHHHHHHHHHHHHHHCCCHHH
AYNLSPSFNWDTTGMTDEQMKQFPEELGKMGFVFNFITYGGHQIDGVAAEEFATSLQQDG
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHCC
MLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKAMGEGSTQHQHLVQT
HHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEECCCCCCEEHHHCCCCCCHHHHHHHH
EVPKKLLEEWLAMWSENYHLGEKLRVQLRPRRAGSDVLELGIYGDGDEQLANVVVDPIKD
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHC
RHGRSILQVRDQNTFAEKLRQKRLMTLIHLWLVHRFKADAVIYVTPTEDNLYQTSKMKSH
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHC
GIFSEVYQEVGEIIVAEVNRPRIAELLQPDRVALRKLITKEG
CHHHHHHHHHHHHEEECCCCCHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
AIIDKETQVRPSFDDEVAATQRYFDDPRFARITRLYTARQVAEQRGTIRTDYTVARDAA
CEECCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHH
AAFYERLRELFAQKKSITTFGPYSPGQAVTMKRMGIEGIYLGGWATSAKGSTTEDPGPDL
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHCCCCEEEECCEECCCCCCCCCCCCCCH
ASYPLSQVPDDAAVLVRALLTADRNQQYLRLQMSEQQRAATKEYDYRPFIIADADTGHGG
HCCCHHHCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHCCCCCCEEEEECCCCCCC
DPHVRNLIRRFVEVGVPGYHIEDQRPGTKKCGHQGGKVLVPSDEQIKRLNAARFQLDIMR
CHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCEEECCCHHHHHHHHHHHHEEEEEE
VPGIIVARTDAEAANLLDSRADERDQPFLLGATNLDIPSYKACFLAMVRRFYELGVKDLN
CCCEEEEECCHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCC
GHLLYALPEAEYAEATAWLERQGIQGVISDAVNAWRENGQQSIDDLFDQVESRFVAAWED
CCEEEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECC
DAGLMTYGEAVAEVLEFAASEGEPADMSADEWRAFAARASLYSAKAKAKELGFDPGWDCE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
LAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADAKQFADAIHAEFPDQML
ECCCCCCCEEEECCCCHHHHHHHHHCCHHHHHEEECCCCHHHHHHHHHHHHHHHCCCHHH
AYNLSPSFNWDTTGMTDEQMKQFPEELGKMGFVFNFITYGGHQIDGVAAEEFATSLQQDG
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHCC
MLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKAMGEGSTQHQHLVQT
HHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEECCCCCCEEHHHCCCCCCHHHHHHHH
EVPKKLLEEWLAMWSENYHLGEKLRVQLRPRRAGSDVLELGIYGDGDEQLANVVVDPIKD
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHC
RHGRSILQVRDQNTFAEKLRQKRLMTLIHLWLVHRFKADAVIYVTPTEDNLYQTSKMKSH
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHC
GIFSEVYQEVGEIIVAEVNRPRIAELLQPDRVALRKLITKEG
CHHHHHHHHHHHHEEECCCCCHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7476188; 11234002 [H]