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The map label for this gene is adhA_1

Identifier: 41407669

GI number: 41407669

Start: 1724813

End: 1725844

Strand: Direct

Name: adhA_1

Synonym: MAP1571

Alternate gene names: 41407669

Gene position: 1724813-1725844 (Clockwise)

Preceding gene: 41407668

Following gene: 41407674

Centisome position: 35.71

GC content: 72.67

Gene sequence:

>1032_bases
GTGATGTCTTCTCCGGTGACCACCACGGCGATGCGCGCCTGGAGGGTGCGTCGGCCCGGTCCGATGGACACTCATCCGCT
CGAGGAAGTGACCACCGAGGTGCCGCGCCCCGGGCCGTCCGACCTGCTGGTCGCGGTGCGTGCGTGCGGCGTGTGCCGCA
CCGATCTGCATGTCACCGAGGGCGACCTACCCGTGCACCGCGACCGGGTCACGCCCGGTCATGAGGTGGCCGGCGAGGTC
ATCGAAGTCGGCGCCGAGGCCGGCGACGAGTTCGGCGTCGGGGACCGGGTGGGCATCGCCTGGCTGCGCCACACCTGCGG
GGTGTGCAAATACTGCCGGCGCGGCGACGAGAACCTGTGCCCCGAGTCCCGCTACACCGGCTGGGACGCCGACGGCGGAT
ACGCCGAATTCGCGACCGTGCCAGCGGCTTTCGCGCACCCACTGCCCGGCGGTTATAGCGACAGCGAGCTCGCGCCGCTG
CTGTGTGCGGGCATCATCGGCTACCGGGCGCTGCTGCGCGCCCAGCTACCGCCGGGCGGACGGTTGGGCCTGTACGGTTT
CGGCGGCAGCGCGCACATCACCGCGCAGGTCGCCCTGGCGCAGGGCGCCGAGGTGCACGTGATGACCCGCGGGGACCGGG
CCCGCGAGCTGGCGATCGAACTCGGCGCCGCCTCCGCGCAGGGCGCCGCCGACCCGCCGCCCGTCCCGCTGGACGCCGCC
ATCCTGTTCGCCCCGGTCGGCGATCTGGTACTGCCCGCGCTGGCGGCGCTGGACCGCGGCGGCACCCTGGCGATCGCCGG
CATTCACCTGTCCGACATCCCGTCGCTGAACTACCAGCGCCACCTGTTCCAGGAGCGCCAGGTGCGTTCGGTCACCTCCA
ACACCCGGGCCGACGCGCGGGCCTTCCTCGACTTCGCGGGCACGCATCACATCAGCGTCACCACGCCGGAATATCCCCTC
GGACAAGCGGATCGGGCGCTGGCGGATCTGAGCGCCGGGCGCATCGCCGGTGCGGCGGTGCTGCTGGTCTGA

Upstream 100 bases:

>100_bases
CGCTGCTCGGTTCGGTGATCCTGCTCTGGATCGTCGGCATGGTGCGCAGGACGTAATCGCCTTAACCCGTTGCGGCCGTG
GTGGTTAGCGGCATGATGGG

Downstream 100 bases:

>100_bases
GCGGCCTCGGCCCTCAGGTGGACAGATGCCAGACGAACGCGGCCGCCAGCGCACCGAGCCCGTTCAGTGACCAGTGCAGA
GCGATGGGCGCGATCAGGCT

Product: AdhA_1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MMSSPVTTTAMRAWRVRRPGPMDTHPLEEVTTEVPRPGPSDLLVAVRACGVCRTDLHVTEGDLPVHRDRVTPGHEVAGEV
IEVGAEAGDEFGVGDRVGIAWLRHTCGVCKYCRRGDENLCPESRYTGWDADGGYAEFATVPAAFAHPLPGGYSDSELAPL
LCAGIIGYRALLRAQLPPGGRLGLYGFGGSAHITAQVALAQGAEVHVMTRGDRARELAIELGAASAQGAADPPPVPLDAA
ILFAPVGDLVLPALAALDRGGTLAIAGIHLSDIPSLNYQRHLFQERQVRSVTSNTRADARAFLDFAGTHHISVTTPEYPL
GQADRALADLSAGRIAGAAVLLV

Sequences:

>Translated_343_residues
MMSSPVTTTAMRAWRVRRPGPMDTHPLEEVTTEVPRPGPSDLLVAVRACGVCRTDLHVTEGDLPVHRDRVTPGHEVAGEV
IEVGAEAGDEFGVGDRVGIAWLRHTCGVCKYCRRGDENLCPESRYTGWDADGGYAEFATVPAAFAHPLPGGYSDSELAPL
LCAGIIGYRALLRAQLPPGGRLGLYGFGGSAHITAQVALAQGAEVHVMTRGDRARELAIELGAASAQGAADPPPVPLDAA
ILFAPVGDLVLPALAALDRGGTLAIAGIHLSDIPSLNYQRHLFQERQVRSVTSNTRADARAFLDFAGTHHISVTTPEYPL
GQADRALADLSAGRIAGAAVLLV
>Mature_343_residues
MMSSPVTTTAMRAWRVRRPGPMDTHPLEEVTTEVPRPGPSDLLVAVRACGVCRTDLHVTEGDLPVHRDRVTPGHEVAGEV
IEVGAEAGDEFGVGDRVGIAWLRHTCGVCKYCRRGDENLCPESRYTGWDADGGYAEFATVPAAFAHPLPGGYSDSELAPL
LCAGIIGYRALLRAQLPPGGRLGLYGFGGSAHITAQVALAQGAEVHVMTRGDRARELAIELGAASAQGAADPPPVPLDAA
ILFAPVGDLVLPALAALDRGGTLAIAGIHLSDIPSLNYQRHLFQERQVRSVTSNTRADARAFLDFAGTHHISVTTPEYPL
GQADRALADLSAGRIAGAAVLLV

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI87081918, Length=312, Percent_Identity=29.1666666666667, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87082401, Length=304, Percent_Identity=27.3026315789474, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786518, Length=309, Percent_Identity=28.4789644012945, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790045, Length=276, Percent_Identity=30.0724637681159, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI226510992, Length=156, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788073, Length=258, Percent_Identity=28.2945736434109, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787863, Length=225, Percent_Identity=28.8888888888889, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788075, Length=212, Percent_Identity=27.3584905660377, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082125, Length=193, Percent_Identity=27.979274611399, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=318, Percent_Identity=26.1006289308176, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17562582, Length=331, Percent_Identity=26.5861027190332, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562584, Length=298, Percent_Identity=28.5234899328859, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562876, Length=209, Percent_Identity=33.4928229665072, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=195, Percent_Identity=31.2820512820513, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=344, Percent_Identity=31.3953488372093, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323961, Length=352, Percent_Identity=30.3977272727273, Blast_Score=132, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6323729, Length=320, Percent_Identity=28.4375, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6324486, Length=248, Percent_Identity=33.8709677419355, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323980, Length=190, Percent_Identity=32.6315789473684, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319949, Length=199, Percent_Identity=34.6733668341709, Blast_Score=102, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36107; Mature: 36107

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSSPVTTTAMRAWRVRRPGPMDTHPLEEVTTEVPRPGPSDLLVAVRACGVCRTDLHVTE
CCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCEECCCEEEC
GDLPVHRDRVTPGHEVAGEVIEVGAEAGDEFGVGDRVGIAWLRHTCGVCKYCRRGDENLC
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
PESRYTGWDADGGYAEFATVPAAFAHPLPGGYSDSELAPLLCAGIIGYRALLRAQLPPGG
CCCCCCCCCCCCCEEHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
RLGLYGFGGSAHITAQVALAQGAEVHVMTRGDRARELAIELGAASAQGAADPPPVPLDAA
CEEEEEECCCCEEEEEEEEECCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCHH
ILFAPVGDLVLPALAALDRGGTLAIAGIHLSDIPSLNYQRHLFQERQVRSVTSNTRADAR
HHHHCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
AFLDFAGTHHISVTTPEYPLGQADRALADLSAGRIAGAAVLLV
HHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure
MMSSPVTTTAMRAWRVRRPGPMDTHPLEEVTTEVPRPGPSDLLVAVRACGVCRTDLHVTE
CCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCEECCCEEEC
GDLPVHRDRVTPGHEVAGEVIEVGAEAGDEFGVGDRVGIAWLRHTCGVCKYCRRGDENLC
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
PESRYTGWDADGGYAEFATVPAAFAHPLPGGYSDSELAPLLCAGIIGYRALLRAQLPPGG
CCCCCCCCCCCCCEEHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
RLGLYGFGGSAHITAQVALAQGAEVHVMTRGDRARELAIELGAASAQGAADPPPVPLDAA
CEEEEEECCCCEEEEEEEEECCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCHH
ILFAPVGDLVLPALAALDRGGTLAIAGIHLSDIPSLNYQRHLFQERQVRSVTSNTRADAR
HHHHCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
AFLDFAGTHHISVTTPEYPLGQADRALADLSAGRIAGAAVLLV
HHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]