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The map label for this gene is ctaB

Identifier: 41407277

GI number: 41407277

Start: 1239119

End: 1240045

Strand: Direct

Name: ctaB

Synonym: MAP1179

Alternate gene names: 41407277

Gene position: 1239119-1240045 (Clockwise)

Preceding gene: 41407269

Following gene: 41407279

Centisome position: 25.66

GC content: 68.61

Gene sequence:

>927_bases
GTGAGCGTTCGCGGGCGCGTCGCGCCGAGCCAAACGCCAAGCCGGATACCAGGCACCGTGCTGGCGTATCTGGCGCTGAC
CAAGCCGCGGGTCATCGAACTGCTGCTGGTGACCGCGATTCCGGCGATGCTGCTCGCCCAGCGCGGCACCGTGAACCCGC
TGTTGATCGTCAACACGCTGATCGGCGGGATGCTGGCCGCGGGCGGCGCCAACGCGCTGAACTGCGTGGCCGACGCGGAT
ATCGACAAGGTGATGAAGCGCACCGCACGCCGGCCGCTGGCCCGGGCGGCGGTGCCGACCCGCAACGCCCTGGTGTTCGG
GCTGGTGCTGACGGCCGGCTCGTTCTTGTGGCTGTGGTGGACGACGAATCTGCTGTCGGGGCTGCTGGCGCTGGCGACGA
TCGCGTTTTACGTGTTCATTTACACACTGCTGCTCAAGCGGCGCACCTCGCAGAACGTGGTGTGGGGCGGCGCGGCCGGC
TGCATGCCGGTGATGATCGGCTGGTCGGCGGTCACCGGCACGATTCAGTGGCCGGCGCTGGTGATGTTCGCCATCATCTT
CTTCTGGACGCCGCCGCACACCTGGGCGCTGGCGATGCGGTACAAGGACGACTACAAGGCGGCAGGCGTCCCGATGCTGC
CGGCCGTGGCGACCGAGCGTCAGGTGACCAAGCAGATCGTGGTCTACACCTGGCTGACGGTGCTGGCCACGCTGGCGCTG
GCGCTGGCCACGGGCTGGCTGTACGCGGCGGTCGCCCTGGTGGCCGGGGTGTGGTTCCTGGCGATGGCCCACCAGCTCTA
TGCCGGGGTGCGCGCCGGCGAGCCGGTCAAGCCGCTGCGGTTGTTCCTGCAGTCGAACAACTACCTGGCGGTGGTGTTCT
GCGCGCTGGCGATCGACTCGGCGATCGGGTTGCCGCACCTGTTCTGA

Upstream 100 bases:

>100_bases
TCGGCCGGGAAGGGACCCACGGGCCCGGCATCGCCGCCACCCGGTCTACCATCGTGTGTAGTAGATGCTGCGCGCCGCTG
CGACCCCAAGGAGTTATTGC

Downstream 100 bases:

>100_bases
GTTGTTGGCGCCGGGCCCGGTCCCGCGTCACATCCGTCACGCCCGTCCCTGCGCGGAAGTGGACCGCGTGTGCCCGCCTC
GCAGCGACAATCGGCTCGCC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSVRGRVAPSQTPSRIPGTVLAYLALTKPRVIELLLVTAIPAMLLAQRGTVNPLLIVNTLIGGMLAAGGANALNCVADAD
IDKVMKRTARRPLARAAVPTRNALVFGLVLTAGSFLWLWWTTNLLSGLLALATIAFYVFIYTLLLKRRTSQNVVWGGAAG
CMPVMIGWSAVTGTIQWPALVMFAIIFFWTPPHTWALAMRYKDDYKAAGVPMLPAVATERQVTKQIVVYTWLTVLATLAL
ALATGWLYAAVALVAGVWFLAMAHQLYAGVRAGEPVKPLRLFLQSNNYLAVVFCALAIDSAIGLPHLF

Sequences:

>Translated_308_residues
MSVRGRVAPSQTPSRIPGTVLAYLALTKPRVIELLLVTAIPAMLLAQRGTVNPLLIVNTLIGGMLAAGGANALNCVADAD
IDKVMKRTARRPLARAAVPTRNALVFGLVLTAGSFLWLWWTTNLLSGLLALATIAFYVFIYTLLLKRRTSQNVVWGGAAG
CMPVMIGWSAVTGTIQWPALVMFAIIFFWTPPHTWALAMRYKDDYKAAGVPMLPAVATERQVTKQIVVYTWLTVLATLAL
ALATGWLYAAVALVAGVWFLAMAHQLYAGVRAGEPVKPLRLFLQSNNYLAVVFCALAIDSAIGLPHLF
>Mature_307_residues
SVRGRVAPSQTPSRIPGTVLAYLALTKPRVIELLLVTAIPAMLLAQRGTVNPLLIVNTLIGGMLAAGGANALNCVADADI
DKVMKRTARRPLARAAVPTRNALVFGLVLTAGSFLWLWWTTNLLSGLLALATIAFYVFIYTLLLKRRTSQNVVWGGAAGC
MPVMIGWSAVTGTIQWPALVMFAIIFFWTPPHTWALAMRYKDDYKAAGVPMLPAVATERQVTKQIVVYTWLTVLATLALA
LATGWLYAAVALVAGVWFLAMAHQLYAGVRAGEPVKPLRLFLQSNNYLAVVFCALAIDSAIGLPHLF

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=155, Percent_Identity=32.258064516129, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1786631, Length=247, Percent_Identity=34.0080971659919, Blast_Score=136, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6325085, Length=277, Percent_Identity=27.0758122743682, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19921064, Length=275, Percent_Identity=25.8181818181818, Blast_Score=81, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 33288; Mature: 33157

Theoretical pI: Translated: 10.70; Mature: 10.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRGRVAPSQTPSRIPGTVLAYLALTKPRVIELLLVTAIPAMLLAQRGTVNPLLIVNTL
CCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
IGGMLAAGGANALNCVADADIDKVMKRTARRPLARAAVPTRNALVFGLVLTAGSFLWLWW
HHHHHHCCCCCHHHHHHCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHCCHHHHHH
TTNLLSGLLALATIAFYVFIYTLLLKRRTSQNVVWGGAAGCMPVMIGWSAVTGTIQWPAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCCHHHH
VMFAIIFFWTPPHTWALAMRYKDDYKAAGVPMLPAVATERQVTKQIVVYTWLTVLATLAL
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALATGWLYAAVALVAGVWFLAMAHQLYAGVRAGEPVKPLRLFLQSNNYLAVVFCALAIDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
AIGLPHLF
HCCCCCCC
>Mature Secondary Structure 
SVRGRVAPSQTPSRIPGTVLAYLALTKPRVIELLLVTAIPAMLLAQRGTVNPLLIVNTL
CCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
IGGMLAAGGANALNCVADADIDKVMKRTARRPLARAAVPTRNALVFGLVLTAGSFLWLWW
HHHHHHCCCCCHHHHHHCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHCCHHHHHH
TTNLLSGLLALATIAFYVFIYTLLLKRRTSQNVVWGGAAGCMPVMIGWSAVTGTIQWPAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCCHHHH
VMFAIIFFWTPPHTWALAMRYKDDYKAAGVPMLPAVATERQVTKQIVVYTWLTVLATLAL
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALATGWLYAAVALVAGVWFLAMAHQLYAGVRAGEPVKPLRLFLQSNNYLAVVFCALAIDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHH
AIGLPHLF
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA