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The map label for this gene is yhdN [H]

Identifier: 41407269

GI number: 41407269

Start: 1230017

End: 1231003

Strand: Direct

Name: yhdN [H]

Synonym: MAP1171

Alternate gene names: 41407269

Gene position: 1230017-1231003 (Clockwise)

Preceding gene: 41407268

Following gene: 41407277

Centisome position: 25.47

GC content: 67.78

Gene sequence:

>987_bases
TTGAAGACCATCACATTCGGCAAGACGGGGCTCGAGGTTTCCCGGTTGGCGTTCGGCACCTGGGAGTTCTGCAGTGACTG
GGGCCATGCAGACGAGGACGCCGCGATCACCATGATCCGCAGCGCCCGCGACCTCGGGATCAACTTCTTCGACACCGCCC
AGCAGTACGGCTTCGGGGCGTCTGAACGCCTGCTGGGCAAGGCTTTGCGCGACGACCTCGCCCGCGCACGCGACGAGGTG
GTGATCGCCACCAAGGGTGGATTGCGCGCCACCGACGGCGGACTGGTCCGCGATGCCAGCCCACAATGGCTGCGCAAGGG
CGTGGAGTCCAGCCTGACCGCGCTGGGCATCGACCACATCGACGTGTACCTGGTGCACTGGCCCGACCCCCGGATGCCGG
CCGCCGAAACCGCCGGGGCGCTCGCGGAATTGGTGTCGGAGGGCAAGATTCGGCATGTCGGGGTGTCCAACTACGACACC
GCACAGGTGGAGGAGTTTTCGGCCACGCTGCCGGTGGAGGTCGTGCAGCCGCCGTATCACCTGTTCCGGCGTGACATCGA
GGAGACGCTGCTGCCGTATGCCCGCGAGCACGACATCGGGGTGATGGTGTACGGCCCGCTGGCGCACGGTTTGCTGACCG
GGACGGTCAAGCCGGACACCCGGTTCGCCCCGCAGGATTGGCGCGCCAAGAGCGACATCTTCAGCGGTGACGGCTTCCTG
CGCAACCTGGAAGTCGTTGCGCAGCTTCAGGAATTGGCGTCCGACCTGGGGGTGACGATCAGCCAGCTGGCGATCGCGCG
GGTGCTGGCGCAGCCGGGTGTGCACGTCGCCATCGTGGGTGCCCAGCACCTGCACTACCTGCAGGAGAGCGCCCGCGCGG
CCGACGTCACGCTGTCGGATGCCGACCTGGCCGCCGTCGACAACGTCCTGGCGGCGGCGACACCGGTCGGCGGGCCCTAT
CCCGAGATGCACCAGAAGGCGAGCTGA

Upstream 100 bases:

>100_bases
AGCGTTGGCGTTGCGTCACCGCGCTGCGGCGTCGTTATGGTTGAGTTGGCCGCGCCGCCCGCGCGCCGGGGGCGCCTACA
CCAACGGGGGAGGTTGGCAT

Downstream 100 bases:

>100_bases
GTCAGCCCTTCAGCAGCTCACCGACATGCGCGGTGACGGAATCGGCAAGGGCCTGCAGGTCATAACCGCCTTCCAGCACC
GCCACCAGCCGGCCGTCGCA

Product: hypothetical protein

Products: NA

Alternate protein names: GSP69; AKR11B [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MKTITFGKTGLEVSRLAFGTWEFCSDWGHADEDAAITMIRSARDLGINFFDTAQQYGFGASERLLGKALRDDLARARDEV
VIATKGGLRATDGGLVRDASPQWLRKGVESSLTALGIDHIDVYLVHWPDPRMPAAETAGALAELVSEGKIRHVGVSNYDT
AQVEEFSATLPVEVVQPPYHLFRRDIEETLLPYAREHDIGVMVYGPLAHGLLTGTVKPDTRFAPQDWRAKSDIFSGDGFL
RNLEVVAQLQELASDLGVTISQLAIARVLAQPGVHVAIVGAQHLHYLQESARAADVTLSDADLAAVDNVLAAATPVGGPY
PEMHQKAS

Sequences:

>Translated_328_residues
MKTITFGKTGLEVSRLAFGTWEFCSDWGHADEDAAITMIRSARDLGINFFDTAQQYGFGASERLLGKALRDDLARARDEV
VIATKGGLRATDGGLVRDASPQWLRKGVESSLTALGIDHIDVYLVHWPDPRMPAAETAGALAELVSEGKIRHVGVSNYDT
AQVEEFSATLPVEVVQPPYHLFRRDIEETLLPYAREHDIGVMVYGPLAHGLLTGTVKPDTRFAPQDWRAKSDIFSGDGFL
RNLEVVAQLQELASDLGVTISQLAIARVLAQPGVHVAIVGAQHLHYLQESARAADVTLSDADLAAVDNVLAAATPVGGPY
PEMHQKAS
>Mature_328_residues
MKTITFGKTGLEVSRLAFGTWEFCSDWGHADEDAAITMIRSARDLGINFFDTAQQYGFGASERLLGKALRDDLARARDEV
VIATKGGLRATDGGLVRDASPQWLRKGVESSLTALGIDHIDVYLVHWPDPRMPAAETAGALAELVSEGKIRHVGVSNYDT
AQVEEFSATLPVEVVQPPYHLFRRDIEETLLPYAREHDIGVMVYGPLAHGLLTGTVKPDTRFAPQDWRAKSDIFSGDGFL
RNLEVVAQLQELASDLGVTISQLAIARVLAQPGVHVAIVGAQHLHYLQESARAADVTLSDADLAAVDNVLAAATPVGGPY
PEMHQKAS

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=325, Percent_Identity=32.9230769230769, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI4504825, Length=325, Percent_Identity=32.9230769230769, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI27436964, Length=329, Percent_Identity=30.6990881458967, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI27436962, Length=325, Percent_Identity=30.4615384615385, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI27436966, Length=325, Percent_Identity=30.4615384615385, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI27436971, Length=331, Percent_Identity=32.6283987915408, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI223718702, Length=213, Percent_Identity=32.3943661971831, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI41327764, Length=193, Percent_Identity=33.160621761658, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI41152114, Length=143, Percent_Identity=33.5664335664336, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1788070, Length=318, Percent_Identity=36.4779874213836, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1789375, Length=327, Percent_Identity=31.1926605504587, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI87081735, Length=325, Percent_Identity=32, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1788081, Length=304, Percent_Identity=29.6052631578947, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1789199, Length=340, Percent_Identity=28.5294117647059, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI48994888, Length=313, Percent_Identity=30.6709265175719, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787674, Length=320, Percent_Identity=27.1875, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082198, Length=209, Percent_Identity=28.7081339712919, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786400, Length=202, Percent_Identity=27.7227722772277, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538386, Length=219, Percent_Identity=30.5936073059361, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI212645785, Length=312, Percent_Identity=25, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17552492, Length=206, Percent_Identity=30.5825242718447, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17561298, Length=215, Percent_Identity=30.6976744186047, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17564128, Length=336, Percent_Identity=24.1071428571429, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6325169, Length=339, Percent_Identity=27.7286135693215, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6323998, Length=324, Percent_Identity=23.7654320987654, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319958, Length=329, Percent_Identity=22.7963525835866, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325384, Length=270, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319951, Length=294, Percent_Identity=22.4489795918367, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322615, Length=255, Percent_Identity=23.921568627451, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24646155, Length=314, Percent_Identity=32.1656050955414, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24640980, Length=352, Percent_Identity=26.9886363636364, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI45549126, Length=343, Percent_Identity=26.8221574344023, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646159, Length=242, Percent_Identity=33.0578512396694, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI20129731, Length=320, Percent_Identity=26.25, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35519; Mature: 35519

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTITFGKTGLEVSRLAFGTWEFCSDWGHADEDAAITMIRSARDLGINFFDTAQQYGFGA
CCEEECCCCCCCHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCH
SERLLGKALRDDLARARDEVVIATKGGLRATDGGLVRDASPQWLRKGVESSLTALGIDHI
HHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCEECCCHHHHHHHHHHHHHHCCCCCE
DVYLVHWPDPRMPAAETAGALAELVSEGKIRHVGVSNYDTAQVEEFSATLPVEVVQPPYH
EEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHCCCCCCEECCCCHH
LFRRDIEETLLPYAREHDIGVMVYGPLAHGLLTGTVKPDTRFAPQDWRAKSDIFSGDGFL
HHHHHHHHHHCCCCCCCCCEEEEECCHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCHH
RNLEVVAQLQELASDLGVTISQLAIARVLAQPGVHVAIVGAQHLHYLQESARAADVTLSD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHCEEECC
ADLAAVDNVLAAATPVGGPYPEMHQKAS
CHHHHHHHHHHHCCCCCCCCHHHHCCCC
>Mature Secondary Structure
MKTITFGKTGLEVSRLAFGTWEFCSDWGHADEDAAITMIRSARDLGINFFDTAQQYGFGA
CCEEECCCCCCCHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCH
SERLLGKALRDDLARARDEVVIATKGGLRATDGGLVRDASPQWLRKGVESSLTALGIDHI
HHHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCEECCCHHHHHHHHHHHHHHCCCCCE
DVYLVHWPDPRMPAAETAGALAELVSEGKIRHVGVSNYDTAQVEEFSATLPVEVVQPPYH
EEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHCCCCCCEECCCCHH
LFRRDIEETLLPYAREHDIGVMVYGPLAHGLLTGTVKPDTRFAPQDWRAKSDIFSGDGFL
HHHHHHHHHHCCCCCCCCCEEEEECCHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCHH
RNLEVVAQLQELASDLGVTISQLAIARVLAQPGVHVAIVGAQHLHYLQESARAADVTLSD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHCEEECC
ADLAAVDNVLAAATPVGGPYPEMHQKAS
CHHHHHHHHHHHCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 9298659 [H]