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The map label for this gene is tpiA

Identifier: 41407264

GI number: 41407264

Start: 1224167

End: 1224952

Strand: Direct

Name: tpiA

Synonym: MAP1166

Alternate gene names: 41407264

Gene position: 1224167-1224952 (Clockwise)

Preceding gene: 41407263

Following gene: 41407265

Centisome position: 25.35

GC content: 68.96

Gene sequence:

>786_bases
GTGAGCCGCAAGCCGCTGATCGCCGGCAACTGGAAGATGAACCTCAACCACTTCGAGGCCATCGCGCTGGTGCAAAAGAT
CGCGTTCGCGCTGCCGGACAAGTACTACGACAAGGTGGACGTCACGGTGCTGCCGCCGTTCACCGACCTGCGCAGCGTGC
AGACCCTGGTCGACGGCGACAAGCTGCGGCTCAGCTACGGCGCCCAGGACCTGTCCCAGCACGACTCGGGCGCCTACACC
GGCGACATCAGCGGCGCCTTCCTGGCCAAGCTGGGCTGCACGTTCGTCGTCGTCGGGCACTCGGAGCGGCGCACCTACCA
CAACGAGGACGACGCGCTGGTGGCCGCCAAGGCCGCGACCGCGCTCAAGCACGAGCTGACCCCGATCATCTGCATTGGCG
AGCACCTCGAGGTCCGCGAGGCGGGCAACCACGTCATCCACTGCGAGGAGCAGCTGCGCGGCTCGCTGGCCGGGCTGTCC
GCCGAGCAGATCGGCAAGGTCGTCATCGCCTACGAGCCGGTGTGGGCGATTGGAACCGGACGGGTGGCCAGTGCGTCCGA
TGCTCAAGAGGTGTGCGCGGCGATCCGGAAAGAGTTGGCGTCACTCGCCTCGGCGCAGATCGCCGACTCGGTGCGGGTGC
TCTACGGCGGCTCGGTGAACGCGAAGAACGTCGGGGAGCTGATCGCCCAGGACGACATCGACGGCGGCCTGGTGGGCGGC
GCGTCGCTGGACGGCGAGCAGTTCGCCACGCTGGCCGCCATCGCCGCCGGCGGGCCGCTGCCGTGA

Upstream 100 bases:

>100_bases
ACATTTCCACCGGCGGCGGGGCGTCGCTGGAATACCTTGAGGGCAAGGCACTTCCGGGCATCGAGGTGCTGGGACGTCCG
CAACCGACGGGAGGCGCCGC

Downstream 100 bases:

>100_bases
GAACGAGCCCGCCCCGGTAGGCTGGCCGTCATGCAGTTGGCTTTGCAGATCACCCTGGTCGTCACCAGCATCCTGGTGGT
GTTGCTGGTGCTGCTGCACC

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MSRKPLIAGNWKMNLNHFEAIALVQKIAFALPDKYYDKVDVTVLPPFTDLRSVQTLVDGDKLRLSYGAQDLSQHDSGAYT
GDISGAFLAKLGCTFVVVGHSERRTYHNEDDALVAAKAATALKHELTPIICIGEHLEVREAGNHVIHCEEQLRGSLAGLS
AEQIGKVVIAYEPVWAIGTGRVASASDAQEVCAAIRKELASLASAQIADSVRVLYGGSVNAKNVGELIAQDDIDGGLVGG
ASLDGEQFATLAAIAAGGPLP

Sequences:

>Translated_261_residues
MSRKPLIAGNWKMNLNHFEAIALVQKIAFALPDKYYDKVDVTVLPPFTDLRSVQTLVDGDKLRLSYGAQDLSQHDSGAYT
GDISGAFLAKLGCTFVVVGHSERRTYHNEDDALVAAKAATALKHELTPIICIGEHLEVREAGNHVIHCEEQLRGSLAGLS
AEQIGKVVIAYEPVWAIGTGRVASASDAQEVCAAIRKELASLASAQIADSVRVLYGGSVNAKNVGELIAQDDIDGGLVGG
ASLDGEQFATLAAIAAGGPLP
>Mature_260_residues
SRKPLIAGNWKMNLNHFEAIALVQKIAFALPDKYYDKVDVTVLPPFTDLRSVQTLVDGDKLRLSYGAQDLSQHDSGAYTG
DISGAFLAKLGCTFVVVGHSERRTYHNEDDALVAAKAATALKHELTPIICIGEHLEVREAGNHVIHCEEQLRGSLAGLSA
EQIGKVVIAYEPVWAIGTGRVASASDAQEVCAAIRKELASLASAQIADSVRVLYGGSVNAKNVGELIAQDDIDGGLVGGA
SLDGEQFATLAAIAAGGPLP

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=245, Percent_Identity=40.4081632653061, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI226529917, Length=245, Percent_Identity=40.4081632653061, Blast_Score=155, Evalue=5e-38,
Organism=Escherichia coli, GI1790353, Length=249, Percent_Identity=42.570281124498, Blast_Score=181, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17536593, Length=244, Percent_Identity=43.8524590163934, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320255, Length=247, Percent_Identity=40.4858299595142, Blast_Score=162, Evalue=5e-41,
Organism=Drosophila melanogaster, GI28572008, Length=246, Percent_Identity=41.0569105691057, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI28572006, Length=246, Percent_Identity=41.0569105691057, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI28572004, Length=246, Percent_Identity=41.0569105691057, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 27545; Mature: 27414

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKPLIAGNWKMNLNHFEAIALVQKIAFALPDKYYDKVDVTVLPPFTDLRSVQTLVDGD
CCCCCEEECCEEECCHHHHHHHHHHHHHHHCCHHHHCEEEEEEECCCHHHHHHHHHHCCC
KLRLSYGAQDLSQHDSGAYTGDISGAFLAKLGCTFVVVGHSERRTYHNEDDALVAAKAAT
EEEEEECCHHHHHCCCCCEECCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCEEHHHHHH
ALKHELTPIICIGEHLEVREAGNHVIHCEEQLRGSLAGLSAEQIGKVVIAYEPVWAIGTG
HHHHCCCEEEEECCCEEHHHCCCEEEEEHHHHHHHHCCCCHHHHCCEEEEECCEEEECCC
RVASASDAQEVCAAIRKELASLASAQIADSVRVLYGGSVNAKNVGELIAQDDIDGGLVGG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHCCCCCCEECC
ASLDGEQFATLAAIAAGGPLP
CCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SRKPLIAGNWKMNLNHFEAIALVQKIAFALPDKYYDKVDVTVLPPFTDLRSVQTLVDGD
CCCCEEECCEEECCHHHHHHHHHHHHHHHCCHHHHCEEEEEEECCCHHHHHHHHHHCCC
KLRLSYGAQDLSQHDSGAYTGDISGAFLAKLGCTFVVVGHSERRTYHNEDDALVAAKAAT
EEEEEECCHHHHHCCCCCEECCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCEEHHHHHH
ALKHELTPIICIGEHLEVREAGNHVIHCEEQLRGSLAGLSAEQIGKVVIAYEPVWAIGTG
HHHHCCCEEEEECCCEEHHHCCCEEEEEHHHHHHHHCCCCHHHHCCEEEEECCEEEECCC
RVASASDAQEVCAAIRKELASLASAQIADSVRVLYGGSVNAKNVGELIAQDDIDGGLVGG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHCCCCCCEECC
ASLDGEQFATLAAIAAGGPLP
CCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA