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The map label for this gene is frdA

Identifier: 41407209

GI number: 41407209

Start: 1162003

End: 1164723

Strand: Direct

Name: frdA

Synonym: MAP1111

Alternate gene names: 41407209

Gene position: 1162003-1164723 (Clockwise)

Preceding gene: 41407208

Following gene: 41407212

Centisome position: 24.06

GC content: 72.62

Gene sequence:

>2721_bases
ATGCAGATACCCGACCCCACCGCCCCGCTCCGGCTGGACTGTGACGTCCTGGTGATCGGCGGCGGCACCGCGGGCACCAT
GGCCGCGCTGTCGGCCGCCGAGCACGGGGCGCAGGTGCTGCTGCTGGAGAAGGCGCACGTGCGGCACTCCGGCGCGCTGG
CGATGGGCATGGACGGCGTCAACAACGCGGTGATCCCGGGCAAGGCCGAACCCGAGGACTACGTCGCCGAGATCACCCGC
GCCAACGACGGAATCGTCAACCAGCGCACCATCTATCAGACCGCCACCCGCGGCTTCGCCATGGTGCAGCGGCTGGAGCG
CTACGGGGTGAAGTTCGAAAAGAACGAGCACGGCGAATACGCCGTGCGCCGCGTGCACCGCTCCGGGTCGTACGTGCTGC
CCATGCCCGAGGGCAAGGACGTCAAGAAGGCGCTGTACCGGGTGCTGCGGCAACGCTCGATGCGCGAGCGGATCCGCATC
GAGAACCGGCTGATGCCGGTGCGGGTGTTGGTCGACCCCGACAGCGGTGGCCGCGCCGTCGGCGCCGCCGCGTTGCACAC
CCGCACCGGCGAATTCGTCACGGTCGGCGCCAAGGCGGTCATCCTGGCCACCGGGGCGTGCGGCCGGCTCGGGCTGCCCG
CGTCGGGCTACCTGTACGGCACCTACGAGAACCCGACCAACGCCGGCGACGGCTACTCGATGGCCTACCACGCCGGCGCG
GAGCTCTCGGGCATCGAGTGCTTCCAAGTCAACCCGCTGATCAAGGACTACAACGGCCCGGCGTGCGCCTACGTCGCCAA
TCCGTTCGGCGGGTACCAGGTCAACGCGCAGGGCGAGCGGTTCGTGGACTCCGACTACTGGTCCGGCCAGATGATGGCCG
AGGTGAAACGCGAGATCGACTCCGCGCGCGGACCGATCTATCTCAAGGTGTCGCACCTGCCCGACGAGACGCTGACCGCG
TTGGAGAACATCCTGCACACCACGGAACGGCCCACCCGGGGCACCTTCCACGCCAACCGCGGGCACGACTACCGCACCCA
CGACATCGAGATGCACATCTCCGAAATCGGTTTGTGCAGCGGGCATTCCGCGTCGGGTGTGTGGGTCGACGAGCATGCCC
GCACCACGGTGCCCGGGCTGTACGCCGCGGGCGACCTGGCCTGCGTCCCGCACAACTACATGATCGGGGCGTTCGTGTTC
GGCGACCTGGCCGGCACCCATGCCGCCTCGACCCTGGCCGATGTGGCCGTGCCGCAACAGCTTCCGGCCGACCAGCTGCG
CGAGGCGCACGAGCTGATCTACCGGCCGCTGCGCCACCCGGACGGGCCGCCGCAGCCGCAGGTGGAGTACAAGCTGCGCC
GGTTCGTCAACGACTACGTCGCGCCGCCCAAGACGGCGGCCAAGCTGTCCATCGCGATCCGCACCTTCGAGCGGATGAGC
GCCGAGATCGCCGAGATGGGCGCCCGCAACCCGCACGAGCTGATGCGCGCGGTGGAGGTGTCGTTCATCCGGGACTGCGC
CGAGATGGCCGCCCGGTCCTCGCACACCCGCACAGAATCGCGCTGGGGCCTCTACCACGACCGGGCCGACCTGCCCGGCC
GCGACGACAATCAATGGGGCTATCACCTCAACCTGCGCAAGGGCGACGACGGCCGGATGGTGTTCCTCAAGCGGCCGGTG
GCACCGTATTTCGTGCCGGTTCCGGAGCTGGACGGGCTGCCGCCGGTCGACCAGACCGTGCACCCGGTGCAGCAGCCGCC
GCTGATCGGCGGCCAGGCCCCGGCCAGCGCTGTCTCCCGCATCGCTTCCCCCGCAACGGGTTTCGAGCCGCCGTCGCCGC
GCATCGCCGCGGTGCTGGCACTCGACGAGCCGAGTGTGGCCGAGCTGGCGCCCTACCTGGGTGACCCGGATCCGGGAGTG
CGCCGCACCGCGGTGGCGACGCTGACCGAGAACACCCCCGAGGGATACGCCCCCGCCCTGCTGGCCGCGCTGGGCGACGA
CGCCGCCGCGGTGCGCGCCGCCGCCGCCGAGGGCGTCCGGGAGCTGGTCGAGGTGCTGTCCGAGCCGGAATCGGTTCGCG
CCCATCTGGATTCGTCCGACCGGGTGGTGCGGGCGGCCGCGCTGTACGTGCTGGCCGCGCGCCGCGCCGGCGACGCCGCC
CGGTACCGGCGCGCCCTGGGCGATCCCGATCACCGGGTGCGCATCGAGGCGGTGCGGGCGCTGGTGTCCGTCGACGACGT
GGACGGGGTGGTCGACGCCGCCGGCGACGAGAACCGGGAGGTGCGCATCGCGGCCGCCGCCGGGCTGGCGACGCTGCGCG
ACGGGACGGGCCCGGCCGGCGGGGCGGTGCGCGCGCTGGTCGCCGACCCCGACCCGCTGGTGCGTGCCGCCGGGCTGGCC
GCGCTCGGCGAATTGGGCTGCGGCCCAGACGATTACGGGGCCATCACGCAGGCGCTGCGCGCGTCGGCGTGGCAGGTGCG
CGAAGGCGCGGCGCGGGCGCTGGCCGGTGCGGCCGCCGAGGTCGCGGTGCCGCTGCTGGGCGAGGCGCTGGGCGACGCGC
ACCTGGACGTGCGCAAGGCCGCGGTGCTCGCCCTGACCCGGTGGGCCGGCGAGCCGGCCGCCCGCGACGCCCTGGGGATC
GCGCTCAAGGACACCGACGCCGATGTGCGCGCGTACGCGCGCCGGGCGCTGGAACACCCCGAGCGGGCTGTGAAAAGCTA
G

Upstream 100 bases:

>100_bases
CGCGTGCGTCGGTCGAGGTGCCCGAGCCGCGCAGCGACCGCCCGCACGCCGAGTTGCGGGCGCAGATCATCGACGCACTC
AACCACGCGGAGGCCGCCTG

Downstream 100 bases:

>100_bases
TCAGCGCAGGATCTTTGCATACAGCAGGCTGTCCTGCGGTTCGGGCCCCATGGTGGGGTAGACGGCATGCCGGGCCAGCC
GGCCCTCCAGGAAGAACCCG

Product: putative oxidoreductase/HEAT repeat-containing protein

Products: NA

Alternate protein names: LASPO; Quinolinate synthase B [H]

Number of amino acids: Translated: 906; Mature: 906

Protein sequence:

>906_residues
MQIPDPTAPLRLDCDVLVIGGGTAGTMAALSAAEHGAQVLLLEKAHVRHSGALAMGMDGVNNAVIPGKAEPEDYVAEITR
ANDGIVNQRTIYQTATRGFAMVQRLERYGVKFEKNEHGEYAVRRVHRSGSYVLPMPEGKDVKKALYRVLRQRSMRERIRI
ENRLMPVRVLVDPDSGGRAVGAAALHTRTGEFVTVGAKAVILATGACGRLGLPASGYLYGTYENPTNAGDGYSMAYHAGA
ELSGIECFQVNPLIKDYNGPACAYVANPFGGYQVNAQGERFVDSDYWSGQMMAEVKREIDSARGPIYLKVSHLPDETLTA
LENILHTTERPTRGTFHANRGHDYRTHDIEMHISEIGLCSGHSASGVWVDEHARTTVPGLYAAGDLACVPHNYMIGAFVF
GDLAGTHAASTLADVAVPQQLPADQLREAHELIYRPLRHPDGPPQPQVEYKLRRFVNDYVAPPKTAAKLSIAIRTFERMS
AEIAEMGARNPHELMRAVEVSFIRDCAEMAARSSHTRTESRWGLYHDRADLPGRDDNQWGYHLNLRKGDDGRMVFLKRPV
APYFVPVPELDGLPPVDQTVHPVQQPPLIGGQAPASAVSRIASPATGFEPPSPRIAAVLALDEPSVAELAPYLGDPDPGV
RRTAVATLTENTPEGYAPALLAALGDDAAAVRAAAAEGVRELVEVLSEPESVRAHLDSSDRVVRAAALYVLAARRAGDAA
RYRRALGDPDHRVRIEAVRALVSVDDVDGVVDAAGDENREVRIAAAAGLATLRDGTGPAGGAVRALVADPDPLVRAAGLA
ALGELGCGPDDYGAITQALRASAWQVREGAARALAGAAAEVAVPLLGEALGDAHLDVRKAAVLALTRWAGEPAARDALGI
ALKDTDADVRAYARRALEHPERAVKS

Sequences:

>Translated_906_residues
MQIPDPTAPLRLDCDVLVIGGGTAGTMAALSAAEHGAQVLLLEKAHVRHSGALAMGMDGVNNAVIPGKAEPEDYVAEITR
ANDGIVNQRTIYQTATRGFAMVQRLERYGVKFEKNEHGEYAVRRVHRSGSYVLPMPEGKDVKKALYRVLRQRSMRERIRI
ENRLMPVRVLVDPDSGGRAVGAAALHTRTGEFVTVGAKAVILATGACGRLGLPASGYLYGTYENPTNAGDGYSMAYHAGA
ELSGIECFQVNPLIKDYNGPACAYVANPFGGYQVNAQGERFVDSDYWSGQMMAEVKREIDSARGPIYLKVSHLPDETLTA
LENILHTTERPTRGTFHANRGHDYRTHDIEMHISEIGLCSGHSASGVWVDEHARTTVPGLYAAGDLACVPHNYMIGAFVF
GDLAGTHAASTLADVAVPQQLPADQLREAHELIYRPLRHPDGPPQPQVEYKLRRFVNDYVAPPKTAAKLSIAIRTFERMS
AEIAEMGARNPHELMRAVEVSFIRDCAEMAARSSHTRTESRWGLYHDRADLPGRDDNQWGYHLNLRKGDDGRMVFLKRPV
APYFVPVPELDGLPPVDQTVHPVQQPPLIGGQAPASAVSRIASPATGFEPPSPRIAAVLALDEPSVAELAPYLGDPDPGV
RRTAVATLTENTPEGYAPALLAALGDDAAAVRAAAAEGVRELVEVLSEPESVRAHLDSSDRVVRAAALYVLAARRAGDAA
RYRRALGDPDHRVRIEAVRALVSVDDVDGVVDAAGDENREVRIAAAAGLATLRDGTGPAGGAVRALVADPDPLVRAAGLA
ALGELGCGPDDYGAITQALRASAWQVREGAARALAGAAAEVAVPLLGEALGDAHLDVRKAAVLALTRWAGEPAARDALGI
ALKDTDADVRAYARRALEHPERAVKS
>Mature_906_residues
MQIPDPTAPLRLDCDVLVIGGGTAGTMAALSAAEHGAQVLLLEKAHVRHSGALAMGMDGVNNAVIPGKAEPEDYVAEITR
ANDGIVNQRTIYQTATRGFAMVQRLERYGVKFEKNEHGEYAVRRVHRSGSYVLPMPEGKDVKKALYRVLRQRSMRERIRI
ENRLMPVRVLVDPDSGGRAVGAAALHTRTGEFVTVGAKAVILATGACGRLGLPASGYLYGTYENPTNAGDGYSMAYHAGA
ELSGIECFQVNPLIKDYNGPACAYVANPFGGYQVNAQGERFVDSDYWSGQMMAEVKREIDSARGPIYLKVSHLPDETLTA
LENILHTTERPTRGTFHANRGHDYRTHDIEMHISEIGLCSGHSASGVWVDEHARTTVPGLYAAGDLACVPHNYMIGAFVF
GDLAGTHAASTLADVAVPQQLPADQLREAHELIYRPLRHPDGPPQPQVEYKLRRFVNDYVAPPKTAAKLSIAIRTFERMS
AEIAEMGARNPHELMRAVEVSFIRDCAEMAARSSHTRTESRWGLYHDRADLPGRDDNQWGYHLNLRKGDDGRMVFLKRPV
APYFVPVPELDGLPPVDQTVHPVQQPPLIGGQAPASAVSRIASPATGFEPPSPRIAAVLALDEPSVAELAPYLGDPDPGV
RRTAVATLTENTPEGYAPALLAALGDDAAAVRAAAAEGVRELVEVLSEPESVRAHLDSSDRVVRAAALYVLAARRAGDAA
RYRRALGDPDHRVRIEAVRALVSVDDVDGVVDAAGDENREVRIAAAAGLATLRDGTGPAGGAVRALVADPDPLVRAAGLA
ALGELGCGPDDYGAITQALRASAWQVREGAARALAGAAAEVAVPLLGEALGDAHLDVRKAAVLALTRWAGEPAARDALGI
ALKDTDADVRAYARRALEHPERAVKS

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786942, Length=576, Percent_Identity=24.3055555555556, Blast_Score=93, Evalue=7e-20,
Organism=Escherichia coli, GI1788928, Length=578, Percent_Identity=26.1245674740484, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322701, Length=608, Percent_Identity=24.8355263157895, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322416, Length=617, Percent_Identity=25.4457050243112, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 97028; Mature: 97028

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS50077 HEAT_REPEAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIPDPTAPLRLDCDVLVIGGGTAGTMAALSAAEHGAQVLLLEKAHVRHSGALAMGMDGV
CCCCCCCCCEEECCCEEEECCCCHHHHHHHHHHHCCCEEEEEEHHHHCCCCCEEECCCCC
NNAVIPGKAEPEDYVAEITRANDGIVNQRTIYQTATRGFAMVQRLERYGVKFEKNEHGEY
CCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHH
AVRRVHRSGSYVLPMPEGKDVKKALYRVLRQRSMRERIRIENRLMPVRVLVDPDSGGRAV
HHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEE
GAAALHTRTGEFVTVGAKAVILATGACGRLGLPASGYLYGTYENPTNAGDGYSMAYHAGA
EHHHHCCCCCCEEEECCEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCC
ELSGIECFQVNPLIKDYNGPACAYVANPFGGYQVNAQGERFVDSDYWSGQMMAEVKREID
CCCCEEEEEECCHHHCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHH
SARGPIYLKVSHLPDETLTALENILHTTERPTRGTFHANRGHDYRTHDIEMHISEIGLCS
HCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCEEEEEHHHHCEEC
GHSASGVWVDEHARTTVPGLYAAGDLACVPHNYMIGAFVFGDLAGTHAASTLADVAVPQQ
CCCCCCCEECCCCCCCCCCEEECCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCC
LPADQLREAHELIYRPLRHPDGPPQPQVEYKLRRFVNDYVAPPKTAAKLSIAIRTFERMS
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AEIAEMGARNPHELMRAVEVSFIRDCAEMAARSSHTRTESRWGLYHDRADLPGRDDNQWG
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCCCC
YHLNLRKGDDGRMVFLKRPVAPYFVPVPELDGLPPVDQTVHPVQQPPLIGGQAPASAVSR
EEEEEEECCCCCEEEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
IASPATGFEPPSPRIAAVLALDEPSVAELAPYLGDPDPGVRRTAVATLTENTPEGYAPAL
HCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHH
LAALGDDAAAVRAAAAEGVRELVEVLSEPESVRAHLDSSDRVVRAAALYVLAARRAGDAA
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHH
RYRRALGDPDHRVRIEAVRALVSVDDVDGVVDAAGDENREVRIAAAAGLATLRDGTGPAG
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCCEEEEEEECCHHHHCCCCCCCC
GAVRALVADPDPLVRAAGLAALGELGCGPDDYGAITQALRASAWQVREGAARALAGAAAE
CCEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAVPLLGEALGDAHLDVRKAAVLALTRWAGEPAARDALGIALKDTDADVRAYARRALEHP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHEEEEEECCCHHHHHHHHHHHHCH
ERAVKS
HHHHCC
>Mature Secondary Structure
MQIPDPTAPLRLDCDVLVIGGGTAGTMAALSAAEHGAQVLLLEKAHVRHSGALAMGMDGV
CCCCCCCCCEEECCCEEEECCCCHHHHHHHHHHHCCCEEEEEEHHHHCCCCCEEECCCCC
NNAVIPGKAEPEDYVAEITRANDGIVNQRTIYQTATRGFAMVQRLERYGVKFEKNEHGEY
CCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHH
AVRRVHRSGSYVLPMPEGKDVKKALYRVLRQRSMRERIRIENRLMPVRVLVDPDSGGRAV
HHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEE
GAAALHTRTGEFVTVGAKAVILATGACGRLGLPASGYLYGTYENPTNAGDGYSMAYHAGA
EHHHHCCCCCCEEEECCEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCC
ELSGIECFQVNPLIKDYNGPACAYVANPFGGYQVNAQGERFVDSDYWSGQMMAEVKREID
CCCCEEEEEECCHHHCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHH
SARGPIYLKVSHLPDETLTALENILHTTERPTRGTFHANRGHDYRTHDIEMHISEIGLCS
HCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCEEEEEHHHHCEEC
GHSASGVWVDEHARTTVPGLYAAGDLACVPHNYMIGAFVFGDLAGTHAASTLADVAVPQQ
CCCCCCCEECCCCCCCCCCEEECCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCC
LPADQLREAHELIYRPLRHPDGPPQPQVEYKLRRFVNDYVAPPKTAAKLSIAIRTFERMS
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AEIAEMGARNPHELMRAVEVSFIRDCAEMAARSSHTRTESRWGLYHDRADLPGRDDNQWG
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCCCC
YHLNLRKGDDGRMVFLKRPVAPYFVPVPELDGLPPVDQTVHPVQQPPLIGGQAPASAVSR
EEEEEEECCCCCEEEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
IASPATGFEPPSPRIAAVLALDEPSVAELAPYLGDPDPGVRRTAVATLTENTPEGYAPAL
HCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHH
LAALGDDAAAVRAAAAEGVRELVEVLSEPESVRAHLDSSDRVVRAAALYVLAARRAGDAA
HHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHH
RYRRALGDPDHRVRIEAVRALVSVDDVDGVVDAAGDENREVRIAAAAGLATLRDGTGPAG
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCCEEEEEEECCHHHHCCCCCCCC
GAVRALVADPDPLVRAAGLAALGELGCGPDDYGAITQALRASAWQVREGAARALAGAAAE
CCEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAVPLLGEALGDAHLDVRKAAVLALTRWAGEPAARDALGIALKDTDADVRAYARRALEHP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHEEEEEECCCHHHHHHHHHHHHCH
ERAVKS
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7737518; 10984043; 7961421 [H]