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The map label for this gene is thlA [H]

Identifier: 41406784

GI number: 41406784

Start: 706327

End: 707496

Strand: Direct

Name: thlA [H]

Synonym: MAP0686

Alternate gene names: 41406784

Gene position: 706327-707496 (Clockwise)

Preceding gene: 41406783

Following gene: 41406785

Centisome position: 14.62

GC content: 69.74

Gene sequence:

>1170_bases
CTGCACCTGCTGGTTGAACTGGAGAAGACTGTGGCTGAAGCCGTCATCGTGTCCGCGCTGCGCACACCCATCGGAACCGC
CCGCAAGGGCACCCTGCGCGACACCAGCGCATTCGACCTGGCCCACCACGTCGTCAGCGAAGCGGTGAAAGATATTGACC
CGACCCAGGTCGACGACGTGATCCTGGGCGAGGGCCTCTACGGCGGCGGCGTGCTGGCCCGCCACGCGGCCATCACGGCG
GGGCTGACCCAGGTGCCCGGCCTGGCCAACAACCGGCACTGCGCGGCGGGTCAGGCGGCCGTACAGAGCGCCGCGGCCAG
CGTGCGCGCCGGAATGGACCAACTGGTCATCGCCGGCGGCGTCAACTCGGCTTCCACGTCGCCGCGATCGCGGATGCAGG
TCGACGGCGAGTGGGTCGACTGGTTCCCGCCGACCCACCCGGACCGGCCCGACGCCCCGAACATGGACATGTCGATCACC
GTCGGCTGGAACGCTGCCGTCAAAGCCGGGGTGAGCCGCGAGGAGATGGACGCCTGGGCGCTGCGGTCGCACCGCAACGC
CATCGCCGCCATCGACGAGGGCCGCTTCAAAGAGGAGATCGTGCCCATCGACACCCCGCACGGGCTGTTCTCGGTCGACG
AACACCCGCGCCGCGACACCAGCATGGAGAAGTTGGCCGCGCTCAAGCCGTTACATCCGGAAATCGAGGGCTTCTCCATC
ACCGCCGGCAACGCCTGCGGCGCCAACGACGGTGCCGCGGTGCTGACGATCGCCAGCGACCGGCTCGGGCTGCGGCCGTT
GGCCACCATCCGGTCCTGGGCGTCGGTCGGGGTCGACCCGGCGATCACCGGCCTGGCGCCGGTGGAGGCGATACCGAAAG
CCCTTGGACGCGCTGGGCTTTCGATCTCCGATGTGGACCTCTTCGAGATCAACGAGGCCTTCGCGGCGATGTGTGTGGCC
ACGGTCAAGCTGCTCGAACTCGACCCGGACAAGGTCAACGTCAGCGGCAGCGGCTGCTCGCTGGGGCATCCCGTGGCGGC
GACCGGGGCCCGGATGCTGGTCACCCTGGTGCACGAATTGCGCCGCCGCGGCGGCGGTATCGGCGTCGCGGCGATGTGCG
CGGGCGGGGGCATGGGTTCGGCGACGGTGATCGAGGTCGCGGGCGAATAA

Upstream 100 bases:

>100_bases
GCACCAACTGACCCGCCGGCCGCCACCCCGCGCTGGTTGCAACTGACGCTCTCCTACTGAGAGAATAATATTCTCGTGAG
GTGCGGATGGCGCACGGGCG

Downstream 100 bases:

>100_bases
TGCGCACATGACCATCGGAGAGCTGATCGACCGGGCGCGCAACGGATCTCCCCGGGCGGCCGGTCGGCTGCTCAGCCTCG
TGGAGGGCGAGCGGCGCGAC

Product: hypothetical protein

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MHLLVELEKTVAEAVIVSALRTPIGTARKGTLRDTSAFDLAHHVVSEAVKDIDPTQVDDVILGEGLYGGGVLARHAAITA
GLTQVPGLANNRHCAAGQAAVQSAAASVRAGMDQLVIAGGVNSASTSPRSRMQVDGEWVDWFPPTHPDRPDAPNMDMSIT
VGWNAAVKAGVSREEMDAWALRSHRNAIAAIDEGRFKEEIVPIDTPHGLFSVDEHPRRDTSMEKLAALKPLHPEIEGFSI
TAGNACGANDGAAVLTIASDRLGLRPLATIRSWASVGVDPAITGLAPVEAIPKALGRAGLSISDVDLFEINEAFAAMCVA
TVKLLELDPDKVNVSGSGCSLGHPVAATGARMLVTLVHELRRRGGGIGVAAMCAGGGMGSATVIEVAGE

Sequences:

>Translated_389_residues
MHLLVELEKTVAEAVIVSALRTPIGTARKGTLRDTSAFDLAHHVVSEAVKDIDPTQVDDVILGEGLYGGGVLARHAAITA
GLTQVPGLANNRHCAAGQAAVQSAAASVRAGMDQLVIAGGVNSASTSPRSRMQVDGEWVDWFPPTHPDRPDAPNMDMSIT
VGWNAAVKAGVSREEMDAWALRSHRNAIAAIDEGRFKEEIVPIDTPHGLFSVDEHPRRDTSMEKLAALKPLHPEIEGFSI
TAGNACGANDGAAVLTIASDRLGLRPLATIRSWASVGVDPAITGLAPVEAIPKALGRAGLSISDVDLFEINEAFAAMCVA
TVKLLELDPDKVNVSGSGCSLGHPVAATGARMLVTLVHELRRRGGGIGVAAMCAGGGMGSATVIEVAGE
>Mature_389_residues
MHLLVELEKTVAEAVIVSALRTPIGTARKGTLRDTSAFDLAHHVVSEAVKDIDPTQVDDVILGEGLYGGGVLARHAAITA
GLTQVPGLANNRHCAAGQAAVQSAAASVRAGMDQLVIAGGVNSASTSPRSRMQVDGEWVDWFPPTHPDRPDAPNMDMSIT
VGWNAAVKAGVSREEMDAWALRSHRNAIAAIDEGRFKEEIVPIDTPHGLFSVDEHPRRDTSMEKLAALKPLHPEIEGFSI
TAGNACGANDGAAVLTIASDRLGLRPLATIRSWASVGVDPAITGLAPVEAIPKALGRAGLSISDVDLFEINEAFAAMCVA
TVKLLELDPDKVNVSGSGCSLGHPVAATGARMLVTLVHELRRRGGGIGVAAMCAGGGMGSATVIEVAGE

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=40.6169665809769, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI4501853, Length=408, Percent_Identity=38.9705882352941, Blast_Score=225, Evalue=4e-59,
Organism=Homo sapiens, GI167614485, Length=397, Percent_Identity=38.0352644836272, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=34.2639593908629, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI4504327, Length=429, Percent_Identity=29.3706293706294, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=30.7692307692308, Blast_Score=148, Evalue=8e-36,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=42.2110552763819, Blast_Score=238, Evalue=7e-64,
Organism=Escherichia coli, GI87082165, Length=394, Percent_Identity=42.6395939086294, Blast_Score=237, Evalue=8e-64,
Organism=Escherichia coli, GI48994986, Length=392, Percent_Identity=36.9897959183673, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=38.75, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1788683, Length=408, Percent_Identity=32.5980392156863, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=394, Percent_Identity=36.2944162436548, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI25147385, Length=394, Percent_Identity=32.994923857868, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=30.3030303030303, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17551802, Length=436, Percent_Identity=29.5871559633028, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17535917, Length=386, Percent_Identity=28.2383419689119, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=33.3333333333333, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=34.7394540942928, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24655093, Length=395, Percent_Identity=40, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24640423, Length=406, Percent_Identity=34.2364532019704, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17648125, Length=402, Percent_Identity=33.8308457711443, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI17137578, Length=431, Percent_Identity=30.8584686774942, Blast_Score=144, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40359; Mature: 40359

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLLVELEKTVAEAVIVSALRTPIGTARKGTLRDTSAFDLAHHVVSEAVKDIDPTQVDDV
CCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHCCE
ILGEGLYGGGVLARHAAITAGLTQVPGLANNRHCAAGQAAVQSAAASVRAGMDQLVIAGG
EECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECC
VNSASTSPRSRMQVDGEWVDWFPPTHPDRPDAPNMDMSITVGWNAAVKAGVSREEMDAWA
CCCCCCCCCHHEEECCCEEECCCCCCCCCCCCCCCCEEEEECCCHHHHCCCCHHHHHHHH
LRSHRNAIAAIDEGRFKEEIVPIDTPHGLFSVDEHPRRDTSMEKLAALKPLHPEIEGFSI
HHHCCCEEEEECCCCCHHCCCCCCCCCCCEECCCCCCCCCHHHHHHHHCCCCCCCCCEEE
TAGNACGANDGAAVLTIASDRLGLRPLATIRSWASVGVDPAITGLAPVEAIPKALGRAGL
ECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHCCC
SISDVDLFEINEAFAAMCVATVKLLELDPDKVNVSGSGCSLGHPVAATGARMLVTLVHEL
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
RRRGGGIGVAAMCAGGGMGSATVIEVAGE
HHCCCCCEEEEEECCCCCCCEEEEEECCC
>Mature Secondary Structure
MHLLVELEKTVAEAVIVSALRTPIGTARKGTLRDTSAFDLAHHVVSEAVKDIDPTQVDDV
CCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHCCE
ILGEGLYGGGVLARHAAITAGLTQVPGLANNRHCAAGQAAVQSAAASVRAGMDQLVIAGG
EECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECC
VNSASTSPRSRMQVDGEWVDWFPPTHPDRPDAPNMDMSITVGWNAAVKAGVSREEMDAWA
CCCCCCCCCHHEEECCCEEECCCCCCCCCCCCCCCCEEEEECCCHHHHCCCCHHHHHHHH
LRSHRNAIAAIDEGRFKEEIVPIDTPHGLFSVDEHPRRDTSMEKLAALKPLHPEIEGFSI
HHHCCCEEEEECCCCCHHCCCCCCCCCCCEECCCCCCCCCHHHHHHHHCCCCCCCCCEEE
TAGNACGANDGAAVLTIASDRLGLRPLATIRSWASVGVDPAITGLAPVEAIPKALGRAGL
ECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHCCC
SISDVDLFEINEAFAAMCVATVKLLELDPDKVNVSGSGCSLGHPVAATGARMLVTLVHEL
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
RRRGGGIGVAAMCAGGGMGSATVIEVAGE
HHCCCCCEEEEEECCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]